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1. 发明公开

EP2998329A3 CROSSLINKED POLYVINYLAMINE, POLYALLYLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS 审中-公开
标题翻译： VERNETZTES POLYVINYLAMIN，POLYALLALAMIN UND POLYETHYLENIMIN ZUR VERWENDUNG ALSGALLENSÄUREKOMPLEXBILDNER
公开(公告)号：EP2998329A3
公开(公告)日：2016-04-06
申请号：EP15180706.2
申请日：2011-02-24
申请人： Relypsa, Inc.
发明人： Kopping, Jordon , Biyani, Kalpesh , Connor, Eric , Hecker, Scott , Lees, Inez , Quaker, Grace , Salameyeh, Faleh , Zhang, Hongmin , Bergbreiter, David , Mansky, Paul , Mu, YongQi , Cope, Michael James , Goka, Elizabeth , Lee, Angela , Madsen, Deidre , Shao, Jun
IPC分类号： C08F20/52 , C08F22/38 , C08L39/02 , C08F26/02 , C08F232/08
CPC分类号： A61K31/785 , A61K45/06 , C08F20/52 , C08F22/385 , C08F222/385 , C08F226/02 , C08F232/08
摘要： The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndromediarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译：本发明提供了一种有效地从胃肠道结合和去除胆汁盐的交联的胺和酰胺聚合物。这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征性腹泻（IBS-D），胆汁酸吸收不良等。

2. 发明公开

EP0960141A1 VERNETZTE VINYLPOLYMERE MIT GALLENSÄURE-ADSORBERWIRKUNG 失效
标题翻译：乙烯基聚合物与酸性染料GALLEN ADSORBERWIRKUNG NETWORKS
公开(公告)号：EP0960141A1
公开(公告)日：1999-12-01
申请号：EP98910693.0
申请日：1998-02-17
申请人： Aventis Research & Technologies GmbH & Co. KG
发明人： VON SEGGERN, Heinke , HOFFMANN, Axel , FALK, Eugen , HÖRSCH, Brigitte , LINKIES, Adolf, Heinz , GLOMBIK, Heiner
IPC分类号： C07D295 , A61K31 , A61K47 , A61P3 , A61P9 , A61P43 , C07C233 , C07D317 , C08F20 , C08F22 , C08F271
CPC分类号： C08F271/00 , A61K47/58 , C08F20/36 , C08F22/105 , C08F22/385
摘要： Compounds have the general formula (II), in which A stands for hydrogen or C1-9-alkyl; G and E independently represent O or NH; d and a independently represent an integer from 2 to 10; R?1 and R2¿ independently represent C¿1-9?-alkyl; T stands for C2-200-alkylene, optionally interrupted by phenylene, one of the groups (a), (b), (c), (d) or (e), 1 to 10 non-adjacent oxygen atoms or groups -N?+R3R4¿-, in which R?3 and R4¿ independently represent C¿1-9?-alkyl, and X?-¿ stands for an acid anion. Also disclosed are polymers produced from these compounds and their use as lipid lowering agents.

3. 发明公开

EP2998329A2 CROSSLINKED POLYVINYLAMINE, POLYALLYLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS 审中-公开
标题翻译：交联聚乙烯胺，聚烯丙胺和聚乙烯亚胺用作胆汁酸类化合物
公开(公告)号：EP2998329A2
公开(公告)日：2016-03-23
申请号：EP15180706.2
申请日：2011-02-24
申请人： Relypsa, Inc.
发明人： Kopping, Jordon , Biyani, Kalpesh , Connor, Eric , Hecker, Scott , Lees, Inez , Quaker, Grace , Salameyeh, Faleh , Zhang, Hongmin , Bergbreiter, David , Mansky, Paul , Mu, YongQi , Cope, Michael James , Goka, Elizabeth , Lee, Angela , Madsen, Deidre , Shao, Jun
IPC分类号： C08F20/52 , C08F22/38 , C08L39/02 , C08F26/02 , C08F232/08
CPC分类号： A61K31/785 , A61K45/06 , C08F20/52 , C08F22/385 , C08F222/385 , C08F226/02 , C08F232/08
摘要： The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndromediarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译：本发明提供了有效用于从胃肠道结合和除去胆汁盐的交联胺和酰胺聚合物。这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征中毒（IBS-D），胆汁酸吸收不良等。

