专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP2769988A4 ANTI-GAP43 ANTIBODY 有权
标题翻译： ANTI-GAP43抗体
公开(公告)号：EP2769988A4
公开(公告)日：2015-08-05
申请号：EP12842284
申请日：2012-10-19
申请人： UNIV NIIGATA
发明人： TAKEUCHI KOSEI , IGARASHI MICHIHIRO , NOZUMI MOTOHIRO , KAWASAKI ASAMI
IPC分类号： C07K16/18 , C12N5/10 , C12N15/09 , C12P21/08 , G01N33/53 , G01N33/543 , G01N33/577
CPC分类号： G01N33/566 , C07K16/18 , C07K16/44 , C07K2317/33 , C07K2317/82 , G01N33/6854 , G01N2440/14

2. 发明授权

EP1713501B1 TREATMENT OF NEURODEGENERATIVE DISEASES BY THE USE OF GPR49 有权
标题翻译：治疗GPR49的神经退行性疾病
公开(公告)号：EP1713501B1
公开(公告)日：2008-01-16
申请号：EP04803345.0
申请日：2004-11-29
申请人： CELLZOME AG
发明人： HOPF, Carsten , DREWES, Gerard , RUFFNER, Heinz
IPC分类号： A61K39/00
CPC分类号： C07K16/28 , A61K31/7088 , C07K2317/82
摘要： The invention relates to the use of a GPR49-interacting molecule for the preparation of a pharmaceutical composition for the treatment of a neurogenerative disease. Hereby s the GPR49-interacting molecule is preferably an inhibitor of GPR49 and particularly it has the capacity to modulate the activity of gamma-secretase and/or beta-secretase. Furthermore the invention concerns a process for identifying a gamma-secretase and/or a beta-secretase modulator, comprising the following steps: a. identifying of a GPR49-interacting molecule by determining whether a given test compound is a GPR49-interacting molecule, b. determining whether the GPR49-interacting molecule of step a) is capable of modulating gamma-secretase and/or beta-secretase activity.

3. 发明公开

EP1599572A4 COMPOSITIONS AND METHODS FOR CANCER IMMUNOTHERAPY 审中-公开
标题翻译：组合物和用于癌症免疫疗法方法
公开(公告)号：EP1599572A4
公开(公告)日：2007-06-13
申请号：EP04711085
申请日：2004-02-13
申请人： UNIV SOUTHERN CALIFORNIA
发明人： EPSTEIN ALAN L , LI JIALI , HU PEISHENG
IPC分类号： A61K38/19 , A61K39/395 , A61K47/42 , A61K47/48 , A61K51/10 , A61P35/00 , C07K14/52 , C07K14/525 , C07K14/535 , C07K14/55 , C07K14/57 , C07K16/00 , C07K16/28 , C07K16/30 , C07K16/46 , C12N20060101 , C12N1/00 , C07K19/00
CPC分类号： A61K47/48569 , A61K38/195 , A61K47/6813 , A61K47/6849 , A61K47/6851 , A61K51/1033 , A61K51/1045 , A61K2039/505 , A61K2039/507 , C07K14/521 , C07K14/525 , C07K14/535 , C07K14/55 , C07K14/57 , C07K16/2866 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/82 , C07K2319/00

4. 发明公开

EP1501869A4 PHOSPHORYLATED HISTONE H2B AS AN APOPTOSIS MARKER 审中-公开
标题翻译：磷酸化组蛋白H2B凋亡MARKER
公开(公告)号：EP1501869A4
公开(公告)日：2006-01-11
申请号：EP02756877
申请日：2002-08-01
申请人： UNIV VIRGINIA
发明人： ALLIS C DAVID , CHEUNG WANG L , AJIRO KOZO
IPC分类号： C07K14/00 , C07K16/00 , C07K16/18 , G01N33/53
CPC分类号： C07K16/44 , C07K16/18 , C07K2317/82 , C12Q1/485 , G01N2440/14 , G01N2500/04 , G01N2510/00

5. 发明公开

EP1577671A1 Diagnostic drugs for autoimmune diseases 失效
标题翻译：药物用于治疗自身免疫性疾病的诊断
公开(公告)号：EP1577671A1
公开(公告)日：2005-09-21
申请号：EP05076056.0
申请日：1997-05-15
申请人： KANEKA CORPORATION
发明人： Ozaki, Shoichi , Sobajima, Junko , Uesugi, Hiroko, Urushino-yakata-kohei 2-C 1 , Okazaki, Takahiro, Berube-takaragaike 105, 211-2 , Tanaka, Masao , Nakao, Kazuwa , Yoshida, Michiteru , Shirakawa, Hitoshi , Osakada, Fumio
IPC分类号： G01N33/564 , C07K14/47
CPC分类号： C07K14/4702 , C07K16/00 , C07K16/18 , C07K2317/82 , G01N33/564 , G01N2800/24 , Y10S435/975
摘要： A diagnostic drug and a diagnostic kit for autoimmune diseases including at least one of a polypeptide selected from an HMG-1 family, a polypeptide selected from an HMG-2 family, a fragment thereof which is reactable with an antibody of an autoimmune disease patient, and a method for detecting an antibody of an autoimmune disease patient using the same are provided.

