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1. 发明公开

EP3132022A1 SYNTHETIC METHANOTROPHIC AND METHYLOTROPHIC MICROORGANISMS 审中-公开
标题翻译：甲基化合物的合成甲基化
公开(公告)号：EP3132022A1
公开(公告)日：2017-02-22
申请号：EP15780357.8
申请日：2015-04-14
申请人： Industrial Microbes, Inc.
发明人： HELMAN, Noah , CLARKE, Elizabeth , GREENFIELD, Derek
IPC分类号： C12N1/00
CPC分类号： C12P7/46 , C12N9/0006 , C12N9/0008 , C12N9/0014 , C12N9/1022 , C12N9/88 , C12N9/90 , C12Y101/01001 , C12Y101/01224 , C12Y101/02007 , C12Y101/03013 , C12Y101/99037 , C12Y102/01002 , C12Y102/01046 , C12Y111/01006 , C12Y114/13025 , C12Y202/01003 , C12Y401/01043 , C12Y503/01027
摘要： Provided herein are non-naturally occurring microbial organisms comprising a methane-oxidizing metabolic pathway. The invention additionally comprises non-naturally occurring microbial organisms comprising pathways for the production of chemicals. The invention additionally provides methods for using said organisms for the production of chemicals.
摘要翻译：本文提供了包含甲烷氧化代谢途径的非天然存在的微生物生物。本发明还包含非天然存在的微生物生物体，其包含用于生产化学品的途径。本发明另外提供了使用所述生物体来生产化学品的方法。

2. 发明公开

EP2865750A3 Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them 审中-公开
标题翻译：转移酶和氧化还原酶，编码它们的核酸以及制备和使用它们的方法
公开(公告)号：EP2865750A3
公开(公告)日：2015-08-05
申请号：EP14194469.4
申请日：2008-12-31
申请人： BASF Enzymes LLC
发明人： Weiner, David , Luginbuhl, Peter , Bueno, Analia , Cuenca, Joslin , Marasco, Erin
IPC分类号： C12N9/10 , C12N9/02 , C12Q1/48 , C12Q1/26 , C07K14/38 , C07K16/40 , C07K9/00 , A61K38/44 , A61K38/45
CPC分类号： C12N9/1096 , A21D8/042 , A61K38/00 , C12N9/0004 , C12N9/0006 , C12N9/0014 , C12N9/10 , C12N15/1137 , C12N15/63 , C12N15/86 , C12P7/10 , C12Q1/6876 , C12Y206/01021 , D06L4/40 , D06M16/003 , G01N33/573 , Y02E50/16 , Y02P20/52 , Y02T50/678
摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity, e.g., transaminase activity, e.g., d-amino-acid transferase activity, and/or oxidoreductase activity, e.g., dehydrogenase activity, e.g., damino-acid dehydrogenase activity, and/or catalyze the transfer of a chemical group, catalyze transamination, catalyze the reaction: D-alanine + 2-oxoglutarate pyruvate + D-glutamate, and/or catalyze an oxidation-reduction reaction, catalyze the removal of hydrogen atoms, and/or catalyze the reaction: D-amino acid + H 2 O + acceptor a 2-oxo acid + NH 3 + reduced acceptor. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.
摘要翻译：本发明一般涉及酶，编码酶的多核苷酸，此类多核苷酸和多肽的用途，更具体地涉及具有转移酶活性例如转氨酶活性例如d-氨基酸转移酶活性和/或氧化还原酶活性的酶的用途，例如，脱氢酶活性，例如dam酸脱氢酶活性，和/或催化化学基团的转移，催化转氨基化，催化反应：D-丙氨酸+ 2-酮戊二酸<=>丙酮酸+ D-谷氨酸和/或催化氧化还原反应，催化去除氢原子和/或催化反应：D-氨基酸+ H 2 O +受体2-氧代酸+ NH 3 +还原受体。因此，本发明提供了用于生产药物组合物，药物中间体，抗生素，甜味剂，肽酶，肽激素，燃料和燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂的酶，组合物，药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆和包含根据本发明的多肽或多核苷酸的去污剂。

