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1. 发明公开

EP3223808A1 TREATMENT OF SKIN ATROPHY WITH A COMBINATION OF TRIIODOTHYROACETIC ACID (TRIAC) AND DEHYDROEPIANDROSTERONE (DHEA) 审中-公开
标题翻译：三碘甲状腺原氨酸（TRIAC）与脱氢表雄酮（DHEA）联合治疗皮肤萎缩
公开(公告)号：EP3223808A1
公开(公告)日：2017-10-04
申请号：EP15798133.3
申请日：2015-11-24
申请人： Trophea Development AB
发明人： FAERGEMANN, Jan , JOHANNSSON, Gudmundur , OHLSSON, Claes , BATCHELLER, Derek Gregory , JOHNSSON, Jörgen , TÖRNELL, Jan
IPC分类号： A61K31/192 , A61K31/5685 , A61P17/18 , A61P17/16 , A61P17/10 , A61P17/08 , A61P17/06 , A61P17/02 , A61P17/00
CPC分类号： A61K31/5685 , A61K8/06 , A61K8/062 , A61K8/365 , A61K8/63 , A61K9/0014 , A61K9/06 , A61K9/107 , A61K31/192 , A61K45/06 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/08 , A61P17/10 , A61P17/16 , A61P17/18 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： The aim of the present study was to investigate the effect of a combination of triiodothyroacetic acid (TRIAC) and dehydroepiandrosterone (DHEA) compared with TRIAC, DHEA or placebo alone on corticosteroid induced effect on collagen synthesis in humans. Six healthy male human volunteers aged 40-65 participated. Four areas of abdominal skin were pre-treated for 3 weeks with betamethasone valerate cream. The same areas were then treated with one of the following alternatives in the same cream vehicle: TRIAC, DHEA, TRIAC+DHEA and placebo for 2 weeks. Then suction blisters were raised in each of these areas with a vacuum pump. The blister fluid from each area was collected and frozen until analysis. Analysis of amino terminal propeptide of human type I procollagen (PINP) in suction blister fluid was performed using a commercially available immunoassay (Orion Diagnostics) kit. This study has for the first time shown that a combination of TRIAC and DHEA could effectively stimulate collagen synthesis in skin pretreated with betamethasone valerate demonstrated by an increase in PINP, and that the combination was more effective than TRIAC or DHEA alone. This combination could be used to effectively treat skin atrophy in corticosteroid induced skin atrophy. It could also be used to treat skin atrophy due to other circumstances such as e. g. sun damaged skin and skin atrophy due to high age. Another interesting application would be to combine TRIAC and DHEA with a potent corticosteroid in order to prevent corticosteroid induced skin atrophy. If this combination still is effective in the treatment of eczema and psoriasis and without the risk of skin atrophy this combination will be a major breakthrough for the use of potent topical corticosteroids.
摘要翻译：本研究的目的是研究三碘甲状腺原氨酸（TRIAC）和脱氢表雄酮（DHEA）联合应用与单纯TRIAC，DHEA或安慰剂联合应用对皮质类固醇诱导人体胶原合成的影响。六名年龄在40-65岁的健康男性志愿者参加。用戊酸倍他米松乳膏预处理腹部皮肤的四个区域3周。然后在相同的乳膏媒介物中使用以下替代品之一处理相同的区域：TRIAC，DHEA，TRIAC + DHEA和安慰剂2周。然后用真空泵在这些区域中的每一个区域内提起吸水泡。收集每个区域的疱液并冷冻直至分析。使用市售免疫测定（Orion Diagnostics）试剂盒对吸入泡罩液中的人I型前胶原（PINP）的氨基末端前肽进行分析。这项研究首次表明，TRIAC和DHEA的联合应用可以有效地刺激用戊酸倍他米松预处理的皮肤中的胶原蛋白合成，PINP的增加表明该组合比单独使用TRIAC或DHEA更有效。这种组合可用于有效治疗皮质类固醇诱导的皮肤萎缩中的皮肤萎缩。它也可以用于治疗由于其他情况造成的皮肤萎缩，例如e。 G。由于年龄太高，晒伤皮肤和皮肤萎缩。另一个有趣的应用是将TRIAC和DHEA与有效的皮质类固醇组合以防止皮质类固醇诱导的皮肤萎缩。如果这种组合仍然有效治疗湿疹和牛皮癣，并且没有皮肤萎缩的风险，这种组合对于使用有效的局部皮质类固醇是一个重大突破。

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