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1. 发明公开

EP3318124A3 PHARMACOKINETIC ANIMAL MODEL 无效转让
公开(公告)号：EP3318124A3
公开(公告)日：2018-05-30
申请号：EP17186961.3
申请日：2014-02-14
申请人： Albumedix A/S
发明人： CAMERON, Jason , SLEEP, Darrell , SANDLIE, Inger , ANDERSEN, Jan Terje
IPC分类号： A01K67/00 , G01N33/68
CPC分类号： G01N33/68 , A01K67/0275 , A01K67/0278 , A01K2217/052 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2227/107 , A01K2227/108 , A01K2267/02 , A01K2267/03 , C07K14/70535 , C07K14/765 , G01N2333/765 , G01N2500/20
摘要： The present invention relates to a method of assessing pharmacokinetic properties of a variant of human serum albumin using a non-primate animal species where the native albumin of the animal provides minimal competition for HSA binding to the FcRn receptor in said animal. In the non-primate animal species, the binding affinity of wild type HSA to the native FcRn of said animal is the same as or higher than the binding affinity of the native albumin of said animal to the native FcRn. The present invention also relate to animal models which are particularly suitable for assessing pharmacokinetics of human serum albumin variants.

2. 发明公开

EP3294125A1 DEVICE AND METHOD FOR DETECTING CREATININE AND ALBUMIN TO CREATININE RATIO 有权
公开(公告)号：EP3294125A1
公开(公告)日：2018-03-21
申请号：EP16792263
申请日：2016-01-22
申请人： INDIAN INST SCIENT
发明人： KUMAR VINAY , BHAT NAVAKANTA , KASHYAP DHANVANTARI MADHURESH NIKHILA
IPC分类号： A61B5/05 , C07K14/76 , G01N27/327 , G01N27/447 , G01N33/48 , G01N33/493
CPC分类号： G01N27/327 , A61B5/14507 , A61B5/14546 , A61B5/1468 , A61B5/207 , A61B10/007 , C07K14/76 , G01N33/493 , G01N33/5438 , G01N2333/765
摘要： An electrochemically active, creatinine-binding device is provided to detect and measure quantitatively, creatinine in biological samples. The device of the present invention is also provided with a device to detect and measure quantitatively creatinine and albumin bioanalytes, simultaneously and to determine albumin to creatinine ratio (ACR). The present invention also provides an electrochemically active, creatinine-binding and albumin-binding device, for collection and retention of biological samples, having creatinine and albumin bioanalytes. In the present invention, a device holder is provided to receive the electrochemically active, creatinine-binding and albumin-binding device. The device, point-of-care biosensor and the method of the present invention, facilitate quantitative measurement of creatinine and albumin bioanalytes in urine and blood samples, and albumin to creatinine ratio (ACR), in urine samples, electrochemically, by determining redox current values.

3. 发明授权

EP3039082B1 A SQUARAINE BASED FLUORESCENT PROBE AND A PROCESS FOR THE PREPARATION THEREOF 失效
标题翻译：一种方形荧光探针及其制备方法
公开(公告)号：EP3039082B1
公开(公告)日：2017-10-04
申请号：EP13821731.0
申请日：2013-12-09
申请人： Council of Scientific and Industrial Research
发明人： AYYAPPANPILLAI, Ajayaghosh , PALAPPURAVAN, Anees
IPC分类号： C09B57/00 , G01N33/533 , G01N33/58
CPC分类号： G01N33/582 , C09B57/007 , G01N21/6428 , G01N33/68 , G01N33/84 , G01N2021/6439 , G01N2333/765
摘要： The present invention describes the use of a fluorescent NIR dye for various applications by simply changing the solvent conditions. Molecule of formula 1 in the monomeric state (30% ACN/25 mM phosphate buffer) can be used for the sensitive detection of thiols and monitoring minor fluctuations in the thiol concentration inside live cells. Molecule 1 in the self-assembled state (25 mM phosphate buffer) can be used for labeling of serum albumin protein either covalently or noncovalently at specific pH. The probe 1 specifically bind with the serum albumin proteins noncovalently at lower pH gives a “turn-on” NIR emission whereas it binds covalently at higher pH gives a “turn-on” green fluorescence. Since the probe detects serum albumin proteins selectively in presence of other thiol containing small molecules, the probe can be used as an excellent sensor for serum albumin proteins. The dye-protein complex of various ratios can be used as sensors to detect the pH variations in a broad window from 4.6-11.6 with high sensitivity. Due to the high biocompatibility and water solubility the dye protein complex is useful for ratiometric detection of minor pH variations inside cellular environment.
摘要翻译：本发明描述了通过简单地改变溶剂条件来将荧光NIR染料用于各种应用。单体状态下的式1分子（30％ACN / 25mM磷酸盐缓冲液）可用于硫醇的灵敏检测并监测活细胞内硫醇浓度的微小波动。处于自组装状态的分子1（25mM磷酸盐缓冲液）可用于在特定pH下共价或非共价标记血清白蛋白蛋白质。探针1在较低pH下非共价地与血清白蛋白蛋白特异性结合产生“开启”NIR发射，而其在较高pH下共价结合产生“开启”绿色荧光。由于探针在含有其他含巯基的小分子的存在下选择性地检测血清白蛋白蛋白质，该探针可以用作血清白蛋白蛋白质的优异传感器。各种比例的染料 - 蛋白质复合物可用作传感器，以高灵敏度检测4.6-11.6的宽窗口中的pH变化。由于高度的生物相容性和水溶性，染料蛋白复合物可用于细胞环境内微小pH变化的比例检测。

