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1. 发明授权

EP1375670B1 Recombinant measles viruses expressing epitopes of antigens of RNA viruses and use of the recombinant viruses for the preparation of vaccine compositions 有权
标题翻译：重组麻疹病毒表达的RNA病毒的抗原表位，并用于疫苗生产用的重组病毒
公开(公告)号：EP1375670B1
公开(公告)日：2013-06-12
申请号：EP02291550.8
申请日：2002-06-20
申请人： INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： Tangy, Frédéric , Lorin, Clarisse , Mollet, Lucile , Delebecque, Frédéric
IPC分类号： C12N15/86 , C12N7/00
CPC分类号： C12N15/86 , A61K39/12 , A61K39/165 , A61K39/21 , A61K47/6901 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2740/16022 , C12N2740/16122 , C12N2760/18421 , C12N2760/18422 , C12N2760/18434 , C12N2760/18443 , C12N2760/18452 , C12N2770/24122 , Y02A50/388 , Y02A50/394
摘要： The invention relates to a recombinant measles virus expressing a heterologous amino acid sequence derived from an antigen of a determined RNA virus, said recombinant measles virus being capable of eliciting a humoral and/or a cellular immune response against measles virus or against said RNA virus or against both measles virus and against said RNA virus. It also relates to the use of said recombinant measles virus for the preparation of immunogenic composition.

2. 发明授权

EP2290091B1 Recombinant measles viruses expressing epitopes of antigens of RNA viruses and use of the recombinant viruses for the preparation of vaccine compositions 无效
标题翻译：表达RNA病毒抗原表位的重组麻疹病毒和重组病毒用于制备疫苗组合物的用途
公开(公告)号：EP2290091B1
公开(公告)日：2017-05-10
申请号：EP10184907.3
申请日：2003-06-20
申请人： Institut Pasteur , Centre National de la Recherche Scientifique
发明人： Tangy, Frédéric , Lorin, Clarisse , Mollet, Lucile , Delebecque, Frédéric
IPC分类号： C12N15/86 , C12N7/00
CPC分类号： C12N15/86 , A61K39/12 , A61K39/165 , A61K39/21 , A61K47/6901 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2740/16022 , C12N2740/16122 , C12N2760/18421 , C12N2760/18422 , C12N2760/18434 , C12N2760/18443 , C12N2760/18452 , C12N2770/24122 , Y02A50/388 , Y02A50/394
摘要： The invention relates to a recombinant measles virus expressing a heterologous amino acid sequence derived from an antigen of a determined RNA virus, said recombinant measles virus being capable of eliciting a humoral and/or a cellular immune response against measles virus or against said RNA virus or against both measles virus and against said RNA virus. It also relates to the use of said recombinant measles virus for the preparation of immunogenic composition.
摘要翻译：本发明涉及表达源自确定的RNA病毒的抗原的异源氨基酸序列的重组麻疹病毒，所述重组麻疹病毒能够引发针对麻疹病毒或针对所述RNA病毒的体液和/或细胞免疫应答，或针对麻疹病毒和针对所述RNA病毒。它还涉及所述重组麻疹病毒用于制备免疫原性组合物的用途。

3. 发明授权

EP1516058B1 RECOMBINANT MEASLES VIRUSES EXPRESSING EPITOPES OF ANTIGENS OF RNA VIRUSES AND USE OF THE RECOMBINANT VIRUSES FOR THE PREPARATION OF VACCINE COMPOSITIONS 无效
标题翻译：重组麻疹病毒了表达的RNA病毒抗原表位，及重组病毒的疫苗的生产中使用
公开(公告)号：EP1516058B1
公开(公告)日：2012-06-13
申请号：EP03760697.7
申请日：2003-06-20
申请人： INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： TANGY, Frédéric , LORIN, Clarisse , MOLLET, Lucile , DELEBECQUE, Frédéric
IPC分类号： C12N15/86 , C12N7/00 , A61K47/48 , C07K14/18 , C07K14/12
CPC分类号： C12N15/86 , A61K39/12 , A61K39/165 , A61K39/21 , A61K47/6901 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2740/16022 , C12N2740/16122 , C12N2760/18421 , C12N2760/18422 , C12N2760/18434 , C12N2760/18443 , C12N2760/18452 , C12N2770/24122 , Y02A50/388 , Y02A50/394
摘要： The invention relates to a recombinant measles virus expressing a heterologous amino acid sequence derived from an antigen of a determined RNA virus, said recombinant measles virus being capable of eliciting a humoral and/or a cellular immune response against measles virus or against said RNA virus or against both measles virus and against said RNA virus. It also relates to the use of said recombinant measles virus for the preparation of immunogenic composition.

