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1. 发明公开

EP1205224A1 Chromatographic separation process 有权
标题翻译：斯特凡恩zur色谱仪Trennung
公开(公告)号：EP1205224A1
公开(公告)日：2002-05-15
申请号：EP01109456.2
申请日：2001-04-24
申请人： NIPPON RENSUI CO.
发明人： Tanimura, Masatake , Ikemoto, Manabu, Nippon Rensui Co.
IPC分类号： B01D15/08 , B01J47/02
CPC分类号： C13B20/144 , B01D15/1814 , B01D15/1864 , B01D15/361 , B01D15/362 , B01J39/26 , B01J47/026
摘要： A chromatographic separation process of a type wherein a feedstock fluid containing a plurality of components is supplied into a circulative chromatographic separation system, the process comprising the steps of (i) supplying the feedstock fluid and withdrawing a fraction enriched in a component, (ii) supplying a desorbent fluid and withdrawing a fraction enriched in another component, and (iii) circulating the fluid through the bed without supplying or withdrawing any fluid thereby making a mixed zone comprising a plurality of components move, a cycle including steps (i), (ii) and (iii) being repeated, wherein the packed bed comprises a first unit bed packed with an adsorbent, to which the feedstock fluid is supplied, and at least one other unit bed packed with an adsorbent, and the adsorbent (e.g., ion-exchange resin) packed into the first unit bed, to which the feedstock fluid is supplied, has a greater average particle size and/or a higher degree of crosslinking than that packed in the at least one other unit packed bed.
摘要翻译：一种类型的色谱分离方法，其中将含有多种组分的原料流体供应到循环色谱分离系统中，该方法包括以下步骤：（i）供应原料流体并萃取富含组分的级分，（ii）提供解吸流体并抽出富集另一组分的级分，以及（iii）使流体循环通过床而不提供或排出任何流体，从而使包含多个组分的混合区域移动，包括步骤（i），（ ii）和（iii）重复，其中填充床包括填充有供给原料流体的吸附剂的第一单元床和填充有吸附剂的至少一个其它单元床，以及吸附剂（例如离子 - 交换树脂）填充到供应原料流体的第一单元床中具有比包装的平均粒度更大的平均粒度和/或更高的交联度所述至少一个其他单元填充床。

2. 发明公开

EP0981399A1 SINGLE COLUMN CLOSED-LOOP RECYCLING WITH PERIODIC INTRA-PROFILE INJECTION 失效
标题翻译：通过定期INTRA-PROFILE注射单Säule酒店回路
公开(公告)号：EP0981399A1
公开(公告)日：2000-03-01
申请号：EP98925537.7
申请日：1998-05-05
申请人： MERCK PATENT GmbH
发明人： GRILL, M., Charles
IPC分类号： B01D15/08
CPC分类号： B01D15/1814 , B01D15/1857 , G01N30/44
摘要： A preparative chromatographic cyclical process utilizing a single column comprising, at steady state: (a) establishing and maintaining a circulating chromatographic profile through said column and through one solvent pump; (b) discontinuously and periodically injecting a sample comprising at least two components, into the interior of said maintained circulating profile; and (c) collecting, discontinuously and periodically, at least two enriched fractions from said circulating profile.

3. 发明公开

EP3386937A1 TWO-BED PARAFFIN TO OLEFIN ENHANCEMENT PROCESS 有权
公开(公告)号：EP3386937A1
公开(公告)日：2018-10-17
申请号：EP16873560.3
申请日：2016-11-16
申请人： UOP LLC
发明人： LUEBKE, Charles P. , WANG, Zheng , GORAWARA, Jayant K. , SOHN, Stephen W.
IPC分类号： C07C7/12 , B01D15/00
CPC分类号： C07C7/12 , B01D15/1814 , B01D15/1864 , B01D53/0423 , B01D2256/24 , B01D2257/7027 , B01D2259/40092 , B01D2259/402 , C07C2/66 , C10G25/00 , C10G29/205 , C10G53/08 , C07C11/02
摘要： A process is presented for the purification of an olefins feed stream to a benzene alkylation unit. The process removes heavy aromatics in a two adsorbent unit system. The unit passes the olefins feed stream to a first adsorbent unit, while the second adsorbent unit is either in regeneration mode, or standby mode. The process switches the feed stream to the second adsorbent unit and displaces the fluid in the second adsorbent unit, while maintaining the flow of the purified feed stream to the benzene alkylation unit.