4. 发明授权

EP2956002B1 PHARMACOKINETIC ANIMAL MODEL 失效转让
标题翻译：药代动力学模型
公开(公告)号：EP2956002B1
公开(公告)日：2017-09-06
申请号：EP14705493.6
申请日：2014-02-14
申请人： Albumedix A/S
发明人： CAMERON, Jason , SLEEP, Darrell , SANDLIE, Inger , ANDERSEN, Jan Terje
IPC分类号： A01K67/00
CPC分类号： G01N33/68 , A01K67/0275 , A01K67/0278 , A01K2217/052 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2227/107 , A01K2227/108 , A01K2267/02 , A01K2267/03 , C07K14/70535 , C07K14/765 , G01N2333/765 , G01N2500/20

5. 发明公开

EP3191842A1 METHODS TO DIAGNOSE AND TREAT MULTIPLE SCLEROSIS VIA DETECTION OF ALTERED PROTEIN COMPONENTS OF SERUM 审中-公开
标题翻译：通过检测血清中改变的蛋白质组分诊断和治疗多发性硬化的方法
公开(公告)号：EP3191842A1
公开(公告)日：2017-07-19
申请号：EP15771803.2
申请日：2015-09-08
申请人： Yuscience, LLC
发明人： YU, Xiaoli
IPC分类号： G01N33/564 , A61K38/00 , G01N33/68
CPC分类号： G01N33/564 , G01N33/6827 , G01N33/6854 , G01N2333/765 , G01N2440/38 , G01N2800/285 , G01N2800/52
摘要： The methods disclosed herein include diagnosing a patient with MS, selecting a patient for further testing for MS, should the patient show elevated level of human IgG relative to an appropriate control. The methods also include differentiating subtypes of MS. The methods also include evaluating the efficacy of an MS drug or course of drug treatments, and/or treating MS. The methods include determining whether patients have elevated levels of IgG3-IgG1 immune complexes (which can include glycosylated IgG antibodies) in both blood and CSF. Methods also include diagnosing patients with primary-progressive MS (PPMS) and secondary-progressive MS (SPMS) where patients have higher levels of IgG3-IgG1 complexes in both CSF and blood, and reduced levels of albumin compared to patients with relapsing-remitting MS (RRMS). The methods optionally include treating the sample to dissociate immune and/or protein complexes, contacting the sample with a reagent that binds specifically to a human IgG or other protein, comparing the results to an appropriate control, and determining whether the patient has an altered level of IgG or other protein consistent with MS.
摘要翻译：本文公开的方法包括诊断患有MS的患者，如果患者相对于适当的对照显示升高水平的人IgG，则选择患者进一步测试MS。这些方法还包括区分MS的亚型。该方法还包括评估MS药物的疗效或药物治疗疗程，和/或治疗MS。该方法包括确定患者在血液和CSF中是否具有升高水平的IgG3-IgG1免疫复合物（其可以包括糖基化IgG抗体）。方法还包括诊断患有原发性进行性MS（PPMS）和继发性进行性MS（SPMS）的患者，其中患者在CSF和血液中具有较高水平的IgG3-IgG1复合物，并且与具有复发 - 缓解MS的患者相比白蛋白水平降低（RRMS）。所述方法任选地包括处理样品以解离免疫和/或蛋白质复合物，使样品与特异性结合人IgG或其他蛋白质的试剂接触，将结果与适当的对照进行比较，并确定患者是否具有改变的水平的IgG或其他与MS相一致的蛋白质。

