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1. 发明公开

EP4337196A1 COCRYSTALLINE FORMS OF A BRUTON'S TYROSINE KINASE INHIBITOR 审中-实审
公开(公告)号：EP4337196A1
公开(公告)日：2024-03-20
申请号：EP22729864.3
申请日：2022-05-11
申请人： Loxo Oncology, Inc.
发明人： COATES, David Andrew , HILDEN, Lori Raquel
IPC分类号： A61K31/415 , C07D231/38 , C07C55/14 , C07C61/06

2. 发明公开

EP4296255A1 METHOD FOR CO-PRODUCING ADIPIC ACID AND CYCLOHEXANONE OXIME FROM CYCLOHEXANE 审中-实审
公开(公告)号：EP4296255A1
公开(公告)日：2023-12-27
申请号：EP21926342.3
申请日：2021-11-15
申请人： Xiangtan University
发明人： LUO, He'an , YOU, Kuiyi , JIAN, Jian , LIU, Pingle , NI, Wenjin , AI, Qiuhong
IPC分类号： C07C51/27 , C07C249/10 , C07C55/14 , C07C251/44
摘要： A method for producing adipic acid and cyclohexanone oxime from cyclohexane is provided. Cyclohexane and NO x undergo oxidation-nitration reaction to produce a mixture of adipic acid, nitrocyclohexane, nitrogen oxides and by-product A, from which adipic acid and nitrocyclohexane are separated. The nitrocyclohexane is catalytically hydrogenated with hydrogen to produce cyclohexanone oxime and a small amount of cyclohexylamine, where cyclohexanone oxime is collected, and the cyclohexylamine is partially oxidized with molecular oxygen to obtain cyclohexanone oxime and by-product B. Without separation, or after removing part or all of water from the reaction mixture, under the action of a catalyst, the reaction mixture undergoes hydrogenation and amination simultaneously or sequentially, or the hydrogenation alone, and separation to give cyclohexanone oxime.

3. 发明公开

EP3782976A1 SUSTAINABLE PROCESS FOR PRODUCING MUCONIC, HEXENEDIOIC AND ADIPIC ACID (AND THEIR ESTERS) FROM ALDARIC ACIDS BY HETEROGENEOUS CATALYSIS 有权
公开(公告)号：EP3782976A1
公开(公告)日：2021-02-24
申请号：EP19192802.7
申请日：2019-08-21
申请人： Kemijski Institut
发明人： HOCEVAR, Brigita , LIKOZAR, Blaz , GRILC, Miha
IPC分类号： C07C67/08 , C07C69/593 , C07C69/602 , C07C69/44 , C07C51/377 , C07C55/14
摘要： The present invention relates to the use of a heterogeneous Re catalyst for the conversion of biobased aldaric acids to muconic, hexenedioic acid, adipic acid and their esters in a batch stirred slurry reactor or continuous fixed-bed reactor. The process comprises conversion of aldaric acid (preferably mucic or glucaric acid) into muconic, hexenedioic or adipic acid and their esters. Aldaric acid in the concentration range of 0.01 - 50 wt% (with regards to the total mass of the liquid phase) is dissolved in the short chain primary or secondary alcohol (e.g. methanol) and a Re-based solid catalyst (0.1 - 400 wt% based on the mass of aldaric acid) is added to the reaction mixture, which is proceeded at the temperature within 80 - 250 °C under inert (N 2 ) or hydrogen atmosphere for 1 - 340 h to yield esters of muconic, hexenedioic acid, adipic acid. Further hydrolysis of ester converts products into their free carboxylic acid form.

