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    • 5. 发明公开
    • RESILIENT CONTAINERS FOR HYPERPOLARIZED GASES
    • 超高压气体弹性容器
    • EP1090249A2
    • 2001-04-11
    • EP99928724.6
    • 1999-06-16
    • Medi-Physics, Inc.
    • ZOLLINGER, David, L.DEATON, Daniel, M.DRIEHUYS, BastiaanHASSON, Kenton, C.
    • F17C1/00
    • G01R33/282A61K49/1815F17C1/00F17C1/16F17C3/00F17C13/002F17C13/005F17C2201/0128F17C2201/0157F17C2201/0176F17C2203/032F17C2203/0604F17C2203/0619F17C2203/0646F17C2203/066F17C2203/0697F17C2205/0115F17C2205/0323F17C2205/0329F17C2205/0364F17C2205/0394F17C2221/017F17C2221/07F17C2223/0123F17C2260/013F17C2260/018F17C2260/02F17C2260/026F17C2260/05F17C2270/02F17C2270/025
    • A resilient multi-layer container is configured to receive a quantity of hyperpolarized noble fluid such as gas and includes a wall with at least two layers, a first layer with a surface which minimizes contact-induced spin-relaxation and a first or second layer which is substantially impermeable to oxygen. The container is especially suitable for collecting and transporting 3He. The resilient container can be formed of material layers which are concurrently responsive to pressure such as polymers, deuterated polymers, or metallic films. The container can include a capillary stem and/or a port or valve isolation means to inhibit the flow of gas from the main volume of the container during transport. The resilient container can be configured to directly deliver the hyperpolarized noble gas to a target interface by deflating or collapsing the inflated resilient container. In addition, single layer resilient containers with T¿1?'s of above 4 hours for ?129¿Xe and above 6 hours for 3He include materials with selected relaxivity values. In addition, a bag with a port fitting or valve member and one or more of a capillary stem and port isolation means is configured to minimize the depolarizing effect of the container valve or fitting(s). Also disclosed is a method for determining the gas solubility in an unknown polymer or liquid using the measured relaxation time of a hyperpolarized gas.
    • 弹性多层容器被构造成接收一定量的超极化惰性流体,例如气体,并包括具有至少两层的壁,具有使接触引起的自旋松弛最小化的表面的第一层以及第一层或第二层, 基本上不透氧气。 该容器特别适合于收集和运输3He。 弹性容器可以由对压力同时响应的材料层形成,例如聚合物,氘化聚合物或金属膜。 容器可以包括毛细管杆和/或端口或阀隔离装置,以在运输期间抑制气体从容器的主体积流动。 弹性容器可以构造成通过使膨胀的弹性容器放气或收缩而将超极化的惰性气体直接输送至目标界面。 另外,单层弹性容器的T 1≥4小时对于〜129°Xe和对于3 He而言在6个小时以上包括具有选择的弛豫值的材料。 另外,具有端口配件或阀构件以及毛细管杆和端口隔离装置中的一个或多个的袋被构造成使容器阀或配件的去极化作用最小化。 还公开了一种使用所测量的超极化气体的弛豫时间来确定未知聚合物或液体中的气体溶解度的方法。