6. 发明公开

EP3132269A2 DIAGNOSIS OF CHRONIC KIDNEY DISEASE BY QUANTITATIVE ANALYSIS OF POST-TRANSLATIONAL MODIFICATIONS OF PLASMA PROTEINS 有权
标题翻译： DIAGNOSE VON CHRONISCHER NIERENERKRANKUNG DURCH定量分析仪VON POSTTRANSLATIONALEN MODIFIKATIONEN VON PLASMAPROTEINEN
公开(公告)号：EP3132269A2
公开(公告)日：2017-02-22
申请号：EP15714830.5
申请日：2015-04-09
申请人： eXcorLab GmbH
发明人： LEMKE, Horst-Dieter , RÜTH, Marieke , JANKOWSKI, Joachim , JANKOWSKI, Vera
IPC分类号： G01N33/68 , C07K16/18
CPC分类号： G01N33/6893 , C07K16/18 , C07K2317/30 , C07K2317/92 , G01N2333/765 , G01N2440/00 , G01N2800/347
摘要： The present invention relates to methods for diagnosing and/or monitoring the onset or progression of chronic kidney disease (CKD) in a patient by the analysis of post-translational modification of plasma proteins. The present invention provides improved means for diagnosing chronic kidney disease (CKD) especially for the early recognition of CKD.
摘要翻译：本发明涉及通过分析血浆蛋白的翻译后修饰来诊断和/或监测患者中慢性肾脏疾病（CKD）发病或进展的方法。本发明提供用于诊断慢性肾脏疾病（CKD）的改进方法，特别是用于CKD的早期识别。

7. 发明公开

EP2972395A4 RAPID TEST FOR URINE ALBUMIN AND URINE CREATININE 审中-公开
标题翻译：快速检测尿素中的白蛋白和肌酸酐
公开(公告)号：EP2972395A4
公开(公告)日：2016-08-17
申请号：EP14779179
申请日：2014-03-11
申请人： EPINEX DIAGNOSTICS INC
发明人： LIU WING T , TRAN THIEN-TOAN , SCOTT JOHN , PRASAD SRISHTI , ZAIDI AZRA , LEE THOMAS
IPC分类号： G01N33/70 , G01N33/53 , G01N33/538 , G01N33/58
CPC分类号： G01N33/558 , G01N33/70 , G01N2333/765
摘要： Disclosed herein is an immunochromatographic system for measuring albumin and creatinine in a urine sample and a reader that detects signals from the test cassette, calculates, and displays the results for albumin concentration, creatinine concentration, and albumin-creatinine ratio.
摘要翻译：本文公开了一种用于测量尿液样品中的白蛋白和肌酐的免疫色谱系统，以及检测来自测试盒的信号的读数器，计算并显示白蛋白浓度，肌酐浓度和白蛋白肌酐比的结果。

8. 发明公开

EP3031801A1 SPECIFIC FLUORESCENT PROBE BASED ON ALBUMIN PSEUDO-ESTERASE HYDROLYSIS REACTION AND USE THEREOF 审中-公开
标题翻译： SONDE MIT SPEZIFISCHER FLUORESZENZ AUF BASIS EINER ALBUMIN-PSEUDO-ESTERASE-HYDROLYSEREAKTION UND VERWENDUNG DAVON
公开(公告)号：EP3031801A1
公开(公告)日：2016-06-15
申请号：EP14834394.0
申请日：2014-03-27
申请人： Dalian Institute Of Chemical Physics Chinese Academy of Sciences
发明人： YANG, Ling , CUI, Jingnan , GE, Guangbo , LIU, Zhaoming , FENG, Lei
IPC分类号： C07D221/14 , C09K11/06 , G01N21/64
CPC分类号： C12Q1/46 , C07D221/14 , C09B57/08 , C09K11/06 , C09K2211/1007 , C09K2211/1029 , G01N33/582 , G01N2333/765
摘要： A pseudo-esterase activity -based fluorescent probe for specific detection of albumin and its applications. This probe is based on human serum albumin's pseudo-esterase activity, that is to say, under the condition of physiological pH value, the carboxylic ester bond of the probe (λex = 342 nm, λem = 416 nm) could be selectively cleaved by human serum albumin (HSA) to release the 4-hydroxy-1,8-naphthalimide fluorophore, while the dibenzoyl group covalently bound to the amino acid residues of HSA. The fluorescence emission spectrum of the product is significantly different from that of the substrate molecule (λex = 452 nm, λe m = 564 nm), and according to the fluorescence intensity of substrate and product we can detect the content of HSA in the system. This probe can be used for the determination of the absolute content of albumin in biological samples with the advantage of high accuracy, sensitivity, little influence from the environment and it is compatible with a variety of endogenous substances, exogenous drugs, and surfactant and so on.
摘要翻译：用于特异性检测白蛋白的基于假酯酶活性的荧光探针及其应用。该探针基于人血清白蛋白的假酯酶活性，也就是说，在生理pH值的条件下，探针的羧酸酯键（»ex = 342nm，»em = 416nm）可以选择性地裂解通过人血清白蛋白（HSA）释放4-羟基-1,8-萘二甲酰亚胺荧光团，而二苯甲酰基共价结合到HSA的氨基酸残基。产物的荧光发射光谱与底物分子（»ex = 452 nm，»em = 564 nm）的荧光发射光谱显着不同，根据底物和产物的荧光强度，我们可以检测系统中HSA的含量。该探针可用于测定生物样品中白蛋白的绝对含量，具有精度高，灵敏度高，环境影响小等优点，与各种内源性物质，外源药物和表面活性剂等相容。

