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1. 发明公开

EP3376234A1 METHOD FOR REMOVING LIQUID, AND LIQUID OPERATION DEVICE 有权转让
公开(公告)号：EP3376234A1
公开(公告)日：2018-09-19
申请号：EP16864098.5
申请日：2016-11-02
申请人： Konica Minolta, Inc.
发明人： IWASHITA, Atsuo , AOKI, Youichi , MIYAZAKI, Koji
IPC分类号： G01N35/08 , G01N35/10 , G01N37/00
CPC分类号： G01N35/1004 , G01N35/1009 , G01N35/1016 , G01N37/00 , G01N2035/00237 , G01N2035/0437 , G01N2035/1034
摘要： The present invention provides a method for removing liquid from the interior of a flow channel tip, which enables both to reduce the amount of liquid remaining and prevent the time spent removing the liquid from being longer than necessary. The method comprises: suctioning a liquid within a flow channel, the liquid being suctioned into the interior of a liquid suction implement inserted into a first through-hole of a flow channel tip; and removing the liquid within the flow channel. This method comprises: a first suction step for suctioning some of the liquid within the flow channel at a first suction speed; and a second suction step for suctioning the liquid remaining within the flow channel at a second suction speed that is less than the first suction speed, the second suction step being performed in continuation from the first suction step.

2. 发明公开

EP3262397A1 APPARATUSES AND METHODS FOR SUSPENDING AND WASHING THE CONTENTS OF A PLURALITY OF CUVETTES 有权转让
标题翻译：用于暂停和洗涤多个CUVETTES的内容的装置和方法
公开(公告)号：EP3262397A1
公开(公告)日：2018-01-03
申请号：EP16756294.1
申请日：2016-02-24
申请人： Hycor Biomedical, LLC
发明人： DIAMOND, Ronald Norman , GANN, Steve Michael , HALL, Eric Darnell , HWANG, Tae Ho , MORTON, John Lewis , MOSKALEV, Anatoly , SARGEANT, Bruce Alan , RIEGER, Dennis Edwin , GOMBOSEV, Marinela , VAN CLEVE, Mark David
IPC分类号： G01N21/00
CPC分类号： G01N35/02 , B03C1/01 , B03C1/0332 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N21/01 , G01N35/0098 , G01N35/025 , G01N35/1011 , G01N2035/0437 , G01N2035/0455 , G01N2035/0477
摘要： Apparatuses and methods for washing a plurality of fluid samples are disclosed herein. In an embodiment, a system for washing a plurality of fluid samples respectively located within a plurality of cuvettes includes a rotor configured to rotate the plurality of cuvettes about an axis, a traveler mechanism located beneath the rotor, the traveler mechanism configured to move a plurality of magnets parallel to the axis of rotation of the rotor to position the plurality of magnets so that each cuvette of the plurality of cuvettes is located adjacent to at least one magnet of the plurality of magnets, and a wash system located above the rotor, the wash system configured to at least one of inject fluid into or aspirate fluid from the plurality of the cuvettes, while the plurality of magnets suspend magnetic particles located within each of the plurality of cuvettes.

4. 发明公开

EP2316570A3 Automated diagnostic analyzer and method 审中-公开
标题翻译：自动诊断分析仪和方法
公开(公告)号：EP2316570A3
公开(公告)日：2011-07-27
申请号：EP10012007.0
申请日：1999-04-30
申请人： Gen-Probe Incorporated
发明人： Ammann, Kelly G , Schneider, Robert E. , Smith, Robert J-
IPC分类号： B01L7/00 , G01N35/00
CPC分类号： C12Q1/6834 , B01F9/0001 , B01F9/0014 , B01F9/0021 , B01F2009/0074 , B01L7/52 , B01L7/5255 , B01L9/06 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , B03C1/282 , B03C1/288 , B03C1/30 , B03C2201/26 , C12Q1/6813 , C12Q1/6832 , C12Q2537/10 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/1065 , G01N2035/00356 , G01N2035/00524 , G01N2035/0437 , G01N2035/0455 , G01N2035/103 , Y10T29/53657 , Y10T29/53683 , Y10T29/53843 , Y10T156/1105 , Y10T156/1906 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and a device for holding containers of reagents in a temperature controlled environment. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte.
摘要翻译：用于同时进行多种诊断测定的自动化分析仪包括多个站或模块，其中对包含在反应容器中的流体样本进行测定的离散方面。分析仪包括用于自动制备样本样本的站点，将样本在规定温度下孵育规定的时间，执行分析物分离程序以及确定目标分析物的存在。自动化的容器运输系统将反应容器从一个站移动到下一个站。该分析仪还包括用于以机器可接近的方式携带多个标本管和一次性移液管吸头的装置，用于搅拌靶标捕获试剂的容器的装置，该装置包括固体支持材料的悬浮液和用于容纳温度控制环境。用于执行自动化诊断测定的方法包括用于分离和扩增目标分析物的自动化过程。

