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1. 发明授权

EP3199633B1 HERABREGULATION DER GENEXPRESSION MITTELS NUKLEINSÄURE-BELADENER VIRUS-ÄHNLICHER PARTIKEL 有权
公开(公告)号：EP3199633B1
公开(公告)日：2018-11-14
申请号：EP17151870.7
申请日：2008-09-12
申请人： Deutsches Primatenzentrum GmbH
发明人： Lüke, Wolfgang , Gruber, Jens
IPC分类号： C12N15/11 , C12N7/04 , A61K31/713 , A61K47/42 , C07K14/025
CPC分类号： C12N15/113 , A61K39/39 , A61K48/0025 , C07K2319/09 , C12N15/111 , C12N15/1138 , C12N15/117 , C12N2310/14 , C12N2320/32 , C12N2710/22022 , C12N2710/22023 , C12N2710/22042 , C12N2710/22045

2. 发明授权

EP2061887B1 VLP BASED INFLUENZA VACCINE DELIVERY SYSTEM 有权
标题翻译：基于VLP的流感疫苗传递系统
公开(公告)号：EP2061887B1
公开(公告)日：2018-01-24
申请号：EP07815285.7
申请日：2007-10-04
申请人： The University Of Queensland
发明人： HWEE-LIN LUA, Linda , MIDDELBERG, Anton, Peter, Jacob
IPC分类号： C12N15/35 , C12N15/44 , C07K14/025 , C07K14/11 , A61K39/145 , C12N7/04 , C12N7/00 , C07K19/00 , A61K35/76 , C12P21/00
CPC分类号： A61K39/145 , A61K39/12 , A61K39/385 , A61K2039/5258 , A61K2039/6075 , C07K14/005 , C07K2319/735 , C12N7/00 , C12N2710/22022 , C12N2710/22023 , C12N2760/16122 , C12N2760/16134 , Y02A50/467
摘要： An isolated protein comprising a VP1 amino acid sequence wherein one or more exposed loops within said VP1 has an insertion of an amino acid sequence from a virus protein other than VP1, and encoding nucleic acid, are provided. Typically, the virus protein other than VP1 is derived from an influenza virus and in particular, avian influenza virus. The isolated protein may have an insertion of amino acid sequence from a single protein or a plurality of proteins. Also provided are expression constructs, VLPs, pharmaceutical compositions, vaccines and methods of treatment that may be useful in the prophylactic and/or therapeutic treatment of any disease of viral origin, and in particular, influenza virus.

3. 发明授权

EP2823048B1 A NOVEL DRUG DELIVERY SYSTEM BASED ON JCV-VLP 有权
标题翻译：一种基于JCV-VLP的新型药物递送系统
公开(公告)号：EP2823048B1
公开(公告)日：2017-11-08
申请号：EP13714195.8
申请日：2013-03-06
申请人： Life Science Inkubator Betriebs GmbH & Co. KG
发明人： DEMINA, Victoria , MANNINGA, Heiko , GÖTZKE, Armin , GLASSMANN, Alexander
IPC分类号： C12N15/86 , A61K48/00
CPC分类号： A61K48/0025 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2710/22022 , C12N2710/22023 , C12N2710/22041 , C12N2710/22042 , C12N2710/22043 , C12N2710/22071 , C12N2710/24023 , C12N2710/24042 , C12N2710/24043 , C12N2710/24071

4. 发明授权

EP2195430B1 HERABREGULATION DER GENEXPRESSION MITTELS NUKLEINSÄURE-BELADENER VIRUSÄHNLICHER PARTIKEL 有权转让
标题翻译： REDUCE基因表达调控同位素标记加载的病毒样颗粒
公开(公告)号：EP2195430B1
公开(公告)日：2017-01-18
申请号：EP08802132.4
申请日：2008-09-12
申请人： Deutsches Primatenzentrum GmbH
发明人： LÜKE, Wolfgang , Dr. GRUBER, Jens
IPC分类号： C12N15/11 , C12N7/04 , A61K31/713 , A61K47/42
CPC分类号： C12N15/113 , A61K39/39 , A61K48/0025 , C07K2319/09 , C12N15/111 , C12N15/1138 , C12N15/117 , C12N2310/14 , C12N2320/32 , C12N2710/22022 , C12N2710/22023 , C12N2710/22042 , C12N2710/22045

