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1. 发明授权

EP3522713B1 FLUORESCENT DETECTION OF AMINES AND HYDRAZINES AND ASSAYING METHODS THEREOF 有权
公开(公告)号：EP3522713B1
公开(公告)日：2022-11-30
申请号：EP17858974.3
申请日：2017-10-02
发明人： ASADI, Ali , LI, Jian-Sen
IPC分类号： A01N43/707 , C07D251/42 , G07C3/14 , G01N31/22 , C09K11/06 , C07D209/62 , C07D471/04 , C07D237/26

2. 发明公开

EP3789379A1 4-PHENYLBENZO[G]QUINAZOLINE OR 4-(3,5-DIMETHYLPHENYLBENZO[G]QUINAZOLINE IRIDIUM COMPLEXES FOR USE AS NEAR-INFRARED OR INFRARED EMITTING MATERIALS IN OLEDS 审中-实审转让
公开(公告)号：EP3789379A1
公开(公告)日：2021-03-10
申请号：EP20201935.2
申请日：2017-11-07
申请人： Universal Display Corporation
发明人： BOUDREAULT, Pierre-Luc T. , ALLEYNE, Bert
IPC分类号： C07D239/78 , C07D239/70 , C07D251/42 , C07D209/82 , C09B57/00 , C07F15/00 , C09K11/06 , G09F9/30 , H01L51/00 , H01L51/50 , H01L51/54 , H01L27/32 , H05B33/12 , H05B33/14
摘要： This present invention includes novel ligands for metal complexes, which include three fused cycles or heterocycles. The first ring may be either a pyridine or a pyrimidine ring, which coordinates with the iridium metal. The second ring may be a six-membered ring, which may or may not contain nitrogen atoms. The third ring may be either a five or six membered ring. The combination of these aromatic rings provides near infrared or infrared emission in PHOLEDs devices. The bottom ring of the ligand is an alkylated cycle or heterocycle which provides a good efficiency and emission line shape.

3. 发明公开

EP3522713A1 FLUORESCENT DETECTION OF AMINES AND HYDRAZINES AND ASSAYING METHODS THEREOF 有权
公开(公告)号：EP3522713A1
公开(公告)日：2019-08-14
申请号：EP17858974.3
申请日：2017-10-02
申请人： Illumina, Inc.
发明人： ASADI, Ali , LI, Jian-Sen
IPC分类号： A01N43/707 , C07D251/42 , G07C3/14

4. 发明授权

EP2791120B1 1,3,5 -TRIAZINE-2-AMINE DERIVATIVES, PREPARATION THEREOF AND DIAGNOSTIC AND THERAPEUTIC USE THEREOF 有权
标题翻译： 1,3,5-三嗪2阿明衍生物，生产以及诊断和治疗用途
公开(公告)号：EP2791120B1
公开(公告)日：2016-02-24
申请号：EP12798331.0
申请日：2012-12-11
申请人： SANOFI
发明人： ARNAUD, Joëlle , ARTIAGA, Martine , BARTH, Francis , HORTALA, Laurent , MARTINEZ, Serge , ROUX, Pascale
IPC分类号： C07D251/16 , C07D251/42 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , A61K31/53 , A61P3/00 , A61P9/00 , A61P25/28 , A61P1/00 , A61P35/00 , A61P37/00
CPC分类号： C07D413/04 , C07B2200/05 , C07D251/16 , C07D251/42 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04

