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1. 发明公开

EP1441586A1 SYSTEMS AND METHODS FOR FREEZING AND STORING BIOPHARMACUETICAL MATERIAL 有权
标题翻译：用于冷冻和储存生物药物材料的系统和方法
公开(公告)号：EP1441586A1
公开(公告)日：2004-08-04
申请号：EP02778703.5
申请日：2002-11-01
申请人： Integrated Biosystems Inc.
发明人： VOUTE, Nicolas , LOK, Maxime , LEONARD, Leonidas, Cartwright , HUGHES, Timothy, Gerard , WISNIEWSKI, Richard
IPC分类号： A01N1/00
CPC分类号： F25D31/001 , A01N1/02 , A01N1/0257 , A01N1/0263 , A23L3/364 , A23L3/365 , A61M1/0277 , A61M1/0281 , F25B2600/07 , F25D25/00 , F25D2331/8014 , F25D2400/20 , F25D2400/30 , F25D2500/02
摘要： The present invention provides a system for freezing, thawing, and storing biopharmaceutical materials which includes a flexible container, a conduit, and a temperature control unit. The flexible container is adapted to receive a biopharmaceutical material therein for freezing, thawing, and storing. The container is formed of a first substantially flat sheet of flexible material joined together by a seam with a second substantially flat sheet of flexible material so as to lie substantially flat when empty. The container fully encloses an interior portion for receiving the biopharmaceutical material. Also, the container is configured to form a three dimensional shape when filled with the biopharmaceutical material, wherein the three dimensional shape has a first side and a second side opposite the first side. The conduit is connected to the flexible container with the outside of the container being in fluid communication with the interior portion via the conduit. The temperature control unit includes a first surface and a second surface facing the first surface and the temperature control unit is configured to receive the flexible container therein, when the container is filled with the biopharmaceutical material. The container conforms to the shape of the interior of the temperature control unit and the first side and the second side of the container contact the first surface and the second surface of the temperature control unit. The first surface and/or the second surface of temperature control unit include heat transfer surface(s).
摘要翻译：本发明提供了一种用于冷冻，解冻和储存生物制药材料的系统，其包括柔性容器，导管和温度控制单元。柔性容器适于在其中接收生物制药材料以进行冷冻，解冻和储存。容器由第一基本上平的柔性材料片形成，该第一基本上平的柔性材料片通过接缝与第二基本上平的柔性材料片结合在一起，从而当空的时基本平放。容器完全包围用于接收生物制药材料的内部部分。而且，容器构造成在填充生物药物材料时形成三维形状，其中三维形状具有第一侧和与第一侧相对的第二侧。导管连接到柔性容器，容器的外部通过导管与内部流体连通。温度控制单元包括第一表面和面对第一表面的第二表面，并且温度控制单元构造成当容器填充有生物制药材料时在其中容纳柔性容器。容器符合温度控制单元内部的形状，并且容器的第一侧和第二侧接触温度控制单元的第一表面和第二表面。温度控制单元的第一表面和/或第二表面包括传热表面。

2. 发明授权

EP1441586B1 SYSTEMS AND METHODS FOR FREEZING AND STORING BIOPHARMACUETICAL MATERIAL 有权
标题翻译：装置和方法用于冷冻和储存生物制药材料
公开(公告)号：EP1441586B1
公开(公告)日：2006-06-21
申请号：EP02778703.5
申请日：2002-11-01
申请人： Integrated Biosystems Inc.
发明人： VOUTE, Nicolas , LOK, Maxime , LEONARD, Leonidas, Cartwright , HUGHES, Timothy, Gerard , WISNIEWSKI, Richard
IPC分类号： A01N1/00
CPC分类号： F25D31/001 , A01N1/02 , A01N1/0257 , A01N1/0263 , A23L3/364 , A23L3/365 , A61M1/0277 , A61M1/0281 , F25B2600/07 , F25D25/00 , F25D2331/8014 , F25D2400/20 , F25D2400/30 , F25D2500/02
摘要： The present invention provides a system for freezing, thawing, and storing biopharmaceutical materials which includes a flexible container, a conduit, and a temperature control unit. The flexible container is adapted to receive a biopharmaceutical material therein for freezing, thawing, and storing. The container is formed of a first substantially flat sheet of flexible material joined together by a seam with a second substantially flat sheet of flexible material so as to lie substantially flat when empty. The container fully encloses an interior portion for receiving the biopharmaceutical material. Also, the container is configured to form a three dimensional shape when filled with the biopharmaceutical material, wherein the three dimensional shape has a first side and a second side opposite the first side. The conduit is connected to the flexible container with the outside of the container being in fluid communication with the interior portion via the conduit. The temperature control unit includes a first surface and a second surface facing the first surface and the temperature control unit is configured to receive the flexible container therein, when the container is filled with the biopharmaceutical material. The container conforms to the shape of the interior of the temperature control unit and the first side and the second side of the container contact the first surface and the second surface of the temperature control unit. The first surface and/or the second surface of temperature control unit include heat transfer surface(s).

3. 发明授权

EP0960311B1 FREEZING AND THAWING VESSEL WITH THERMAL BRIDGES 失效
标题翻译：冻结和带热桥解冻
公开(公告)号：EP0960311B1
公开(公告)日：2005-11-09
申请号：EP98906117.1
申请日：1998-02-04
申请人： Integrated Biosystems, Inc.
发明人： WISNIEWSKI, Richard , LEONARD, Leonidas, Cartwright
IPC分类号： F25D31/00 , F28D7/12 , F28F1/14
CPC分类号： F28D7/024 , F25D31/006 , F28D1/06 , F28D7/12 , F28D2021/0077 , F28F1/02 , F28F1/14
摘要： The present invention relates to a thermal transfer system for heating or cooling a medium. A structure (8, 37, 46, 50, 72, 81, 82, 89, 93, 98, 108, 306, 404) positioned inside a container (4, 34, 124, 302). The structure (8, 37, 46, 50, 72, 81, 82, 89, 93, 108, 306, 404) segments the container (4, 34, 124, 302) into a plurality of compartments (36, 95) wherein a distal end of the structure (8, 37, 46, 50, 72, 81, 82, 89, 93, 108, 306, 404) is in close proximity to an interior surface of the container (10, 33, 42, 91, 122, 210, 316, 414) to allow formation of a thermal transfer bridge (35, 208, 424, 426) that conducts heat into or out of the medium.

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