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1. 发明公开

EP3540803A2 ORGANIC LIGHT-EMITTING DEVICE 有权
公开(公告)号：EP3540803A2
公开(公告)日：2019-09-18
申请号：EP18202929.8
申请日：2018-10-26
申请人： Samsung Display Co., Ltd.
发明人： KIM, Youngkook , KIM, Jongwoo , BAEK, Jangyeol , JEONG, Eunjae , HAN, Sanghyun , HWANG, Seokhwan
IPC分类号： H01L51/00 , H01L51/50 , C07D491/00 , C07C13/00 , C07C15/00
摘要： An organic light-emitting device including a hole transport region including two or more different hole transport compounds has a low driving voltage, a high efficiency, and an unexpectedly long life span.

2. 发明授权

EP2920191B1 METHODS FOR THE TOTAL CHEMICAL SYNTHESIS OF ENANTIOMERICALLY-PURE 7-(2'-TRIMETHYLSILYL) ETHYL CAMPTOTHECIN 有权
标题翻译：全化学合成7-（2'-三甲基甲硅烷基）乙基吗啡啉的方法
公开(公告)号：EP2920191B1
公开(公告)日：2017-07-19
申请号：EP13855448.0
申请日：2013-11-07
申请人： BIONUMERIK PHARMACEUTICALS, INC.
发明人： CHEN, Xinghai , HAUSHEER, Frederick, H. , MALAKHOV, Andrey , KOCHAT, Harry
IPC分类号： C07F17/02 , C07D471/00 , C07D491/00
CPC分类号： C07F7/10 , C07F7/0812

3. 发明公开

EP2882435A4 PHARMACEUTICAL FORMULATIONS CONTAINING 3-(4-CINNAMYL-L-PIPERAZINYL) AMINO DERIVATIVES OF 3-FORMYLRIFAMYCIN SV AND 3-FORMYLRIFAMYCIN S AND A PROCESS OF THEIR PREPARATION 有权转让
标题翻译：制药学MIT 3-（4-氰基-L-哌嗪基）氨基 - 取代-3-甲酰基 - 利福霉素-VV UND 3-甲酰基利福霉素S VERFAHREN ZU DEREN HERSTELLUNG
公开(公告)号：EP2882435A4
公开(公告)日：2017-05-03
申请号：EP13829445
申请日：2013-08-09
申请人： ADIPHARM EAD , KONSTANTINOVA ROUMIANA GUEORGUIEVA , NINOV KIRIL ASENOV , APOSTOLOVA-DIMOVA VELICHKA LLIEVA , STEFANOVA EVTIMIA IVANOVA , KOYTCHEV ROSSEN KRUMOV , DITCHEV CONSULTING OOD
发明人： KONSTANTINOVA RUMYANA GUEORGUIEVA , NINOV KIRIL ASENOV , APOSTOLOVA-DIMOVA VELICHKA LLIEVA , STEFANOVA EVTIMIA IVANOVA , KOYTCHEV ROSSEN KRUMOV
IPC分类号： A61K31/395 , A61K9/00 , A61K9/48 , A61K31/495 , A61K31/496 , A61P31/04 , A61P31/06 , C07D491/00 , C07D498/08
CPC分类号： C07D498/08 , A61K9/4866 , A61K31/496
摘要： The present invention related to a process of preparation of pharmaceutically acceptable formulations containing as active substance 3-(4-cinnamyl-1-piperazinyl)-amino derivatives of 3-formylrifamycine SV and 3-formylrifamycine S, which possess high activity against Gram-positive and Gram-negative microorganisms, as well as against tuberculous micobacteria (including atypical and rifamycin resistant), and to a method for the preparation of 3-(4-cinnamyl-1-piperazinyl)-amino derivatives of 3-formylrifamycine SV and 3-formylrifamycine S. The method for the preparation of pharmaceutical compositions is readily feasible, and does not require special equipment for its implementation. The process for preparing the compounds is characterized by high yield and purity, using an environmental clean solvent—ethanol and water in the preparation and isolation of substances, and the absence of residual organic solvents in the final product.
摘要翻译：本发明涉及含有作为活性物质的3-甲酰基利福霉素SV和3-甲酰基利福霉素S的3-（4-肉桂基-1-哌嗪基） - 氨基衍生物的药学上可接受的制剂的制备方法，其对革兰氏阳性和革兰氏阴性微生物以及抗结核微球菌（包括非典型和利福霉素抗性）的方法，以及制备3-甲酰基利福霉素SV和3-甲酰基利福霉素的3-（4-肉桂基-1-哌嗪基） - 氨基衍生物的方法，甲酰基利福霉素S.用于制备药物组合物的方法是容易实现的，并且不需要特殊的设备来实施。制备该化合物的方法的特征在于高产率和高纯度，使用环境清洁溶剂 - 乙醇和水制备和分离物质，并且在最终产物中不存在残余有机溶剂。