5. 发明公开

EP2912023A1 IMINOXYTRIAZINES AS RADICAL GENERATORS 有权
标题翻译：作为基础生成物的亚胺基三嗪
公开(公告)号：EP2912023A1
公开(公告)日：2015-09-02
申请号：EP13779846.8
申请日：2013-10-22
申请人： BASF SE
发明人： NESVADBA, Peter , BUGNON FOLGER, Lucienne , CARROY, Antoine , FALLER, Marc
IPC分类号： C07D251/30 , C07D251/42 , C07D403/14
CPC分类号： C09J133/14 , C07D251/30 , C07D251/42 , C07D403/14 , C09D11/107
摘要： Iminoxytriazine compounds of the formula (I), wherein n is 1 or 2; R
1 and R
2 independently of each other are hydrogen, NH
2 , NHR
5 , NR
5 R
6 , COR
5 , COOR
5 , CONH
2 , CONHR
5 , CONR
5 R
6 , CN, SR
5 , OR
5 , C
1 -C
18 alkyl, C
3 -C
12 cycloalkyl, C
6 -C
14 aryl or C
2 -C
14 heteroaryl, wherein said C
3 -C
12 cycloalkyl, C
6 -C
14 aryl or C
2 -C
14 heteroaryl is unsubstituted or substituted by one or more radicals selected from the group consisting of C
1 -C
12 alkyl, C
3 -C
12 -cycloalkyl, phenyl, halogen and C
1 -C
12 alkoxy, or R
1 and R
2 together with the C atom to which they are linked form a 4 to 12 membered carbocyclic or heterocyclic saturated or unsaturated ring which is unsubstituted or substituted by one or more radicals selected from the group consisting of C
1 -C
12 alkyl, C
3 -C
12 -cycloalkyl, phenyl, halogen and C
1 -C
12 alkoxy; R
3 is F, Cl, OH, OR, SH, SR
5 , NH
2 , NHR
5 , NR
5 R
6 or R
1 R
2 C=N-O-; wherein R
1 and R
2 in all groups R
1 R
2 C=N-O- in the compound of the formula I are identical or different; if n is 1, R
4 is F, Cl, OH, OR
5 , SH, SR
5 , NH
2 , NHR
5 , NR
5 R
6 or R
1 R
2 C=N-O-; wherein R
1 and R
2 in all groups R
1 R
2 C=N-O- in the compound of the formula I are identical or different; if n is 2, R
4 is a difunctional group derived from a diol, diamine, aminoalcohol or mercaptoalcohol; R
5 and R
6 independently of each other are C
1 -C
18 alkyl, C
3 -C
12 cycloalkyl, C
6 -C
14 aryl or C
2 -C
14 heteroaryl; are suitable as radical generating agents.
摘要翻译：式（I）的氨基氧基三嗪化合物，其中n是1或2; R 1和R 2彼此独立地为氢，NH 2，NHR 5，NR 5 R 6，COR 5，COOR 5，CONH 2，CONHR 5，CONR 5R 6，CN，SR 5，OR 5，C 1 -C 18烷基，C 3 -C 12环烷基，C 6 -C 14芳基或C 2 -C 14杂芳基，其中所述C 3 -C 12环烷基，C 6 -C 14芳基或C 2 -C 14杂芳基未被取代或被一个或多个选自C 1 -C 12烷基，C 3 -C 12环烷基，苯基，卤素和C 1 -C 12烷氧基的基团，或者R 1和R 2与它们连接的C原子一起形成4 至12元碳环或杂环饱和或不饱和环，其未被取代或被一个或多个选自C 1 -C 12烷基，C 3 -C 12环烷基，苯基，卤素和C 1 -C 12烷氧基 ; R 3是F，Cl，OH，OR，SH，SR 5，NH 2，NHR 5，NR 5 R 6或R 1 R 2C = N-O-; 其中式I化合物中所有基团R 1 R 2 C = N-O-中的R 1和R 2相同或不同; 如果n为1，则R 4为F，Cl，OH，OR 5，SH，SR 5，NH 2，NHR 5，NR 5 R 6或R 1R 2C = N-O-; 其中式I化合物中所有基团R 1 R 2 C = N-O-中的R 1和R 2相同或不同; 如果n是2，则R 4是衍生自二醇，二胺，氨基醇或巯基醇的双官能团; R 5和R 6彼此独立地为C 1 -C 18烷基，C 3 -C 12环烷基，C 6 -C 14芳基或C 2 -C 14杂芳基; 适合作为自由基生成剂。

6. 发明授权

EP1170290B1 Compounds having ultra-violet absorption properties 失效
标题翻译：具有紫外吸收特性的化合物
公开(公告)号：EP1170290B1
公开(公告)日：2006-06-07
申请号：EP01123273.3
申请日：1995-06-12
申请人： Ciba Specialty Chemicals Holding Inc.
发明人： Bacher, Jean-Pierre , Kaufmann, Werner , Reinehr, Dieter
IPC分类号： C07D251/24 , D06M13/00 , C07D405/12 , C07D251/70 , C07D251/44 , C07D251/50 , C07D403/12 , C07D403/14 , C07D251/42
CPC分类号： C07D403/12 , C07C235/20 , C07D249/20 , C07D251/24 , C07D251/42 , C07D251/44 , C07D251/50 , C07D251/70 , C07D403/14 , C07D405/12 , D06M13/12 , D06M13/352 , D06M13/358 , D06M2200/25 , D06P1/6426 , D06P1/65112 , Y10T442/2762

