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1. 发明公开

EP2695934A4 ANIMAL CELL CULTURE KIT, METHOD FOR CULTURING ANIMAL CELLS, METHOD FOR SELECTIVE CULTURE OF ANIMAL CELLS AND CELL DIFFERENTIATION METHOD 审中-公开
标题翻译： KULTURKIT动物细胞，方法进行繁殖动物细胞，方法的选育动物细胞和细胞分化过程中
公开(公告)号：EP2695934A4
公开(公告)日：2014-12-31
申请号：EP12768652
申请日：2012-04-04
申请人： UNIV HIROSHIMA
发明人： KATO YUKIO , HIRATA ISAO , KANAWA MASAMI
IPC分类号： C12M3/00 , C12M1/00 , C12M1/12 , C12N5/00 , C12N5/07 , C12N5/071 , C12N5/0775
CPC分类号： C12N5/0675 , C12M23/20 , C12M25/02 , C12N5/0068 , C12N5/0663 , C12N2533/20
摘要： The invention provides an animal cell culture kit to be used favorably for culturing animal cells, a method for culturing animal cells, a method for culturing selectively animal cells, and a method for differentiating a cell. An animal cell culture kit according to the invention includes an incubator containing one or more types of functional groups selected from the group consisting ofhydrophilic functional groups and hydrophobic functional groups at predetermined contents on a surface, and a serum-free culture medium. Since the animal cell culture kit includes an incubator having a functional group suitable for adhesion and proliferation of specific animal cells, proliferation of animal cells can be promoted even with a serum-free culture medium.

2. 发明公开

EP2229433A1 OSTEOGENIC DIFFERENTIATION OF BONE MARROW STEM CELLS AND MESENCHYMAL STEM CELLS USING A COMBINATION OF GROWTH FACTORS 有权转让
标题翻译：骨髓干细胞和干细胞成骨分化的间充质使用生长因子的组合
公开(公告)号：EP2229433A1
公开(公告)日：2010-09-22
申请号：EP09700353.7
申请日：2009-01-09
申请人： Bone Therapeutics S.A.
发明人： BADOER, Cindy , BASTIANELLI, Enrico , PESESSE, Xavier
IPC分类号： C12N5/06
CPC分类号： C12N5/0675 , A61K35/12 , C12N5/0654 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2501/115 , C12N2501/15
摘要： The invention relates to methods for osteogenic differentiation of human bone marrow stem cells (BMSC) or mesenchymal stem cells (MSC), in particular using human plasma or serum and FGF and TGFB growth factors. The invention also provides the so-obtained cells and cell populations, as well as further products comprising such and uses thereof in bone therapy.
摘要翻译：本发明涉及使用人血浆或血清以及FGF和TGFB生长因子对人骨髓干细胞（BMSC）或间充质干细胞（MSC）的成骨细胞分化，在具体方法。因此本发明提供将如此获得的细胞和细胞群，以及另外的产品，其包括搜索和在骨治疗用途。

3. 发明公开

EP2516627A1 EXPANSION MEDIUM FOR CD34-NEGATIVE STEM CELLS 有权
标题翻译：扩增蛋白CD34-阴性STAMMZELLEN
公开(公告)号：EP2516627A1
公开(公告)日：2012-10-31
申请号：EP10807702.5
申请日：2010-12-23
申请人： Apceth GmbH & Co. KG
发明人： ASEEVA, Elena , GÜNTHER, Christine
IPC分类号： C12N5/0775
CPC分类号： C12N5/0675 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2500/84 , C12N2500/90 , C12N2501/91 , C12N2502/115
摘要： This invention provides a cell growth medium comprising (a) a human platelet lysate free of solid matter greater than 0.22 μm in diameter, wherein the lysate constitutes from 2% to 15% of the total volume of the cell growth medium; (b) a human fresh frozen plasma (FFP) filtrate free of solid matter greater than 0.22 μm in diameter, wherein the FFP filtrate constitutes from 1 % to 10% of the total volume of the cell growth medium; (c) heparin at a concentration of from 0 U/ml to 10 U/ml of the cell growth medium; (d) L-glutamine at a concentration of from 0.5 mM to 10 mM; and (e) a serum-free, low glucose medium suitable for mammalian cell growth, wherein the serum-free, low glucose medium constitutes from 75% to 97% of the total volume of the cell growth medium, and may contain the L-glutamine of part (d); wherein the cell growth medium permits the expansion of human CD34" stem cells and wherein the resulting expanded CD34" stem cells retain the ability to differentiate. This invention also provides related cell growth medium supplements, a sterile human platelet lysate and human fresh frozen plasma (FFP) filtrate, kits, CD34' stem cell-containing compositions, and related production and cell expansion methods.
摘要翻译：本发明提供一种细胞生长培养基，其包含（a）直径大于0.22μm的固体物质的人血小板裂解物，其中裂解物构成细胞生长培养基总体积的2％至15％; （b）不含直径大于0.22μm的固体物质的人新鲜冷冻血浆（FFP）滤液，其中FFP滤液占细胞生长培养基总体积的1％至10％; （c）浓度为0U / ml至10U / ml细胞生长培养基的肝素; （d）浓度为0.5mM至10mM的L-谷氨酰胺; 和（e）适合于哺乳动物细胞生长的无血清低葡萄糖培养基，其中无血清低葡萄糖培养基构成细胞生长培养基总体积的75％至97％，并且可含有L- 部分（d）的谷氨酰胺; 其中所述细胞生长培养基允许人CD34-干细胞的扩增，并且其中所产生的扩增的CD34-干细胞保留分化能力。本发明还提供相关的细胞生长培养基补充剂，无菌人血小板裂解物和人新鲜冷冻血浆（FFP）滤液，试剂盒，含有CD34-干细胞的组合物，以及相关的生产和细胞扩增方法。

