专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP2180059B1 Method for producing alpha-L-aspartyl-L-phenylalanine-beta-ester and method for producing alpha-L-aspartyl-L-phenylalanine-alpha-methyl ester 有权
标题翻译：一种制备的α-L-天冬氨酰基-L-苯丙氨酸-β-酯和方法的用于α-L-天冬氨酰-L-苯丙氨酸-α-甲基酯的制备方法
公开(公告)号：EP2180059B1
公开(公告)日：2012-06-27
申请号：EP09011829.0
申请日：2004-01-23
申请人： Ajinomoto Co., Inc.
发明人： Yokozeki, Kenzo , Ohno, Ayako , Hara, Seiichi , Abe, Isao
IPC分类号： A23L1/236 , C07K5/06 , C12P21/02 , C12N15/57 , C12N9/48 , C07K5/075
CPC分类号： C07K5/0613 , A23L27/32 , C07K5/06113 , C12P21/02 , C12P21/06

2. 发明授权

EP2139910B1 PROCEDE DE SYNTHESE DE PEPTIDES SANS SOLVANT 有权
标题翻译：方法肽无溶剂合成
公开(公告)号：EP2139910B1
公开(公告)日：2011-05-25
申请号：EP08718144.2
申请日：2008-03-21
申请人： Centre National de la Recherche Scientifique (CNRS) , Université de Montpellier I
发明人： MARTINEZ, Jean , LAMATY, Frédéric , DECLERCK, Valérie
IPC分类号： C07K1/06 , C07K5/075 , C07K5/06 , C07K5/062 , C07K5/065
CPC分类号： C07K1/06 , C07K1/061 , C07K5/06052 , C07K5/06078 , C07K5/0613 , Y02P20/55
摘要： The invention relates to a method for the synthesis of a compound of the formula (I) in which: n is an integer higher than or equal to 1; Rb and each Rn are independently a hydrogen atom, a C1-C6 arylalkyl group or a C1-C6 alkyl group substituted or not by an aryl group, -COOH, C1-C6 -COO-(alkyl), -CONH2, - SH, heteroaryl, -NH2, -NHC(NH)(NH2), C1-C6 -S-(alkyl), -OH or phenol; Ra is a N-protective group; Rc is a ORd group in which Rd is a C1-C6 alkyl group or a NReRf group in which Re and Rf Re independently an N-protective group.

3. 发明授权

EP1509300B2 PRODUCTION OF CRYSTALLINE MATERIALS BY USING HIGH INTENSITY ULTRASOUND 有权
标题翻译：晶体材料具有高功率超声生产
公开(公告)号：EP1509300B2
公开(公告)日：2010-02-24
申请号：EP03722816.0
申请日：2003-05-08
申请人： Prosonix Limited
发明人： McCausland, Linda Jane
IPC分类号： B01D9/00
CPC分类号： C07K5/0613 , B01D9/0013 , B01D9/0036 , B01D9/0063
摘要： A crystalline material sufficiently pure for use in pharmaceuticals may be made by forming a saturated solution of the material, changing the temperature of the solution so it becomes supersaturated, and briefly subjecting the solution to irradiation by high intensity ultrasound, before allowing the solution to cool gradually without further irradiation. The ultrasound may be applied using a vessel with an array of ultrasonic transducers attached to a wall, so each transducer radiates no more than 3 W/cm yet the power dissipation within the vessel is between 25 and 150 W/litre. This method can reduce the metastable zone width to less than 10 K. There is no erosion of the wall and consequently no formation of small particles of metal. It is applicable for example to aspartame, and to amino acids.

4. 发明公开

EP1509301A1 PRODUCTION OF CRYSTALLINE MATERIALS BY USING HIGH INTENSITY ULTRASOUND 有权
标题翻译：晶体材料采用高性能超声生产
公开(公告)号：EP1509301A1
公开(公告)日：2005-03-02
申请号：EP03722846.7
申请日：2003-05-13
申请人： Accentus plc
发明人： McCAUSLAND, Linda, Jane20 Shepherd Gardens , PERKINS, John, PatrickThe Cottage
IPC分类号： B01D9/00
CPC分类号： B01D9/0013 , B01D9/0036 , B01D9/0063 , B01D9/0081 , C07K5/0613 , Y10T117/1024 , Y10T117/1028
摘要： A crystalline material sufficiently pure for use in pharmaceuticals may be made by forming a saturated solution of the material, changing the temperature of the solution so it becomes supersaturated, and subjecting the solution to irradiation by high intensity ultrasound, the frequency of the ultrasound being scanned over a range of frequencies. For example the ultrasound may be varied between 19.5 and 20.5 kHz, and this variation may be sinusoidal. Preferably the ultrasound is provided only briefly, say for less than 5 s, before allowing the solution to cool gradually without further irradiation. The ultrasound may be applied using a vessel with an array of ultrasonic transducers attached to a wall, so each transducer radiates no more than 3 W/cm 2 yet the power dissipation within the vessel is between 25 and 150 W/litre. This method can reduce the metastable zone width to less than 10 K. It is applicable in particular to aspartame.