7. 发明公开

EP1170290A3 Compounds having ultra-violet absorption properties 失效
标题翻译：具有UV吸收性能的化合物
公开(公告)号：EP1170290A3
公开(公告)日：2003-11-05
申请号：EP01123273.3
申请日：1995-06-12
申请人： Ciba Specialty Chemicals Holding Inc.
发明人： Bacher, Jean-Pierre , Kaufmann, Werner , Reinehr, Dieter
IPC分类号： C07D251/24 , D06M13/00 , C07D405/12 , C07D251/70 , C07D251/44 , C07D251/50 , C07D403/12 , C07D403/14 , C07D251/42
CPC分类号： C07D403/12 , C07C235/20 , C07D249/20 , C07D251/24 , C07D251/42 , C07D251/44 , C07D251/50 , C07D251/70 , C07D403/14 , C07D405/12 , D06M13/12 , D06M13/352 , D06M13/358 , D06M2200/25 , D06P1/6426 , D06P1/65112 , Y10T442/2762
摘要： The present invention relates to new compounds which are useful as ultraviolet absorbing agents (UVAs) and to a method of improving the sun protection factor (SPF) of textile fibre material treated with the new compounds.

8. 发明授权

EP0975584B1 SYNTHESIS AND USE OF ALPHA-KETOAMIDE DERIVATIVES AND ARRAYS 失效
标题翻译：生产和使用ALPHA酮酰胺衍生物和ANORDNUNGE的
公开(公告)号：EP0975584B1
公开(公告)日：2002-09-25
申请号：EP98918344.7
申请日：1998-04-16
申请人： ARQULE, INC.
发明人： BALDINO, Carmen, M. , COFFEN, David, L. , CHIPMAN, Stewart, D. , CHENG, Hong
IPC分类号： C07C235/78 , C07D333/60 , C07D263/42 , C07D251/42 , A61K31/38 , A61K31/42 , A61K31/17 , C07C335/20
CPC分类号： C07D333/68 , C07C335/20 , C40B40/00