3. 发明公开

EP2744897A2 BIOTECHNOLOGISCHES SYNTHESEVERFAHREN VON OMEGA-FUNKTIONALISIERTEN CARBONSÄUREN UND CARBONSÄURE-ESTERN AUS EINFACHEN KOHLENSTOFFQUELLEN 审中-公开
标题翻译：从简单的碳源OMEGA官能化的酸和羧酸酯的生物合成方法
公开(公告)号：EP2744897A2
公开(公告)日：2014-06-25
申请号：EP12745886.7
申请日：2012-08-15
申请人： Evonik Degussa GmbH
发明人： SCHAFFER, Steffen , DECKER, Nicole , GIELEN, Jasmin , HÄGER, Harald , HAAS, Thomas , PÖTTER, Markus , HENNEMANN, Hans-Georg , WESSEL, Mirja , VOLLAND, Michael
IPC分类号： C12N9/10 , C12N9/88 , C12P1/04 , C12N9/00
CPC分类号： C12P13/02 , C08G69/08 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0014 , C12N9/0077 , C12N9/1029 , C12N9/16 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/40 , C12P7/42 , C12P7/6409 , C12P7/6436 , C12P13/005 , Y02P20/52
摘要： The invention relates to a biotechnological process for the preparation of functionalized carbon acids and functionalized carbon acid esters from simple carbon sources.
摘要翻译：本发明的主题是一种用于生产ω-官能羧酸和从简单碳源ω官能羧酸酯的生物技术方法。

4. 发明公开

EP1839058A1 NOVEL USE OF FLUORESCENCE RESONANCE ENERGY TRANSFER 审中-公开
标题翻译：荧光共振能量转移的新用途
公开(公告)号：EP1839058A1
公开(公告)日：2007-10-03
申请号：EP05850394.7
申请日：2005-12-23
申请人： LEIDEN UNIVERSITY
发明人： Canters, Gerard W.,Leiden University , Aartsma, Thijs J., Leiden University
IPC分类号： G01N33/542 , C12Q1/26
CPC分类号： G01N33/542 , C12N9/0014 , C12Q1/26 , C12Q1/32 , C12Y104/99003
摘要： A novel use of Fluorescence Resonance Energy Transfer wherein a labelled protein comprising a Fluorescent energy donor label and at least one energy acceptor moiety capable of accepting energy from the donor label by Förster energy transfer is exposed to incident electromagnetic energy to excite the donor moiety and the fluorescence emission of the donor is measured. The or each energy acceptor moiety has a more and less active energy acceptor state and the level of quenching of donor fluorescence is indicative of this state. The energy acceptor moiety may be converted between its states by a redox reaction, optionally involving a partner redox protein. A novel system comprising the labelled protein, a redox partner protein, 'a light source for imposing incident light at the excitation wavelength for the fluorescent label and a light detector capable of detecting the fluorescence emitted by the label may be used in biosensors and/or to monitor enzymatic turnover.

5. 发明公开

EP3132022A4 SYNTHETIC METHANOTROPHIC AND METHYLOTROPHIC MICROORGANISMS 审中-公开
公开(公告)号：EP3132022A4
公开(公告)日：2017-12-13
申请号：EP15780357
申请日：2015-04-14
申请人： IND MICROBES INC
发明人： HELMAN NOAH , CLARKE ELIZABETH , GREENFIELD DEREK
IPC分类号： C12N9/00 , C12N9/10 , C12N9/88 , C12N9/90
CPC分类号： C12P7/46 , C12N9/0006 , C12N9/0008 , C12N9/0014 , C12N9/1022 , C12N9/88 , C12N9/90 , C12Y101/01001 , C12Y101/01224 , C12Y101/02007 , C12Y101/03013 , C12Y101/99037 , C12Y102/01002 , C12Y102/01046 , C12Y111/01006 , C12Y114/13025 , C12Y202/01003 , C12Y401/01043 , C12Y503/01027
摘要： Provided herein are non-naturally occurring microbial organisms comprising a methane-oxidizing metabolic pathway. The invention additionally comprises non-naturally occurring microbial organisms comprising pathways for the production of chemicals. The invention additionally provides methods for using said organisms for the production of chemicals.