4. 发明公开

EP1807510A1 MULTIPOTENTIAL EXPANDED MESENCHYMAL PRECURSOR CELL PROGENY (MEMP) AND USES THEREOF 审中-公开
标题翻译： MEMP（MULTI潜在膨化间充质前体细胞的子代）及其用途
公开(公告)号：EP1807510A1
公开(公告)日：2007-07-18
申请号：EP05787106.3
申请日：2005-09-26
申请人： Angioblast Systems Incorporated
发明人： GRONTHOS, Stan , ZANNETTINO, Andrew, Christopher, William
IPC分类号： C12N5/08 , C12N5/06 , A61K35/12 , A61K35/28 , A61P9/00
CPC分类号： C12N5/0675 , A61K35/28 , A61K38/1858 , A61K38/1875 , A61K38/191 , A61K38/195 , A61K38/2006 , A61L27/3804 , A61L27/3839 , A61L27/3886 , A61L27/3895 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2510/00 , A61K2300/00
摘要： This invention relates to multipotential expanded mesenchymal precursor cell progeny (MEMPs). The present invention also relates to methods for producing MEMPs and to uses of MEMPs for therapeutic applications.

5. 发明授权

EP2229433B1 OSTEOGENIC DIFFERENTIATION OF BONE MARROW STEM CELLS AND MESENCHYMAL STEM CELLS USING A COMBINATION OF GROWTH FACTORS 有权转让
标题翻译：生长因子联合诱导骨髓干细胞和间质干细胞向成骨细胞的分化
公开(公告)号：EP2229433B1
公开(公告)日：2017-09-20
申请号：EP09700353.7
申请日：2009-01-09
申请人： Bone Therapeutics S.A.
发明人： BADOER, Cindy , BASTIANELLI, Enrico , PESESSE, Xavier
IPC分类号： C12N5/077 , A61K35/12 , C12N5/0775
CPC分类号： C12N5/0675 , A61K35/12 , C12N5/0654 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2501/115 , C12N2501/15
摘要： The invention relates to methods for osteogenic differentiation of human bone marrow stem cells (BMSC) or mesenchymal stem cells (MSC), in particular using human plasma or serum and FGF and TGFB growth factors. The invention also provides the so-obtained cells and cell populations, as well as further products comprising such and uses thereof in bone therapy.
摘要翻译：本发明涉及人骨髓干细胞（BMSC）或间充质干细胞（MSC）成骨分化的方法，特别是使用人血浆或血清以及FGF和TGFB生长因子。本发明还提供如此获得的细胞和细胞群，以及包含其的其他产品和其在骨治疗中的用途。

6. 发明公开

EP1807510A4 MULTIPOTENTIAL EXPANDED MESENCHYMAL PRECURSOR CELL PROGENY (MEMP) AND USES THEREOF 审中-公开
标题翻译： MEMP（MULTI潜在膨化间充质前体细胞的子代）及其用途
公开(公告)号：EP1807510A4
公开(公告)日：2008-01-23
申请号：EP05787106
申请日：2005-09-26
申请人： ANGIOBLAST SYSTEMS INC
发明人： GRONTHOS STAN , ZANNETTINO ANDREW CHRISTOPHER
IPC分类号： A61K35/12 , A61K35/28 , A61P9/00 , C12N5/077 , C12N5/0775
CPC分类号： C12N5/0675 , A61K35/28 , A61K38/1858 , A61K38/1875 , A61K38/191 , A61K38/195 , A61K38/2006 , A61L27/3804 , A61L27/3839 , A61L27/3886 , A61L27/3895 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2510/00 , A61K2300/00
摘要： This invention relates to multipotential expanded mesenchymal precursor cell progeny (MEMPs). The present invention also relates to methods for producing MEMPs and to uses of MEMPs for therapeutic applications.

