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1. 发明公开

EP4429669A1 STEROID AS A MODULATOR OF GABAA RECEPTOR 审中-实审
公开(公告)号：EP4429669A1
公开(公告)日：2024-09-18
申请号：EP22817598.0
申请日：2022-11-10
申请人： Umecrine AB
发明人： BÄCKSTRÖM, Torbjörn , RAGAGNIN, Gianna , LÖFGREN, Magnus , SJÖSTEDT, Jessica
IPC分类号： A61K31/5685 , A61P3/04 , A61P3/10 , A61P5/04 , A61P15/08 , A61P25/30 , A61P25/32 , A61P43/00 , A61K8/63
CPC分类号： A61K31/5685 , A61P3/04 , A61P3/10 , A61P15/08 , A61P25/32 , A61P25/30 , A61P5/04 , A61P43/00

2. 发明公开

EP4286381A3 TREATMENT OF MERKEL CELLL CARCINOMA 审中-实审
公开(公告)号：EP4286381A3
公开(公告)日：2024-02-28
申请号：EP23204042.8
申请日：2017-08-09
申请人： Celgene Quanticel Research, Inc.
发明人： XU, Jiangchun , CHO, Robert , NGUYEN, Aaron
IPC分类号： A61K31/513 , A61K31/7048 , A61K31/357 , A61K31/436 , A61K31/551 , A61K31/5685 , A61K31/5377 , A61P35/00 , C07D401/14 , C07D405/14 , C07D401/04
摘要： Methods are provided for the treatment of relapsed and/or refractory solid tumors (including neuroendocrine carcinomas (NEC)) and non-Hodgkin's lymphomas (NHLs) and the like, using substituted heterocyclic derivative compounds and pharmaceutical compositions comprising compounds useful for the inhibition of lysine specific demethylase-1 (LSD-1).

3. 发明公开

EP3988095A1 SULFATED C19 STEROID HORMONES TO EXTEND LIFESPAN AND PROTECT AGAINST AGING-ASSOCIATED PROTEOTOXICITY 审中-公开
公开(公告)号：EP3988095A1
公开(公告)日：2022-04-27
申请号：EP20382930.4
申请日：2020-10-26
申请人： Universidad Pablo de Olavide
发明人： MUÑOZ, Manuel J. , PÉREZ-JIMÉNEZ, Mercedes M. , CARRIÓN, Ángel M.
IPC分类号： A61K31/37 , A61K31/404 , A61K31/47 , A61K31/566 , A61K31/568 , A61K31/5685 , A61K45/06 , A61P25/28
摘要： The present invention is encompassed within the field of medicine and provides a composition for use in
(a) a method for improving age-related cognitive function and/or treating disorders involving age-related cognitive dysfunction, or age-related cognitive impairment in a subject in need thereof; or
(b) in a method of increasing the lifespan of a eukaryotic organism in a subject in need thereof.

4. 发明公开

EP3976048A1 PHARMACEUTICAL FORMULATIONS AND SYSTEMS FOR DELIVERY OF AN ANDROGENIC AGENT AND AN AROMATASE INHIBITOR AND METHODS FOR USE 审中-实审
公开(公告)号：EP3976048A1
公开(公告)日：2022-04-06
申请号：EP20818587.6
申请日：2020-06-03
申请人： Havah Therapeutics Pty Ltd
发明人： BIRRELL, Stephen Nigel
IPC分类号： A61K31/568 , A61K31/5685 , A61K31/4196 , A61K47/12 , A61K9/00 , A61P5/26 , A61P43/00