5. 发明公开

EP2180325A1 CLEANING DEVICE AND ANALYSIS DEVICE 审中-公开
标题翻译： REINIGUNGSVORRICHTUNG UND ANALYSEVORRICHTUNG
公开(公告)号：EP2180325A1
公开(公告)日：2010-04-28
申请号：EP08791556.7
申请日：2008-07-24
申请人： Beckman Coulter, Inc.
发明人： TSURUTA, Hiroshi , OZAKI, Motoaki , NISHIMURA, Isao , TAKEYA, Mariko
IPC分类号： G01N35/02 , G01N1/00
CPC分类号： B01L99/00 , B01L3/5082 , G01N2035/0437
摘要： A cleaning device and an analyzer capable of reducing an amount of cleaning liquid required for cleaning a cuvette are provided. In the analyzer according to the present invention, wall cross-sectional areas (S12) and (S22) are made larger than respective inner-diameter cross-sectional areas (S11) and (S21) of the supply nozzle (191) and the suction nozzle (192) that form a cleaning nozzle, so that a wall of each of the supply nozzle (191) and the suction nozzle (192) is thickened to increase the volume occupied by the nozzle in the cuvette 21. Thus, a percentage of the cleaning liquid (Ls) in the cuvette (21) can be reduced, resulting in reducing the amount of the cleaning liquid required for cleaning the cuvette (21).
摘要翻译：提供了能够减少清洗比色皿所需的清洗液量的清洗装置和分析装置。在本发明的分析装置中，壁部横截面积（S12）和（S22）比供给喷嘴191的内径截面积（S11）和（S21）大，形成清洁喷嘴的喷嘴（192），使得供给喷嘴（191）和吸嘴（192）中的每一个的壁变厚，以增加在试管21中由喷嘴占据的体积。因此，可以减小反应杯（21）中的清洗液（Ls），从而减少清洗比色皿（21）所需的清洗液量。

6. 发明公开

EP2124065A1 CLEANING DEVICE AND AUTOMATIC ANALYZER 审中-公开
标题翻译： REINIGUNGSVORRICHTUNG UND ANALYSEAUTOMAT
公开(公告)号：EP2124065A1
公开(公告)日：2009-11-25
申请号：EP08721685.9
申请日：2008-03-10
申请人： Olympus Corporation
发明人： TSURUTA, Hiroshi
IPC分类号： G01N35/02 , B08B3/02 , G01N1/00
CPC分类号： B01L99/00 , B01L3/5082 , G01N2035/0437
摘要： A cleaning device (20) includes a nozzle unit (21) that has a supply nozzle (211), a suction nozzle (213), and an overflow nozzle (215). An end of the suction nozzle (213) is located at a position slightly lower than an end of the supply nozzle (211) in a vertical direction. An end of the overflow nozzle (215) is located at a position higher than the end of the supply nozzle (211) in the vertical direction. The supply nozzle (211) has an inner diameter area larger than an area of a section where reaction liquid and cleaning water are held. The supply nozzle (211) is arranged such that there is provided a space between the outer wall surface of the supply nozzle (211) and the entire inner wall surface of a reaction vessel (C) to flow the cleaning water supplied from the supply nozzle 211 through the space. The cleaning water supplied from the supply nozzle (211) flows through the space between the outer wall surface of the supply nozzle (211) and the inner wall surface of the reaction vessel (C) and is sucked by the overflow nozzle (215).
摘要翻译：清洁装置（20）包括具有供给喷嘴（211），吸嘴（213）和溢流喷嘴（215）的喷嘴单元（21）。吸嘴213的一端在垂直方向上位于比供给喷嘴211的端部略低的位置。溢流喷嘴215的一端位于高于供给喷嘴211的垂直方向端部的位置。供应喷嘴（211）的内径面积大于保持反应液体和清洁水的部分的面积。供给喷嘴211被配置为在供给喷嘴211的外壁面与反应容器C的内壁面整体之间设置有空间，使从供给喷嘴供给的清洗水 211通过空间。从供给喷嘴211供给的清洗水通过供给喷嘴211的外壁面与反应容器C的内壁面之间的空间流过溢流喷嘴215。

