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1. 发明公开

EP4368294A1 CELL CENTRIFUGATION APPARATUS AND CELL CENTRIFUGATION, CLEANING, AND CULTURING METHODS 审中-实审
公开(公告)号：EP4368294A1
公开(公告)日：2024-05-15
申请号：EP22836762.9
申请日：2022-06-28
申请人： Shenzhen Cellbri Bio-Innovation Technology Co., Ltd.
发明人： GUO, Xiaoliang , SHANG, Yuanfang , YAO, Jialin , ZHANG, Jinxin , LIU, Fujing
IPC分类号： B04B1/00 , B04B7/12 , B04B15/00 , B04B11/02 , C12M1/00 , C12M3/00 , C12M1/12 , C12M1/10 , C12M1/04 , C12M1/02 , C12N5/00
CPC分类号： B04B1/00 , B04B7/12 , B04B11/02 , B04B15/00 , C12M1/00 , C12M1/02 , C12M1/04 , C12M1/10 , C12M1/12 , C12M3/00 , C12N5/00
摘要： The present application disclosed a cell centrifugation apparatus and a cell centrifugation, washing and culture method. The cell centrifugation apparatus comprises a centrifuge chamber (1) and a liquid pushing plate (2); the centrifuge chamber (1) has a rotation axis, and the centrifuge chamber (1) is used to connected with a rotation drive mechanism (4) and rotate around its rotation axis under drive of the rotation drive mechanism (4), so as to centrifuge a blood sample contained in the centrifuge chamber (1); and one or more liquid pushing plates (2) are arranged in the centrifuge chamber (1), when the centrifuge chamber (1) rotates, the liquid pushing plate (2) is used to push the blood sample to rotate synchronously along the same rotation direction as the centrifuge chamber (1).

2. 发明公开

EP3389838A1 CELL BAG ROTATOR 有权转让
公开(公告)号：EP3389838A1
公开(公告)日：2018-10-24
申请号：EP17741830.8
申请日：2017-01-18
申请人： Novartis AG , The Trustees of the University of Pennsylvania
发明人： CALLAHAN, Thomas , DUFFY, Charles, JR.
IPC分类号： B01F9/00 , B01F9/02 , B01F9/10 , B01F11/00 , C12M1/10
CPC分类号： B01F9/0021 , B01F9/04 , B01F9/10 , B01F2009/0063 , B01F2009/0065 , C12M1/10 , C12M23/14 , C12M27/10
摘要： A cell bag rotator is constructed to slowly agitate a plurality of cell bags by rotation along a rotation axis that is at least partially horizontal. The cell bag rotator comprises a plurality of plates to which a respective cell bag is attached. The cell bag rotator is suitable for mixing cells with particles for performing various types of subsequent cell therapy processes on the cells.

3. 发明公开

EP3305885A1 CULTURING DEVICE 有权
标题翻译：培养设备
公开(公告)号：EP3305885A1
公开(公告)日：2018-04-11
申请号：EP16800017.2
申请日：2016-05-24
申请人： Nipro Corporation
发明人： TAKEUCHI, Masakatsu , TAGUCHI, Atsushi
IPC分类号： C12M3/00 , C12M1/10
CPC分类号： C12M3/043 , B01L3/50 , B01L3/563 , B01L2200/025 , B01L2200/026 , B01L2300/046 , C12M1/007 , C12M1/065 , C12M1/10 , C12M1/38 , C12M3/02 , C12M23/14 , C12M23/34 , C12M23/42 , C12M23/44 , C12M23/50 , C12M29/00 , C12M41/48
摘要： [Object] To provide a compact culture device 10 capable of performing large-scale culture in an aseptic state.
[Solution] The culture device 10 has a culture bag 70 which has ports 73 and 74 through which a liquid flows and enables cell culture, a bag holding portion 31 having holding plates 42 and 43 holding the culture bag 70 and rotating shafts 48 and 49, a rotation mechanism 34 supporting and rotating the rotating shaft 48, a liquid supply/discharge mechanism 37 supplying and discharging a liquid to/from the culture bag 70, and a rotation control portion 20 controlling the rotation of the rotation mechanism 34. The rotation control portion 20 brings the bag holding portion 31 into a first position in parallel with the approximately horizontal direction according to a first information, brings the bag holding portion 31 into a second position when a culture medium in the culture bag 70 is caused to flow out of the port 74 according to a second information, and brings the bag holding portion 31 into a third position in parallel with the approximately vertical direction at least when a cell suspension in the culture bag 70 is caused to flow out of the port 74 according to a third information.
摘要翻译：本发明的目的是提供一种能够在无菌状态下进行大规模培养的小型培养装置10。培养装置10具有培养袋70，该培养袋70具有供液体流动并能够进行细胞培养的端口73,74;袋保持部31，其具有保持培养袋70的保持板42,43;以及旋转轴48,49 ，支承旋转轴48并使其旋转的旋转机构34，向培养袋70供给液体并从培养袋70排出液体的液体供给排出机构37，以及控制旋转机构34的旋转的旋转控制部20。控制部20根据第一信息使袋保持部31进入与大致水平方向平行的第一位置，当使培养袋70中的培养基流出时使袋保持部31进入第二位置根据第二信息，将袋保持部31置于与大致垂直方向平行的第三位置，至少在单元su 根据第三信息使培养袋70中的张力从端口74流出。

