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2. 发明授权

EP2897523B1 NUCLEAR MAGNETIC RESONANCE (NMR) FINGERPRINTING 有权
公开(公告)号：EP2897523B1
公开(公告)日：2024-05-22
申请号：EP13838364.1
申请日：2013-09-19
IPC分类号： G01R33/46 , G01R33/465 , G01R33/54 , G01R33/561 , G01R33/48 , G01R33/50 , G01R33/563 , G01R33/44 , G01R33/24
CPC分类号： G01R33/4828 , G01R33/50 , G01R33/561 , G01R33/24 , G01R33/448 , G01R33/4616 , G01R33/4625 , G01R33/465 , G01R33/543 , G01R33/56341

3. 发明公开

EP3408679A1 SYSTEM AND METHOD FOR OPTIMIZED DIFFUSION--WEIGHTED IMAGING 审中-公开
公开(公告)号：EP3408679A1
公开(公告)日：2018-12-05
申请号：EP17744789.3
申请日：2017-01-25
申请人： The Regents of the University of California
发明人： ENNIS, Daniel B. , ALIOTTA, Eric , WU, Holden H.
IPC分类号： G01R33/56
CPC分类号： G01R33/56341 , G01R33/5614 , G01R33/5616
摘要： A system and method for optimized diffusion-weighted imaging is provided. In one aspect, the method includes providing a plurality of constraints for imaging a target at a selected diffusion weighting, and applying an optimization framework to generate an optimized diffusion encoding gradient waveform satisfying the plurality of constraints. The method also includes performing, using the MRI system, a pulse sequence comprising the optimized diffusion encoding gradient waveform to generate diffusion-weighted data, and generating at least one image of the target using the diffusion-weighted data.

4. 发明公开

EP3407295A1 FIBRE-TRACKING FROM A DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGE 审中-公开
公开(公告)号：EP3407295A1
公开(公告)日：2018-11-28
申请号：EP17172137.6
申请日：2017-05-22
申请人： Koninklijke Philips N.V.
发明人： ZAGORCHEV, Lyubomir Georgiev
IPC分类号： G06T7/00 , G01R33/56 , A61B5/055 , G01R33/563
CPC分类号： G01R33/56341 , A61B5/055 , G01R33/5608 , G06T7/0012 , G06T2207/10092 , G06T2207/30016
摘要： In fibre-tracking from a diffusion weighted magnetic resonance image one or more regions-of-interest are selected from a high-resolution morphological magnetic resonance image. The geometrical relationship between the diffusion-weighted magnetic resonance image and the high-resolution magnetic resonance image is determined. Using the geometrical relationship, one or more region-of-interest corresponding to the anatomical structures represented in the high-resolution morphological image are identified and transferred to the diffusion weighted image space. These regions-of-interest in the diffusion-weighted images form the basis of a fibre tracking procedure. This yields fibre tracts that pass through the selected anatomical structures and enables functional interconnectivity analysis.

5. 发明公开

EP3299836A1 LOKALE KORREKTUR VON GRADIENTEN-NICHTLINEARITÄTEN IN DER DIFFUSIONSGEWICHTETEN MRT 审中-实审转让
标题翻译：扩散加权MRI中梯度非线性的局部修正
公开(公告)号：EP3299836A1
公开(公告)日：2018-03-28
申请号：EP17173750.5
申请日：2017-05-31
申请人： Siemens Healthcare GmbH
发明人： Feiweier, Thorsten , Nickel, Marcel Dominik
IPC分类号： G01R33/563 , G01R33/565
CPC分类号： G01R33/5608 , G01R33/5602 , G01R33/56341 , G01R33/56572
摘要： Die vorliegende Erfindung betrifft ein Verfahren zum Erzeugen eines genäherten spurgewichteten MR-Bildes einer Untersuchungsperson. Dabei werden mindestens drei diffusionsgewichtete MR-Bilder der Untersuchungsperson erstellt, welche auf unterschiedlichen Diffusionskodierungsrichtungen und Diffusionsgradientenfeldern mit im Wesentlichen gleichen Diffusionskodierungsstärken basieren. Weiter wird basierend auf räumlichen Inhomogenitäten der Diffusionsgradientenfelder für jeden Bildpunkt jedes der mindestens drei diffusionsgewichteten MR-Bilder ein Wichtungsfaktor durch ein Optimierungsverfahren bestimmt. Basierend auf den Wichtungsfaktoren werden die mindestens drei diffusionsgewichteten MR-Bilder zum Erzeugen des genäherten spurgewichteten MR-Bildes kombiniert. Weiterhin wird basierend auf genäherten spurgewichteten Bildern und der effektiven Diffusionskodierungsstärke eine ADC-Karte bestimmt. Zudem wird basierend auf einem spurgewichteten Bild bei effektiver Diffusionskodierungsstärke ein spurgewichtetes MR-Bild bei nomineller Diffusionskodierungsstärke synthetisiert.
摘要翻译：本发明涉及一种用于生成检查者的近似轨道加权MR图像的方法。在这种情况下，创建至少三个检查对象的扩散加权MR图像，其基于具有基本相同的扩散编码强度的不同扩散编码方向和扩散梯度场。此外，基于至少三个扩散加权MR图像中的每一个的每个像素的扩散梯度场的空间不均匀性，通过优化方法来确定加权因子。基于加权因子，组合至少三个扩散加权MR图像以产生近似的轨道加权MR图像。此外，基于近似的轨道加权图像和有效扩散编码强度来确定ADC图。另外，基于具有有效扩散编码强度的轨道加权图像，以标称扩散编码强度合成轨道加权MR图像。