4. 发明授权

EP1688418B1 Chemokine receptor antagonists and methods of use thereof 有权
标题翻译：趋化因子受体拮抗剂和它们的使用方法
公开(公告)号：EP1688418B1
公开(公告)日：2017-03-15
申请号：EP06004401.3
申请日：2002-11-13
申请人： MILLENNIUM PHARMACEUTICALS, INC. , Kyowa Hakko Kirin Co., Ltd.
发明人： Luly, Jay R. , Nakasato, Yoshisuke , Ohshima, Etsuo , Harriman, Geraldine C. B. , Carson, Kenneth G. , Ghosh, Shomir , Elder, Amy M. , Mattia, Karen M.
IPC分类号： C07D491/04 , C07D497/04 , C07D223/20 , C07D313/12 , C07D337/12 , A61P1/00 , A61K31/4353 , A61K31/55 , C07D313/00 , C07D221/00 , C07D471/04 , C07D223/00 , C07D519/00 , C07D491/00 , C07D513/04 , C07D337/00 , C07D451/00
CPC分类号： C07D491/04 , C07D211/46

5. 发明公开

EP3091014A1 FLUORESCENT CELLULAR MARKERS 审中-公开
标题翻译： FLUORESZIERENDE ZELLENMARKER
公开(公告)号：EP3091014A1
公开(公告)日：2016-11-09
申请号：EP16172043.8
申请日：2010-05-27
申请人： Zayas, Beatriz , Cox, Osvaldo
发明人： Zayas, Beatriz , Cox, Osvaldo
IPC分类号： C07D471/00 , C07D491/00 , C07D513/00
CPC分类号： C07D471/04 , C07D513/04
摘要： A synthesis procedure for benzazolo[3,2-a]quinolinium chloride salts and the inclusion of amino-substituent and nitro-substituent resulting in four compounds such as NBQ-38(7-Ethyl-3-nitrobenzimidazolo[3,2-a]quinolinium Chloride), NBQ-95(2-Chloro-10-methyl-3-nitrobenzothiazolo[3,2-a] quinolinium chloride), ABQ-38 (3-amino-7-ethylbenzimidazo[3,2-a]quinolinium chloride), and ABQ-95(3-amino-2-chloro-10-methylbenzothiazolo[3,2-a]quinolinium chloride) wherein said procedures provides an increment in the compounds biological activity. The compounds are further used for intra cellular binding, cytotoxicity on malignant cells through apoptosis activation mediated by mitochondrial damage and caspases 3 and 7 activation, cellular organelles binding and damage, and a marker due to the auto-fluorescent properties.
摘要翻译：苯并唑并[3,2-a]喹啉鎓盐的合成方法，包括氨基取代基和硝基取代基，得到四种化合物如NBQ-38（7-乙基-3-硝基苯并咪唑并[3,2-a] 氯化喹啉），NBQ-95（2-氯-10-甲基-3-硝基苯并噻唑并[3,2-a]喹啉氯化物），ABQ-38（3-氨基-7-乙基苯并咪唑并[3,2-a] ）和ABQ-95（3-氨基-2-氯-10-甲基苯并噻唑并[3,2-a]喹啉氯化物），其中所述方法提供了化合物生物活性的增量。该化合物进一步用于细胞内结合，通过线粒体损伤介导的细胞凋亡和胱天蛋白酶3和7激活，细胞器结合和损伤以及由于自身荧光性质引起的标志物对恶性细胞的细胞毒性。

6. 发明公开

EP2734525A2 EMBODIMENTS OF A PROBE AND METHOD FOR TARGETING NUCLEIC ACIDS 审中-公开
标题翻译：探头和方法进行目标SIGHTING NUCLEIC具体实施方式
公开(公告)号：EP2734525A2
公开(公告)日：2014-05-28
申请号：EP12814839.2
申请日：2012-07-19
申请人： University Of Idaho
发明人： HRDLICKA, Patrick, J.
IPC分类号： C07D491/00 , C07F9/02 , C07D471/04
CPC分类号： C12Q1/6876 , C07H19/06 , C07H21/00 , C12Q1/6879 , C12Q1/6886 , C12Q1/689 , Y10T436/143333
摘要： Disclosed embodiments concern a probe comprising one or more pairs of monomers capable of targeting a nucleic acid target. The pair of monomers may be arranged in a manner that promotes thermoinstability of the probe complex, thus producing a probe capable of locating and/or detecting a target. The probe also may comprise one or more natural or non-natural nucleotides capable of Watson-Crick base pairing with an isosequential nucleic acid target. Particular disclosed embodiments concern a method of using the disclosed probe to target nucleic acids. In particular disclosed embodiments, the probe may be incubated with a target nucleic acid and then be detected.