7. 发明公开

EP1614475A2 Device for agitating the fluid contents of a container 有权
标题翻译：用于搅动容器内液体内容物的装置
公开(公告)号：EP1614475A2
公开(公告)日：2006-01-11
申请号：EP05019229.3
申请日：1999-04-30
申请人： GEN-PROBE INCORPORATED
发明人： Ammann, Kelly G. , Burns, Ralph E. , Hansberry, Ernest V. , Horner, Glenn A. , Jakub, Cheryl A. , Kling, John E. , Nieglos, Donald J. , Schneider, Robert E. , Smith, Robert J.
IPC分类号： B01L7/00 , G01N35/00
CPC分类号： C12Q1/6834 , B01F9/0001 , B01F9/0014 , B01F9/0021 , B01F2009/0074 , B01L7/52 , B01L7/5255 , B01L9/06 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , B03C1/282 , B03C1/288 , B03C1/30 , B03C2201/26 , C12Q1/6813 , C12Q1/6832 , C12Q2537/10 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/1065 , G01N2035/00356 , G01N2035/00524 , G01N2035/0437 , G01N2035/0455 , G01N2035/103 , Y10T29/53657 , Y10T29/53683 , Y10T29/53843 , Y10T156/1105 , Y10T156/1906 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： A device for agitating the fluid contents of at least one container, said device comprising:

a turntable structure constructed and arranged to be rotatable about a first axis of rotation;
one or more container holders, each of said container holders having an axis of rotation and being constructed and arranged to hold a container therein, said container holders being mounted on said turntable structure so as to be rotatable therewith and so that said axis of rotation of each container holder is generally parallel to said first axis of rotation;
a container holder mounting assembly associated with each container holder, said container holder mounting assembly being constructed and arranged to mount said associated container holder to said turntable structure and to permit said associated container holder to rotate about a second axis of rotation that is generally parallel to and spaced from both said first axis of rotation and said axis of rotation of said associated container holder; and
rotational motion coupling elements operatively associated with said turntable structure and said container holder mounting structure and constructed and arranged to cause each container holder to rotate about said second axis of rotation as said turntable structure rotates about said first axis of rotation.
摘要翻译： 1。一种用于搅动至少一个容器的流体内容物的装置，所述装置包括：转台结构，所述转台结构被构造和布置成可围绕第一旋转轴线旋转; 一个或多个容器保持器，每个所述容器保持器具有旋转轴线并被构造和布置成将容器保持在其中，所述容器保持器安装在所述转台结构上以便与其一起旋转，并且所述容器保持器的旋转轴线每个容器保持器大致平行于所述第一旋转轴线; 与每个容器保持器相关联的容器保持器安装组件，所述容器保持器安装组件被构造和布置成将所述相关联的容器保持器安装到所述转台结构并且允许所述相关联的容器保持器围绕大致平行于第二轴线的第二旋转轴线旋转并且与所述第一旋转轴线和所述相关容器保持器的所述旋转轴线间隔开; 以及与所述转台结构和所述容器支架安装结构可操作地相关联的旋转运动联接元件，并且所述旋转运动联接元件被构造和布置成当所述转台结构围绕所述第一旋转轴线旋转时使得每个容器支架围绕所述第二旋转轴线旋转。