6. 发明授权

EP3017312B1 BILDGEBUNGSVERFAHREN FÜR KERNSPINTOMOGRAPHISCHE DIFFUSIONSDATEN, COMPUTERPROGRAMMPRODUKT UND BILDGEBUNGSVORRICHTUNG 有权
标题翻译：成像过程中用于MRI扩散数据，计算机程序产品及摄像装置
公开(公告)号：EP3017312B1
公开(公告)日：2017-03-08
申请号：EP14734396.6
申请日：2014-07-01
申请人： Fachhochschule Stralsund
发明人： EHRICKE, Hans-Heino , OTTO, Kay Michael , HÖLLER, Mark
IPC分类号： G01R33/563 , G01R33/56
CPC分类号： G01R33/5608 , G01R33/56341

7. 发明公开

EP3118644A1 REAL-TIME PROSPECTIVE MOTION CORRECTION FOR MRI 审中-公开
标题翻译： PROSPEKTIVE ECHTZEIT-BEWEGUNGSKORREKTURFÜRMRT
公开(公告)号：EP3118644A1
公开(公告)日：2017-01-18
申请号：EP16180003.2
申请日：2016-07-18
申请人： Siemens Medical Solutions USA, Inc. , Massachusetts General Hospital Corporation
发明人： Bhat, Himanshu , Cauley, Stephen Farman , Heberlein, Keith Aaron , Setsompop, Kawin , Tisdall, Matthew Dylan , Van Der Kouwe, Andre Jan Willem
IPC分类号： G01R33/54 , G01R33/561 , G01R33/567 , G01R33/56 , G01R33/563
CPC分类号： G01R33/56509 , G01R33/54 , G01R33/5602 , G01R33/5611 , G01R33/5616 , G01R33/5617 , G01R33/56341 , G01R33/56366 , G01R33/5676
摘要： A magnetic resonance (MR) method and system are provided for generating real-time prospective motion-corrected images using fast navigators. The real-time motion correction is achieved by using a 2D EPI navigator that is obtained using a simultaneous multi-slice blipped-CAIPI technique. The navigator parameters such as field of view, voxel size, and matrix size can be selected to facilitate fast acquisition while providing information sufficient to detect rotational motions on the order of several degrees or more and translational motions on the order of several millimeters or more. The total time interval for obtaining and reconstructing navigator data, registering the navigator image, and providing feedback to correct for detected motion, can be on the order of about 100 ms or less. This prospective motion correction can be used with a wide range of MR imaging techniques where the pulse sequences do not have significant intervals of "dead" time.
摘要翻译：提供磁共振（MR）方法和系统用于使用快速导航器生成实时预期的运动校正图像。通过使用使用同时多片片blipped-CAIPI技术获得的2D EPI导航器来实现实时运动校正。可以选择诸如视场，体素大小和矩阵大小的导航器参数以便于快速获取，同时提供足以检测几度或更多次的旋转运动的信息以及几毫米以上的平移运动。用于获取和重构导航器数据，登记导航器图像以及提供用于校正检测到的运动的反馈的总时间间隔可以在大约100ms或更少的量级上。这种前瞻性运动校正可用于广泛的MR成像技术，其中脉冲序列不具有显着的“死”时间间隔。