5. 发明公开

EP2742139A4 IMMUNOGENIC COMPOSITIONS AND METHODS THEREFOR 审中-公开
标题翻译：免疫组织ZUSAMMENSETZUNGEN UND VERFAHRENDAFÜR
公开(公告)号：EP2742139A4
公开(公告)日：2015-04-15
申请号：EP12822010
申请日：2012-08-13
申请人： UNIV QUEENSLAND
发明人： MIDDELBERG ANTON PETER JACOB , LUA LINDA HWEE-LIN
IPC分类号： C12N15/62 , A61K39/09 , A61K39/145 , A61K39/155 , A61K39/21 , A61P31/22
CPC分类号： C07K14/315 , A61K9/1075 , A61K9/5184 , A61K39/09 , A61K39/092 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/21 , A61K2039/523 , A61K2039/5256 , A61K2039/5258 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , C07K14/005 , C12N15/62 , C12N2710/22022 , C12N2710/22043 , C12N2760/16134 , C12N2760/18234
摘要： The present invention provides compositions relating to viral capsomeres which comprise foreign immunogenic sequences for use in pharmaceutical compositions and methods of producing such compositions, and related isolated or purified protein and nucleic acid molecules, vectors, host cells, compositions, and methods of use to augment an immune response, immunize an animal and prophylactically or therapeutically treat a disease, disorder or condition. The viral capsomere may be derived from a polyomavirus and comprise an immunogen of interest at the N-terminus and further at the C-terminus and/or at one or more exposed loops of the capsomere.
摘要翻译：本发明提供了涉及病毒壳聚糖的组合物，其包含用于药物组合物的外源免疫原性序列和生产此类组合物的方法，以及相关的分离或纯化的蛋白质和核酸分子，载体，宿主细胞，组合物和增加使用的方法免疫应答，免疫动物并预防性或治疗性地治疗疾病，病症或病症。病毒性胶质瘤可以衍生自多瘤病毒，并且在N-末端和进一步在辣根瘤菌的C末端和/或一个或多个暴露的环上包含感兴趣的免疫原。

6. 发明公开

EP2636746A1 A novel drug delivery system based on JCV-VLP 审中-公开
标题翻译： Neuartiges System zur Verabreichung von Arzneimitteln auf der Grundlage von JCV-VLP
公开(公告)号：EP2636746A1
公开(公告)日：2013-09-11
申请号：EP12001507.8
申请日：2012-03-06
申请人： Life Science Inkubator
发明人： Demina, Victoria , Manninga, Helko , Götzke, Armin , Glassmann, Alexander
IPC分类号： C12N15/86 , A61K48/00
CPC分类号： A61K48/0025 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2710/22022 , C12N2710/22023 , C12N2710/22041 , C12N2710/22042 , C12N2710/22043 , C12N2710/22071 , C12N2710/24023 , C12N2710/24042 , C12N2710/24043 , C12N2710/24071
摘要： The invention relates to VLP derived from human polyoma virus loaded with a drug (cargo) as a drug delivery system for transporting said drug into the CNS, in particular of living humans.
摘要翻译：本发明涉及来自装载有药物（货物）的人多瘤病毒作为药物递送系统的VLP，用于将所述药物转运到CNS中，特别是活的人。

7. 发明公开

EP2314707A1 Method for the expression of a recombinant protein in a mammalian cell 审中-公开
标题翻译： Verfahren zur表达在einerSäugetierzelle中重组重组蛋白
公开(公告)号：EP2314707A1
公开(公告)日：2011-04-27
申请号：EP09174068.8
申请日：2009-10-26
申请人： Amarna Therapeutics B.V.
发明人： De Vries, Walter Gerhardus
IPC分类号： C12N15/85 , C12N5/10
CPC分类号： C12N15/85 , C12N2710/22022 , C12N2800/108
摘要： The invention relates to methods for the production of a recombinant protein in a mammalian cell and methods to enhance the production of recombinant proteins in mammalian cells. More in particular, the invention provides a cell for the production of a recombinant protein of interest wherein said cell is permissive to a polyomavirus and wherein said cell comprises the genetic elements A and B wherein A encodes a polyomaviral large T antigen or a functional equivalent thereof and B comprises a gene encoding a protein of interest under the functional control of a polyomaviral origin of replication or a functional equivalent thereof, wherein said cell lacks the capability to express a polyomaviral small T antigen or a functional equivalent thereof as well as the capability to express a polyomavirus capsid protein.
摘要翻译：本发明涉及用于在哺乳动物细胞中产生重组蛋白的方法以及增强哺乳动物细胞中重组蛋白产生的方法。更具体地，本发明提供了用于产生感兴趣的重组蛋白质的细胞，其中所述细胞允许多瘤病毒，并且其中所述细胞包含遗传元件A和B，其中A编码多分子量大的抗原或其功能等同物和B包含编码目的蛋白质的基因在复合多功能病毒复制起点或其功能等同物的功能控制下，其中所述细胞缺乏表达多细胞病毒小T抗原或其功能等同物的能力，以及表达多瘤病毒衣壳蛋白。