5. 发明公开

EP1264896A1 Enzymatic coupling of L-phenylalanine methyl ester and N-benzyloxycarbonyl-l-aspartic acid in a continuous or fed-batch process 审中-公开
标题翻译：在连续或分批补料工艺L-Phenylalaninemethylester和N-苄氧羰基Asparagensäure的酶促偶联
公开(公告)号：EP1264896A1
公开(公告)日：2002-12-11
申请号：EP01202172.1
申请日：2001-06-07
申请人： Holland Sweetener Company V.o.F.
发明人： Tokuda, Akira , Nakamura, Shiichiro , Yamamoto, Norihiro , Quaedflieg, Peter Jan Leonard Mario
IPC分类号： C12P21/02 , C07K5/075
CPC分类号： C07K5/0613 , C12P21/02
摘要： The invention relates to a process for the preparation of N-benzyloxycarbonyl-α-L-aspartyl-L-phenylalanine methyl ester (Z-APM) by high-conversion enzymatic coupling of N-benzyloxycarbonyl-L-aspartic acid (Z-Asp) and L-phenylalanine methyl ester (L-PM) in a reaction mixture comprising an aqueous medium, a neutral protease as enzyme and an alkali metal salt, alkaline earth metal salt or ammonium salt, with formation of a precipitate. The enzymatic coupling of Z-Asp and L-PM is carried out in a continuous or fed-batch process at a pH of from 5.0 to 6.5 and an average charged molar ratio of Z-Asp and L-PM between 1:1 and 2:1 and wherein the actual molar ratio of Z-Asp and L-PM is higher than the average charge molar ratio. Preferably the alkali metal salt, alkaline earth metal salt or ammonium salt is present in an amount of from 3 to 25 %, calculated as % by weight based on the total reaction mixture.
摘要翻译：本发明涉及一种用于制备N-苄氧羰的α-L-天冬氨酰-L-苯丙氨酸甲基酯（Z-APM）通过的高转化率酶促偶联N-苄氧羰基-L-天门冬氨酸（Z-ASP）和L-苯丙氨酸甲酯（L-PM）中的反应混合物，其包括wässrige介质的，中性蛋白酶作为酶和碱金属盐，碱土金属盐或铵盐，与形成沉淀的。 Z-Asp和L-PM的酶促偶联以连续或补料分批过程在pH为5.0的情况下进行，以6.5和Z-Asp组成和平均加入摩尔比L-PM 1之间：和2 1 1和worin Z-Asp组成的实际摩尔比和L-PM比平均电荷的摩尔比越高。优选地，碱金属盐，碱土金属盐或铵盐存在于以3至25％的量，基于总反应混合物重量计算为％。

6. 发明授权

EP0768384B1 Improved enzymatic coupling reaction of N-protected-L-aspartic acid and phenylalanine methyl ester 失效
标题翻译： N-保护的L-天冬氨酸和苯丙氨酸的提高酶促偶联反应
公开(公告)号：EP0768384B1
公开(公告)日：2001-06-13
申请号：EP96202653.0
申请日：1996-09-23
申请人： Holland Sweetener Company V.o.F.
发明人： Harada, Tsuneo , Irino, Shigeaki , Kunisawa, Yukio , Oyama, Kiyotaka
IPC分类号： C12P21/02
CPC分类号： C07K5/0613 , C12P21/02

7. 发明授权

EP0718306B1 Crystallization of alpha-L-aspartyl-L-phenylalanine methyl ester from aqueous solution 失效
标题翻译：从水溶液中结晶α-L-天冬氨酰-L-苯丙氨酸甲酯
公开(公告)号：EP0718306B1
公开(公告)日：2001-05-30
申请号：EP95203533.5
申请日：1995-12-18
申请人： HOLLAND SWEETENER COMPANY V.O.F.
发明人： Rijkers, Marinus P.W.M. , Toussaint, Antoon G.T. , Vrinzen, Alexander P.M.
IPC分类号： C07K5/06
CPC分类号： C07K5/0613