4. 发明公开

EP1917082A1 PROCEDE ET INSTALLATION POUR LA REGULATION DU TAUX DE MODIFICATEUR DANS UNE CHROMATOGRAPHIE OU EXTRACTION SUPERCRITIQUE AVEC RECYCLAGE 有权
标题翻译：方法和装置用于调节MODIFIKATORNIVEAUS色谱或超临界萃取回收
公开(公告)号：EP1917082A1
公开(公告)日：2008-05-07
申请号：EP06794327.4
申请日：2006-08-11
申请人： Pic Solution
发明人： SHAIMI, Mohamed
IPC分类号： B01D15/16 , B01D15/40 , B01D11/02 , B01D11/04
CPC分类号： B01D15/40 , B01D15/166 , B01D15/1814
摘要： The invention relates to a chromatography or supercritical extraction method in which the eluent comprises a mixture of a fluid and a modifier and in which the fluid is recycled. The invention comprises an operation consisting in determining at least one quantity linked to the level of modifier that is mixed with the recycled fluid and, if necessary, a correction operation in order to limit variations in the level of modifier in the eluent at the inlet of the column or the extractor. The invention also relates to a chromatography or extraction installation.

5. 发明公开

EP1773802A1 ENANTIOSELECTIVE METHOD FOR SEPARING SUBSTITUTED 2-TRIFLUOROMETHYL-2H-CHROMENE-3-CARBOXYLIC ACID DERIVATIVES 审中-公开
标题翻译：分离取代的2-三氟甲基-2H-色烯-3-羧酸衍生物的对映选择性方法
公开(公告)号：EP1773802A1
公开(公告)日：2007-04-18
申请号：EP05759425.1
申请日：2005-07-11
申请人： Pharmacia & Upjohn Company LLC
发明人： CHEKAL, Brian P., Pfizer Global R & D , FREUND, Ernst , GRILL, Charles Minard, Pfizer Global R & D , HUTHMANN, Elke , JUZA, Markus , LESHCHINSKAYA, Véra , MALONEY, Mark Thomas, Pfizer Global R & D , MILLER, Lawrence, Marvin, Jr. , WANG, Ying , ZENG, Ming, Pfizer Global Research and Development
IPC分类号： C07D311/24 , C07D311/92 , C07D215/48 , C07D335/06 , C07D335/08
CPC分类号： C07B57/00 , B01D15/1814 , B01D15/1857 , B01D15/1864 , C07D311/04 , C07D311/58 , C07D335/06
摘要： This in rention relates to a method for separating enantiomers of a substituted 2-tr:ifluoromethyl-2H-chromene-3-carboxylic acid or ester, a substituted 2-triifluoromethyl-1,2-dihydro-quinoline-3-carboxylic acid or ester, a substituted 2-triifluoromethyl-2H-thiochromene-3-carboxylic acid or ester, a substituted 3-tri.fluoromethyl-3,4-dihydro-naphthalene-2-carboxylic acid or ester, or a pharmaceutically acceptable salt of the acids or esters, using enantioselective fractional crystallization, enantioselective high performance liquid chromatograph yy, enantioselective steady state recycling chromatography, or enantioselective multicolumn chromatography.

6. 发明授权

EP0981399B1 SINGLE COLUMN CLOSED-LOOP RECYCLING WITH PERIODIC INTRA-PROFILE INJECTION 失效
标题翻译：通过定期INTRA-PROFILE注射单Säule酒店回路
公开(公告)号：EP0981399B1
公开(公告)日：2004-08-18
申请号：EP98925537.7
申请日：1998-05-05
申请人： NOVASEP
发明人： GRILL, M., Charles
IPC分类号： B01D15/08
CPC分类号： B01D15/1814 , B01D15/1857 , G01N30/44
摘要： A preparative chromatographic cyclical process utilizing a single column comprising, at steady state: (a) establishing and maintaining a circulating chromatographic profile through said column and through one solvent pump; (b) discontinuously and periodically injecting a sample comprising at least two components, into the interior of said maintained circulating profile; and (c) collecting, discontinuously and periodically, at least two enriched fractions from said circulating profile.