8. 发明公开

EP2061887A4 VLP BASED VACCINE DELIVERY SYSTEM 有权
标题翻译： ZUFÜHRUNGSSYSTEMFÜRIMPFSTOFF AUF VLP-BASIS
公开(公告)号：EP2061887A4
公开(公告)日：2010-10-06
申请号：EP07815285
申请日：2007-10-04
申请人： UNIV QUEENSLAND
发明人： HWEE-LIN LUA LINDA , MIDDELBERG ANTON PETER JACOB
IPC分类号： C12N15/35 , A61K35/76 , C07K14/025 , C12N7/00 , C12P21/00
CPC分类号： A61K39/145 , A61K39/12 , A61K39/385 , A61K2039/5258 , A61K2039/6075 , C07K14/005 , C07K2319/735 , C12N7/00 , C12N2710/22022 , C12N2710/22023 , C12N2760/16122 , C12N2760/16134
摘要： An isolated protein comprising a VP1 amino acid sequence wherein one or more exposed loops within said VP1 has an insertion of an amino acid sequence from a virus protein other than VP1, and encoding nucleic acid, are provided. Typically, the virus protein other than VP1 is derived from an influenza virus and in particular, avian influenza virus. The isolated protein may have an insertion of amino acid sequence from a single protein or a plurality of proteins. Also provided are expression constructs, VLPs, pharmaceutical compositions, vaccines and methods of treatment that may be useful in the prophylactic and/or therapeutic treatment of any disease of viral origin, and in particular, influenza virus.
摘要翻译：提供了包含VP1氨基酸序列的分离的蛋白质，其中所述VP1内的一个或多个暴露的环具有来自除了VP1以外的病毒蛋白的氨基酸序列的插入和编码核酸。通常，除VP1以外的病毒蛋白来自流感病毒，特别是禽流感病毒。分离的蛋白质可以具有来自单一蛋白质或多种蛋白质的氨基酸序列的插入。还提供了可用于预防和/或治疗任何病毒来源疾病，特别是流感病毒的表达构建体，VLP，药物组合物，疫苗和治疗方法。

9. 发明授权

EP1232257B1 MODULARE TRANSPORTSYSTEME FÜR MOLEKULARE SUBSTANZEN UND DEREN HERSTELLUNG UND VERWENDUNG 有权
标题翻译：模块化运输系统及分子物质和其生产和使用
公开(公告)号：EP1232257B1
公开(公告)日：2009-10-14
申请号：EP00983106.6
申请日：2000-11-03
申请人： ACGT Progenomics AG
发明人： BÖHM, Gerald , RUDOLPH, Rainer , SCHMIDT, Ulrich , ESSER, Dirk
IPC分类号： C12N15/00
CPC分类号： C07K14/005 , A61K38/00 , A61K47/6901 , A61K48/00 , C12N7/00 , C12N2710/22022 , C12N2710/22023 , C12N2810/50 , Y02A50/467
摘要： The invention relates to transport systems for molecular substances, comprising a mosaic of recombinant partial units (individual components). The invention further relates to production of the modular transport system and use thereof.

10. 发明公开

EP1849799A1 MODIFIED VIRUS CAPSID PROTEIN AND THE USE THEREOF 审中-公开
标题翻译：修改VIRUSCAPSIDPROTEIN UND ANWENDUNG DAVON
公开(公告)号：EP1849799A1
公开(公告)日：2007-10-31
申请号：EP06714349.5
申请日：2006-02-16
申请人： THE CIRCLE FOR THE PROMOTION OF SCIENCE AND ENGINE , KONICA MINOLTA HOLDINGS, INC.
发明人： HANDA, Hiroshi , NAKANISHI, Akira , KANESASHI, Shin-Nosuke , TAKAHASHI, Ryou-u
IPC分类号： C07K14/015 , A61K35/76 , A61K48/00 , A61P43/00 , C12N7/00 , C12N15/09
CPC分类号： C07K14/005 , A61K38/00 , A61K2039/5258 , C07K2319/00 , C07K2319/41 , C07K2319/42 , C07K2319/43 , C12N7/00 , C12N2710/22022 , C12N2710/22023 , Y02A50/467
摘要： An altered capsid protein of SV40 that a foreign peptide sandwiched by 1 to several glycine residues each is inserted into at least one of DE-loop and HI-loop of the capsid protein of SV40, and a virus-like particle formed from this protein.
摘要翻译： SV40的衣壳蛋白的改变将被1〜数个甘氨酸残基夹杂的外来肽插入到SV40的衣壳蛋白的DE环和HI环中的至少一个中，以及由该蛋白形成的病毒样颗粒。

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