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1. 发明公开

EP3031821A1 polyomavirus VLPs with a fusion protein 审中-公开
标题翻译：病毒 - 维生素（VLP）aus多瘤病毒融合蛋白
公开(公告)号：EP3031821A1
公开(公告)日：2016-06-15
申请号：EP14196847.9
申请日：2014-12-08
申请人： Life Science Inkubator
发明人： Franken, Sebastian , Glassmann, Alexander , Temme, Nadine
IPC分类号： C07K14/005 , C12N7/04
CPC分类号： C07K14/005 , C07K2319/06 , C07K2319/70 , C12N7/00 , C12N7/04 , C12N15/113 , C12N2310/14 , C12N2320/32 , C12N2710/22022 , C12N2710/22023 , C12N2710/22042
摘要： The disclosure relates to a fusion protein comprising a VP1 binding protein and an exogenous peptide, wherein the exogenous peptide comprises a cargo-securing peptide (CSP) and/or an endosome translocating peptide (ETP) and to virus like particles (VLP) comprising the fusion protein for use as drug delivery system.
Also provided are polynucleotides encoding the fusion protein, suitable expression vectors, host cells, production methods for the fusion protein and the VLP comprising the fusion protein.
摘要翻译：本公开涉及包含VP1结合蛋白和外源肽的融合蛋白，其中所述外源肽包含货物确保肽（CSP）和/或内体易位肽（ETP）和包含病毒样颗粒（VLP）的病毒样颗粒（VLP）融合蛋白用作药物递送系统。还提供了编码融合蛋白的多核苷酸，合适的表达载体，宿主细胞，融合蛋白的产生方法和包含融合蛋白的VLP。

2. 发明公开

EP3031820A1 JC Polyomavirus VLP (virus-like particle) with a targeting peptide 审中-公开
标题翻译： JC多瘤病毒病毒 - 维生素（VLP）靶向肽
公开(公告)号：EP3031820A1
公开(公告)日：2016-06-15
申请号：EP14196845.3
申请日：2014-12-08
申请人： Life Science Inkubator
发明人： Franken, Sebastian , Glassmann, Alexander , Temme, Nadine
IPC分类号： C07K14/005 , C07K14/01 , C12N7/04
CPC分类号： C07K14/01 , C07K2/00 , C07K14/005 , C07K2319/01 , C12N7/04 , C12N2710/22022 , C12N2710/22023 , C12N2710/22042 , C12N2810/40
摘要： The disclosure relates to a fusion protein comprising at least a first and a second peptide, wherein
- the second peptide comprises a targeting region and a first and a second interaction region,
- the second peptide is located on the surface of the fusion protein;
- the second peptide comprises at least two interaction pairs, wherein an interaction pair is formed by an amino acid of the first interaction region and an amino acid of the second interaction region,
- the interaction between the amino acids of an interaction pair is covalent or noncovalent; and
- at least one interaction pair is a covalent interaction pair in which the amino acids are covalently bound,

and to virus like particles (VLP) comprising the fusion protein for use as drug delivery system.
Also provided are polynucleotides encoding the fusion protein, suitable expression vectors, host cells, production methods for the fusion protein and the VLP comprising the fusion protein.
摘要翻译：本公开涉及包含至少第一和第二肽的融合蛋白，其中 - 所述第二肽包含靶向区和第一和第二相互作用区，所述第二肽位于所述融合蛋白的表面上; - 第二肽包含至少两个相互作用对，其中相互作用对由第一相互作用区域的氨基酸和第二相互作用区域的氨基酸形成， - 相互作用对的氨基酸之间的相互作用是共价的或非共价键; 和 - 至少一个相互作用对是氨基酸共价结合的共价相互作用对，以及包含用作药物递送系统的融合蛋白的病毒样颗粒（VLP）。还提供了编码融合蛋白的多核苷酸，合适的表达载体，宿主细胞，融合蛋白的产生方法和包含融合蛋白的VLP。

3. 发明公开

EP2836598A1 GENE EXPRESSSION FROM MITOTICALLY STABLE EPISOMES 审中-公开
标题翻译：基因XPRESS SION从稳定有丝分裂的游离体
公开(公告)号：EP2836598A1
公开(公告)日：2015-02-18
申请号：EP13713483.9
申请日：2013-03-27
申请人： Royal Holloway And Bedford New College
发明人： DICKSON, George , YANEZ-MUNOS, Rafael , KYMALAINEN, Hanna
IPC分类号： C12N15/67 , C12N15/867
CPC分类号： C12N15/67 , C12N15/79 , C12N15/86 , C12N2710/22022 , C12N2740/16043 , C12N2800/108 , C12N2820/60 , C12N2830/46
摘要： The invention provides a method of expressing a transgene in a host cell. The method comprises exposing a host cell, which comprises a genetic construct comprising a transgene, to conditions which substantially block mitosis in the host cell, such that the construct forms a mitotically stable episome resulting in expression of the transgene. The invention extends to the use of such constructs for expressing transgenes in a range of different medical and heterologous protein production applications.