7. 发明授权

EP2516627B1 EXPANSION MEDIUM FOR CD34-NEGATIVE STEM CELLS 有权
标题翻译： CD34阴性干细胞的扩增培养基
公开(公告)号：EP2516627B1
公开(公告)日：2017-11-01
申请号：EP10807702.5
申请日：2010-12-23
申请人： Apceth GmbH & Co. KG
发明人： ASEEVA, Elena , GÜNTHER, Christine
IPC分类号： C12N5/0775
CPC分类号： C12N5/0675 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2500/84 , C12N2500/90 , C12N2501/91 , C12N2502/115

8. 发明公开

EP2723354A4 COMPOSITIONS, USES, AND PREPARATION OF PLATELET LYSATES 有权
标题翻译： US ET N EN N N N N N N N N N N N N N N N N N N N
公开(公告)号：EP2723354A4
公开(公告)日：2015-03-11
申请号：EP12804449
申请日：2012-06-26
申请人： UNIV EMORY , CHILDRENS HEALTHCARE ATLANTA INC
发明人： COPLAND IAN B , GALIPEAU JACQUES
IPC分类号： A61K35/14 , A61K38/17 , A61P17/02 , A61P27/02 , C12N5/071
CPC分类号： A61K35/19 , A61K31/727 , A61K38/1858 , A61L15/40 , A61L15/44 , A61L17/005 , A61L24/0005 , A61L24/0015 , A61L2300/406 , A61L2300/42 , C12N5/0018 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0675 , C12N2502/115
摘要： In certain embodiments, this disclosure describes compositions comprising platelet lysates depleted of fibrinogen. In a further embodiment, the composition further comprises a cell culture medium component. This disclosure also provides a method for preparing the composition, comprising the steps of (a) lysing platelets providing a lysate; (b) removing cell debris; and (c) depleting fibrinogen by forming a removable mass by adding a metal salt such as calcium chloride. Furthermore, the disclosure also describes the product produced using said method.
摘要翻译：在某些实施方案中，本公开描述了包含贫血纤维蛋白原的血小板裂解物的组合物。在另一个实施方案中，组合物还包含细胞培养基组分。本公开还提供了制备组合物的方法，包括以下步骤：（a）裂解提供裂解物的血小板; （b）去除细胞碎片; 和（c）通过加入金属盐如氯化钙形成可除去的物质来消耗纤维蛋白原。此外，本公开还描述了使用所述方法生产的产品。

9. 发明公开

EP2752484A4 METHOD FOR PREPARING A BASIC CULTURE MEDIUM FOR MESENCHYMAL STEM CELLS, BASIC CULTURE MEDIUM FOR MESENCHYMAL STEM CELLS, AND CELL THERAPEUTIC AGENT CULTURED AND DIFFERENTIATED USING SAME 有权
标题翻译：用于生产碱性培养基中的间充质干细胞，二元培养基，间充质干细胞
公开(公告)号：EP2752484A4
公开(公告)日：2015-04-15
申请号：EP11871607
申请日：2011-09-06
申请人： SEWON CELLONTECH CO LTD
发明人： SUH DONG-SAM , LEE JUN KEUN , CHANG DONG IL , CHOI MIN JUNG , KIM JANG HOON , KIM GA RAM , CHANG CHEONG HO
IPC分类号： C12N5/0775 , A61K35/12 , C12N1/38
CPC分类号： C12N5/0667 , C12N5/0663 , C12N5/0675 , C12N2500/32 , C12N2500/34 , C12N2500/38
摘要： Disclosed is a basic culture medium for mesenchymal stem cells, and a cell therapeutic agent cultured and differentiated using same. The basic culture medium reduces the time taken from collection to mass culturing by increasing the proliferation rate of undifferentiated mesenchymal stem cells derived from an adult tissue such as human marrow and adipose tissue, and also is capable of various differentiations into treating agents for bone-forming cells, for cartilage cells, or for fat cells.

10. 发明公开

EP2638147A2 METHOD FOR CONTROLLING BINDING OF CELLS TO A SUBSTRATE 审中-公开
标题翻译：方法控制使细胞结合的在衬底
公开(公告)号：EP2638147A2
公开(公告)日：2013-09-18
申请号：EP11790569.5
申请日：2011-11-09
申请人： Lonza Cologne GmbH
发明人： SCHENK, Judith , VAN DEN BOS, Christian , ROSENBAUM, Claudia , NIE, Ying
IPC分类号： C12N5/0775 , C12N5/0735
CPC分类号： C12N5/0675 , C12N5/0606 , C12N5/0663 , C12N2501/727 , C12N2501/999 , C12N2531/00 , C12N2533/30 , C12N2533/90
摘要： The invention relates to a method for promoting the adhesion of cells to a substrate to which these cells usually have no or only low affinity, wherein the adhesion of the cells to the substrate is promoted by supplying the cells with the non-muscle myosin II inhibitor Blebbistatin so as to enable the cells to attach to surfaces to which they otherwise would not have sufficient affinity. Surprisingly, supplying the cells with the inhibitor enhances the capability of these cells to attach to surfaces to which they usually have no or only low affinity, for example, PTFE (Teflon
® ). The invention further concerns uses of the non- muscle myosin II inhibitor Blebbistatin and devices having at least one surface which is coated with cells that have no or only low affinity to said surface.

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