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1. 发明公开

EP3274324A1 PROCESSES AND INTERMEDIATES FOR PREPARING A MACROCYCLIC PROTEASE INHIBITOR OF HCV 审中-公开
标题翻译：制备HCV的大环蛋白酶抑制剂的过程和中间体
公开(公告)号：EP3274324A1
公开(公告)日：2018-01-31
申请号：EP16715347.7
申请日：2016-03-25
申请人： Janssen Pharmaceuticals, Inc.
发明人： DEPRÉ, Dominique Paul Michel , ORMEROD, Dominic John , HORVATH, Andras , MOODY, Thomas Shaw , BROSSAT, Maude , RIANT, Olivier , VRIAMONT, Nicolas , LEMAIRE, Sébastien François Emmanuel , HERMANT, Sébastien Nicolas J.
IPC分类号： C07C67/08 , C07C67/30 , C07C67/31 , C07C67/60 , C07D417/04 , C07D417/14 , C07C231/02 , C07C231/12
CPC分类号： C07C235/82 , C07B2200/07 , C07C67/31 , C07C69/757 , C07C231/02 , C07C231/12 , C07C233/60 , C07C233/61 , C07C2601/08 , C07D417/04 , C07D417/14 , C12P41/001
摘要： Disclosed is a process for the preparation of certain intermediates, e.g. those in the scheme below: which intermediates and processes are useful in the preparation of the macrocyclic HVC inhibitor Simeprevir.

2. 发明授权

EP2092060B1 R-HNL RANDOM VARIANTS AND THEIR USE FOR PREPARING OPTICALLY PURE, STERICALLY HINDERED CYANOHYDRINS 有权
标题翻译：偶然的R-HNL变化及其用于生产光学纯阻碍氰醇
公开(公告)号：EP2092060B1
公开(公告)日：2014-01-22
申请号：EP07857382.1
申请日：2007-12-11
申请人： DSM IP Assets B.V.
发明人： GLIEDER, Anton , LIU, Zhibin , PSCHEIDT, Beate , GAISSBERGER, Richard
IPC分类号： C12N9/88 , C12P13/00 , C12P41/00
CPC分类号： C12N9/88 , C12P13/004 , C12P41/001

3. 发明公开

EP2179050A4 MICROBIAL KINETIC RESOLUTION OF ETHYL-3,4-EPOXYBUTYRATE 审中-公开
标题翻译： 3,4-环氧丁酸乙酯的微生物动力学拆分
公开(公告)号：EP2179050A4
公开(公告)日：2010-12-29
申请号：EP07769070
申请日：2007-07-12
申请人： AGENCY SCIENCE TECH & RES
发明人： WON JAE CHOI
IPC分类号： C12P41/00 , C12N9/14 , C12P17/02 , C12P39/00
CPC分类号： C12N9/14 , C12N9/0018 , C12P7/62 , C12P41/001 , C12Y303/0201

4. 发明公开

EP2092060A1 R-HNL RANDOM VARIANTS AND THEIR USE FOR PREPARING OPTICALLY PURE, STERICALLY HINDERED CYANOHYDRINS 有权
标题翻译：偶然的R-HNL变化及其用于生产光学纯阻碍氰醇
公开(公告)号：EP2092060A1
公开(公告)日：2009-08-26
申请号：EP07857382.1
申请日：2007-12-11
申请人： DSM IP Assets B.V.
发明人： GLIEDER, Anton , LIU, Zhibin , PSCHEIDT, Beate , GAISSBERGER, Richard
IPC分类号： C12N9/88 , C12P13/00 , C12P41/00
CPC分类号： C12N9/88 , C12P13/004 , C12P41/001
摘要： The invention relates to R-hydroxynitrile lyases with improved substrate acceptance, increased activity and increased selectivity, obtainable by introducing random mutations with the aid of random mutagenesis and/or saturation mutagenesis techniques, identifyingby means of screening or selection and, where appropriate, subsequently combining advantageous mutations, and to the use thereof.