6. 发明公开

EP1204674A4 METHODS AND COMPOSITIONS FOR INHIBITING POLYPEPTIDE ACCUMULATION ASSOCIATED WITH NEUROLOGICAL DISORDERS 审中-公开
标题翻译：方法和化合物预防多肽集合在神经系统疾病CONNECTION
公开(公告)号：EP1204674A4
公开(公告)日：2005-06-01
申请号：EP00948919
申请日：2000-07-24
申请人： ABGENIX INC , NEW YORK STATE DEPT OF HEALTH
发明人： HUSTON JAMES S , MESSER ANNE , LECERF JEAN-MICHEL
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K39/00 , A61K39/395 , A61K48/00 , A61P3/10 , A61P21/04 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , C07K14/47 , C07K16/18 , C12N5/06 , C07K5/00 , C07K14/00 , C07K16/00
CPC分类号： C07K14/47 , A61K2039/53 , C07K16/18 , C07K2317/622 , C07K2317/82

7. 发明公开

EP1071458A1 HUMANIZED ANTIBODY AND USES THEREOF 审中-公开
标题翻译：人源化抗体及其用途
公开(公告)号：EP1071458A1
公开(公告)日：2001-01-31
申请号：EP99911300.4
申请日：1999-03-11
申请人： DANA-FARBER CANCER INSTITUTE, INC. , Immunotherapeutics Inc. , CHIRON CORPORATION
发明人： MARASCO, Wayne , LAVECCHIO, Joyce , MHASHILKAR, Abner, M. , RAMSTEDT, Urban , RING, David , EBERHARDT, Bridge , PORTER-BROOKS, Julie
IPC分类号： A61K39/395 , A61K39/42 , C07K16/00 , C12P21/04 , C12P21/06 , C12Q1/70
CPC分类号： C07K16/1072 , A61K48/00 , C07K2317/24 , C07K2317/622 , C07K2317/81 , C07K2317/82 , C07K2319/00
摘要： A humanized antibody framework motif is described. Preferably, the motif is encoded by the VH gene of K5B8 and the VL gene of TR1.6. This humanized antibody preferably contains the variable region of a tat antibody.

8. 发明公开

EP3173428A4 METHOD FOR POSITIONING, IN CYTOPLASM, ANTIBODY HAVING COMPLETE IMMUNOGLOBULIN FORM BY PENETRATING ANTIBODY THROUGH CELL MEMBRANE, AND USE FOR SAME 有权
公开(公告)号：EP3173428A4
公开(公告)日：2018-01-24
申请号：EP15825418
申请日：2015-07-22
申请人： ORUM THERAPEUTICS INC
发明人： KIM YONG SUNG , CHOI DONG KI , SHIN SEUNG MIN , KIM SUNG HOON
IPC分类号： C07K16/46 , A61K39/395 , A61K47/50 , A61P35/00 , C07K16/32
CPC分类号： C07K16/32 , A61K2039/505 , C07K16/00 , C07K16/2863 , C07K16/30 , C07K16/40 , C07K16/46 , C07K2317/24 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/73 , C07K2317/77 , C07K2317/82 , C07K2317/92 , G01N33/574
摘要： The present invention relates to a method of localizing an intact immunoglobulin-format antibody in cytosol by permeating membrane of cells. The present invention also relates to a light-chain variable region (VL) that induces an intact immunoglobulin-format antibody to penetrate the membrane of living cells and be localized in the cytosol, and to an antibody comprising the same. The present invention also relates to a biologically active molecule fused to the antibody and selected from the group consisting of peptides, proteins, small-molecule drugs, nanoparticles and liposomes. The present invention also relates to a composition for prevention, treatment or diagnosis of cancer, comprising: the antibody; or a biological active molecule fused to the antibody and selected from the group consisting of peptides, proteins, small-molecule drugs, nanoparticles and liposomes. The present invention also relates to a polynucleotide that encodes the light-chain variable region and the antibody. The present invention also relates to a method for producing an antibody which penetrates cells and is localized in the cytosol. According to the method of the present invention, which allows an intact immunoglobulin-format antibody to actively penetrate living cells and be localized in the cytosol, the antibody can penetrate living cells and be localized in the cytosol, without having to use a special external protein delivery system. Moreover, the use of the cytosol-penetrating light-chain variable region according to the present invention and the intact immunoglobulin-format antibody comprising the same can penetrate cells and remain in the cytosol, without affecting the high specificity and affinity of a human antibody heavy-chain variable region (VH) for antigens, and thus can be localized in the cytosol which is currently classified as a target in disease treatment based on small-molecule drugs, and at the same time, can exhibit high effects on the treatment and diagnosis of tumor and disease-related factors that show structurally complex interactions through a wide and flat surface between protein and protein. In addition, these can selectively inhibit KRas mutants, which are major drug resistance-associated factors in the use of various conventional tumor therapeutic agents, and at the same time, can be used in combination with conventional therapeutic agents to thereby exhibit effective anticancer activity.