7. 发明公开

EP2675868A1 VERBINDUNGEN FÜR ELEKTRONISCHE VORRICHTUNGEN 有权
标题翻译： CONNECTIONS于电子设备
公开(公告)号：EP2675868A1
公开(公告)日：2013-12-25
申请号：EP12701829.9
申请日：2012-01-18
申请人： Merck Patent GmbH
发明人： MARTYNOVA, Irina , PARHAM, Amir, Hossain , PFLUMM, Christof
IPC分类号： C09K11/06 , C07D491/00 , H01L51/00 , H01L51/50 , H05B33/20
CPC分类号： H01L51/0072 , C07D471/22 , C07D487/04 , C07D487/14 , C07D491/14 , C07D495/14 , C07D498/14 , C07D513/14 , C07D519/00 , C07F9/6561 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1033 , C09K2211/1037 , C09K2211/1044 , C09K2211/1059 , C09K2211/1088 , C09K2211/1092 , H01L51/0035 , H01L51/0036 , H01L51/006 , H01L51/0067 , H01L51/0071 , H01L51/0073 , H01L51/0074 , H01L51/0077 , H01L51/0508 , H01L51/42 , H01L51/5012 , H01L51/5056 , H01L51/5072 , H01L51/5096 , H05B33/14 , Y02E10/549
摘要： The invention relates to a compound of formula (I), (II) or (III), to the use of said compound in an electronic device, and to an electronic device containing one or more compounds of formula (I), (II) or (III). The invention further relates to a method for producing a compound of formula (I), (II) or (III), and to a formulation containing one or more compounds of formula (I), (II) or (III).

8. 发明公开

EP2376080A4 SYNTHESIS OF CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS AND INTERMEDIATES 有权转让
标题翻译：合成CARBAMOYLPYRIDON-HIV整合酶抑制剂及中间体
公开(公告)号：EP2376080A4
公开(公告)日：2012-07-11
申请号：EP09832226
申请日：2009-12-08
申请人： SHIONOGI & CO , GLAXOSMITHKLINE LLC
发明人： YOSHIDA HIROSHI , TAODA YOSHIYUKI , JOHNS BRIAN ALVIN , KAWASUJI TAKASHI , NAGAMATSU DAIKI
IPC分类号： A61K31/4412 , A61K31/351 , C07D471/00 , C07D491/00 , C07D498/00
CPC分类号： C07D498/14 , A61K31/351 , A61K31/4412 , C07D213/803 , C07D213/81 , C07D471/22 , C07D487/22 , Y02P20/55

9. 发明授权

EP1913002B9 METHOD OF ACYLATING MAYTANSINOL WITH CHIRAL AMINO ACIDS 有权
标题翻译：与手性氨基酰化方法美登木
公开(公告)号：EP1913002B9
公开(公告)日：2012-04-25
申请号：EP06800952.1
申请日：2006-08-08
申请人： MILLENNIUM PHARMACEUTICALS, INC.
发明人： HO, Guojie , CARROZZELLA, Darren, J.
IPC分类号： C07D491/00
CPC分类号： C07D498/18 , C07D471/04
摘要： This invention provides a method for making maytansinoids having a chiral amino acid side chain, such as DM1 and DM4 that are used to treat cancer. According to this method, the side chain may be added with little epimerization of the amino acid chiral center.

10. 发明授权

EP1913002B1 METHOD OF ACYLATING MAYTANSINOL WITH CHIRAL AMINO ACIDS 有权
标题翻译：与手性氨基酰化方法美登木
公开(公告)号：EP1913002B1
公开(公告)日：2011-11-30
申请号：EP06800952.1
申请日：2006-08-08
申请人： MILLENNIUM PHARMACEUTICALS, INC.
发明人： HO, Guojie , CARROZZELLA, Darren, J.
IPC分类号： C07D491/00
CPC分类号： C07D498/18 , C07D471/04
摘要： This invention provides a method for making maytansinoids having a chiral amino acid side chain, such as DM1 and DM4 that are used to treat cancer. According to this method, the side chain may be added with little epimerization of the amino acid chiral center.

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