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1. 发明公开

EP2940474A1 NOVEL LABELING COMPOSITION FOR CANCER LESION 有权
标题翻译： NEUARTIGE MARKIERUNGSZUSAMMENSETZUNGFÜRKREBSLÄSIONEN
公开(公告)号：EP2940474A1
公开(公告)日：2015-11-04
申请号：EP13866879.3
申请日：2013-12-04
申请人： National Cancer Center
发明人： KIM, Seok Ki , KANG, Se Hun , KIM, Seok Won , JUNG, So Youn
IPC分类号： G01N33/60 , G01N33/58 , G01N33/68 , G01N33/50
CPC分类号： A61K51/081 , A61K49/0056 , A61K49/006 , G01N33/574 , G01N33/58 , G01N2333/765
摘要： The present invention relates to: a labeling composition for a cancer lesion, comprising a complex in which a pigment for straining living tissues, a radioactive isotrope, or a combination thereof binds to macroaggregated albumin (MAA); a method for providing information regarding a cancer lesion site using the labeling composition for a cancer lesion; a labeling kit for a cancer lesion comprising the labeling composition for a cancer lesion; and a complex in which a pigment for straining living tissues binds to MAA included in the labeling composition for a cancer lesion. The labeling composition for a cancer lesion according to the present invention binds to a cancer lesion to detect a site, size, and the like of the cancer lesion in real time, thereby improving the success rate of a surgical operation for the cancer lesion and also preventing excessive loss of normal tissues. Therefore, the present invention can be widely used for effective anticancer therapy.
摘要翻译：本发明涉及：用于癌症病变的标记组合物，其包含其中用于使活组织变应性颜料，放射性各向同性或其组合的颜料与大聚集白蛋白（MAA）结合的复合物; 使用癌症病变的标记组合物提供关于癌症病变部位的信息的方法; 用于癌症病变的标记试剂盒，其包含癌症病变的标记组合物; 以及其中用于紧张活组织的颜料与包括在癌症病变的标记组合物中的MAA结合的复合物。根据本发明的癌症病变的标记组合物结合癌症病变以实时检测癌症病变的部位，大小等，从而提高癌症病变的外科手术的成功率，并且还防止正常组织的过度损失。因此，本发明可广泛用于有效的抗癌治疗。

2. 发明授权

EP2940474B1 NOVEL LABELING COMPOSITION FOR CANCER LESION 有权
公开(公告)号：EP2940474B1
公开(公告)日：2019-02-13
申请号：EP13866879.3
申请日：2013-12-04
申请人： National Cancer Center
发明人： KIM, Seok Ki , KANG, Se Hun , KIM, Seok Won , JUNG, So Youn
IPC分类号： G01N33/60 , G01N33/58 , G01N33/68 , G01N33/50 , G01N33/574

3. 发明授权

EP2605019B1 SENTINEL LYMPH NODE MARKER CAPABLE OF MULTI-MODE IMAGING 有权
公开(公告)号：EP2605019B1
公开(公告)日：2019-04-17
申请号：EP11816661.0
申请日：2011-08-16
申请人： National Cancer Center
发明人： KIM, Seok Ki , KANG, Se Hun , KIM, Seo Il , KIM, Young Sang , BAEK, Nam Suk , NOH, Jin Hee
IPC分类号： A61K51/08 , A61K49/00 , G01N33/534 , A61K103/10 , G01N33/60 , G01N33/52 , A61K51/00

4. 发明公开

EP2605019A2 SENTINEL LYMPH NODE MARKER CAPABLE OF MULTI-MODE IMAGING 有权
标题翻译： SENTINEL-LYMPHKNOTEN-MARKERFÜRMEHRMODUS-BILDGEBUNG
公开(公告)号：EP2605019A2
公开(公告)日：2013-06-19
申请号：EP11816661.0
申请日：2011-08-16
申请人： National Cancer Center
发明人： KIM, Seok Ki , KANG, Se Hun , KIM, Seo Il , KIM, Young Sang , BAEK, Nam Suk , NOH, Jin Hee
IPC分类号： G01N33/60 , G01N33/52 , A61K51/00 , G21H5/00
CPC分类号： A61K51/081 , A61K49/0002 , A61K49/0021 , A61K49/0034 , A61K49/0056 , A61K49/006 , G01N33/534 , G01N2333/765
摘要： The present invention relates to a sentinel lymph node marker comprising an albumin; a radioactive isotope and/or near infrared dye which is bound to the albumin; and a visible dye which is bound to the albumin, a preparation method thereof, a kit for multimode imaging of a sentinel lymph node to prepare the sentinel lymph node marker, and a method for multimode imaging of a sentinel lymph node using the same. The sentinel lymph node marker of the invention remains in the sentinel lymph node for a long period of time and allows for multimode imaging of the sentinel lymph node. Thus, using this marker the sentinel lymph node can be accurately identified in vivo by near infrared imaging and/or gamma imaging without incision of skin, and the location of the identified sentinel lymph node can be precisely identified with the naked eye during a surgical operation of removing the identified sentinel lymph node.
摘要翻译：本发明涉及包含白蛋白的前哨淋巴结标记物; 与白蛋白结合的放射性同位素和/或近红外染料; 和与白蛋白结合的可见染料，其制备方法，用于前哨淋巴结多模成像以制备前哨淋巴结标记的试剂盒，以及使用其的前哨淋巴结的多模成像方法。本发明的前哨淋巴结标志物长期保留在前哨淋巴结中，并允许前哨淋巴结的多模成像。因此，使用该标记物可以通过近红外成像和/或γ成像在体内精确地识别前哨淋巴结而无需切开皮肤，并且可以在外科手术期间用肉眼精确地识别所识别的前哨淋巴结的位置去除鉴定的前哨淋巴结。

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