9. 发明公开

EP2769988A1 ANTI-GAP43 ANTIBODY 有权
标题翻译：抗GAP43抗体
公开(公告)号：EP2769988A1
公开(公告)日：2014-08-27
申请号：EP12842284.7
申请日：2012-10-19
申请人： Niigata University
发明人： TAKEUCHI, Kosei , IGARASHI, Michihiro , NOZUMI, Motohiro , KAWASAKI, Asami
IPC分类号： C07K16/18 , C12N5/10 , G01N33/53 , G01N33/543 , G01N33/577 , C12N15/09 , C12P21/08
CPC分类号： G01N33/566 , C07K16/18 , C07K16/44 , C07K2317/33 , C07K2317/82 , G01N33/6854 , G01N2440/14
摘要： An anti-GAP43 antibody which is capable of distinguishing a non-phosphorylated threonine residue at position 89 (T89) from a phosphorylated threonine residue at position 89 (pT89) of mouse GAP43 set forth in SEQ ID NO: 13, and which is capable of specifically detecting a growth cone; an anti-GAP43 antibody which is capable of distinguishing a non-phosphorylated serine residue at position 96 (S96) from a phosphorylated serine residue at position 96 (pS96) of mouse GAP43, and which is capable of specifically detecting a growth cone; an anti-GAP43 antibody which is capable of distinguishing a non-phosphorylated threonine residue at position 172 (T172) from a phosphorylated threonine residue at position 172 (pT172) of mouse GAP43, and which is capable of specifically detecting a growth cone; and an immunological analysis method using these anti-GAP43 antibodies.
摘要翻译：能够区分89位（T89）的非磷酸化苏氨酸残基和SEQ ID NO：13所示的小鼠GAP43的89位（pT89）的磷酸化苏氨酸残基的抗GAP43抗体，其能够具体检测生长锥; 抗GAP43抗体，其能够区分96位上的非磷酸化丝氨酸残基（S96）与小鼠GAP43的96位磷酸化丝氨酸残基（pS96），并且能够特异性检测生长锥; 能够区分位置172（T172）处的非磷酸化苏氨酸残基与小鼠GAP43的位置172（pT172）处的磷酸化苏氨酸残基并且能够特异性检测生长锥的抗GAP43抗体; 以及使用这些抗GAP43抗体的免疫学分析方法。

10. 发明公开

EP2766485A1 A NUCLEIC ACID ASSEMBLY, VECTOR, CELL, METHODS AND KIT THEREOF 有权
标题翻译： NUKLEINSÄUREANORDNUNGSOWIE VEKTOR，ZELLE，VERFAHREN UND KITDAFÜR
公开(公告)号：EP2766485A1
公开(公告)日：2014-08-20
申请号：EP12840407.6
申请日：2012-10-11
申请人： National Centre for Biological Sciences
发明人： KRISHNAN, Yamuna , MODI, Souvik
IPC分类号： C12N15/62 , C12Q1/68
CPC分类号： C12N15/85 , C07K16/44 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/82 , C07K2317/92 , C07K2319/00 , C12N15/113 , C12N2810/85 , C12N2810/859
摘要： The present disclosure relates to a nucleic acid assembly (NAA), comprising sensor domain and handle domain; an assembly interfaceable motif (AIM) sequence optionally along with intracellular targeting motif (ITM) sequence; and an AIM- NAA complex. It also relates to a vector comprising assembly interfaceable motif sequence optionally along with intracellular targeting motif sequence and a cell comprising the vector. Further, the instant disclosure also provides a method to obtain the nucleic acid assembly, method of intracellular targeting and kit thereof.
摘要翻译：本公开涉及包含传感器结构域和手柄结构域的核酸组装体（NAA）; 任选地与细胞内靶向基序（ITM）序列的组装接口基序（AIM）序列; 和AIM-NAA复合体。它还涉及包含任选地与细胞内靶向基序序列的组装可接合基序序列的载体和包含载体的细胞。此外，本公开还提供了获得核酸组装，细胞内靶向方法及其试剂盒的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式