4. 发明公开

EP2785731A1 VECTORS AND HOST CELLS COMPRISING A MODIFIED SV40 PROMOTER FOR PROTEIN EXPRESSION 无效转让
标题翻译： VEKTOREN UND WIRTSZELLEN MIT EINEM MODIFIZIERTEN SV40-PROMOTER ZUR PROTEINEXPRESSION
公开(公告)号：EP2785731A1
公开(公告)日：2014-10-08
申请号：EP11815647.0
申请日：2011-11-30
申请人： AbbVie Biotherapeutics Inc.
发明人： HARTMAN, Taymar , TSO, Yun J. , HE, Yimin
IPC分类号： C07K14/025 , C12N15/85 , C07K16/00
CPC分类号： C12P21/00 , C07K14/005 , C07K16/00 , C07K16/2896 , C07K2317/14 , C07K2317/51 , C07K2317/515 , C12N7/00 , C12N15/85 , C12N2710/22022 , C12N2710/22043 , C12N2800/107 , C12N2800/24 , C12N2830/20 , C12N2830/60
摘要： The present disclosure is directed to expression vectors, comprising a weakened SV40 promoter, and recombinant mammalian cells capable of producing high levels of a polypeptide of interest, methods of generating and using such recombinant mammalian cells.
摘要翻译：本公开涉及包含弱化SV40启动子和能够产生高水平目标多肽的重组哺乳动物细胞的表达载体，产生和使用这些重组哺乳动物细胞的方法。

5. 发明公开

EP2742139A1 IMMUNOGENIC COMPOSITIONS AND METHODS THEREFOR 审中-公开
标题翻译：免疫原性组合物及其方法
公开(公告)号：EP2742139A1
公开(公告)日：2014-06-18
申请号：EP12822010.0
申请日：2012-08-13
申请人： The University Of Queensland
发明人： MIDDELBERG, Anton Peter Jacob , LUA, Linda Hwee-Lin
IPC分类号： C12N15/62 , A61K39/09 , A61K39/145 , A61K39/21 , A61K39/155 , A61P31/22
CPC分类号： C07K14/315 , A61K9/1075 , A61K9/5184 , A61K39/09 , A61K39/092 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/21 , A61K2039/523 , A61K2039/5256 , A61K2039/5258 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , C07K14/005 , C12N15/62 , C12N2710/22022 , C12N2710/22043 , C12N2760/16134 , C12N2760/18234 , Y02A50/467
摘要： The present invention provides compositions relating to viral capsomeres which comprise foreign immunogenic sequences for use in pharmaceutical compositions and methods of producing such compositions, and related isolated or purified protein and nucleic acid molecules, vectors, host cells, compositions, and methods of use to augment an immune response, immunize an animal and prophylactically or therapeutically treat a disease, disorder or condition. The viral capsomere may be derived from a polyomavirus and comprise an immunogen of interest at the N-terminus and further at the C-terminus and/or at one or more exposed loops of the capsomere.

6. 发明公开

EP2548567A1 Polyoma virus JC peptides and proteins in vaccination and diagnostic applications 审中-公开
标题翻译： Polyomavirus-JC-Peptide und-Proteine in Impf- und Diagnoseanwendungen
公开(公告)号：EP2548567A1
公开(公告)日：2013-01-23
申请号：EP11006031.6
申请日：2011-07-22
申请人： Universitätsklinikum Hamburg-Eppendorf , Universität Zürich
发明人： Martin, Roland, Prof. Dr. med. , Sospedra, Mireia , Jelcic, Ilijas , Yousef, Sara , Schippling, Sven, Dr. med.
IPC分类号： A61K38/04 , A61K38/16 , C07K14/025
CPC分类号： C07K14/005 , A61K38/00 , A61K38/162 , A61K38/2046 , A61K39/12 , A61K2039/55511 , A61K2039/55527 , C07K7/08 , C12N7/00 , C12N2710/22022 , C12N2710/22023 , C12N2710/22034 , C12N2710/22071 , C12Q1/70
摘要： The present invention relates to the field of vaccination or immunization, in particular therapeutic vaccination, and diagnosis. Pharmaceutical compositions and kits capable of eliciting a protective immune response against polyoma virus JC (JCV) are disclosed, which may be used e.g., for therapy or for prevention of progressive multifocal leukoencephalopathy (PML) and/or progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS). Individuals in danger of such PML or PML-IRIS may, e.g., be immunocompromised or immunosuppressed patients or patients having an autoimmune disease eligible for immunosuppressive treatment. The invention also relates to compositions comprising at least one CD4+ epitope of a JCV protein and to diagnostic uses thereof.
摘要翻译：本发明涉及疫苗接种或免疫领域，特别是治疗性疫苗接种和诊断。公开了能够引起针对多瘤病毒JC（JCV）的保护性免疫应答的药物组合物和试剂盒，其可用于例如用于治疗或预防进行性多灶性脑白质脑病（PML）和/或进行性多灶性脑白质脑病 - 免疫重建炎症综合征（PML-IRIS）。危及此类PML或PML-IRIS的个体可能例如免疫功能低下或免疫抑制患者或患有自身免疫性疾病的患者符合免疫抑制治疗。本发明还涉及包含JCV蛋白质的至少一种CD4 +表位的组合物及其诊断用途。

