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1. 发明公开

EP3411692A1 EXTREME ULTRAVIOLET RADIATION IN GENOMIC SEQUENCING AND OTHER APPLICATIONS 审中-公开
公开(公告)号：EP3411692A1
公开(公告)日：2018-12-12
申请号：EP17748097.7
申请日：2017-02-01
申请人： Jaiswal, Supriya
发明人： Jaiswal, Supriya
IPC分类号： G01N21/64 , G02B21/06 , G02B21/16 , C12Q1/68
CPC分类号： C12Q1/6869 , C12N15/102 , G01N21/33 , G01N21/59 , G01N23/083 , G01N33/6818 , G01N33/6893 , G01N2021/335 , G01N2223/612 , H05G2/001
摘要： Methods, apparatus, and processes which use Extreme ultraviolet radiation (EUV) and/or soft X-ray wavelengths to read, image, edit, locate, identify, map, alter, delete, repair and sequence genes are described. An EUV scanning tool which allows high throughput genomic scanning of DNA, RNA and protein sequences is also described. A database which records characteristic absorption spectra of gene sequences is also described.

2. 发明公开

EP3368552A1 A FUSION PROTEIN CRYSTAL COMPRISING A MOIETY 有权
公开(公告)号：EP3368552A1
公开(公告)日：2018-09-05
申请号：EP16860402.3
申请日：2016-10-31
申请人： Agency for Science, Technology and Research
发明人： BASKARAN, Yohendran , ROBINSON, Robert , MANSER, Edward
IPC分类号： C07K14/47 , C12N9/12 , C12N15/62
CPC分类号： C30B29/58 , C07K14/4703 , C07K2319/00 , C07K2319/43 , C12N9/12 , C12N15/62 , C12Y207/11001 , C12Y207/11022 , C30B29/66 , G01N23/2055 , G01N2223/612
摘要： A protein crystal comprising a first protein crystal having available space in the lattice, wherein a second protein crystal and a moiety can be accommodated in the available space in the lattice. The first and second proteins are co-expressed from one or more nucleic acid constructs. In a preferred embodiment, the first protein is the p21-activated kinase PAK4, the second protein is the PAK4 kinase inhibitor Inka1, and the moiety comprises a reporter molecule such as fluorescent proteins or tags and is fused to the iBox or iBox-C or Inka1. Preferably the crystal is formed in cellulo. Also provided is a fusion protein comprising the first protein and the second protein, wherein upon crystallisation the second protein fits within the available space in the lattice of the first protein, along with the moiety. Methods for producing the protein crystal are also disclosed.

3. 发明授权

EP2972254B1 EXTENDED FIELD ITERATIVE RECONSTRUCTION TECHNIQUE (EFIRT) FOR CORRELATED NOISE REMOVAL 有权转让
标题翻译：用于相关噪声去除的扩展场迭代重建技术（EFIRT）
公开(公告)号：EP2972254B1
公开(公告)日：2018-05-09
申请号：EP14764705.1
申请日：2014-03-05
申请人： Okinawa Institute of Science and Technology Graduate University
发明人： MAHMOOD, Faisal , OFVERSTEDT, Lars-Goran Wallentin , SKOGLUND, Bo Ulf
IPC分类号： G06T11/00 , G01N23/04
CPC分类号： G01N23/046 , G01N2223/401 , G01N2223/419 , G01N2223/42 , G01N2223/612 , G06T11/006 , G06T2211/432
摘要： Computerized method and system for improving 3D reconstruction images involves applying the Extended Field Iterative Reconstruction Technique (EFIRT) to remove correlated noise, in addition to with COMET (constrained maximum relative entropy tomography) or other regularization techniques to eliminate uncorrelated noise, wherein the EFIRT is applied by performing a set of successive reconstructions on an extended field larger than a region of interest (ROI); and extracting and averaging the ROI from said set of successive reconstructions.