5. 发明公开

EP3632445A1 COMBINATIONS WITH A C-19 STEROID FOR TREATING CANCERS 审中-公开
公开(公告)号：EP3632445A1
公开(公告)日：2020-04-08
申请号：EP18198631.6
申请日：2018-10-04
申请人： Curadis GmbH
发明人： UNTEREGGER, Gerhard , SCHÖNFELD, Wolfgang
IPC分类号： A61K31/568 , A61K45/06 , A61P35/00 , A61K31/337 , A61K31/519 , A61K31/565 , A61K31/138 , A61K31/277 , A61K31/4166 , A61K31/5685 , A61K31/58
摘要： The present invention relates to the field of medicine, particularly to novel uses of C-19 steroid compounds, more particularly to C-19 steroids having an androsten-3-one structure with specific structural configurations, in particular at the 4- and/or 17-position, for inhibition of cancer cell growth in combination with another anticancer agent or as second or third line treatment. The present invention particularly relates to selected C-19 steroids inhibiting the proliferation of tumor cells expressing an androgen receptor and show only limited sensitivity to other cancer agents such as aromatase inhibitors, androgen receptor antagonists, androgen synthesis inhibitors, chemotherapeutics as well as CDK4/CDK6 inhibitors.

7. 发明公开

EP3185872A4 FORMULATIONS OF TESTOSTERONE AND METHODS OF TREATMENT THEREWITH 有权转让
公开(公告)号：EP3185872A4
公开(公告)日：2018-03-07
申请号：EP15834874
申请日：2015-08-28
申请人： UNIV TEXAS , MEDCARA PHARMACEUTICALS LLC
发明人： JOSEPHS ROBERT A , HERMAN CRAIG
IPC分类号： A61K31/56 , A61K9/00 , A61K9/107 , A61K31/568 , A61K31/5685 , A61K31/573 , A61K45/06 , A61K47/14 , A61K47/44
CPC分类号： A61K31/5685 , A61K9/0043 , A61K9/107 , A61K31/568 , A61K31/573 , A61K45/06 , A61K47/14 , A61K47/44 , A61K2300/00
摘要： The present disclosure relates to novel pharmaceutical composition for the administration of testosterone or testosterone derivatives. The present disclosure also provides methods of treatment of diseases and disorders associated with fear and anxiety, a decrease in libido, or hypogonadism.

8. 发明公开

EP3116510A4 TREATMENT OF MALE ANDROGEN DEFICIENCY SYMPTOMS OR DISEASES WITH SEX STEROID PRECURSOR COMBINED WITH SERM 审中-公开
标题翻译： BEHANDLUNG VONMÄNNLICHENANDROGENMANGELSYMPTOMEN ODER -ERKRANKUNGEN MITSEXSTEROIDVORLÄUFERN在KOMBINATION MIT SERMERM
公开(公告)号：EP3116510A4
公开(公告)日：2017-08-16
申请号：EP15761680
申请日：2015-03-09
申请人： ENDORECHERCHE INC
发明人： LABRIE FERNAND , GAUTHIER SYLVAIN
IPC分类号： A61K31/5685 , A61K31/352 , A61P5/26 , A61P5/32 , C07D311/60 , C07J1/00
CPC分类号： A61K31/5685 , A61K9/0019 , A61K9/0031 , A61K9/0053 , A61K31/453 , A61K38/24 , A61K45/06 , A61K2300/00
摘要： Novel methods for prevention, reduction or elimination of the incidence of male androgen deficiency symptoms or diseases including male hypogonadism-associated symptoms and diseases associated with low serum testosterone and/or low DHEA or low total androgens in susceptible warm-blooded animals including humans involving administration of an amount of a sex steroid precursor, particularly dehydroepiandrosterone (DHEA) and a selective estrogen receptor modulator (SERM) (particularly acolbifene), an antiestrogen or a prodrug of the two. The symptoms or diseases are loss of libido, erectile dysfunction, tiredness, loss of energy, depression, bone loss, muscle loss, muscle weakness, fat accumulation, memory loss, cognition loss, Alzheimer's disease, dementia, loss of body hair, fertility problems, insomnia, gynecomastia, anemia, hot flushes, sweats, decreased sense of well-being, obesity, osteoporosis, hypercholesterolemia, hyperlipidemia, atherosclerosis, hypertension, insulin resistance, cardiovascular disease and type 2 diabetes. Pharmaceutical compositions for delivery of active ingredient(s) and kit(s) useful to the invention are also disclosed.
摘要翻译：包括人类在内的包括人在内的预防，减少或消除男性雄激素缺乏症状或疾病包括男性性腺功能减退症相关症状和与低血清睾酮和/或低DHEA或低总雄激素相关疾病发病率的新方法一定量的性类固醇前体，特别是脱氢表雄酮（DHEA）和选择性雌激素受体调节剂（SERM）（特别是阿考比芬），这两者的抗雌激素或前药。症状或疾病是性欲减退，勃起功能障碍，疲倦，精力不集中，抑郁症，骨质流失，肌肉损失，肌肉无力，脂肪堆积，记忆丧失，认知丧失，阿尔茨海默病，痴呆，体毛脱落，生育问题，失眠，男子女性型乳房，贫血，热潮红，汗水，幸福感减退，肥胖，骨质疏松症，高胆固醇血症，高脂血症，动脉粥样硬化，高血压，胰岛素抵抗，心血管疾病和2型糖尿病。还公开了用于递送用于本发明的活性成分和试剂盒的药物组合物。