4. 发明公开

EP3008176A1 COMPOSITIONS AND METHODS FOR ENHANCING VIRUS REPLICATION 有权转让
标题翻译：组合物及用于增强病毒的复制
公开(公告)号：EP3008176A1
公开(公告)日：2016-04-20
申请号：EP14811047.1
申请日：2014-06-16
申请人： Ottawa Hospital Research Institute
发明人： ILKOW, Carolina Solange , LEBOEUF, Fabrice , BELL, John Cameron , DIALLO, Jean-simon , ARULANANDAM, Rozanne
IPC分类号： C12N7/01 , A61K35/76 , A61K38/18 , A61K47/48 , A61P35/00 , C07K14/50 , C12N5/07 , C12N7/00
CPC分类号： C12N7/00 , A61K35/76 , A61K35/766 , A61K35/768 , A61K38/1793 , A61K38/1825 , C07K14/50 , C07K2319/02 , C12N2710/16651 , C12N2710/24151 , C12N2720/12051 , C12N2760/16151 , C12N2760/16152 , C12N2760/18451 , C12N2760/18452 , C12N2760/20232 , C12N2760/20251 , Y02A50/385 , Y02A50/393 , Y02A50/465 , A61K2300/00
摘要： Described herein is a method of enhancing virus replication in permissive cells that express a receptor to FGF2 protein. The method includes administering FGF2 protein or a functional variant thereof and the virus to the permissive cells. An oncolytic virus having a genome that includes an open reading frame that encodes FGF2 protein or a functional variant thereof is also described.

5. 发明公开

EP2290091A3 Recombinant measles viruses expressing epitopes of antigens of RNA viruses and use of the recombinant viruses for the preparation of vaccine compositions 无效
标题翻译：重组麻疹病毒表达的RNA病毒的抗原表位，并用于疫苗生产用的重组病毒
公开(公告)号：EP2290091A3
公开(公告)日：2011-05-04
申请号：EP10184907.3
申请日：2003-06-20
申请人： Institut Pasteur , Centre National de la Recherche Scientifique
发明人： Tangy, Frédéric , Lorin, Clarisse , Mollet, Lucile , Delebecque, Frédéric
IPC分类号： C12N15/86 , C12N7/00
CPC分类号： C12N15/86 , A61K39/12 , A61K39/165 , A61K39/21 , A61K47/6901 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2740/16022 , C12N2740/16122 , C12N2760/18421 , C12N2760/18422 , C12N2760/18434 , C12N2760/18443 , C12N2760/18452 , C12N2770/24122 , Y02A50/388 , Y02A50/394
摘要： The invention relates to a recombinant measles virus expressing a heterologous amino acid sequence derived from an antigen of a determined RNA virus, said recombinant measles virus being capable of eliciting a humoral and/or a cellular immune response against measles virus or against said RNA virus or against both measles virus and against said RNA virus.
It also relates to the use of said recombinant measles virus for the preparation of immunogenic composition.

6. 发明公开

EP2290091A2 Recombinant measles viruses expressing epitopes of antigens of RNA viruses and use of the recombinant viruses for the preparation of vaccine compositions 无效
标题翻译：重组麻疹病毒表达的RNA病毒的抗原表位，并用于疫苗生产用的重组病毒
公开(公告)号：EP2290091A2
公开(公告)日：2011-03-02
申请号：EP10184907.3
申请日：2003-06-20
申请人： Institut Pasteur , Centre National de la Recherche Scientifique
发明人： Tangy, Frédéric , Lorin, Clarisse , Mollet, Lucile , Delebecque, Frédéric
IPC分类号： C12N15/86 , C12N7/00
CPC分类号： C12N15/86 , A61K39/12 , A61K39/165 , A61K39/21 , A61K47/6901 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2740/16022 , C12N2740/16122 , C12N2760/18421 , C12N2760/18422 , C12N2760/18434 , C12N2760/18443 , C12N2760/18452 , C12N2770/24122 , Y02A50/388 , Y02A50/394
摘要： The invention relates to a recombinant measles virus expressing a heterologous amino acid sequence derived from an antigen of a determined RNA virus, said recombinant measles virus being capable of eliciting a humoral and/or a cellular immune response against measles virus or against said RNA virus or against both measles virus and against said RNA virus.
It also relates to the use of said recombinant measles virus for the preparation of immunogenic composition.
摘要翻译：本发明涉及的重组麻疹病毒表达来自在确定性开采RNA病毒的抗原的异源氨基酸序列，所述重组麻疹病毒能够引发体液和/或针对麻疹病毒或抵靠所述RNA病毒或细胞免疫应答的双方对麻疹病毒和针对所述RNA病毒。因此，它涉及使用所述重组麻疹病毒的用于免疫原性组合物的制备。