4. 发明授权

EP2526411B1 PRÜFEINRICHTUNG ZUR BESTIMMUNG DER QUALITÄT VON LEDER 失效
标题翻译：测定皮革质量的试验设备
公开(公告)号：EP2526411B1
公开(公告)日：2018-04-04
申请号：EP10798339.7
申请日：2010-12-23
申请人： Wollsdorf Leder Schmidt & Co. Ges.m.b.H.
发明人： KRAUS-GUENTNER, Georg , KRAUS-GUENTNER, Elisabeth
IPC分类号： G01N23/16 , G01N23/18 , G01N33/44 , C14B17/00 , G01N23/04
CPC分类号： G01N33/447 , C14B17/16 , G01N23/043 , G01N2223/612 , G01N2223/646

5. 发明公开

EP3147659A4 SAMPLE COMPONENT ANALYSIS METHOD, METHOD OF SPECIFIC SEPARATION OF COMPONENTS IN SAMPLE, AND SAMPLE FOR USE IN MASS SPECTROMETRY 有权
标题翻译： PRINENKOMPONENTENANALYSEVERFAHREN，VERFAHREN ZUR SPEZIFISCHEN ABTRENNUNG VON KOMPONENTEN IN EERER PROBE UND PROBE ZUR VERWENDUNG IN MASSENSPEKTROMETRIE
公开(公告)号：EP3147659A4
公开(公告)日：2017-06-07
申请号：EP15796600
申请日：2015-05-12
申请人： NAT UNIV CORP NAGOYA UNIV
发明人： SAWADA MAKOTO
IPC分类号： G01N27/64 , G01N27/62
CPC分类号： G01N27/64 , G01N27/62 , G01N2223/612 , H01J49/164
摘要： A trace component in a sample is quickly and accurately analyzed using a small sample quantity without performing preprocessing such as concentration. Trace components in a sample can be analyzed quickly and accurately using a small sample quantity and without preprocessing such as concentration, by a method for analyzing a component in a sample, the method including a step for irradiating a thermoplastic resin film internally containing the sample with ionizing laser light of a mass spectrometer.
摘要翻译：样品中的痕量组分可以在不进行浓缩等预处理的情况下使用少量样品快速准确地进行分析。利用样品中的成分分析方法，可以使用少量的样品量快速且准确地分析样品中的微量成分，而不需要进行浓缩等预处理，该方法包括以下步骤：将内部包含样品的热塑性树脂膜电离质谱仪的激光。

6. 发明公开

EP3161463A1 VORRICHTUNG UND VERFAHREN FÜR DIE STÖCHIOMETRISCHE ANALYSE VON PROBEN 有权
标题翻译： VORRICHTUNG UND VERFAHRENFÜRDIE STOCHIOMETRISCHE ANALYSE VON PROBEN
公开(公告)号：EP3161463A1
公开(公告)日：2017-05-03
申请号：EP15752911.6
申请日：2015-06-18
申请人： Leibniz-Institut für Neue Materialien gemeinnützige GmbH
发明人： DE JONGE, Niels , PECKYS, Diana B.
IPC分类号： G01N23/225 , H01J37/20
CPC分类号： G01N23/2251 , G01N2223/307 , G01N2223/418 , G01N2223/612 , H01J37/20 , H01J37/3178
摘要： The present invention relates to a device and a method for the stoichiometric analysis of samples. In order to study the spatial distribution of different proteins in the plasma membrane of a complete cell within a short time frame, a device and a method are proposed for the stoichiometric analysis of samples. The problem is solved by a device for the stoichiometric analysis of samples, wherein the device comprises a) a sample processing device, comprising a sample holder for holding the sample, means for setting the temperature, means for adding and removing fluid (also gases) and at least one fluid reservoir, b) an electron microscope with a detector, and c) a process control device, controlled by a computer, for controlling the means for setting the temperature and the means for adding and removing fluids (also gases) and an image recording device, automated and controlled by a computer, which captures images by means of the electron microscope, a unit storing the captured images, and an image analysis unit controlled by the computer.
摘要翻译：本发明涉及用于样品的化学计量分析的装置和方法。为了在短时间内研究完整细胞质膜中不同蛋白质的空间分布，提出了一种装置和方法用于样品的化学计量分析。该问题通过用于样品的化学计量分析的装置来解决，其中该装置包括a）样品处理装置，该样品处理装置包括用于保持样品的样品保持器，用于设定温度的装置，用于添加和去除流体（还有气体）和至少一个流体储存器，b）带有检测器的电子显微镜，以及c）由计算机控制的过程控制装置，用于控制设定温度的装置和用于添加和除去流体（也包括气体）的装置，以及由计算机自动控制的图像记录装置，其通过电子显微镜捕获图像，存储捕获的图像的单元以及由计算机控制的图像分析单元。