4. 发明授权

EP2858748B1 PROCESS FOR PRODUCTION OF ADIPIC ACID FROM 1,6-HEXANEDIOL 无效转让
标题翻译：由1,6-己二醇生产己二酸的方法
公开(公告)号：EP2858748B1
公开(公告)日：2018-04-11
申请号：EP13730095.0
申请日：2013-06-11
申请人： Rennovia Inc.
发明人： DIAS, Eric, L. , MURPHY, Vincent, J. , SHOEMAKER, James, A.W.
IPC分类号： B01J23/42 , B01J23/44 , B01J23/52 , C07C51/235 , C07C55/14 , B01J21/06 , B01J35/10
CPC分类号： C07C51/235 , B01J21/066 , B01J23/42 , B01J23/44 , B01J23/52 , B01J23/6527 , B01J23/687 , B01J35/0006 , B01J35/1014 , B01J35/1019 , B01J35/1061 , B01J35/1066 , C07C55/14
摘要： Processes are disclosed for the conversion of 1,6-hexanediol to adipic acid employing a chemocatalytic reaction in which 1,6-hexanediol is reacted with oxygen in the presence of particular heterogeneous catalysts including at least one of platinum or gold. The metals are preferably provided on a support selected from the group of titania, stabilized titania, zirconia, stabilized zirconia, silica or mixtures thereof, most preferably zirconia stabilized with tungsten. The reaction with oxygen is carried out at a temperature from about 100° C. to about 300° C. and at a partial pressure of oxygen from about 50 psig to about 2000 psig.

5. 发明授权

EP2733136B1 CYCLOHEXANOL, METHOD FOR PRODUCING CYCLOHEXANOL, AND METHOD FOR PRODUCING ADIPIC ACID 有权
标题翻译：环己醇，用于生产环己醇及其制造方法ADIPIC
公开(公告)号：EP2733136B1
公开(公告)日：2016-05-04
申请号：EP12811125.9
申请日：2012-06-28
申请人： Asahi Kasei Chemicals Corporation
发明人： NARISAWA, Naoki , TANAKA, Katsutoshi
IPC分类号： C07C29/04 , C07C29/80 , C07C35/08 , C07C51/31 , C07C55/14
CPC分类号： C07C51/31 , C07C29/04 , C07C29/80 , C07C35/08 , C07C51/313 , C07C51/316 , C07C2601/14 , C07C55/14
摘要： A purified cyclohexanol of the present invention has a methylcyclopentanol concentration of 10 to 1000 ppm by weight and a cyclohexylcyclohexene isomer concentration of 15 to 500 ppm by weight. A method for producing cyclohexanol of the present invention comprises: Step 1 of producing a solution (I) containing cyclohexanol, methylcyclopentanol, and water by a hydration reaction of cyclohexene; Step 2 of separating the solution (I) into a water phase and an oil phase; Step 3 of obtaining a partially purified cyclohexanol containing methylcyclopentanol from the oil phase; and Step 4 of separating and removing methylcyclopentanol in the partially purified cyclohexanol so as to obtain a purified cyclohexanol having a methylcyclopentanol concentration of 10 to 1000 ppm by weight and a cyclohexylcyclohexene isomer concentration of 15 to 500 ppm by weight.

6. 发明公开

EP2858748A2 PROCESS FOR PRODUCTION OF ADIPIC ACID FROM 1,6-HEXANEDIOL 无效转让
标题翻译： VERFAHREN ZUR HERSTELLUNG冯ADIPINSÄUREAUS 1,6-HEXANDIOL
公开(公告)号：EP2858748A2
公开(公告)日：2015-04-15
申请号：EP13730095.0
申请日：2013-06-11
申请人： Rennovia, Inc.
发明人： DIAS, Eric, L. , MURPHY, Vincent, J. , SHOEMAKER, James, A.W.
IPC分类号： B01J23/42 , B01J23/44 , B01J23/52 , C07C51/235 , C07C55/14 , B01J21/06 , B01J35/10
CPC分类号： C07C51/235 , B01J21/066 , B01J23/42 , B01J23/44 , B01J23/52 , B01J23/6527 , B01J23/687 , B01J35/0006 , B01J35/1014 , B01J35/1019 , B01J35/1061 , B01J35/1066 , C07C55/14
摘要： Processes are disclosed for the conversion of 1,6-hexanediol to adipic acid employing a chemocatalytic reaction in which 1,6-hexanediol is reacted with oxygen in the presence of particular heterogeneous catalysts including at least one of platinum or gold. The metals are preferably provided on a support selected from the group of titania, stabilized titania, zirconia, stabilized zirconia, silica or mixtures thereof, most preferably zirconia stabilized with tungsten. The reaction with oxygen is carried out at a temperature from about 100° C. to about 300° C. and at a partial pressure of oxygen from about 50 psig to about 2000 psig.
摘要翻译：公开了使用化学催化反应将1,6-己二醇转化为己二酸的方法，其中1,6-己二醇在特定的非均相催化剂（包括至少一种铂或金）存在下与氧反应。金属优选提供在选自二氧化钛，稳定的二氧化钛，氧化锆，稳定的氧化锆，二氧化硅或其混合物，最优选用钨稳定的氧化锆的载体上。与氧的反应在约100℃至约300℃的温度和约50psig至约2000psig的氧分压下进行。