4. 发明公开

EP2837650A1 METHOD FOR PRODUCING SUPER ABSORBENT POLYMER 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG VONSUPERSAUGFÄHIGENPOLYMEREN
公开(公告)号：EP2837650A1
公开(公告)日：2015-02-18
申请号：EP13855770.7
申请日：2013-10-14
申请人： LG Chem, Ltd.
发明人： LEE, Hye Min , LEEM, Gyu , WON, Tae Young
IPC分类号： C08J3/075 , C08F20/10 , C08J3/24 , B01J20/26
CPC分类号： C08F22/385 , B01J20/261 , B01J20/3085 , B01J2220/68 , C08F2/48 , C08F6/008 , C08F220/06 , C08F220/28 , C08J3/245 , C08J2333/02
摘要： The present invention relates to a preparation method of a super absorbent polymer. In the preparation method of the super absorbent polymer according to the present invention, (meth)acrylated polyalkylene glycol is used, thereby preparing a super absorbent polymer having more improved absorbency, water holding capacity and absorbency under pressure while improving dispersibility of a monomer composition containing acrylic acid-based monomers.
摘要翻译：本发明涉及一种高吸水性聚合物的制备方法。在本发明的高吸水性聚合物的制备方法中，使用（甲基）丙烯酸酯化的聚亚烷基二醇，由此制备具有吸收性，保水能力和压力吸收性更好的高吸水性聚合物，同时提高含有丙烯酸类单体。

5. 发明公开

EP2308431A1 Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use 有权
标题翻译：水凝胶，其在环境条件下，生产方法的变化膨胀和使用为水凝胶。
公开(公告)号：EP2308431A1
公开(公告)日：2011-04-13
申请号：EP10188630.7
申请日：2002-02-28
申请人： Microvention, Inc.
发明人： Cruise, Gregory M. , Constant, Michael J.
IPC分类号： A61F13/00 , A61F2/00 , A61K9/70 , A61K9/14 , A61K31/74
CPC分类号： C08F22/385 , A61K9/0024 , A61K49/0457 , A61L31/145
摘要： Hydrogels that expand volumetrically in response to a change in their environment (e.g., a change in pH or temperature) and their methods of manufacture and use. Generally, the hydrogels are prepared by forming a liquid reaction mixture that contains a) monomer(s) and/or polymer(s) at least portion(s) of which are sensitive to environmental changes (e.g., changes in pH or temperature), b) a crosslinker and c) a polymerization initiator. If desired, a porosigen may be incorporated into the liquid reaction mixture to create pores. After the hydrogel is formed, the porosigen is removed to create pores in the hydrogel. The hydrogel may also be treated to cause it to assume a non-expanded volume in which it remains until a change in its environment causes it to expand. These hydrogels may be prepared in many forms including pellets, filaments, and particles. Biomedical uses of these hydrogels include applications wherein the hydrogel is implanted in the body of a patient and an environmental condition at the implantation site causes the hydrogel to expand it situ.
摘要翻译：水凝胶也响应于环境的变化体积膨胀及其（E. G.，pH或温度的变化）和它们的制造和使用方法。通常，水凝胶通过形成液体反应混合物制备确实含有：a）单体（多种）和/或聚合物（S）的至少部分（一个或多个），其中对环境的变化敏感（例如，pH或温度的变化） b）交联剂和c）聚合引发剂。如果需要清除，成孔可以被并入液体反应混合物以产生孔隙。水凝胶形成后，孔剂去除以创建水凝胶毛孔。因此，水凝胶进行处理，以使其承担非膨胀体积在它保持，直到在其环境中的变化会发生膨胀。这些水凝胶可以以许多形式，包括小球，细丝，和粒子来制备。合成水凝胶生物医学用途包括worin的水凝胶在患者体内，并在植入部位的环境条件植入应用使得水凝胶将其展开原位。

6. 发明公开

EP3239192A4 NOVEL BROMINE-CONTAINING POLYMER AND PROCESS FOR PRODUCING SAME 有权
公开(公告)号：EP3239192A4
公开(公告)日：2018-07-18
申请号：EP15872371
申请日：2015-09-11
申请人： MANAC INC
发明人： YASHIKI KATSUYORI , SUDO ATSUSHI
IPC分类号： C08F20/54 , C08F22/38 , C09K21/14 , G02B1/04
CPC分类号： C08F22/385 , C08F12/08 , C08F20/14 , C08F20/22 , C08F20/54 , C08F26/10 , C08F122/385 , C08F226/08 , C09K21/14 , G02B1/04 , C08F222/385 , C08F2220/585 , C08F212/08 , C08F220/14 , C08F2220/185 , C08F220/54
摘要： The invention provides novel bromine-containing polymers which have excellent heat resistance and are capable of imparting flame retardance or novel flame-retardant, bromine-containing polymers which have excellent heat resistance and optical characteristics, and methods for producing such polymers. The invention relates to a polymer which includes structural units of the following general formula (1): wherein R 1 s, R 2 s, m, p and the asterisks are as defined in the specification and the claims, and to a method for producing such polymers.