9. 发明公开

EP2994542A1 COMPOSITIONS FOR OVARIAN CANCER ASSESSMENT HAVING IMPROVED SPECIFICITY 有权转让
标题翻译：组合物技术提高的特异性OVARIALKARZINOMBEURTEILUNG WITH
公开(公告)号：EP2994542A1
公开(公告)日：2016-03-16
申请号：EP14794184.3
申请日：2014-05-08
申请人： Johns Hopkins University , Vermillion, Inc.
发明人： MUNROE, Donald , CHAN, Daniel, W. , ZHANG, Zhen
IPC分类号： C12Q1/68 , G01N33/573 , G01N33/566 , C40B30/04
CPC分类号： G01N33/57449 , G01N2333/4703 , G01N2333/4725 , G01N2333/5412 , G01N2333/59 , G01N2333/70539 , G01N2333/765 , G01N2333/775 , G01N2333/79 , G01N2333/81 , G01N2333/811 , G01N2800/50
摘要： The present invention provides compositions and methods that provide a high degree of sensitivity and a high degree of specificity for the preoperative assessment of ovarian tumors in a variety of subject's (e.g., pre- and post- menopausal women) having a variety of ovarian cancer types (e.g., clear cell/mucinous, low malignant potential, high malignant potential) and at a variety of disease states (e.g., early and late stage).

10. 发明公开

EP2940474A1 NOVEL LABELING COMPOSITION FOR CANCER LESION 有权
标题翻译： NEUARTIGE MARKIERUNGSZUSAMMENSETZUNGFÜRKREBSLÄSIONEN
公开(公告)号：EP2940474A1
公开(公告)日：2015-11-04
申请号：EP13866879.3
申请日：2013-12-04
申请人： National Cancer Center
发明人： KIM, Seok Ki , KANG, Se Hun , KIM, Seok Won , JUNG, So Youn
IPC分类号： G01N33/60 , G01N33/58 , G01N33/68 , G01N33/50
CPC分类号： A61K51/081 , A61K49/0056 , A61K49/006 , G01N33/574 , G01N33/58 , G01N2333/765
摘要： The present invention relates to: a labeling composition for a cancer lesion, comprising a complex in which a pigment for straining living tissues, a radioactive isotrope, or a combination thereof binds to macroaggregated albumin (MAA); a method for providing information regarding a cancer lesion site using the labeling composition for a cancer lesion; a labeling kit for a cancer lesion comprising the labeling composition for a cancer lesion; and a complex in which a pigment for straining living tissues binds to MAA included in the labeling composition for a cancer lesion. The labeling composition for a cancer lesion according to the present invention binds to a cancer lesion to detect a site, size, and the like of the cancer lesion in real time, thereby improving the success rate of a surgical operation for the cancer lesion and also preventing excessive loss of normal tissues. Therefore, the present invention can be widely used for effective anticancer therapy.
摘要翻译：本发明涉及：用于癌症病变的标记组合物，其包含其中用于使活组织变应性颜料，放射性各向同性或其组合的颜料与大聚集白蛋白（MAA）结合的复合物; 使用癌症病变的标记组合物提供关于癌症病变部位的信息的方法; 用于癌症病变的标记试剂盒，其包含癌症病变的标记组合物; 以及其中用于紧张活组织的颜料与包括在癌症病变的标记组合物中的MAA结合的复合物。根据本发明的癌症病变的标记组合物结合癌症病变以实时检测癌症病变的部位，大小等，从而提高癌症病变的外科手术的成功率，并且还防止正常组织的过度损失。因此，本发明可广泛用于有效的抗癌治疗。

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