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1. 发明授权

EP1857549B1 Control of gene expression 有权
公开(公告)号：EP1857549B1
公开(公告)日：2018-10-17
申请号：EP07008204.5
申请日：1999-03-19
申请人： Commonwealth Scientific and Industrial Research Organisation
发明人： Graham, Michael Wayne , Rice, Robert Norman , Waterhouse, Peter Michael , Wang, MingBo
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , A01K2217/05 , A61K48/00 , C12N9/1051 , C12N9/127 , C12N9/503 , C12N15/111 , C12N15/1131 , C12N15/63 , C12N15/69 , C12N15/8216 , C12N15/8218 , C12N15/8283 , C12N15/85 , C12N2310/111 , C12N2310/14 , C12N2310/531 , C12N2320/10 , C12N2320/30 , C12N2330/30 , C12N2330/50 , C12N2330/51 , C12N2800/108 , C12N2830/00 , C12N2830/002 , C12N2830/15 , C12N2830/38 , C12N2830/42 , C12N2830/55 , C12N2830/60 , C12N2840/20
摘要： The present invention relates generally to a method of modifying gene expression and to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention utilises recombinant DNA technology to post-transcriptionally modify or modulate the expression of a target gene in a cell, tissue, organ or whole organism, thereby producing novel phenotypes. Novel synthetic genes and genetic constructs which are capable or repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced thereto are also provided.

2. 发明公开

EP3246406A1 GENE EXPRESSION SYSTEM USING STEALTHY RNA, AND GENE INTRODUCTION/EXPRESSION VECTOR INCLUDING SAID RNA 有权
标题翻译：使用STEALTHY RNA的基因表达系统，以及包含SAID RNA的基因导入/表达载体
公开(公告)号：EP3246406A1
公开(公告)日：2017-11-22
申请号：EP16737476.8
申请日：2016-01-18
申请人： National Institute of Advanced Industrial Science and Technology , Tokiwa-bio Inc.
发明人： NAKANISHI, Mahito , IIJIMA, Minoru
IPC分类号： C12N15/09 , C12N5/14 , C12N7/00
CPC分类号： C12N15/86 , C07K16/2863 , C07K16/32 , C07K16/468 , C07K2317/14 , C07K2317/21 , C07K2317/31 , C12N5/0696 , C12N5/14 , C12N9/127 , C12N15/09 , C12N2506/02 , C12N2510/00 , C12N2760/18843 , C12N2800/22 , C12N2800/70 , C12N2820/60 , C12N2830/60 , C12Y207/07048
摘要： The present invention enables simultaneous and stable expression of a plurality of foreign genes by using a stealthy RNA gene expression system that is a complex that does not activate the innate immune mechanism and is formed from an RNA-dependent RNA polymerase, a single-strand RNA binding protein, and negative-sense single-strand RNAs including the following (1) to (8): (1) a target RNA sequence that codes for any protein or functional RNA; (2) an RNA sequence forming a noncoding region and derived from mRNA expressed in animal cells; (3) a transcription initiation signal sequence recognized by the RNA-dependent RNA polymerase; (4) a transcription termination signal sequence recognized by the polymerase; (5) an RNA sequence containing a replication origin recognized by the polymerase; (6) an RNA sequence that codes for the polymerase and of which codons are optimized for the species from which an introduction target cell is derived; (7) an RNA sequence that codes for a protein for regulating the activity of the polymerase and of which codons are optimized for the species from which the introduction target cell is derived; and (8) an RNA sequence that codes for the single-strand RNA binding protein and of which codons are optimized for the species from which the introduction target cell is derived.
摘要翻译：本发明通过使用隐身RNA基因表达系统能够同时且稳定地表达多种外源基因，所述隐性RNA基因表达系统是不激活先天免疫机制并由RNA依赖性RNA聚合酶，单链RNA形成的复合体（1）〜（8）的负链单链RNA：（1）编码任何蛋白质或功能性RNA的靶RNA序列; （2）形成非编码区并源自动物细胞中表达的mRNA的RNA序列; （3）由RNA依赖性RNA聚合酶识别的转录起始信号序列; （4）由聚合酶识别的转录终止信号序列; （5）含有由聚合酶识别的复制起点的RNA序列; （6）编码聚合酶的RNA序列，以及针对导入靶细胞来源的物种优化哪些密码子的RNA序列; （7）编码用于调节聚合酶活性的蛋白质的RNA序列，以及针对引入靶细胞来源的物种优化哪些密码子的RNA序列; 和（8）编码单链RNA结合蛋白的RNA序列，以及针对导入靶细胞来源的物种优化了哪些密码子。