5. 发明授权

EP1550730B1 Method for producing optically active 3-chloro-2-methyl-1,2-propanediol taking advantage of microorganism 有权
标题翻译：一种用于光学活性的3-氯-2-甲基-1,2-丙二醇的微生物制备方法
公开(公告)号：EP1550730B1
公开(公告)日：2007-08-29
申请号：EP05250004.8
申请日：2005-01-04
申请人： DAISO CO., LTD.
发明人： Nishikawa, Kouji , Suzuki, Toshio , Nakagawa, Atsushi , Suzuki, Keiko , Nakayama, Satoshi
IPC分类号： C12P41/00 , C12R1/38 , C12R1/05
CPC分类号： C12P41/001 , C12P7/18

6. 发明公开

EP1550730A1 Method for producing optically active 3-chloro-2-methyl-1,2-propanediol taking advantage of microorganism 有权
标题翻译： Verfahren zur mikrobiologischen Herstellung von optisch aktiven 3-氯-2-甲基-1,2-丙二醇
公开(公告)号：EP1550730A1
公开(公告)日：2005-07-06
申请号：EP05250004.8
申请日：2005-01-04
申请人： DAISO CO., LTD.
发明人： Nishikawa, Kouji , Suzuki, Toshio , Nakagawa, Atsushi , Suzuki, Keiko , Nakayama, Satoshi
IPC分类号： C12P41/00
CPC分类号： C12P41/001 , C12P7/18
摘要： The present invention provides a method for obtaining optically active 3-chloro-2-methyl-1,2-propanediol, the method comprising: a first step of letting at least one kind of microorganism or processed product thereof having an ability to leave untouched (R)-3-chloro-2-methyl-1,2-propanediol or (S)-3-chloro-2-methyl-1,2-propanediol in the presence of an enantiomeric 3-chloro-2-methyl-1,2-propanediol mixture act on an enantiomeric 3-chloro-2-methyl-1,2-propanediol mixture; and a second step of recovering the untouched optically active 3-chloro-2-methyl-1,2-propanediol.
摘要翻译：本发明提供了一种获得光学活性3-氯-2-甲基-1,2-丙二醇的方法，该方法包括：使至少一种微生物或其加工产物具有保持不变的能力的第一步骤（ R）-3-氯-2-甲基-1,2-丙二醇或（S）-3-氯-2-甲基-1,2-丙二醇在对映异构体3-氯-2-甲基-1,2-丙二醇存在下， 2-丙二醇混合物作用于对映异构体3-氯-2-甲基-1,2-丙二醇混合物; 以及回收未接触的光学活性3-氯-2-甲基-1,2-丙二醇的第二步骤。

7. 发明公开

EP1435392A4 PROCESS FOR PRODUCING D-ALANINE 审中-公开
标题翻译：工艺的生产D-丙氨酸
公开(公告)号：EP1435392A4
公开(公告)日：2005-02-09
申请号：EP02765541
申请日：2002-09-13
申请人： MUSASHINO CHEMICAL LABORARORY
发明人： UEDA HIROYUKI
IPC分类号： C12P13/06 , C12P41/00 , C12R1/66 , C12R1/67 , C12R1/685 , C12R1/785
CPC分类号： C12P41/001 , C12P13/06
摘要： A process characterized by treating a DL-alanine-containing solution with a fungus to thereby metabolize L-alanine without forming pyruvic acid as a by-product. Since the fungus can be conveniently separated from a culture medium and its culture medium is free from pyruvic acid, D-alanine can be efficiently produced by the above process. D-Alanine can be isolated from the separated liquor by treating an ion exchange resin or the like. As the fungus, use can be made of commercially available strains belonging to the genera Aspergillus, Penicillium, Mucor, Rhizopus, Circinella, Cladosporium, Trichoderma, Eurotium, Chaetomium, Aureobasidium, Geotrichum, Paecillomyces, etc.