4. 发明公开

EP4379036A1 CELL CAPTURE DEVICE, CENTRIFUGAL CONTAINER, CELL CAPTURE APPARATUS, AND CELL CAPTURE METHOD 失效
公开(公告)号：EP4379036A1
公开(公告)日：2024-06-05
申请号：EP22849127.0
申请日：2022-06-28
申请人： PHC Holdings Corporation
发明人： NISHIO, Akira , MATSUBARA, Fumiya , TANIMOTO, Yasushi , JOHNO, Masahiro
IPC分类号： C12M1/00 , C12M1/10 , C12M1/26 , C12N1/02 , C12N11/02
CPC分类号： C12M1/26 , C12N11/02 , C12N1/02 , C12M1/10 , C12M1/00
摘要： A cell capture apparatus (101-105) comprises a centrifugal container (110, 110', 120) that can be mounted in a centrifuge (201, 202), and that has a space (110s) in which a test liquid containing target cells is held, and an inner surface (113) that defines the space (110s); and a cell adhesion layer (111) that is disposed on the inner surface (113) and adsorbs the target cells (150, 150A, 150B) in the test liquid.

5. 发明公开

EP3305887A1 CONCENTRATING DEVICE AND METHOD FOR CONCENTRATING CELL SUSPENSION 有权
标题翻译：浓缩装置和浓缩细胞悬浮液的方法
公开(公告)号：EP3305887A1
公开(公告)日：2018-04-11
申请号：EP16800018.0
申请日：2016-05-24
申请人： Nipro Corporation
发明人： SASAYAMA, Norihisa , TAKEUCHI, Masakatsu , TAGUCHI, Atsushi
IPC分类号： C12M3/06 , B01D61/00 , C12M1/10
CPC分类号： C12M47/02 , B01D61/00 , B01D63/04 , B01D63/16 , B01D2313/10 , B01D2313/12 , B01D2315/02 , C12M1/10 , C12M3/06 , C12M23/14 , C12M23/50 , C12M29/04 , C12M29/16 , C12M41/48
摘要： [Problem] To provide a means capable of simply and efficiently concentrating a cell suspension.
[Solution] A concentrator 10 has a culture vessel 70 having a port 73 and a port 74, a server bag 40 having a port 96, a case having a hollow fiber bundle 109 in the internal space, a filtering device 120 having an inlet port 110, a first outlet port 111, and a second outlet port 112, a collection vessel 41 having a port 97, a liquid supply circuit connected to the port 73, the inlet port 110, and the port 96 so that flow passages are switchable, a liquid discharge circuit connected to the port 74, the first outlet port 111, the second outlet port 112, and the port 97 so that flow passages are switchable, a liquid supply mechanism 37 having a switching mechanism, a supply pump 91, and a discharge pump 92, and a rotation mechanism 34 rotating the filtering device 120.
摘要翻译： [问题]提供能够简单且有效地浓缩细胞悬液的手段。集中器10具有：具有端口73和端口74的培养容器70;具有端口96的服务器袋40;在内部空间中具有中空纤维束109的壳体;具有入口的过滤装置120 110，第一出口端口111和第二出口端口112;具有端口97，连接到端口73，入口端口110和端口96的液体供应回路的收集容器41，使得流动通道可切换，连接到端口74，第一出口端口111，第二出口端口112和端口97以使得流动通道可切换的液体排放回路，具有切换机构的液体供应机构37，供应泵91和排出泵92以及使过滤装置120旋转的旋转机构34。

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