7. 发明授权

EP2755209B1 SAMPLE-CONTAINING CELL FOR X-RAY MICROSCOPE AND METHOD FOR OBSERVING X-RAY MICROSCOPIC IMAGE 有权
标题翻译：样品含有细胞X射线显微镜和监测方法的X射线图像微观
公开(公告)号：EP2755209B1
公开(公告)日：2016-10-12
申请号：EP12830348.4
申请日：2012-08-31
申请人： National Institute of Advanced Industrial Science and Technology
发明人： OGURA, Toshihiko , TAKAHASHI, Toru
IPC分类号： G21K7/00 , G21K5/08
CPC分类号： G21K5/08 , G01N23/04 , G01N2223/309 , G01N2223/612 , G21K7/00

8. 发明授权

EP1496797B1 VARIABLE-MOTION OPTICAL TOMOGRAPHY OF SMALL OBJECTS 有权
标题翻译：光学成像可变运动小物体
公开(公告)号：EP1496797B1
公开(公告)日：2016-08-17
申请号：EP03721595.1
申请日：2003-04-09
申请人： VisionGate, Inc.
发明人： NELSON, Alan, C.
IPC分类号： G01N21/47 , G01N15/10 , G01N15/14 , G06T11/00
CPC分类号： G01N15/1475 , G01N15/147 , G01N21/4795 , G01N2015/1006 , G01N2015/1075 , G01N2015/1445 , G01N2201/0813 , G01N2223/612 , G06T11/006 , G06T2211/421

9. 发明公开

EP3011321A1 CODED-APERTURE X-RAY IMAGING 有权转让
标题翻译：与编码孔径X射线成像
公开(公告)号：EP3011321A1
公开(公告)日：2016-04-27
申请号：EP14731991.7
申请日：2014-05-29
申请人： UCL Business Plc.
发明人： ENDREZZI, Marco , OLIVO, Alessandro , DIEMOZ, Paul , MILLARD, Thomas , VITTORIA, Fabio
IPC分类号： G01N23/04 , A61B6/00
CPC分类号： G01N23/04 , A61B6/4035 , A61B6/4291 , A61B6/484 , A61B6/5205 , G01N2223/401 , G01N2223/612
摘要： A method of X-ray imaging includes passing an X-ray beam through a pre-sample mask 8 with a plurality of apertures 32, through a sample 10, and then through a detector mask 6 with aligned apertures 34. The beams are detected. The detector mask 6 and pre-sample mask 8 are moved with respect to one another to identify the position of maximum intensity and then moved to two further positions on equal and opposite spacings on either side of the maximum. Images are acquired and a transmission image, refraction image and scattering image calculated.

10. 发明授权

EP1987523B1 Process for imaging 有权转让
标题翻译：一种用于成像方法
公开(公告)号：EP1987523B1
公开(公告)日：2015-12-09
申请号：EP07762817.0
申请日：2007-01-26
申请人： THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： KELLER, Charles , BAHADUR, Ali, N.
IPC分类号： G21K7/00 , G01N23/083 , G01N1/30 , G01N23/04 , A61B6/00
CPC分类号： G01N1/30 , A61B6/508 , G01N23/046 , G01N2223/419 , G01N2223/612
摘要： Processes for producing a microCT image for virtual histology using x-ray microscopic computed tomography are described along with processes for rapid and inexpensive high-throughput methods of high resolution imaging for screening an ex vivo embryo for phenotype using computed tomography imaging. Staining of particular components of specimens with one or more staining agents is described which contributes to high quality image generation and identification of anatomical structures as well as localization of molecular targets. Inventive animal and specimen holders are detailed which allow for reduced post-imaging processing of generated images. In particular, animal and specimen holders are provided which include a highly transparent bed or liner which separates the animal or specimen from a less transparent structure. A further animal holder is provided for placing and/or maintaining the animal in a desired position during an imaging procedure or multiple imaging procedures including a bed conforming to the animal's body.

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