6. 发明公开

EP3201315A2 METHODS AND MATERIALS FOR BIOSYNTHESIS OF MOGROSIDE COMPOUNDS 审中-公开
标题翻译：方法和材料的生物合成莫格化物化合物
公开(公告)号：EP3201315A2
公开(公告)日：2017-08-09
申请号：EP15797018.7
申请日：2015-09-30
申请人： Evolva SA
发明人： HOUGHTON-LARSEN, Jens , KRZYSTANEK, Katarzyna , SEMMLER, Angelika , HANSEN, Iver Klavs Riishede , DAMKIAER, Soren , LIU, Gary , LIU, Yaoquan , HANSEN, Jorgen , KUMAR, Sathish , MURALI, Muthuswamy Panchapagesa , RASMUSSEN, Nina Nicoline
IPC分类号： C12N1/19 , C12N9/06 , C12N9/90 , C12N9/02 , C12N9/14 , C12N9/10 , C12P19/18 , C12P19/56 , C12P33/00
CPC分类号： C12P33/00 , A23L27/36 , A23V2002/00 , C07H1/06 , C12N9/0014 , C12N9/0042 , C12N9/0071 , C12N9/0073 , C12N9/1051 , C12N9/14 , C12N9/90 , C12N15/00 , C12P19/18 , C12P19/56
摘要： Methods for recombinant and enzymatic production of mogroside compounds and compositions containing mogroside compounds are provided by this invention.
摘要翻译：本发明提供了用于重组和酶促生产罗汉果苷化合物和含有罗汉果苷化合物的组合物的方法。

7. 发明公开

EP2940039A1 Verfahren zur Produktion von L-Aminosäuren in Corynebakterien unter Verwendung eines Glycin spaltenden Systems 审中-公开
标题翻译：一种用于使用甘氨酸分裂系统在棒状杆菌生产L-氨基酸的过程
公开(公告)号：EP2940039A1
公开(公告)日：2015-11-04
申请号：EP14166649.5
申请日：2014-04-30
申请人： Evonik Degussa GmbH
发明人： Ochrombel, Ines , Bathe, Brigitte , Hasselmeyer, Marleen
IPC分类号： C07K14/435
CPC分类号： C12P13/12 , C07K14/34 , C12N9/0014 , C12N9/0016 , C12N9/0051 , C12N9/1014 , C12N9/1029 , C12N9/1235 , C12N9/1241 , C12N9/13 , C12N9/16 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/14 , C12Y104/04002 , C12Y108/01004 , C12Y201/0201 , C12Y203/01181 , C12Y203/01204 , C12Y207/07063 , C12Y208/01008
摘要： Überraschenderweise wurde gefunden, dass der Stamm Corynebacterium humireducens ein sehr effektives Glycin spaltendes System enthält.
摘要翻译：已经发现，令人惊讶，做了棒状杆菌菌株humireducens包括一个非常有效的甘氨酸裂解系统。