7. 发明公开

EP2585429A1 VERFAHREN ZUR ABTRENNUNG, GEWINNUNG UND REINIGUNG VON DICARBONSÄUREN 有权转让
标题翻译： VERFAHREN ZUR ABTRENNUNG，GEWINNUNG UND REINIGUNG VONDICARBONSÄUREN
公开(公告)号：EP2585429A1
公开(公告)日：2013-05-01
申请号：EP11726701.3
申请日：2011-05-31
申请人： ThyssenKrupp Uhde GmbH
发明人： TIETZ, Wolfgang , SCHULZE, Joachim
IPC分类号： C07C51/42 , C07C51/43 , C07C51/47 , C07C55/02 , C07C55/10 , C07C55/14 , C07C57/145 , C07C57/15 , C07C57/13 , C07C63/06 , C12P7/46
CPC分类号： C07C51/43 , C07B63/00 , C07C51/42 , C07C51/47 , C12P7/44 , C12P7/46 , C07C57/145 , C07C55/02 , C07C63/06 , C07C55/10 , C07C57/15 , C07C55/14 , C07C57/13
摘要： A process for removing, isolating and purifying dicarboxylic acid from fermentation broths, which comprises the following steps: f) removal of the biomass and any solids present from the fermentation broth in two successive stages, g) removal of the dicarboxylic acid solution from the biomass-free fermentation broth by simulated moving bed (SMB) chromatography, h) fine purification of the dicarboxylic acid solution, i) multistage evaporative concentration and crystallization, j) separation and drying of the crystals.
摘要翻译：一种从发酵液中除去，分离和纯化二羧酸的方法，包括以下步骤：1）连续两步除去发酵液中生物质和任何固体，2）从生物质中除去二羧酸溶液通过模拟移动床（SMB）色谱法分离发酵液，3）二元酸溶液精细化，4）多级蒸发浓缩结晶，5）分离和干燥晶体。

8. 发明公开

EP2582653A1 PROCESSES FOR PRODUCING HEXAMETHYLENEDIAMINE (HMD), ADIPONITRILE (ADN), ADIPAMIDE (ADM) AND DERIVATIVES THEREOF 审中-公开
标题翻译：用于生产己二胺（HMD），己二腈（ADN），二酰己二胺（ADM）及其衍生物
公开(公告)号：EP2582653A1
公开(公告)日：2013-04-24
申请号：EP11726031.5
申请日：2011-06-10
申请人： Bioamber, S.A.S.
发明人： FRUCHEY, Olan, S. , MANZER, Leo, E. , DUNUWILA, Dilum , KEEN, Brian, T. , ALBIN, Brooke, A. , CLINTON, Nye, A. , DOMBEK, Bernard, D.
IPC分类号： C07C51/02 , C07C51/41 , C07C51/46 , C07C55/14 , C07C209/46 , C07C209/48 , C07C209/50 , C07C231/02 , C07C253/20 , C07C253/22 , C07C253/30 , C08G69/26
CPC分类号： C07C253/22 , C07C51/02 , C07C51/412 , C07C51/46 , C07C209/46 , C07C209/48 , C07C209/50 , C07C231/02 , C07C253/20 , C07C253/30 , C08G69/26 , C08G69/28 , C07C55/14 , C07C211/12 , C07C233/05 , C07C255/04 , C07C255/24
摘要： Processes for producing nitrogen containing compounds include producing hexamethylenediamine (HMD), adiponitrile (ADN), adipamide (ADM) and derivatives thereof from adipic acid (AA) obtained from fermentation broths containing diammonium adipate (DAA) or monoammonium adipate (MAA).