8. 发明公开

EP1614474A2 Incubator for automatic analyser 失效
标题翻译：自动分析仪培养箱
公开(公告)号：EP1614474A2
公开(公告)日：2006-01-11
申请号：EP05019228.5
申请日：1999-04-30
申请人： GEN-PROBE INCORPORATED
发明人： Ammann, Kelly G. , Burns, Ralph E. , Hansberry, Ernest V. , Horner, Glenn A. , Jakub, Cheryl A. , Kling, John E. , Nieglos, Donald J. , Schneider, Robert E. , Smith, Robert J.
IPC分类号： B01L7/00 , G01N35/00
CPC分类号： C12Q1/6834 , B01F9/0001 , B01F9/0014 , B01F9/0021 , B01F2009/0074 , B01L7/52 , B01L7/5255 , B01L9/06 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , B03C1/282 , B03C1/288 , B03C1/30 , B03C2201/26 , C12Q1/6813 , C12Q1/6832 , C12Q2537/10 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/1065 , G01N2035/00356 , G01N2035/00524 , G01N2035/0437 , G01N2035/0455 , G01N2035/103 , Y10T29/53657 , Y10T29/53683 , Y10T29/53843 , Y10T156/1105 , Y10T156/1906 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： An incubator for receiving a plurality of reaction receptacles containing reaction fluids and for maintaining the reaction fluids in a temperature controlled environment, said incubator comprising:

a housing including a receptacle access opening formed therein for allowing movement of a reaction receptacle into or out of said housing through said receptacle access opening;
a command-responsive closure mechanism connected to said housing in proximal relation to said receptacle access opening, said command-responsive closure mechanism being constructed and arranged to be movable between a closed position and an open position with respect to said receptacle access opening in response to corresponding closure movement commands to prevent or permit access to said housing through said access opening,
said housing and said command-responsive closure mechanism constituting an enclosure defining an incubation chamber therein;
a heat source in thermal communication with said incubation chamber;
a powered fan mechanism disposed within said incubation chamber and constructed and arranged to generate air movement within said incubation chamber to promote a generally uniform temperature distribution internal to said incubation chamber; and
a receptacle carrier disposed within said incubation chamber and including a plurality of receptacle stations, each of said receptacle stations being constructed and arranged to carry a single reaction receptacle, said receptacle carrier being constructed and arranged to present any of said plurality of receptacle stations in a receptacle transfer position with respect to said access opening.
摘要翻译：一种用于容纳多个容纳反应流体的反应容器并用于将反应流体保持在温度受控的环境中的培养箱，所述培养箱包括：壳体，所述壳体包括在其中形成的容器进入开口，用于允许反应容器移入或移出所述壳体通过所述容器进入开口; 响应于所述壳体以近似于所述容器进入开口的方式连接到所述壳体的命令响应闭合机构，所述命令响应闭合机构被构造并布置成响应于所述命令响应闭合机构而相对于所述容器进入开口在关闭位置和打开位置之间移动相应的关闭运动命令以防止或允许通过所述进入开口进入所述壳体，所述壳体和所述命令响应闭合机构构成限定其中的孵育室的封闭空间; 与所述孵育室热连通的热源; 动力风扇机构，所述动力风扇机构设置在所述孵育室内并且被构造和布置成在所述孵育室内产生空气移动以促进所述孵育室内部的大致均匀的温度分布; 以及设置在所述孵育室内并包括多个容器站的容器载体，所述容器站中的每一个被构造和布置为承载单个反应容器，所述容器载体被构造和布置成将所述多个容器站中的任一个容纳在相对于所述进入开口的容器传送位置。

9. 发明公开

EP1614472A2 Luminometer for automatic analyser 失效
标题翻译：发光仪自动分析仪
公开(公告)号：EP1614472A2
公开(公告)日：2006-01-11
申请号：EP05019226.9
申请日：1999-04-30
申请人： GEN-PROBE INCORPORATED
发明人： Ammann, Kelly G. , Burns, Ralph E. , Hansberry, Ernest V. , Horner, Glenn A. , Jakub, Cheryl A. , Kling, John E. , Nieglos, Donald J. , Schneider, Robert E. , Smith, Robert J.
IPC分类号： B01L7/00 , G01N35/00 , G01N21/76
CPC分类号： C12Q1/6834 , B01F9/0001 , B01F9/0014 , B01F9/0021 , B01F2009/0074 , B01L7/52 , B01L7/5255 , B01L9/06 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , B03C1/282 , B03C1/288 , B03C1/30 , B03C2201/26 , C12Q1/6813 , C12Q1/6832 , C12Q2537/10 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/1065 , G01N2035/00356 , G01N2035/00524 , G01N2035/0437 , G01N2035/0455 , G01N2035/103 , Y10T29/53657 , Y10T29/53683 , Y10T29/53843 , Y10T156/1105 , Y10T156/1906 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： An instrument for detecting the amount of light emitted from the contents of a receptacle vessel, said instrument comprising:

structure defining a transport path along which a plurality of adjacently-arranged receptacle vessels are moved through the instrument;
a photosensitive device disposed along said transport path and constructed and arranged to detect light emitted from the contents of a receptacle vessel operatively positioned with respect to said photosensitive device; and
a receptacle vessel isolating device positioned adjacent said transport path and constructed and arranged to pivot between: (1) a first position permitting the plurality of adjacently-arranged receptacle vessels to be moved along said transport path; and (2) a second position operatively engaging one of said receptacle vessels disposed on said transport path and operatively positioned with respect to said photosensitive device, said receptacle vessel isolating device being constructed and arranged to substantially prevent light from sources other than said operatively positioned receptacle vessel engaged by said receptacle vessel isolating device from being detected by said photosensitive device, said receptacle vessel isolating device being constructed and arranged to pivotally rotate between said first and second positions and including structure at least partially surrounding a receptacle vessel engaged by said receptacle vessel isolating device when said receptacle vessel isolating device is in said second position.
摘要翻译：一种用于检测从容器容器的内容物发射的光量的仪器，所述仪器包括：结构，其限定了多个相邻布置的容器容器沿着该传送路径移动通过所述仪器; 沿着所述传送路径设置并构造和布置成用于检测从相对于所述感光装置可操作地定位的容器容器的内容物发射的光; 以及位于所述传送路径附近的构造和布置成在以下位置之间枢转的容器容器隔离装置：（1）允许所述多个相邻布置的容器容器沿着所述传送路径移动的第一位置; 和（2）第二位置，操作地接合设置在所述传送路径上并且相对于所述感光装置可操作地定位的所述容器容器中的一个，所述容器隔离装置被构造和布置成基本上防止来自除了所述可操作定位的容器由所述容器隔离装置接合的容器不被所述感光装置检测到，所述容器隔离装置被构造和布置成在所述第一和第二位置之间枢转地旋转，并且包括至少部分地围绕由所述容器容器隔离的容器容器当所述容器隔离装置处于所述第二位置时。

10. 发明公开

EP1614470A2 Automated diagnostic analyzer and method 无效
标题翻译：自动诊断分析
公开(公告)号：EP1614470A2
公开(公告)日：2006-01-11
申请号：EP05015156.2
申请日：1999-04-30
申请人： GEN-PROBE INCORPORATED
发明人： Ammann, Kelly G. , Burns, Ralph E. , Hansberry, Ernest V. , Horner, Glenn A. , Jakub, Cheryl A. , Kling, John E. , Nieglos, Donald J. , Schneider, Robert E. , Smith, Robert J.
IPC分类号： B01L7/00 , G01N35/00
CPC分类号： C12Q1/6834 , B01F9/0001 , B01F9/0014 , B01F9/0021 , B01F2009/0074 , B01L7/52 , B01L7/5255 , B01L9/06 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , B03C1/282 , B03C1/288 , B03C1/30 , B03C2201/26 , C12Q1/6813 , C12Q1/6832 , C12Q2537/10 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/1065 , G01N2035/00356 , G01N2035/00524 , G01N2035/0437 , G01N2035/0455 , G01N2035/103 , Y10T29/53657 , Y10T29/53683 , Y10T29/53843 , Y10T156/1105 , Y10T156/1906 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.
摘要翻译：用于执行多个诊断测定的自动分析仪同时包括多个站或模块，其中对反应容器中包含的流体样品进行测定的离散方面。分析仪包括用于自动准备标本样品的台站，在规定温度下培养样品规定的时间，预处理分析物分离程序，并确定目标分析物的存在。自动插座输送系统将反应容器从一个站移动到另一个站。分析仪还包括用于以机器可接近的方式携带多个样品管和一次性移液管尖端的装置，用于搅拌包含固体支持材料的悬浮液并用于提供用于机器通入的容器的靶捕获试剂的容器的装置，以及用于在温度受控的环境中容纳试剂容器的装置，并且提供用于机器通入的容器。执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化过程。该过程是通过在站之间自动移动含有固体支持材料和流体样品的多个反应容器中的每一个来孵育反应容器的内容物并将与固体支持物结合的靶分析物与流体样品分离的步骤。在分析物分离步骤之后和在最终孵育步骤之前，将分离的分析物加入扩增试剂。

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