8. 发明公开

EP1452604A2 Coenzyme useful for the synthesis of L-Carnitine 审中-公开
标题翻译： Coenzym zur Herstellung von L-Carnitin
公开(公告)号：EP1452604A2
公开(公告)日：2004-09-01
申请号：EP04007026.0
申请日：1999-10-22
申请人： SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.
发明人： Elssner, Thomas , Kleber, Hans-Peter
IPC分类号： C12P13/00 , C12P41/00 , C07H19/20
CPC分类号： C07H19/20 , C12P13/007 , C12P41/001
摘要： The invention described herein relates to coenzymes useful for the synthesis of L-carnitine, particularly a compound of coenzyme A, and more particularly gamma-butyrobetainyl-coenzyme A, to procedures for their preparation and to their use for the production of L(-)-carnitine from crotonobetaine and D(-)-carnitine.
摘要翻译：本文描述的本发明涉及可用于合成L-肉毒碱，特别是辅酶A的化合物，更特别是γ-丁酰谷氨酰辅酶A的辅酶，其制备方法及其用于生产L（ - ）来自巴豆甜菜碱和D-（ - ） - 肉碱的肉碱。

9. 发明公开

EP1435392A1 PROCESS FOR PRODUCING D-ALANINE 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG VON D-ALANIN
公开(公告)号：EP1435392A1
公开(公告)日：2004-07-07
申请号：EP02765541.4
申请日：2002-09-13
申请人： Musashino Chemical Laborarory Ltd.
发明人： UEDA, Hiroyuki
IPC分类号： C12P41/00 , C12R1/685 , C12R1/67 , C12R1/66 , C12R1/785
CPC分类号： C12P41/001 , C12P13/06
摘要： This invention is characterized by having filamentous fungi act on a DL-alanine containing solution and assimilate L-alanine without by-producing pyruvic acid. The D-alanine can be produced efficiently because the filamentous fungi can be conveniently and easily separated from the fermentation broth and the fermentation broth contains no pyruvic acid. For the purpose of isolating the D-alanine from the separating solution, it suffices to treat the separating solution by the use of an ion exchange resin. The filamentous fungi effectively usable herein belong to at least one member selected from the class consisting of genus Aspergillus, genus Penicillium, genus Mucor, genus Rhizopus, genus Circinella, genus Cladosporium, genus Trichoderma, genus Eurotium, genus Chaetomium, genus Aureobasidium, genus Geotrichum, and genus Paecilomyces which are commercially available.
摘要翻译：本发明的特征在于具有丝状真菌作用于含有DL-丙氨酸的溶液并吸收L-丙氨酸而不产生丙酮酸。可以有效地生产D-丙氨酸，因为丝状真菌可以方便地容易地从发酵液中分离出来，发酵液不含丙酮酸。为了从分离溶液中分离出D-丙氨酸，可以使用离子交换树脂处理分离溶液。本文中有效使用的丝状真菌属于选自曲霉属，青霉属，毛霉属，根霉属，根际属，枝孢霉属，木霉属，金龟子属，毛壳菌属，金银菌属，地热属，以及可商购的拟青霉属。

10. 发明公开

EP1341927A1 METHOD OF PREPARING 3- 2- (METHYLSULFONYL)OXY ETHOXY]-4-(TRIPHENYLMETHOXY)-1-BUTANOL, METHANE SULFONATE 有权
标题翻译：用于制备3- [2 - {（甲磺酰基）氧基}乙氧基] -4-（三苯甲氧基）-1-丁醇甲磺酸酯
公开(公告)号：EP1341927A1
公开(公告)日：2003-09-10
申请号：EP01994173.1
申请日：2001-10-30
申请人： PPG Industries Ohio, Inc.
发明人： CAILLE, Jean-Claude
IPC分类号： C12P41/00 , C07C303/28 , C07C305/04 , C07C29/136 , C07C31/135
CPC分类号： C12P41/001 , C07C303/28 , C07D309/24 , C12P11/00 , C07C309/66
摘要： A method of producing (S)-3-[2-{(methylsulfonyl)oxy}ethoxy]-4-(triphenylmethoxy)-1-butanol methane sulfonate using 1,3-butadiene and a ketoethanal to form an intermediate racemic mixture. The racemic mixture is resolved to remove one isomer from the reaction product mixture. Following resolution, the following steps are performed: reduce the isomer to an alcohol, react the alcohol with triphenylmethyl chloride, ozonalyze the resulting reaction product, reduce the ozonalyzed product to yield a diol and react the diol with a methane sulfonyl compound to form (S)-3-[2-{(methylsulfonyl)oxy}ethoxy]-4-(triphenylmethoxy)-1-butanol methane sulfonate. Alternatively, the racemic mixture may first be reduced and the resulting racemic alcohol mixture is resolved to isolate one isomer of the alcohol and the remaining process steps are followed.

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