9. 发明公开

EP1132387A1 PYRIMIDINYLBENZIMIDAZOLE AND TRIAZINYLBENZIMIDAZOLE DERIVATIVES AND AGRICULTURA/HORTICULTURAL BACTERICIDES 有权
标题翻译：嘧啶基苯并咪唑和三氮烯基苯并咪唑衍生物与农业/园艺杀菌剂
公开(公告)号：EP1132387A1
公开(公告)日：2001-09-12
申请号：EP99972212.7
申请日：1999-11-15
申请人： KUMIAI CHEMICAL INDUSTRY CO., LTD. , IHARA CHEMICAL INDUSTRY CO., LTD.
发明人： SHIBATA, Masaru K.I Chemical Res. Inst. Co., Ltd. , KAWAI, Kiyoshi K.I Chemical Res. Inst. Co., Ltd. , MAKIHARA, Takechi K.I Chemical Res. Inst. Co., Ltd , YONEKURA, Norihisa K.I Chemi. Res. Inst. Co., Ltd. , KAWASHIMA, Takahiro , SAKAI, Junetsu , MURAMATSU, Norimichi
IPC分类号： C07D403/04 , C07D239/46 , C07D251/42 , C07D251/44 , C07D251/46 , A01N43/52 , A01N43/66
CPC分类号： C07D403/04 , A01N43/54 , A01N43/66
摘要： A pyrimidinylbenzimidazole or triazinylbenzimidazole derivative represented by the general formula [I]:
(wherein A is N or CR 3 , each of R 1 and R 2 which are independent of each other, is a hydrogen atom, a halogen atom, a (C 1 -C 6 ) alkyl group, a (C 2 -C 6 ) alkenyl group, a (C 2 -C 6 ) alkynyl group, a (C 3 -C 6 ) cycloalkyl group, a (C 1 -C 4 ) haloalkyl group, a (C 1 -C 6 ) alkoxy group, a (C 2 -C 6 ) alkenyloxy group, a (C 2 -C 6 ) alkynyloxy group, a (C 3 -C 6 ) cycloalkoxy group, a (C 1 -C 4 ) haloalkoxy group, a cyano (C 1 -C 4 ) alkyloxy group, a (C 1 -C 4 ) alkoxy (C 1 -C 4 ) alkyloxy group, a (C 3 -C 6 ) cycloalkyl (C 1 -C 4 ) alkoxy group, a benzyloxy group [said group may be substituted by a halogen atom, a (C 1 -C 4 ) alkyl group or a (C 1 -C 4 ) alkoxy group], a (C 1 -C 6 ) alkylthio group, a (C 1 -C 4 ) alkoxy (C 1 -C 4 ) alkyl group, a phenoxy group [said group may be substituted by a halogen atom, a (C 1 -C 4 ) alkyl group or a (C 1 -C 4 ) alkoxy group], a (C 1 -C 4 ) alkylcarbonyl group, a formyl group, a phenyl group, a di(C 1 -C 4 ) alkylamino group, a cyano group or a (C 1 -C 6 ) alkylsulfonyl group, R 3 is a hydrogen atom, a (C 1 -C 6 ) alkyl group, a (C 1 -C 6 ) alkoxy group or a halogen atom, X is a hydrogen atom, a halogen atom, a nitro group, a cyano group, a (C 1 -C 6 ) alkyl group, a (C 2 -C 6 ) alkenyl group, a (C 2 -C 6 ) alkynyl group, a (C 3 -C 6 ) cycloalkyl group, a benzyl group [said group may be substituted by a halogen atom, a (C 1 -C 4 ) alkyl group or a (C 1 -C 4 ) alkoxy group], a (C 1 -C 6 ) alkoxy group, a (C 2 -C 6 ) alkenyloxy group, a (C 2 -C 6 ) alkynyloxy group, a (C 1 -C 6 ) alkylthio group, a (C 1 -C 6 ) alkylsulfonyl group, a phenoxy group, a (C 1 -C 4 ) alkoxy (C 1 -C 4 ) alkyl group, a (C 1 -C 4 ) haloalkyl group, a (C 1 -C 4 ) haloalkoxy group, a (C 1 -C 4 ) alkylcarbonyl group, a (C 1 -C 4 ) alkoxycarbonyl group, an amino group, a mono(C 1 -C 4 ) alkylamino group, a di(C 1 -C 4 ) alkylamino group, an anilino group or a phenyl group [said group may be substituted by a halogen atom, a (C 1 -C 4 ) alkyl group or a (C 1 -C 4 ) alkoxy group], Y is a halogen atom, a nitro group, a cyano group, a (C 1 -C 6 ) alkyl group, a (C 2 -C 6 ) alkenyl group, a (C 2 -C 6 ) alkynyl group, a (C 1 -C 6 ) alkoxy group, a (C 2 -C 6 ) alkenyloxy group, a (C 2 -C 6 ) alkynyloxy group, a (C 1 -C 4 ) haloalkoxy group, a (C 1 -C 6 ) alkylthio group, a (C 1 -C 4 ) alkoxy (C 1 -C 4 ) alkyl group, a (C 1 -C 4 ) haloalkyl group, a (C 1 -C 4 ) alkylcarbonyl group, a (C 1 -C 4 ) alkoxycarbonyl group, a benzoyl group, an amino group, a mono(C 1 -C 4 ) alkylamino group, a di(C 1 -C 4 ) alkylamino group, a phenyl group [said group may be substituted by a halogen atom, a (C 1 -C 4 ) alkyl group or a (C 1 -C 4 ) alkoxy group] or a phenoxy group [said group may be substituted by a halogen atom, a (C 1 -C 4 ) alkyl group or a (C 1 -C 4 ) alkoxy group], and n is 0 or an integer of from 1 to 3}.
摘要翻译：由通式[I]表示的嘧啶基苯并咪唑或三嗪基苯并咪唑衍生物：（其中A是N或CR 3，R 1和R 2各自独立地是氢原子，卤原子，（C 1 -C 6）烷基（C 2 -C 6）烯基，（C 2 -C 6）炔基，（C 3 -C 6）环烷基，（C 1 -C 4）卤代烷基，（C 1 -C 6）烷氧基，（C 3 -C 6）环烷氧基，（C 1 -C 4）卤代烷氧基，氰基（C 1 -C 4）烷氧基，（C 1 -C 4）烷氧基（C 1 -C 4）烷氧基，（C 3 -C 6）环烷基（C 1 -C 4）烷氧基，苄氧基[所述基团可以被卤素原子，（C 1 -C 4）烷基或（C 1 -C 4）烷硫基，（C 1 -C 4）烷氧基（C 1 -C 4）烷基，苯氧基[所述基团可以被卤素原子，（C 1 -C 4）烷基或（C 1 -C 4）烷氧基]，（C 1 -C 4）烷基羰基，甲酰基，苯基，二（C 1 -C 4）烷基氨基，氰基或（C1-C6）烷基磺酰基，R3是氢原子，（C1-C6）烷基，（C1-C6）烷氧基或卤素原子，X是氢原子，卤原子，硝基，氰基，（C 1 -C 6）烷基，（C 2 -C 6）烯基，（C 2 -C 6）炔基，（C 3 -C 6）环烷基，苄基[所述（C 1 -C 4）烷基或（C 1 -C 4）烷氧基取代），（C 1 -C 6）烷氧基，（C 2 -C 6）烯氧基，（C 2 -C 6）（C 1 -C 4）烷硫基，（C 1 -C 6）烷基磺酰基，苯氧基，（C 1 -C 4）烷氧基（C 1 -C 4）烷基，（C 1 -C 4）卤代烷基（C 1 -C 4）烷基氨基，（C 1 -C 4）烷基氨基，（C 1 -C 4）烷氧基羰基，（C 1 -C 4）烷基氨基，基团，苯胺基或苯基[所述基团可以被卤素原子，（C1-C4）烷基或（C1-C4）烷氧基取代]，Y是卤素原子，硝基，氰基，a（C，（C 2 -C 6）烯基，（C 2 -C 6）炔基，（C 1 -C 6）烷氧基，（C 2 -C 6）烯氧基，（C1-C4）卤烷氧基，（C1-C6）烷硫基，（C1-C4）烷氧基（C1-C4）烷基，（C1-C4）卤代烷基，烷基羰基，（C1-C4）烷氧基羰基，苯甲酰基，氨基，单（C1-C4）烷基氨基，二（C1-C4）烷基氨基，苯基[所述基团可以被（C 1 -C 4）烷基或（C 1 -C 4）烷氧基取代或未被取代的苯基，所述基团可被卤素原子，（C 1 -C 4）烷基或（C 1 -C 4） C4）烷氧基]，并且n是0或1至3的整数}。

