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1. 发明公开

EP2890808A4 DIAGNOSIS AND TREATMENT OF AUTISM SPECTRUM DISORDER 审中-公开
标题翻译：诊断和自闭症障碍的治疗
公开(公告)号：EP2890808A4
公开(公告)日：2016-09-28
申请号：EP13832132
申请日：2013-08-28
申请人： CALIFORNIA INST OF TECHN
发明人： HSIAO ELAINE , MAZMANIAN SARKIS K , PATTERSON PAUL H , MCBRIDE SARA
IPC分类号： C12Q1/04 , A61K35/37 , A61K35/74 , A61K35/741 , A61P25/00 , C07K16/18 , G01N33/68
CPC分类号： A61K39/3955 , A61K35/74 , A61K35/741 , A61K2039/505 , C07K16/18 , G01N33/6896 , G01N2800/28 , G01N2800/7076 , G01N2800/7085
摘要： Disclosed herein are compositions, systems, and methods for diagnosing and treatment of subjects suffering from anxiety, autism spectrum disorder (ASD), or a pathological condition with one or more of the symptoms of ASD.

2. 发明公开

EP3256860A4 METHODS AND COMPOSITIONS FOR IDENTIFYING NON-ALCOHOLIC FATTY LIVER DISEASE 有权
公开(公告)号：EP3256860A4
公开(公告)日：2018-07-04
申请号：EP16749993
申请日：2016-02-12
申请人： UNIV CALIFORNIA
发明人： DENNIS EDWARD A , QUEHENBERGER OSWALD , LOOMBA ROHIT
IPC分类号： G01N33/68 , G01N33/92
CPC分类号： G01N33/92 , G01N33/6893 , G01N33/88 , G01N2405/00 , G01N2570/00 , G01N2800/085 , G01N2800/7085
摘要： The disclosure provides methods for differentiating between non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. The method includes measuring eicosanoids and fatty acid levels in a biological sample.

3. 发明公开

EP2914736A1 ACYL-COA DEHYDROGENASE ASSAYS 审中-公开
标题翻译： ACYL-COA脱氢酶测定
公开(公告)号：EP2914736A1
公开(公告)日：2015-09-09
申请号：EP13852305.5
申请日：2013-10-30
申请人： Advanced Liquid Logic, Inc.
发明人： FOEGEDING, Nora, J. , GRAHAM, Carrie, A. , ECKHARDT, Allen, E.
IPC分类号： C12Q1/32 , C12Q1/26 , G01N33/48
CPC分类号： C12Q1/32 , G01N33/6893 , G01N2333/90206 , G01N2800/04 , G01N2800/7085
摘要： A method for conducting medium-chain acyl-CoA dehydrogenase (MCAD) and very- long-chain acyl-CoA dehydrogenase (VCAD) enzymatic activity assays is provided. The method may include, but is not limited to, preparing a sample; preparing an enzyme- specific substrate/reagent mixture; mixing an aliquot of the prepared sample with an aliquot of the enzyme-specific substrate/reagent mixture; reading absorbance in the range of about 600 nm; incubating the prepared sample and enzyme-specific substrate/reagent mixture; and reading absorbance in the range of about 600 nm at various time intervals.
摘要翻译：提供了用于进行中链酰基-CoA脱氢酶（MCAD）和超长链酰基-CoA脱氢酶（VCAD）酶活性测定的方法。该方法可以包括但不限于准备样品; 制备酶特异性底物/试剂混合物; 将制备的样品的等分试样与等份的酶特异性底物/试剂混合物混合; 读取约600nm范围内的吸光度; 温育制备的样品和酶特异性底物/试剂混合物; 并以不同的时间间隔读取约600nm范围内的吸光度。

