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2. 发明公开

EP0718306A1 Crystallization of alpha-L-aspartyl-L-phenylalanine methyl ester from aqueous solution 失效
标题翻译：结晶缬氨酸α-L-天冬氨酰基-L-苯丙氨酰甲基酯auswässrigenLösungen
公开(公告)号：EP0718306A1
公开(公告)日：1996-06-26
申请号：EP95203533.5
申请日：1995-12-18
申请人： HOLLAND SWEETENER COMPANY V.O.F.
发明人： Rijkers, Marinus P.W.M. , Toussaint, Antoon G.T. , Vrinzen, Alexander P.M.
IPC分类号： C07K5/06
CPC分类号： C07K5/0613
摘要： The invention relates to a method for cooling an aqueous aspartame solution and crystallization of aspartame therefrom with avoiding of turbulence in the aqueous crystallizing system, by (i) feeding a hot aqueous aspartame solution to means for dispersing droplets; and (ii) dispersing these into a water-immiscible liquid of at least 20°C lower temperature so that no nucleation will occur in the droplets while these are passing the water-immiscible liquid; and (iii) cooling said water-immiscible liquid so that said droplets are effectively cooled to reach an initial relative supersaturation of α-L-aspartyl-L-phenylalanine methyl ester within the droplet in the range of 1 to 6, preferably 1.2 to 4; and (iv) collecting the cooled droplets to crystallize aspartame; (v) and providing sufficient time therefore.
摘要翻译：本发明涉及一种通过（i）将热的阿斯巴甜水溶液加入到分散液滴的方法中，从而避免水结晶体系中的湍流，从而冷却阿斯巴甜水溶液和阿斯巴甜的结晶方法。和（ii）将它们分散在至少20℃以下的与水不混溶的液体中，使得当它们通过与水不混溶的液体时，液滴中不会发生成核; 和（iii）冷却所述与水不混溶的液体，使得所述液滴被有效地冷却以达到液滴中α-L-天冬氨酰-L-苯丙氨酸甲酯的初始相对过饱和度在1至6范围内，优选1.2至4 ; 和（iv）收集冷却的液滴以使阿斯巴甜结晶; （v）并因此提供足够的时间。

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