10. 发明公开

EP1066269A1 TRISUBSTITUTED 1,3,5-TRIAZINE DERIVATIVES FOR TREATMENT OF HIV INFECTIONS 有权
标题翻译：三取代1,3,5-三嗪衍生物为HIV感染治疗
公开(公告)号：EP1066269A1
公开(公告)日：2001-01-10
申请号：EP99917863.5
申请日：1999-03-24
申请人： JANSSEN PHARMACEUTICA N.V.
发明人： DAEYAERT, Frederik, Frans, Desiré , DE CORTE, Bart , DE JONGE, Marc, René , HEERES, Jan , HO, Chih, Yung , JANSSEN, Paul, Adriaan, Jan , KAVASH, Robert, W. , KOYMANS, Lucien, Maria, Henricus , KUKLA, Michael, Joseph , LUDOVICI, Donald, William
IPC分类号： C07D251/70 , C07D251/52 , A61K31/53 , C07D403/12 , C07D251/42 , C07D251/50 , C07D251/66
CPC分类号： C07D251/42 , C07D251/50 , C07D251/52 , C07D251/66 , C07D251/70 , C07D403/12
摘要： This invention concerns the use of the compounds of formula (I) the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR4 or N; n is 0, 1, 2, 3 or 4; R?1 and R2¿ are each independently selected from hydrogen, hydroxy, C¿1-12?alkyl, C1-12alkyloxy, C1-12alkylcarbonyl, C1-12alkyloxycarbonyl, aryl, amino, mono- or di(C1-12alkyl)amino, mono- or di(C1-12alkyl)aminocarbonyl wherein each of the aforementioned C1-12alkyl groups may optionally and each individually be substituted; or R?1 and R2¿ taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C¿1-12?alkyl)aminoC1-4alkylidene; R?3¿ is hydrogen, aryl, C¿1-6?alkylcarbonyl, optionally substituted C1-6alkyl; and each R?4¿ independently is hydroxy, halo, C¿1-6?alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; L is -X-R?5¿ or -X-Alk-R6; wherein R?5 and R6¿ each independently are indanyl, indolyl or phenyl; each of said indanyl, indolyl or phenyl may be substituted; and X is -NR3-, -NH-NH-, -N=N-, -O-, -S-, -S(=O)- or -S(=O)¿2?-; aryl is optionally substituted phenyl; Het is an optionally substituted aliphatic or aromatic heterocyclic radical; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection. It further relates to new compounds being a subgroup of the compounds of formula (I), their preparation and pharmaceutical compositions comprising them.

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