8. 发明公开

EP1900821A1 PROCESS FOR PRODUCTION OF L-AMINO ACID 审中-公开
标题翻译：生产L-氨基酸的方法
公开(公告)号：EP1900821A1
公开(公告)日：2008-03-19
申请号：EP06756916.0
申请日：2006-06-02
申请人： DAICEL CHEMICAL INDUSTRIES, LTD.
发明人： KIMOTO, Norihiro , YAMAMOTO, Hiroaki , HAYASHI, Motoko
IPC分类号： C12P13/04 , C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12R1/01 , C12R1/07 , C12R1/19 , C12R1/645 , C12R1/72
CPC分类号： C12N9/1096 , C12N9/0014 , C12N9/0016 , C12N9/0024 , C12P13/04 , C12P41/001 , C12P41/002
摘要： Disclosed is a process for producing the L-form of an amino acid enzymatically from an enantiomeric mixture of the amino acid. The process includes the step of contacting a transformant or a treated product thereof with an enantiomeric mixture of the amino acid. The transformant includes a single host and one or more recombinant vectors introduced thereinto, in which the one or more recombinant vectors include one or more expression vectors and nucleotide sequences integrated thereinto respectively, and the nucleotide sequences are a nucleotide sequence encoding an enzyme capable of converting the D-form of an amino acid into a keto acid and a nucleotide sequence encoding an enzyme capable of converting a keto acid into the L-form of an amino acid. According to this process, a reaction for converting the D-form of an amino acid into a keto acid and a reaction for converting the keto acid into the L-form of the amino acid can be conducted in a single step. Disclosed also is a transformant capable of converting into the L-form of an amino acid as accumulated in a high concentration. The L-form of an amino acid can be efficiently produced from an inexpensive starting material by using the transformant.
摘要翻译：公开了一种从氨基酸的对映体混合物中酶促生产L-型氨基酸的方法。该方法包括使转化体或其处理产物与氨基酸的对映体混合物接触的步骤。转化体包括单个宿主和导入其中的一种或多种重组载体，其中所述一种或多种重组载体分别包含一种或多种表达载体和核苷酸序列，并且所述核苷酸序列是编码能够转化将D-型氨基酸转化为酮酸和编码能够将酮酸转化为L-型氨基酸的酶的核苷酸序列。根据该方法，将氨基酸的D-型转化为酮酸的反应和将酮酸转化为L-型的氨基酸的反应可以一步进行。还公开了能够以高浓度积累的形式转化成L-型氨基酸的转化体。通过使用转化体，可以从廉价的原料高效地生产L-型氨基酸。

9. 发明公开

EP1896574A2 D-AMINO ACID DEHYDROGENASE AND METHOD OF MAKING D-AMINO ACIDS 审中-公开
标题翻译： D-氨基酸脱氢酶及其制造方法D-氨基酸
公开(公告)号：EP1896574A2
公开(公告)日：2008-03-12
申请号：EP06748972.4
申请日：2006-03-28
申请人： BioCatalytics Inc.
发明人： NOVICK, Scott, J. , ROZZELL, David, J.
IPC分类号： C12N9/06 , C12P13/04 , C12N15/52 , C12N15/11
CPC分类号： C12P13/04 , C12N9/0014 , C12N9/0016
摘要： Polypeptides capable of catalyzing the reductive amination of a 2-ketoacid to its corresponding D-amino acid are provided. The polypeptides can be prepared by mutagenesis of , e.g., a diaminopimelate dehydrogenase. Also provided is a method of making a D-amino acid using a catalytically active polypeptide, wherein a 2-ketoacid is allowed to contact the polypeptide in the presence of a nicotinamide cofactor and ammonia or an ammonia source.

10. 发明公开

EP1786833A2 DETECTION, ISOLATION AND USES OF RENALASE (MONOAMINE OXIDASE C) 审中-公开
标题翻译：检测，隔离和Renalase的使用（单胺氧化酶C）
公开(公告)号：EP1786833A2
公开(公告)日：2007-05-23
申请号：EP05730232.5
申请日：2005-03-21
申请人： Yale University
发明人： XU, Jianchao , DESIR, Gary
IPC分类号： C07K14/435
CPC分类号： C12N9/0014 , C12N9/0022 , C12Y104/03004
摘要： The present invention provides for the identification, isolation and uses of mammalian Monoamine Oxidase C (MAO-C), also known as renalase.

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