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    • 3. 发明公开
    • FORMWERKZEUG, VERFAHREN ZUR HERSTELLUNG EINES GRÜNLINGS UND VERWENDUNG DES FORMWERKZEUGS
    • 模具,生产出绿色书呆子和使用表单工具的方法,
    • EP3107672A1
    • 2016-12-28
    • EP15713621.9
    • 2015-02-13
    • Ceratizit Austria Gesellschaft m.b.H.
    • SCHWARZ, GerhardSINGER-SCHNÖLLER, AlexanderWETZEL, Christoph
    • B22F3/03B30B11/00B30B15/02
    • B22F3/16A61F7/10A61F2007/0095B22F3/03B22F2003/031B22F2005/001B22F2998/10B30B11/004B30B11/007B30B15/0082B30B15/022B30B15/302F25D3/08F25D2303/0822F25D2331/8014
    • Moulding tool, method for powder metallurgical production of a green body, and a use of the moulding tool. The moulding tool (2) comprises an upper die and a lower die which can be displaced along a common pressing axis, a matrix body (4) with a feed chute (14) for receiving powder material, wherein the matrix body (4) has an upper region in which the upper die is moveably guided in the feed chute (14) along the pressing axis, and has a lower region (18) in which the lower die is moveably guided in the feed chute (14) along the pressing axis, and at least two transverse slides (10a-b) which form a moulding region that determines the lateral outer contour of a green body and which slides are arranged on the matrix body (4) displaceable in a direction deviating from the pressing axis. The at least two transverse slides (10a-b), in particular two adjacent transverse slides, only contact each other if the at least two transverse slides (10a-b) are arranged in their respective end positions, and wherein a hollow space, which determines the shape of a pressed green body, is formed in a closed state of the moulding tool (2) by the upper and lower dies arranged in the end positions thereof and the at least two transverse slides (10a-b) arranged in the end positions thereof, wherein the at least two transverse slides (10a-b) form a moulding region that determines the entire lateral outer contour of a green body.
    • 模制工具,用于粉末冶金生产生坯的方法,以及使用模制工具的。 进料槽的成形工具(2)上的爱包括和下部的可沿共同的按压轴线移位,以矩阵主体(4)与(14),用于接收粉末材料,worin基体主体(4)具有 在该上模可移动地被引导在沿按压轴线进料槽(14),并且具有沿按压轴的下部区域(18),在该下模在进料槽(14)可运动地引导上部区域 和至少两个横向滑动(图10A-b),其形成一个模制区域做确定性地雷生坯和滑动的横向外轮廓被布置在基体(4)在一个方向上从所述压制轴线偏离移动。 所述至少两个横向滑动(图10A-B),尤其是两个相邻的横向滑动时,仅彼此接触,如果所述至少两个横向滑动(图10A-B)被布置在它们的respectivement端部位置,并且worin中空的空间,这 确定性地雷压制生坯的形状,在所述模制工具(2)的闭合状态下由上形成,并且降低此布置在端部的位置上,并且所述至少两个横向滑动(图10A-b)在端布置 它们的位置,worin所述至少两个横向滑动(图10A-b)形成模制区域做确定性地雷生坯的整个横向外轮廓。
    • 10. 发明公开
    • SYSTEMS AND METHODS FOR FREEZING AND STORING BIOPHARMACUETICAL MATERIAL
    • 用于冷冻和储存生物药物材料的系统和方法
    • EP1441586A1
    • 2004-08-04
    • EP02778703.5
    • 2002-11-01
    • Integrated Biosystems Inc.
    • VOUTE, NicolasLOK, MaximeLEONARD, Leonidas, CartwrightHUGHES, Timothy, GerardWISNIEWSKI, Richard
    • A01N1/00
    • F25D31/001A01N1/02A01N1/0257A01N1/0263A23L3/364A23L3/365A61M1/0277A61M1/0281F25B2600/07F25D25/00F25D2331/8014F25D2400/20F25D2400/30F25D2500/02
    • The present invention provides a system for freezing, thawing, and storing biopharmaceutical materials which includes a flexible container, a conduit, and a temperature control unit. The flexible container is adapted to receive a biopharmaceutical material therein for freezing, thawing, and storing. The container is formed of a first substantially flat sheet of flexible material joined together by a seam with a second substantially flat sheet of flexible material so as to lie substantially flat when empty. The container fully encloses an interior portion for receiving the biopharmaceutical material. Also, the container is configured to form a three dimensional shape when filled with the biopharmaceutical material, wherein the three dimensional shape has a first side and a second side opposite the first side. The conduit is connected to the flexible container with the outside of the container being in fluid communication with the interior portion via the conduit. The temperature control unit includes a first surface and a second surface facing the first surface and the temperature control unit is configured to receive the flexible container therein, when the container is filled with the biopharmaceutical material. The container conforms to the shape of the interior of the temperature control unit and the first side and the second side of the container contact the first surface and the second surface of the temperature control unit. The first surface and/or the second surface of temperature control unit include heat transfer surface(s).
    • 本发明提供了一种用于冷冻,解冻和储存生物制药材料的系统,其包括柔性容器,导管和温度控制单元。 柔性容器适于在其中接收生物制药材料以进行冷冻,解冻和储存。 容器由第一基本上平的柔性材料片形成,该第一基本上平的柔性材料片通过接缝与第二基本上平的柔性材料片结合在一起,从而当空的时基本平放。 容器完全包围用于接收生物制药材料的内部部分。 而且,容器构造成在填充生物药物材料时形成三维形状,其中三维形状具有第一侧和与第一侧相对的第二侧。 导管连接到柔性容器,容器的外部通过导管与内部流体连通。 温度控制单元包括第一表面和面对第一表面的第二表面,并且温度控制单元构造成当容器填充有生物制药材料时在其中容纳柔性容器。 容器符合温度控制单元内部的形状,并且容器的第一侧和第二侧接触温度控制单元的第一表面和第二表面。 温度控制单元的第一表面和/或第二表面包括传热表面。