8. 发明公开

EP1062878A1 MIXED CRYSTALS COMPRISING ASPARTAME AND ASPARTAME DERIVATIVE AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：混合晶体含有阿斯巴甜和阿斯巴甜衍生物和方法生产同样
公开(公告)号：EP1062878A1
公开(公告)日：2000-12-27
申请号：EP98967073.2
申请日：1998-12-07
申请人： Ajinomoto Co., Inc.
发明人： KISHISHITA, Akihirai, Ajinomoto Co., Inc. , NAGASHIMA, Kazutaka, Ajinomoto Co., Inc.
IPC分类号： A23L1/236
CPC分类号： C07K5/06113 , A23L27/32 , C07K5/0613
摘要： There is provided a novel mixed crystal comprising aspartame (APM) and N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine methyl ester, which can be used as a sweetener having considerably improved quality of sweetness , etc.
The above mixed crystal can be easily produced industrially by subjecting a solution containing the above-mentioned APM and APM derivative to a crystallizing operation followed by the separation of the mixed crystal thus precipitated.
摘要翻译：提供了一种新颖的混合晶体，其包括阿斯巴甜（APM）和N- N-（3,3-二甲基丁基）-L-α-天冬氨酰基-L-苯丙氨酸甲酯，其可被用作具有相当大的改善甜味品质甜味剂等。上述混合晶体可以通过使含上述-APM APM衍生物的溶液，并结晶化操作其次是混晶如此沉淀的分离工业上容易制得。

9. 发明公开

EP1048223A1 SWEETENER COMPOSITIONS CONTAINING ASPARTAME AND ASPARTAME DERIVATIVE 审中-公开
标题翻译：含有ASPARAME和ASPARAME衍生物的甜味剂组合物
公开(公告)号：EP1048223A1
公开(公告)日：2000-11-02
申请号：EP98967081.5
申请日：1998-12-08
申请人： Ajinomoto Co., Inc.
发明人： KISHISHITA, Akihiro , NAGASHIMA, Kazutaka
IPC分类号： A23L1/236
CPC分类号： C07K5/06113 , A23L27/32 , C07K5/0613
摘要： Excellent sweetener compositions containing aspartame (APM) and APM derivative and being similar to sucrose in tasting properties, which can be easily, uniformly and efficiently produced at a high purity by the process for producing N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine methyl ester by the reductive alkylation of APM and 3,3-dimethylbutyraldehyde which comprises using 3,3-dimethylbutyraldehyde in an amount at most equimolar to APM for producing N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine methyl ester from a portion of the APM existing in the reaction system, then separating the reducing agent from the liquid reaction mixture, and effecting crystallization followed by the separation of the crystals thus precipitated.
摘要翻译：优良的甜味剂组合物含有阿斯巴甜（APM）和APM衍生物并且在品尝性质上类似于蔗糖，通过生产N- [N-（3,3-二甲基丁基）氨基甲酸酯）的方法可以容易地， -L-α-天冬氨酰基] -L-苯丙氨酸甲酯通过APM和3,3-二甲基丁醛的还原烷基化反应制备，该方法包括使用最多与APM等摩尔量的3,3-二甲基丁醛生产N- [N-（3 ，3-二甲基丁基）-L-α-天冬氨酰基] -L-苯丙氨酸甲酯从反应体系中存在的部分APM中分离出来，然后从液体反应混合物中分离出还原剂，并进行结晶，随后分离晶体因此沉淀。

10. 发明授权

EP0664338B1 Enzymatic coupling of L-phenylalanine methyl ester and N-benzyloxycarbonyl-aspartic acid 失效转让
标题翻译： L-苯丙氨酸甲酯和N-苄氧基羰基 - 天冬氨酸的酶促偶联
公开(公告)号：EP0664338B1
公开(公告)日：2000-03-22
申请号：EP95200100.6
申请日：1995-01-16
申请人： HOLLAND SWEETENER COMPANY V.O.F.
发明人： Irino, Shigeaki , Nakamura, Shin-ichiro , Oyama, Kiyotaka , Quaedflieg, Peter Jan Leonard , van Dooren, Theodorus Johannes Godfried
IPC分类号： C12P21/02
CPC分类号： C07K5/0613

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式