7. 发明授权

EP1256625B1 IMMORTALIZED VASCULAR ADVENTITIAL CELL LINE 有权
标题翻译： IMMORTAL血管AVENTITIALE细胞系
公开(公告)号：EP1256625B1
公开(公告)日：2010-12-29
申请号：EP01904415.5
申请日：2001-02-14
申请人： Japan Science and Technology Agency
发明人： IIZASA, Hisashi , HATTORI, Kenji Room 202, Shenesuhauze , NAKASHIMA, Emi , TERASAKI, Tetsuya , OBINATA, Masuo
IPC分类号： C12N5/16 , C12N15/18 , G01N33/50 , G01N33/15 , C12N15/37 , C12N15/63 , A01K67/027
CPC分类号： G01N33/5044 , A01K2217/05 , C07K14/005 , C12N5/069 , C12N2503/02 , C12N2510/00 , C12N2510/04 , C12N2517/02 , C12N2710/22022 , G01N33/5008 , G01N33/5011 , G01N33/5017 , G01N33/502 , G01N2500/00
摘要： An immortalized capillary adventitial cell line sustaining the inherent function and characteristics of the tissue from which the cell line is derived; a method of establishing the same; and a method of screening a useful substance by using this cell line. A cerebral tissue of a transgenic rat having large T antigen gene of an SV 40 temperature-sensitive mutant tsA58 transferred thereinto is homogenized and then the thus obtained capillaries are treated with a protease. By subculturing the cerebral capillary cells thus obtained, immortalized cells expressing the temperature sensitive SV40 large T antigen, PDGF receptor β and angiopoietin-1 are established. Also, this immortalized vascular adventitial cell line is capable of depositing calcium matrix mass.

8. 发明授权

EP1450856B1 PACKAGING OF IMMUNOSTIMULATORY CPG INTO VIRUS-LIKE PARTICLES: METHOD OF PREPARATION AND USE 有权转让
标题翻译：包装免疫刺激中央人民政府驻病毒样颗粒：方法和用途
公开(公告)号：EP1450856B1
公开(公告)日：2009-11-11
申请号：EP02777600.4
申请日：2002-09-16
申请人： Cytos Biotechnology AG
发明人： BACHMANN, Martin, F. , STORNI, Tazio , MAURER, Patrick , TISSOT, Alain , SCHWARZ, Katrin , MEIJERINK, Edwin , LIPOWSKY, Gerad , PUMPENS, Paul , CIELENS, Indulis , RENHOFA, Regina
IPC分类号： A61K39/39 , A61P37/04
CPC分类号： A61K39/12 , A61K39/00 , A61K39/0011 , A61K39/02 , A61K39/39 , A61K2039/52 , A61K2039/5258 , A61K2039/55555 , A61K2039/55561 , A61K2039/57 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2710/22022 , C12N2710/22023 , C12N2730/10122 , C12N2730/10123 , C12N2795/00034 , C12N2795/18122 , Y02A50/412 , Y02A50/467
摘要： The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG- VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Thl type. Antigens attached to CpG-loaded VLPs may therefore be ... SIMILAR ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.

9. 发明授权

EP1221283B1 Transgenic animal for screening therapeutic agents for brain tumors 有权
标题翻译：转基因动物对抗脑瘤有效的测试治疗药物
公开(公告)号：EP1221283B1
公开(公告)日：2008-09-03
申请号：EP01309893.4
申请日：2001-11-22
申请人： Chiu, Ing-Ming
发明人： Chiu, Ing-Ming
IPC分类号： A01K67/027 , C12N5/06 , C12N5/10 , C12N15/63 , C12N15/85 , A61K49/00
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0331 , A01K2267/0356 , A01K2267/0393 , A61K49/0008 , C07K14/005 , C07K14/501 , C12N15/85 , C12N2510/00 , C12N2517/02 , C12N2710/22022 , C12N2830/00 , C12N2830/008 , C12N2830/15 , C12N2830/85

10. 发明公开

EP1888620A1 VERFAHREN ZUR HERSTELLUNG VON EINEN WIRKSTOFF ENTHALTENDEN VIRUSARTIGEN PARTIKELN 审中-公开
标题翻译：用于生产活性成分含病毒样颗粒
公开(公告)号：EP1888620A1
公开(公告)日：2008-02-20
申请号：EP06707650.5
申请日：2006-03-28
申请人： responsif GmbH
发明人： REICHEL, Christoph , RÜHLAND, Claus , HESS, Jürgen , REISER, Christian
IPC分类号： C07K14/005
CPC分类号： C12N7/00 , A61K2039/5256 , C07K14/005 , C07K2319/00 , C12N2710/22022 , C12N2710/22023 , C12N2710/22051 , Y02A50/412 , Y02A50/466
摘要： The invention relates to a method for producing virus-type particles containing an active substance. Proteins, which comprise a first amino acid sequence which is derived from a first virus protein, and fusion proteins are assembled in order to form the virus-type particles. The proteins and the fusion proteins are coexpressed in yeast cells.

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