9. 发明授权

EP1412316B1 PROCEDE D'OXYDATION D'HYDROCARBURES EN ACIDES 有权
标题翻译：用于烃的碳氢酸氧化
公开(公告)号：EP1412316B1
公开(公告)日：2011-10-19
申请号：EP02767570.1
申请日：2002-07-15
申请人： Rhodia Opérations
发明人： BONNET, Didier , FACHE, Eric , SIMONATO, Jean-Pierre
IPC分类号： C07C51/31 , C07C55/21 , C07C55/14 , C07C51/215 , C07C51/265 , C07C51/235 , C07C51/245 , C07C55/00 , C07C63/00
CPC分类号： C07C51/313 , C07C55/14 , C07C55/21
摘要： Process for the oxidation of an aliphatic or cycloaliphatic hydrocarbon (optionally substituted) or an alkylaromatic hydrocarbon and/or alcohols and ketones in a liquid medium by molecular oxygen in the presence of a manganese-based catalyst and an organic acid. The organic acid compound conforms to the formula(I) :- HOOC - Ar -(R)n - in which Ar = aromatic radical of one ring or several condensed rings; n = 1, 2 or 3; and R = a radical of formula -C(R1,R2,R3) (R1, R2, R3 = 1 - 4C alkyl or F).

10. 发明公开

EP2234952A1 CYCLOHEXANONE PRODUCTION PROCESS WITH MODIFIED POST-DISTILLATION 审中-公开
标题翻译： Herstellungsverfahren von Cyclohexanon mit modifizierter Post-Destillation
公开(公告)号：EP2234952A1
公开(公告)日：2010-10-06
申请号：EP08864701.1
申请日：2008-12-16
申请人： DSM IP Assets B.V.
发明人： HORSELS, Marleen , PARTON, Rudy Francois Maria Jozef , TINGE, Johan Thomas
IPC分类号： C07C45/82 , C07C49/403 , B01J10/00 , C07C29/48 , C07C45/00 , C07C45/29 , C07C51/00 , C07C55/14 , C07C35/08 , C08F232/00
CPC分类号： C07C29/50 , C07C45/006 , C07C45/82 , C07C51/00 , C07C2601/14 , C07C49/403 , C07C55/14 , C07C35/08
摘要： The present invention relates to a method for continuously preparing cyclohexanone from phenol making use of a catalyst comprising at least one catalytically active metal selected from platinum and palladium comprising a) hydrogenating phenol to form a product stream comprising cyclohexanone and unreacted phenol; b) separating at least part of the product stream, or at least part of the product stream from which one or more components having a lower boiling point than cyclohexanone have been removed, into a first fraction comprising cyclohexanone and a second fraction comprising phenol and cyclohexanol, using distillation; c) separating the second fraction into a third fraction, rich in cyclohexanol, and a fourth fraction, rich in phenol and, using distillation; d) subjecting at least part of the fourth fraction to a further distillation step, thereby forming a fifth fraction and a sixth fraction, wherein the fifth fraction is enriched in phenol compared to the sixth fraction, and wherein the sixth fraction comprises side-products having a higher boiling point than phenol, and phenol, wherein step d) is carried out in a vacuum distillation column equipped with trays in the lower part of the column, and wherein in the upper part of the column, i.e. in the part above the feed inlet, packing material is present instead of trays in at least part of said upper part, which packing material has a comparable or improved separating efficiency, and provides a reduction of the pressure drop by at least 30%, preferably more than 50%, as compared to the case with trays in the upper part, under otherwise similar distillation conditions.
摘要翻译：从苯酚连续制备环己酮的方法使用具有至少一种选自铂和钯的催化活性金属的催化剂。该方法包括与后续馏分相比富集蒸馏馏分中的苯酚，其中后续馏分包括苯酚和沸点高于苯酚的副产物。蒸馏在塔底部装有塔板的真空蒸馏塔中进行。在塔的上部，即在进料入口上方的部分，在其至少一部分中存在填料材料代替塔盘。包装材料具有相当或改进的分离效率，并且与其他类似的蒸馏条件下的上部塔板的情况相比，压降降低至少30％，优选大于50％。

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