7. 发明公开

EP3065719A4 POLYMER PARTICLES 审中-公开
标题翻译： POLYMERPARTIKEL
公开(公告)号：EP3065719A4
公开(公告)日：2017-08-09
申请号：EP14859554
申请日：2014-11-07
申请人： TERUMO CORP
发明人： PLOTKIN STEVE , CRUISE GREGORY M , KEELEY EDWARD MICHAEL , YU RENEE , HARRIS CLAYTON
IPC分类号： C08F290/06 , A61K9/00 , A61K9/50 , A61K31/704
CPC分类号： C08F22/385 , A61K9/0019 , A61K9/146 , A61K9/5026 , A61K31/704 , C08F290/062 , Y10T428/2982 , C08F220/10
摘要： Polymer particle embolics and methods of making same are described. The particle embolics can be used as embolization agents.
摘要翻译：描述了聚合物颗粒栓塞物及其制备方法。颗粒栓塞剂可以用作栓塞剂。

8. 发明授权

EP2539380B1 CROSSLINKED POLYVINYLAMINE, POLYALLYLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS 有权
标题翻译：网络化聚乙烯，聚乙烯亚胺POLYALLALAMIN以及用作胆汁酸螯合剂
公开(公告)号：EP2539380B1
公开(公告)日：2015-08-19
申请号：EP11707038.3
申请日：2011-02-24
申请人： Relypsa, Inc.
发明人： KOPPING, Jordon , BIYANI, Kalpesh , CONNOR, Eric , HECKER, Scott , LEES, Inez , QUAKER, Grace , SALAYMEH, Faleh , ZHANG, Hongmin , BERGBREITER, David , MANSKY, Paul , MU, YongQi , COPE, Michael James , GOKA, Elizabeth , LEE, Angela , MADSEN, Deidre , SHAO, Jun
IPC分类号： C08F20/52
CPC分类号： A61K31/785 , A61K45/06 , C08F20/52 , C08F22/385 , C08F222/385 , C08F226/02 , C08F232/08

9. 发明授权

EP2308431B1 Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use 有权
标题翻译：水凝胶，其在环境条件下，生产方法的变化膨胀和使用为水凝胶。
公开(公告)号：EP2308431B1
公开(公告)日：2012-07-04
申请号：EP10188630.7
申请日：2002-02-28
申请人： Microvention, Inc.
发明人： Cruise, Gregory M. , Constant, Michael J.
IPC分类号： A61F13/00 , A61F2/00 , A61K9/70 , A61K9/14 , A61K31/74
CPC分类号： C08F22/385 , A61K9/0024 , A61K49/0457 , A61L31/145

10. 发明公开

EP3239192A1 NOVEL BROMINE-CONTAINING POLYMER AND PROCESS FOR PRODUCING SAME 有权
标题翻译：新型含溴聚合物及其生产方法
公开(公告)号：EP3239192A1
公开(公告)日：2017-11-01
申请号：EP15872371.8
申请日：2015-09-11
申请人： Manac Inc.
发明人： YASHIKI, Katsuyori , SUDO, Atsushi
IPC分类号： C08F20/54 , C09K21/14 , G02B1/04
CPC分类号： C08F22/385 , C08F12/08 , C08F20/14 , C08F20/22 , C08F20/54 , C08F26/10 , C08F122/385 , C08F226/08 , C09K21/14 , G02B1/04 , C08F222/385 , C08F2220/585 , C08F212/08 , C08F220/14 , C08F2220/185 , C08F220/54
摘要： The invention provides novel bromine-containing polymers which have excellent heat resistance and are capable of imparting flame retardance or novel flame-retardant, bromine-containing polymers which have excellent heat resistance and optical characteristics, and methods for producing such polymers. The invention relates to a polymer which includes structural units of the following general formula (1):

wherein R 1 s, R 2 s, m, p and the asterisks are as defined in the specification and the claims, and
to a method for producing such polymers.
摘要翻译：本发明提供具有优异耐热性并能够赋予阻燃性的新型含溴聚合物或具有优异耐热性和光学特性的新型阻燃剂，含溴聚合物，以及用于生产这种聚合物的方法。本发明涉及包含下列通式（1）的结构单元的聚合物及其制备方法，其中R 1，R 2，m，p和星号如说明书和权利要求书中所定义。

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