7. 发明公开

EP3008176A4 COMPOSITIONS AND METHODS FOR ENHANCING VIRUS REPLICATION 有权转让
标题翻译：增强病毒复制的组合物和方法
公开(公告)号：EP3008176A4
公开(公告)日：2016-12-07
申请号：EP14811047
申请日：2014-06-16
申请人： OTTAWA HOSPITAL RES INST
发明人： ILKOW CAROLINA SOLANGE , LEBOEUF FABRICE , BELL JOHN CAMERON , DIALLO JEAN-SIMON , ARULANANDAM ROZANNE
IPC分类号： C12N7/01 , A61K35/76 , A61K35/766 , A61K35/768 , A61K38/17 , A61K38/18 , A61K47/48 , A61P35/00 , C07K14/50 , C12N5/07 , C12N7/00
CPC分类号： C12N7/00 , A61K35/76 , A61K35/766 , A61K35/768 , A61K38/1793 , A61K38/1825 , C07K14/50 , C07K2319/02 , C12N2710/16651 , C12N2710/24151 , C12N2720/12051 , C12N2760/16151 , C12N2760/16152 , C12N2760/18451 , C12N2760/18452 , C12N2760/20232 , C12N2760/20251 , A61K2300/00
摘要： Described herein is a method of enhancing virus replication in permissive cells that express a receptor to FGF2 protein. The method includes administering FGF2 protein or a functional variant thereof and the virus to the permissive cells. An oncolytic virus having a genome that includes an open reading frame that encodes FGF2 protein or a functional variant thereof is also described.

8. 发明公开

EP2298924A2 Improved method for the recovery of non-segmented, negative-stranded RNA viruses from cDNA 审中-公开
标题翻译： Verbittenes Verfahren zur Gewinnung nichtsegmentierter negativ-strang-RNA-Viren aus cDNA
公开(公告)号：EP2298924A2
公开(公告)日：2011-03-23
申请号：EP10174369.8
申请日：2004-06-08
申请人： Wyeth LLC
发明人： Parks, Christopher L. , Udem, Stephen A. , Sidhu, Modinderjit S.
IPC分类号： C12N15/86 , A61K39/12 , C12N7/00
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , C12N7/00 , C12N15/86 , C12N2760/18022 , C12N2760/18422 , C12N2760/18451 , C12N2760/18452 , C12N2760/18551 , C12N2760/18552 , C12N2760/18622 , C12N2760/18651 , C12N2760/18652 , C12N2760/18662 , C12N2760/20243 , C12N2760/20251 , C12N2760/20252 , C12N2760/20262
摘要： Methods for producing infectious, non-segmented, negative-stranded RNA viruses of the Order Mononegavirales are provided that involve coexpression of a viral cDNA along with essential viral proteins, N, P, and L in a host cell transiently transfected with an expression vector encoding an RNA polymerase. In alternate methods, after the host cell is transfected with a viral cDNA expression vector and one or more vectors encoding the RNA polymerase, N protein, P protein, and L protein, the host cell is exposed to an effective heat shock under conditions sufficient to increase recovery of the recombinant virus. In other alternate embodiments, the host cells are transferred after viral rescue begins into co-culture with a plaque expansion cell, typically a monolayer of expansion cells, and the assembled infectious, non-segmented, negative-stranded RNA virus is recovered from the co-culture. Also provided within the invention are compositions for producing infectious, non-segmented, negative-stranded RNA virus of the Order Mononegavirales, recombinant viruses produced using the foregoing methods and compositions, and immunogenic compositions and methods employing the recombinant viruses. In additional embodiments, the methods and compositions of the invention are employed to produce growth- or replication-defective non-segmented negative-stranded RNA viruses and subviral particles.
摘要翻译：提供了用于产生单宁属病毒感染性，非分段的负链RNA病毒的方法，其涉及病毒cDNA与基本病毒蛋白N，P和L共表达在用表达载体编码的瞬时转染的宿主细胞中 RNA聚合酶。在替代方法中，在用病毒cDNA表达载体和编码RNA聚合酶，N蛋白，P蛋白和L蛋白的一种或多种载体转染宿主细胞后，将宿主细胞暴露于有效的热休克，增加重组病毒的恢复。在其他替代实施方案中，宿主细胞在病毒性拯救开始与斑块扩增细胞（通常为单层扩增细胞）共培养后被转移，并且组装的感染性，非分段的负链RNA病毒从共同 -文化。在本发明中还提供了用于产生单宁属（Mononegavirales）的感染性，非分段的负链RNA病毒的组合物，使用前述方法和组合物产生的重组病毒，以及使用重组病毒的免疫原性组合物和方法。在另外的实施方案中，本发明的方法和组合物用于产生生长或复制缺陷型非分段负链RNA病毒和亚病毒颗粒。