4. 发明公开

EP3314264A1 MEANS AND METHODS FOR DIAGNOSING PANCREATIC CANCER IN A SUBJECT BASED ON A BIOMARKER PANEL 审中-公开
标题翻译：基于生物标志物的诊断胰腺癌的方法和方法
公开(公告)号：EP3314264A1
公开(公告)日：2018-05-02
申请号：EP16732596.8
申请日：2016-06-24
申请人： metanomics Health GmbH
发明人： KAMLAGE, Beate , RESZKA, Regina , SCHATZ, Philipp , DOSTLER, Martin , CARVALHO, Susan , PETER, Erik , MAPPES, Philipp , KALTHOFF, Holger , SCHNIEWIND, Bodo , MAYERLE, Julia , LERCH, Markus , GRUETZMANN, Robert , PILARSKY, Christian
IPC分类号： G01N33/574 , G01N33/68
CPC分类号： G01N33/57438 , G01N33/6806 , G01N33/6812 , G01N2405/08 , G01N2800/60 , G01N2800/7028 , G01N2800/7076 , G01N2800/7085
摘要： The present invention relates to a method for diagnosing pancreatic cancer in a subject comprising the steps of: (a) determining in at least one sample of said subject the amounts of a group of diagnostic biomarkers comprising (i) at least one diagnostic amino acid, said diagnostic amino acid being proline, histidine or tryptophan, preferably, being proline; (ii) at least one diagnostic ceramide, said diagnostic ceramide being ceramide (d18:1,C24:0) or ceramide (d18:2,C24:0), preferably being ceramide (d18:1,C24:0); (iii) at least one diagnostic sphingomyelin, said diagnostic sphingomyelin being sphingomyelin (35:1), sphingomyelin (d17:1,C16:0), sphingomyelin (41:2) or sphingomyelin (d18:2,C17:0), preferably being sphingomyelin (35:1); and (iv) CA19-9; and (b) comparing said amounts of the diagnostic biomarkers with a reference, whereby pancreatic cancer is diagnosed. Moreover, the present invention relates to a method for determining the probability for a subject to suffer from pancreatic cancer, and to devices and uses related to said methods.

5. 发明公开

EP3004889A1 BIOMARKERS 审中-公开
标题翻译：生物标记物
公开(公告)号：EP3004889A1
公开(公告)日：2016-04-13
申请号：EP14726744.7
申请日：2014-05-22
申请人： King's College London
发明人： MAYR, Manuel
IPC分类号： G01N33/68 , G01N33/92
CPC分类号： G01N33/6887 , G01N33/6893 , G01N33/92 , G01N2405/02 , G01N2800/7085
摘要： in one aspect., the present Invention provides a method of determining cardiovascular disease (CVD) risk in a subject comprising (a) determining fatty acid composition of lipids In a sample obtained from the subject, wherein the lipids are selected from the group consisting of: (I) triacylgiycerols (TAGs); and cholesterol esters (CEs); and (b) comparing the fatty acid composition of the lipids in the sample from the subject to a control; wherein a decrease in mean fatty acid chain length in the lipids in the sample from the subject compared to the control indicates an. increased risk of CVD in the subject; and wherein the. CVD is associated with atherosclerotic plaque rupture or thrombosis., and/or the CVD Is an acute ischemic event selected from myocardial infarction, ischemic stroke or sudden cardiac death.
摘要翻译：在一个方面，本发明提供了一种测定受试者心血管疾病（CVD）风险的方法，包括（a）测定脂质的脂肪酸组成在从受试者获得的样品中，其中脂质选自：（I）三酰基胆汁醇（TAG）; 和胆固醇酯（CE）; 和（b）将来自受试者的样品中的脂质的脂肪酸组成与对照相比较; 其中与对照相比，来自受试者的样品中脂质中平均脂肪酸链长度的降低表示a。受试者CVD风险增加; 并且其中。 CVD与动脉粥样硬化斑块破裂或血栓形成有关，和/或CVD是选自心肌梗塞，缺血性卒中或心源性猝死的急性缺血事件。

6. 发明公开

EP2890808A2 DIAGNOSIS AND TREATMENT OF AUTISM SPECTRUM DISORDER 审中-公开
标题翻译：诊断和自闭症障碍的治疗
公开(公告)号：EP2890808A2
公开(公告)日：2015-07-08
申请号：EP13832132.8
申请日：2013-08-28
申请人： California Institute of Technology
发明人： HSIAO, Elaine , MAZMANIAN, Sarkis, K. , PATTERSON, Paul, H. , MCBRIDE, Sara
IPC分类号： C12Q1/04 , A61K35/74 , A61K35/37 , A61P25/00
CPC分类号： A61K39/3955 , A61K35/74 , A61K35/741 , A61K2039/505 , C07K16/18 , G01N33/6896 , G01N2800/28 , G01N2800/7076 , G01N2800/7085
摘要： Disclosed herein are compositions, systems, and methods for diagnosing and treatment of subjects suffering from anxiety, autism spectrum disorder (ASD), or a pathological condition with one or more of the symptoms of ASD.