9. 发明公开

EP2956466A4 NEUROACTIVE ENANTIOMERIC 15-, 16- AND 17-SUBSTITUTED STEROIDS AS MODULATORS FOR GABA TYPE-A RECEPTORS 审中-公开
标题翻译： NEURO活性对映体15-，16-和17-取代类固醇的GABA-A受体调节剂
公开(公告)号：EP2956466A4
公开(公告)日：2016-11-02
申请号：EP14751289
申请日：2014-02-14
申请人： UNIV WASHINGTON
发明人： COVEY DOUGLAS
IPC分类号： C07J1/00 , A61K31/565 , A61K31/5685 , A61K31/58 , A61P25/00 , C07J21/00
CPC分类号： C07J1/00 , C07C35/42 , C07C43/307 , C07C2603/26 , C07C2603/40 , C07J13/002 , C07J15/005 , C07J21/00 , C07J21/008 , C07J31/006 , C07J41/0094 , C07J51/00 , C07J61/00 , C07J63/008 , C07J71/001 , C07J75/005
摘要： The present disclosure is generally directed to neuroactive enantiomeric 15-, 16- and 17-substituted steroids with additional optional substituents at carbons 3, 4, 6, 7, 10 and 13, and pharmaceutically acceptable salts thereof, for use as, for example, modulators for GABA type-A receptors. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.
摘要翻译：本发明是涉及用在碳3，4，6，7，10和13，以及药学上可接受的盐另外的任选的取代基，使用，例如神经活性对映异构体15-，16-和17-substituiertem类固醇基因反弹，调制器，用于GABA A型受体。本公开涉及药物组合物进一步包含测试化合物。

10. 发明授权

EP2806856B1 DRUG/CARRIER INCLUSION COMPOSITES PREPARED BY A MECHANOCHEMICAL ACTIVATION PROCESS USING HIGH-ENERGY FLUID-JET MILLS 有权
标题翻译：通过机械活化工艺高能意味着液体射流厂家生产的ARZNEISTOFF- /坐月子复合材料
公开(公告)号：EP2806856B1
公开(公告)日：2016-04-20
申请号：EP13704377.4
申请日：2013-01-25
申请人： Micro-Macinazione S.A.
发明人： CARLI, Fabio , IAMARTINO, Piero , LEONE, Milko
IPC分类号： A61K9/16 , A61K31/5685 , B02C19/06
CPC分类号： A61K9/14 , A61K9/1635 , A61K9/1652 , A61K31/5685 , B02C19/0056 , B02C19/06 , B02C19/065

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