9. 发明公开

EP1633860A2 IMPROVED METHOD FOR THE RECOVERY OF NON-SEGMENTED, NEGATIVE-STRANDED RNA VIRUSES FROM cDNA 审中-公开
标题翻译：改进方法OBTAINING未分段负链RNA病毒从cDNA
公开(公告)号：EP1633860A2
公开(公告)日：2006-03-15
申请号：EP04754803.7
申请日：2004-06-08
申请人： Wyeth
发明人： PARKS, Christopher, L. , UDEM, Stephen, A. , SIDHU, Modinderjit, S.
IPC分类号： C12N7/00
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , C12N7/00 , C12N15/86 , C12N2760/18022 , C12N2760/18422 , C12N2760/18451 , C12N2760/18452 , C12N2760/18551 , C12N2760/18552 , C12N2760/18622 , C12N2760/18651 , C12N2760/18652 , C12N2760/18662 , C12N2760/20243 , C12N2760/20251 , C12N2760/20252 , C12N2760/20262
摘要： Methods for producing infectious, non-segmented, negative-stranded RNA viruses of the Order Mononegavirales are provided that involve coexpression of a viral cDNA along with essential viral proteins, N, P, and L in a host cell transiently transfected with an expression vector encoding an RNA polymerase. In alternate methods, after the host cell is transfected with a viral cDNA expression vector and one or more vectors encoding the RNA polymerase, N protein, P protein, and L protein, the host cell is exposed to an effective heat shock under conditions sufficient to increase recovery of the recombinant virus. In other alternate embodiments, the host cells are transferred after viral rescue begins into co-culture with a plaque expansion cell, typically a monolayer of expansion cells, and the assembled infectious, non-segmented, negative-stranded RNA virus is recovered from the co-culture. Also provided within the invention are compositions for producing infectious, non-segmented, negative-stranded RNA virus of the Order Mononegavirales, recombinant viruses produced using the foregoing methods and compositions, and immunogenic compositions and methods employing the recombinant viruses. In additional embodiments, the methods and compositions of the invention are employed to produce growth- or replication-defective non-segmented negative-stranded RNA viruses and subviral particles.

10. 发明公开

EP1516058A2 RECOMBINANT MEASLES VIRUSES EXPRESSING EPITOPES OF ANTIGENS OF RNA VIRUSES AND USE OF THE RECOMBINANT VIRUSES FOR THE PREPARATION OF VACCINE COMPOSITIONS 无效
标题翻译：重组麻疹病毒了表达的RNA病毒抗原表位，及重组病毒的疫苗的生产中使用
公开(公告)号：EP1516058A2
公开(公告)日：2005-03-23
申请号：EP03760697.7
申请日：2003-06-20
申请人： INSTITUT PASTEUR , CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： TANGY, Frédéric , LORIN, Clarisse , MOLLET, Lucile , DELEBECQUE, Frédéric
IPC分类号： C12N15/86 , C12N7/00
CPC分类号： C12N15/86 , A61K39/12 , A61K39/165 , A61K39/21 , A61K47/6901 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2740/16022 , C12N2740/16122 , C12N2760/18421 , C12N2760/18422 , C12N2760/18434 , C12N2760/18443 , C12N2760/18452 , C12N2770/24122 , Y02A50/388 , Y02A50/394
摘要： The invention relates to a recombinant measles virus expressing a heterologous amino acid sequence derived from an antigen of a determined RNA virus, said recombinant measles virus being capable of eliciting a humoral and/or a cellular immune response against measles virus or against said RNA virus or against both measles virus and against said RNA virus. It also relates to the use of said recombinant measles virus for the preparation of immunogenic composition.

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