8. 发明公开

EP3081955A1 MRI METHOD FOR DETERMINING SIGNATURE INDICES OF AN OBSERVED TISSUE FROM SIGNAL PATTERNS OBTAINED BY MOTION-PROBING PULSED GRADIENT MRI 审中-公开
标题翻译： FOR鞋面厘定签名指数MRI方法放送从面料的MRI与脉冲BEWEGUNGSTESTGRADIENTEN获得SINGALMUSTERN
公开(公告)号：EP3081955A1
公开(公告)日：2016-10-19
申请号：EP15305546.2
申请日：2015-04-13
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
发明人： Le Bihan, Denis
IPC分类号： G01R33/563 , A61B5/055
CPC分类号： G01R33/56341 , A61B5/055 , G01R33/3607 , G01R33/5635 , G01R33/56358
摘要： A method for determining a signature index of an observed tissue comprises the step of providing (12) a generic attenuation model of a motion-probing gradient pulse MRI attenuated signal S(b), and providing (14) a reference model parameter vector (p R (i)) corresponding to a reference state of the tissue.
On the basis of the evolution of the determined (16) partial differential sensitivities dS ¡ (b) of the model attenuated signal S(b) to each model parameter p(i) at the neutral state attenuated signal S N (b) versus b values, a discrete and narrow size set of key b is built (18) and a series of MRI images of the observed tissue are acquired (20) by using the key b values.
Then, for each voxel a signature index (sADC(V), Sdist(V), SCdist(V), Snl(V), SI(V)) of the voxel V is determined (22) as a scalar function depending on a distance between the voxel signal pattern acquired at the key b values and the signal pattern of the reference state of the tissue at the same key b values.
An apparatus is configured for implementing such a method.
摘要翻译：一种用于确定性采矿方法观察到的组织的签名索引包括提供步骤（12）的运动探测梯度脉冲MRI衰减信号S（b）和提供（14）的参考模型参数向量的一个通用的衰减模型（对 R（i））的对应于该组织的参考状态。在确定性开采（16）偏微分灵敏度DS的进化的基础¡（b）该模型衰减信号S（b）与在中性状态的每个模型参数P（I）的衰减信号SN（B）与B值，离散且窄的尺寸设定密钥b的是通过使用密钥b值构建（18）和一系列所观察到的组织的MRI图像获取（20）。然后，对于每个体素的签名索引（SADC（V），Sdist（V），SCdist（V）SNL（V），SI（V））的体素的V是确定性的开采（22），为标量函数上的悬垂在相同的密钥值b中的组织的参考状态的信号图案在键的b值获取的体素的信号模式之间的距离。的装置是被配置用于实现一个搜索方法。

9. 发明公开

EP2991547A1 DETERMINATION OF PHYSIOLOGICAL PARAMETERS OF TISSUE FROM DYNAMIC CONTRAST-ENHANCED MR DATA 审中-公开
标题翻译：测定生理学FROM动态增强MR-DATA组织的参数
公开(公告)号：EP2991547A1
公开(公告)日：2016-03-09
申请号：EP14721509.9
申请日：2014-03-27
申请人： Koninklijke Philips N.V.
发明人： BREEUWER, Marcel , MISCHI, Massimo , WIJKSTRA, Hessel
IPC分类号： A61B5/055 , A61B5/026
CPC分类号： A61B5/055 , A61B5/0263 , G01R33/5601 , G01R33/56341 , G06F19/00
摘要： A method of determining microvascular architecture is disclosed. Dynamic contrast-enhanced magnetic resonance data acquired from a contrast agent administered to at least a part of a subject to be examined. From the dynamic contrast-enhanced magnetic resonance data a leakage parameter (kep) and a dispersion parameter (&kgr;) are computed. Effects of both convective dispersion and extravasation kinetics of contrast agent are taken into account.

10. 发明公开

EP2933743A1 Method of characterizing molecular diffusion within a body from a set of diffusion-weighted magnetic resonance signals and apparatus for carrying out such a method 审中-公开
标题翻译：分子扩散的表征中一组扩散加权的磁共振信号和装置的主体，用于执行这样的方法的方法
公开(公告)号：EP2933743A1
公开(公告)日：2015-10-21
申请号：EP14165298.2
申请日：2014-04-18
申请人： Université de Rennes 1 , Centre National de la Recherche Scientifique , INRIA - Institut National de Recherche en Informatique et en Automatique
发明人： Stamm, Aymeric , Barillot, Christian , Commowick, Olivier , Perez, Patrick
IPC分类号： G06F19/00 , G06T7/00
CPC分类号： G06F19/702 , A61B5/055 , G01R33/56341 , G06F17/18 , G06F17/5009 , G06F19/707 , G06F2217/16
摘要： A computer-implemented method of characterizing molecular diffusion within a body from a set of diffusion-weighted magnetic resonance signals by computing a weighted average (AVM) of a plurality of multi-compartment diffusion models (EXM1, EXM2) comprising a same number of compartments, fitted to a set of diffusion-weighted magnetic resonance signals, said weighted average being computed using weights representative of a performance criterion of each of said models; wherein each of said multi-compartment diffusion models comprises a different number of subsets of compartments, the compartments of a same subset being identical to each other.
摘要翻译：通过计算多隔室扩散模型（EXM1，EXM2）包括相同数目的隔室中的多个加权平均（AVM）从一组扩散加权磁共振信号的主体内表征分子扩散的一种计算机实现的方法，装配到一组扩散加权磁共振信号的，所述使用权重代表每个所述模型的性能标准的被计算加权平均值; worin每个所述多隔室扩散模型包括不同数量的隔室中的子集，一个子集相同的隔室是相同的海誓山盟。

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