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1. 发明公开

EP3091014A1 FLUORESCENT CELLULAR MARKERS 审中-公开
标题翻译： FLUORESZIERENDE ZELLENMARKER
公开(公告)号：EP3091014A1
公开(公告)日：2016-11-09
申请号：EP16172043.8
申请日：2010-05-27
申请人： Zayas, Beatriz , Cox, Osvaldo
发明人： Zayas, Beatriz , Cox, Osvaldo
IPC分类号： C07D471/00 , C07D491/00 , C07D513/00
CPC分类号： C07D471/04 , C07D513/04
摘要： A synthesis procedure for benzazolo[3,2-a]quinolinium chloride salts and the inclusion of amino-substituent and nitro-substituent resulting in four compounds such as NBQ-38(7-Ethyl-3-nitrobenzimidazolo[3,2-a]quinolinium Chloride), NBQ-95(2-Chloro-10-methyl-3-nitrobenzothiazolo[3,2-a] quinolinium chloride), ABQ-38 (3-amino-7-ethylbenzimidazo[3,2-a]quinolinium chloride), and ABQ-95(3-amino-2-chloro-10-methylbenzothiazolo[3,2-a]quinolinium chloride) wherein said procedures provides an increment in the compounds biological activity. The compounds are further used for intra cellular binding, cytotoxicity on malignant cells through apoptosis activation mediated by mitochondrial damage and caspases 3 and 7 activation, cellular organelles binding and damage, and a marker due to the auto-fluorescent properties.
摘要翻译：苯并唑并[3,2-a]喹啉鎓盐的合成方法，包括氨基取代基和硝基取代基，得到四种化合物如NBQ-38（7-乙基-3-硝基苯并咪唑并[3,2-a] 氯化喹啉），NBQ-95（2-氯-10-甲基-3-硝基苯并噻唑并[3,2-a]喹啉氯化物），ABQ-38（3-氨基-7-乙基苯并咪唑并[3,2-a] ）和ABQ-95（3-氨基-2-氯-10-甲基苯并噻唑并[3,2-a]喹啉氯化物），其中所述方法提供了化合物生物活性的增量。该化合物进一步用于细胞内结合，通过线粒体损伤介导的细胞凋亡和胱天蛋白酶3和7激活，细胞器结合和损伤以及由于自身荧光性质引起的标志物对恶性细胞的细胞毒性。

2. 发明公开

EP2825040A1 METHOD FOR PRODUCING BENZAZOLOQUINOLIUM (BQS) SALTS, USING THE COMPOSITION AS CELLULAR MARKERS, AND USING THE BIOLOGICAL ACTIVITY OF THE COMPOSITION. 审中-公开
标题翻译：用于生产BENZAZOLOQUINOLIUM（BQS）盐，组合物的使用蜂窝标记，这种组合物的生物活性的用途
公开(公告)号：EP2825040A1
公开(公告)日：2015-01-21
申请号：EP12842482.7
申请日：2012-10-19
申请人： Zayas, Beatriz , Cox, Osvaldo
发明人： Zayas, Beatriz , Cox, Osvaldo
IPC分类号： A01N43/42
CPC分类号： C07D471/04 , C07D513/04
摘要： A synthesis procedure for benzazolo[3,2-a]quinolinium chloride salts and the inclusion of chloro-substituent, amino-substituent, and nitro-substituent resulting in several compounds wherein said procedures provides an increment in the compounds biological activity. The compounds are further used for intra cellular binding, cytotoxicity on malignant cells through apoptosis activation mediated by mitochondrial damage, cellular organelles binding and damage, DNA fragmentation, marker of bacterial growth, antibacterial activity, cell cycle disruption, and a marker due to the auto-fluorescent properties.

3. 发明公开

EP2414355A4 FLUORESCENT CELLULAR MARKERS 审中-公开
标题翻译：荧光细胞标记物
公开(公告)号：EP2414355A4
公开(公告)日：2012-11-21
申请号：EP10778536
申请日：2010-05-27
申请人： ZAYAS BEATRIZ , COX OSVALDO
发明人： ZAYAS BEATRIZ , COX OSVALDO
IPC分类号： C07D471/00 , C07D491/00 , C07D513/00
CPC分类号： C07D471/04 , C07D513/04

4. 发明公开

EP2414355A2 FLUORESCENT CELLULAR MARKERS 审中-公开
标题翻译：荧光细胞标记物
公开(公告)号：EP2414355A2
公开(公告)日：2012-02-08
申请号：EP10778536.2
申请日：2010-05-27
申请人： Zayas, Beatriz , Cox, Osvaldo
发明人： Zayas, Beatriz , Cox, Osvaldo
IPC分类号： C07D471/00 , C07D491/00 , C07D513/00
CPC分类号： C07D471/04 , C07D513/04
摘要： A synthesis procedure for benzazolo[3,2-a]quinolinium chloride salts and the inclusion of amino-substituent and nitro-substituent resulting in four compounds such as NBQ-38(7-Ethyl-3-nitrobenzimidazolo[3,2-a]quinolinium Chloride), NBQ-95(2-Chloro-10-methyl-3-nitrobenzothiazolo[3,2-a] quinolinium chloride), ABQ-38 (3-amino-7-ethylbenzimidazo[3,2-a]quinolinium chloride), and ABQ-95(3-amino-2-chloro-10-methylbenzothiazolo[3,2-a]quinolinium chloride) wherein said procedures provides an increment in the compounds biological activity. The compounds are further used for intra cellular binding, cytotoxicity on malignant cells through apoptosis activation mediated by mitochondrial damage and caspases 3 and 7 activation, cellular organelles binding and damage, and a marker due to the auto-fluorescent properties.

5. 发明公开

EP2825040A4 METHOD FOR PRODUCING BENZAZOLOQUINOLIUM (BQS) SALTS, USING THE COMPOSITION AS CELLULAR MARKERS, AND USING THE BIOLOGICAL ACTIVITY OF THE COMPOSITION. 审中-公开
标题翻译：用于生产BENZAZOLOQUINOLIUM（BQS）盐，组合物的使用蜂窝标记，这种组合物的生物活性的用途
公开(公告)号：EP2825040A4
公开(公告)日：2016-03-16
申请号：EP12842482
申请日：2012-10-19
申请人： ZAYAS BEATRIZ , COX OSVALDO
发明人： ZAYAS BEATRIZ , COX OSVALDO
IPC分类号： A01N43/42 , C07D471/04 , C07D513/04
CPC分类号： C07D471/04 , C07D513/04

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