7. 发明授权

EP0877936B1 DISCONTINUOUS COUNTERCURRENT CHROMATOGRAPHIC PROCESS 失效
标题翻译：不连续反流色谱过程
公开(公告)号：EP0877936B1
公开(公告)日：2004-03-17
申请号：EP96939008.7
申请日：1996-11-12
申请人： NOVASEP
发明人： GRILL, M., Charles , HAMPTON, W., Thomas
IPC分类号： G01N30/44 , B01D15/08
CPC分类号： B01D15/1814 , B01D15/1857 , B01D15/1864 , G01N30/44
摘要： A preparative chromatographic cyclical process comprising, at steady state: establishing a figure-of-eight circulating chromatographic profile between two chromatographic columns with the provision that said chromatographic profile never passes through a pump; discontinuously and periodically injecting a sample comprising at least two components, into said circulating profile; and collecting, discontinuously and periodically, at least two enriched fractions from said circulating profile, the apparatus for conducting this process comprising only two chromatographic columns, at least one solvent pump, and injection pump, two 4-way valves, and conduit communicating said columns and the two 4-way valves in the form of a figure-of-eight pattern without traversing a pump, and conduit communicating said at least one solvent pump and at least one of said columns.
摘要翻译：一种制备色谱循环方法，其包括：在稳定状态下：在两个色谱柱之间建立八数循环色谱分布图，条件是所述色谱分布图不会通过泵; 不连续地和周期性地将包含至少两种组分的样品注入到所述循环分布中; 并且不连续地且周期性地从所述循环分布中收集至少两种富集级分，用于进行该方法的装置仅包括两个色谱柱，至少一个溶剂泵和喷射泵，两个四通阀以及连通所述柱以及八个八字形式的两个四通阀不经过泵，以及连通所述至少一个溶剂泵和至少一个所述柱的导管。

8. 发明公开

EP1379673A2 A PRODUCT REMOVAL PROCESS FOR USE IN A BIOFERMENTATION SYSTEM 审中-公开
标题翻译：用于用在BIOFERMENTATIONSSYSTEM移除产品
公开(公告)号：EP1379673A2
公开(公告)日：2004-01-14
申请号：EP02721794.2
申请日：2002-04-22
申请人： E.I. DU PONT DE NEMOURS AND COMPANY
发明人： WILKINS, Antoinette, E. , LOWE, David, J.
IPC分类号： C12P1/00 , C12N9/00 , D06M16/00
CPC分类号： C12M47/12 , B01D15/1814 , B01D15/426 , C12M29/02 , C12M33/14 , C12M47/10 , C12N1/38 , C12P7/18
摘要： This invention relates to a bioprocess engineering solution for a product removal process for use in a biofermentation. The invention discloses a process for withdrawing an aliquot of broth from a biofermentation vessel during at least a portion of the biofermentation, removing biocatalyst and water, chromatographically separating biofermentation products from the withdrawn broth using water as an eluent, and returning the remaining components of the broth back to the biofermentation vessel. Process chromatography permits highly selective separation of the target molecule, preventing feedback inhibition of the biofermentation.

9. 发明授权

EP0464277B1 Process for the separation by adsorption of 2,6- or 3,5-diethyltoluene from a mixture thereof with another diethyltoluene isomer 失效
标题翻译：一种用于从与另一Diethyltoluolisomer它们的混合物通过2,6-或3,5-二乙基的吸附分离过程。
公开(公告)号：EP0464277B1
公开(公告)日：1995-11-22
申请号：EP90307281.7
申请日：1990-07-03
申请人： UOP
发明人： Zinnen, Herman A.
IPC分类号： C07C15/02 , C07C7/13
CPC分类号： B01D15/08 , B01D15/1814 , C07C7/13 , C07C15/02

10. 发明公开

EP3243073A1 VERFAHREN ZUR STEUERUNG KONTINUIERLICHER CHROMATOGRAPHIE UND MULTISÄULEN-CHROMATOGRAPHIE-ANORDNUNG 有权
标题翻译：控制连续色谱和多柱色谱安排的方法
公开(公告)号：EP3243073A1
公开(公告)日：2017-11-15
申请号：EP16825323.5
申请日：2016-11-25
申请人： Karlsruher Institut für Technologie
发明人： HUBBUCH, Jürgen , BRESTRICH, Nina , RÜDT, Matthias , ROLINGER, Laura
IPC分类号： G01N30/86 , G01N30/88 , G01N30/46
CPC分类号： B01D15/1871 , B01D15/1814 , G01N30/46 , G01N30/74 , G01N30/78 , G01N30/86 , G01N30/8658 , G01N30/8675 , G01N2030/8831 , G01N2201/129
摘要： In summary, the invention relates to a method the controlling at least one multi-column chromatography arrangement for the continuous process of purifying in particular biopharmaceuticals, comprising: introducing a first multi-component mixture into a column of the multi-column chromatography arrangement; detecting at least one multivariate signal by means of at least one detector; calculating at least one process parameter on the basis of the multivariate signal by means of at least one data-processing program of a computing unit via application of a chemometric method; controlling the purification process via control of at least one controllable control element on the basis of the at least one process parameter, and a multi-column chromatography arrangement.

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