7. 发明公开

EP3256860A1 METHODS AND COMPOSITIONS FOR IDENTIFYING NON-ALCOHOLIC FATTY LIVER DISEASE 有权
标题翻译：用于鉴定非酒精性脂肪肝病的方法和组合物
公开(公告)号：EP3256860A1
公开(公告)日：2017-12-20
申请号：EP16749993.8
申请日：2016-02-12
申请人： The Regents of the University of California
发明人： DENNIS, Edward, A. , QUEHENBERGER, Oswald , LOOMBA, Rohit
IPC分类号： G01N33/92 , G01N33/48 , G01N33/49 , G01N33/50
CPC分类号： G01N33/92 , G01N33/6893 , G01N33/88 , G01N2405/00 , G01N2570/00 , G01N2800/085 , G01N2800/7085
摘要： The disclosure provides methods for differentiating between non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. The method includes measuring eicosanoids and fatty acid levels in a biological sample.

8. 发明公开

EP3082833A4 BIOMARKERS OF DE NOVO LIPOGENESIS AND METHODS USING THE SAME 有权
标题翻译： BIOMARKERFÜRDE-NOVO-LIPOGENESE UND VERFAHREN DAMIT
公开(公告)号：EP3082833A4
公开(公告)日：2017-08-09
申请号：EP14870759
申请日：2014-12-18
申请人： METABOLON INC
发明人： WATKINS STEVEN M
IPC分类号： G01N33/92
CPC分类号： G01N33/92 , G01N2405/00 , G01N2800/7085
摘要： Biomarkers relating to de novo lipogenesis are provided, as well as methods for using such biomarkers in an Index to assess DNL. In addition, methods for diagnosing, determining predisposition to, and monitoring progression/regression of diseases related to DNL are provided. Also provided are methods of monitoring the efficacy of treatments for diseases related to DNL as well as other methods based on biomarkers of DNL.
摘要翻译：提供了与从头脂肪生成有关的生物标志物，以及在索引中使用这些生物标志物来评估DNL的方法。另外，提供了用于诊断，确定对DNL相关疾病的倾向和监测疾病的进展/消退的方法。还提供了监测DNL相关疾病治疗效果的方法以及基于DNL生物标志物的其他方法。

9. 发明公开

EP2914736A4 ACYL-COA DEHYDROGENASE ASSAYS 审中-公开
标题翻译：酰基辅酶A DEHYDROGENASETESTS
公开(公告)号：EP2914736A4
公开(公告)日：2016-08-31
申请号：EP13852305
申请日：2013-10-30
申请人： ADVANCED LIQUID LOGIC INC
发明人： FOEGEDING NORA J , GRAHAM CARRIE A , ECKHARDT ALLEN E
IPC分类号： C12Q1/32 , G01N33/68
CPC分类号： C12Q1/32 , G01N33/6893 , G01N2333/90206 , G01N2800/04 , G01N2800/7085

10. 发明授权

EP3082833B1 BIOMARKERS OF DE NOVO LIPOGENESIS AND METHODS USING THE SAME 有权
公开(公告)号：EP3082833B1
公开(公告)日：2018-12-05
申请号：EP14870759.9
申请日：2014-12-18
申请人： Metabolon, Inc.
发明人： WATKINS, Steven M.
IPC分类号： G01N33/92
CPC分类号： G01N33/92 , G01N2405/00 , G01N2800/7085
摘要： Biomarkers relating to de novo lipogenesis are provided, as well as methods for using such biomarkers in an Index to assess DNL. In addition, methods for diagnosing, determining predisposition to, and monitoring progression/regression of diseases related to DNL are provided. Also provided are methods of monitoring the efficacy of treatments for diseases related to DNL as well as other methods based on biomarkers of DNL.

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