3. 发明公开

EP3242945A1 SINGLE-VECTOR GENE CONSTRUCT COMPRISING INSULIN AND GLUCOKINASE GENES 有权
标题翻译：包含胰岛素和葡糖激酶基因的单向量基因构建体
公开(公告)号：EP3242945A1
公开(公告)日：2017-11-15
申请号：EP16700161.9
申请日：2016-01-07
申请人： Universitat Autònoma de Barcelona
发明人： BOSCH TUBERT, Fàtima
IPC分类号： C12N15/864 , A61K48/00
CPC分类号： A61K48/005 , A61K38/28 , A61K38/45 , C07K14/62 , C12N9/1205 , C12N15/86 , C12N2710/16143 , C12N2750/14143 , C12N2830/60 , C12Y207/01002
摘要： The invention relates to a viral expression construct and related viral vector and composition and to their use wherein said construct and vector comprise elements a) and b): a) a nucleotide sequence encoding an insulin operably linked to a first promoter, b) a nucleotide sequence encoding a glucokinase operably linked to a second promoter and said viral expression construct and related viral vector comprise at least one of elements c), d) and e): c) the first and the second promoters are positioned in reverse orientation within the expression construct, d) the first and the second promoters are positioned in reverse orientation within the expression construct and are located adjacent to each other and e) the first promoter is a CMV promoter, preferably a mini CMV promoter.

4. 发明授权

EP2848692B1 Alphavirus vectors for influenza virus vaccines 有权转让
标题翻译：用于流感病毒疫苗的甲病毒载体
公开(公告)号：EP2848692B1
公开(公告)日：2017-08-16
申请号：EP14189933.6
申请日：2005-05-20
申请人： Novartis Vaccines and Diagnostics, Inc.
发明人： Perri, Silvia , Polo, John , Uematsu, Yasushi , Greer, Catherine
IPC分类号： C12N15/86 , A61K39/145 , A61K39/155 , A61K39/215 , A61K39/12 , A61K39/02 , A61K39/00 , A61K39/295
CPC分类号： A61K39/12 , A61K39/145 , A61K39/155 , A61K2039/5252 , A61K2039/5256 , A61K2039/53 , A61K2039/543 , A61K2039/545 , A61K2039/55544 , A61K2039/55566 , A61K2039/70 , C12N15/86 , C12N2760/16122 , C12N2760/16134 , C12N2760/18322 , C12N2760/18334 , C12N2760/18522 , C12N2760/18534 , C12N2760/18622 , C12N2760/18634 , C12N2770/20022 , C12N2770/20034 , C12N2770/36143 , C12N2830/20 , C12N2830/60 , C12N2840/20 , C12N2840/203
摘要： Described herein are compositions and methods for stimulating an immune response to one or more proteins derived from one or more respiratory pathogens. In particular, the invention relates to alphavirus replicons, alphavirus vector constructs, alphavirus replicon particles expressing one or more antigens derived from one or more respiratory pathogens as well as to method of making and using these immunogenic compositions.
摘要翻译：本文描述了用于刺激对源自一种或多种呼吸道病原体的一种或多种蛋白质的免疫应答的组合物和方法。具体而言，本发明涉及表达来源于一种或多种呼吸道病原体的一种或多种抗原的α病毒复制子，α病毒载体构建体，α病毒复制子颗粒以及制备和使用这些免疫原性组合物的方法。

5. 发明公开

EP3159414A1 EXPRESSION SYSTEM 无效
标题翻译：表达系统
公开(公告)号：EP3159414A1
公开(公告)日：2017-04-26
申请号：EP16201986.3
申请日：2007-02-12
申请人： Oxitec Limited
发明人： ALPHEY, Luke
IPC分类号： C12N15/85 , A01K67/033 , C12N15/90
CPC分类号： C12N15/90 , A01K67/0339 , A01K2227/706 , A01K2267/02 , C12N15/63 , C12N15/8509 , C12N2800/90 , C12N2830/42 , C12N2830/60 , C12N2840/44
摘要： A polynucleotide expression system is provided that is capable of alternative splicing of RNA transcripts of a polynucleotide sequence to be expressed in an organism.
摘要翻译：提供了能够选择性剪接待在生物体中表达的多核苷酸序列的RNA转录物的多核苷酸表达系统。

