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    • 6. 发明公开
    • NONINVASIVE DETERMINATION OF CARDIAC OUTPUT, PULMONARY BLOOD FLOW, AND BLOOD GAS CONTENT
    • 心脏的非侵入性测定,肺血流量和血液气体含量
    • EP1257201A1
    • 2002-11-20
    • EP00959742.8
    • 2000-09-01
    • NTC Technology Inc.
    • ORR, Joseph, A.KUCK, Kai
    • A61B5/083
    • A61B5/0836A61B5/029G01N33/497G01N2001/2244
    • A method of noninvasively determining the pulmonary capillary blood flow or cardiac output of a patient, including the use of rebreathing techniques to measure the respiratory flow and carbon dioxide pressure of the patient's breathing. These measurements are used to calculate carbon dioxide elimination and an indicator of the carbon dioxide content of the patient's blood, such as the end tidal pressure of carbon dioxide (PetCO2), CaCO2, or pCO2. The location and orientation of a best-fit line through the carbon dioxide elimination data and the data of the indicator of carbon dioxide content is determined by linear regression or by plotting the carbon dioxide elimination data against the data of the indicator of carbon dioxide content. At least one set of the data is modified and at least one other determination of the best-fit line made to find a data set that correlates most closely to the best fit line. The data may be modified by filtering or clustering. The slope of the best-fit line that correlates most closely to the data is then used to determine the pulmonary capillary blood flow or cardiac output of the patient. When the indicator of carbon dioxide content is CaCO2, the negative of the slope of the best fit line is equal to the pulmonary capillary blood flow of the patient.
    • 8. 发明公开
    • A DEVICE FOR COLLECTING PARTICLES IN AN EXHALED AIRFLOW
    • 一种用于在排出的气流中收集颗粒的装置
    • EP3316778A1
    • 2018-05-09
    • EP16729925.4
    • 2016-06-19
    • Munkplast AB
    • STAMBECK, Peter
    • A61B5/097G01N33/497
    • A61B10/00A61B5/082A61B5/097A61B2010/0087G01N1/2247G01N33/497G01N2001/2223G01N2001/2244
    • The invention relates to a device for collecting aerosol particles in an exhaled air flow. Said particles may be aerosol particles such as biomarkers or particles related to drugs or other substances formed or found in the alveoli of the lungs. Said device comprises a housing having an extension direction between a first end with an inlet arranged to receive an exhaled air flow and a second end with an outlet arranged to transmit the exhaled air flow and an inner cross section defined by inner walls of the housing and at least four first type partition walls, arranged in a direction essentially perpendicular to the walls, partly covering the inner cross section of the housing. Said first type partition walls protrude from opposite sides of the inner wall of the housing creating opposite openings between the first type partition walls and the housing inner wall, whereby said first type partition walls are arranged to create a labyrinth shaped flow path from said inlet to said outlet which is arranged to divert the air flowing from the inlet towards the outlet in a direction towards opposite inner wall of the housing so that said particles separate from the air flow and attach on the device and wherein the distance between two opposite first type partition walls is smaller than the distance between the inner walls of the housing.