6. 发明授权

EP2861741B1 CHO EXPRESSION SYSTEM 有权
标题翻译： CHO-EXPRESSIONSSYSTEM
公开(公告)号：EP2861741B1
公开(公告)日：2017-04-12
申请号：EP13732112.1
申请日：2013-06-14
申请人： SANOFI
发明人： DEVAUD, Catherine , DUMAS, Bruno , LOUNIS, Nabil
IPC分类号： C12N9/00 , C07K14/00 , C12N15/85 , C07K16/00
CPC分类号： C12N9/93 , C07K16/00 , C07K2317/14 , C12N15/85 , C12N2800/22 , C12N2820/55 , C12N2830/60 , C12Y603/01002

7. 发明授权

EP2498825B1 NOVEL VIRAL VECTOR CONSTRUCT FOR NEURON SPECIFIC CONTINUOUS DOPA SYNTHESIS IN VIVO 有权
标题翻译：神经病毒VEKTORKONSTRUKT ZUR NEURONENSPEZIFISCHEN KONTINUIERLICHEN DOPA-SYNTHESE IN VIVO
公开(公告)号：EP2498825B1
公开(公告)日：2017-03-29
申请号：EP10784730.3
申请日：2010-11-09
申请人： Genepod Therapeutics Ab
发明人： BJÖRKLUND, Tomas , BJÖRKLUND, Anders , KIRIK, Deniz
IPC分类号： A61K48/00 , C12N15/86 , C12N15/864
CPC分类号： C12N7/00 , A61K48/00 , C12N9/0071 , C12N9/78 , C12N9/88 , C12N15/86 , C12N2750/00043 , C12N2750/14143 , C12N2830/008 , C12N2830/34 , C12N2830/40 , C12N2830/42 , C12N2830/48 , C12N2830/50 , C12N2830/60 , C12Y114/16002 , C12Y305/04016

8. 发明授权

EP2635684B1 PLANT EXPRESSION SYSTEM 失效
标题翻译：植物表达系统
公开(公告)号：EP2635684B1
公开(公告)日：2016-10-26
申请号：EP11837364.6
申请日：2011-11-03
申请人： Medicago Inc.
发明人： D'AOUST, Marc-Andre , LAVOIE, Pierre-Olivier , VEZINA, Louis-Philippe
IPC分类号： C07K14/005 , C12N15/82
CPC分类号： C07K14/005 , C12N15/8203 , C12N15/8216 , C12N15/8221 , C12N15/8257 , C12N15/8258 , C12N2750/12022 , C12N2760/16051 , C12N2770/18022 , C12N2820/60 , C12N2830/60

9. 发明授权

EP2207564B1 USE OF MVA TO TREAT PROSTATE CANCER 有权
标题翻译： MVA在前列腺癌治疗中的应用
公开(公告)号：EP2207564B1
公开(公告)日：2016-10-05
申请号：EP08839145.3
申请日：2008-10-16
申请人： Bavarian Nordic A/S
发明人： DELCAYRE, Alain , LAUS, Reiner , MANDL, Stefanie , ROUNTREE, Ryan, Blair , LEGRAND, Fatema
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K2039/5254 , A61K2039/5256 , C07K16/3069 , C12N2799/023 , C12N2799/04 , C12N2830/60
摘要： The invention relates to compositions, kits, and methods for cancer prophylaxis and therapy using recombinant MVA viruses encoding tumor-associated antigens, such as PSA and PAP. The recombinant MVA viruses can induce B- and T-cell responses. The recombinant MVA viruses can be administered prior to, at the same time as, or after a taxane.

10. 发明授权

EP2655636B1 MODIFIED CMV PROMOTERS THAT ARE RESISTANT TO GENE SILENCING 有权
标题翻译：改性CMV发起人与抗病性的精确的电路
公开(公告)号：EP2655636B1
公开(公告)日：2015-04-22
申请号：EP11850231.9
申请日：2011-12-22
申请人： Agency for Science, Technology and Research
发明人： YANG, Yuansheng , MARIATI, Mariati
IPC分类号： C12N15/67 , C12N15/85
CPC分类号： C12N15/86 , A61K48/00 , C12N9/1077 , C12N15/67 , C12N15/85 , C12N2710/16122 , C12N2830/00 , C12N2830/46 , C12N2830/60 , C12N2830/85 , C12Y204/02007

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