专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP1709170B1 EXPRESSION OF MAMMALIAN PROTEINS IN PSEUDOMONAS FLUORESCENS 有权转让
标题翻译：哺乳动物荧光蛋白中哺乳动物蛋白的表达
公开(公告)号：EP1709170B1
公开(公告)日：2018-02-21
申请号：EP05705852.1
申请日：2005-01-18
申请人： Pfenex Inc.
发明人： RETALLACK, Diane, M. , SQUIRES, Charles, H. , WATKINS, David, C. , GAERTNER, Frank, H. , LEE, Stacey, Lynn , SHUTTER, Robert
IPC分类号： C12N15/10 , C12N15/63 , C12N15/64 , C12N15/67 , C12N15/74 , C12N1/21
CPC分类号： C07K14/61 , C07K14/57 , C12N15/78
摘要： The invention is a process for improved production of a recombinant mammalian protein by expression in a Pseudomonad, particularly in a Pseudomonas fluorescens organism. The process improves production of mammalian proteins, particularly human or human-derived proteins, over known expression systems such as E.coli in comparable circumstances. Processes for improved production of isolated mammalian, particularly human, proteins are provided.

2. 发明公开

EP3088531A4 METHOD FOR DETERMINING SITE HAVING N-LINKED SUGAR CHAIN ADDED THERETO OR PROPORTION OF SAID ADDITION 有权
标题翻译： VERFAHREN ZUR BESTIMMUNG EINER STELLE麻省理工N-VERBUNDENER ZUCKERKETTE，DIE DAZU HINZUGEGEBEN WURDE，ODER DER比例DER BESAGTEN ZUGABE
公开(公告)号：EP3088531A4
公开(公告)日：2017-06-14
申请号：EP14874116
申请日：2014-12-17
申请人： TOSOH CORP
发明人： NAKATA DAISUKE
IPC分类号： C12Q1/34 , C12N9/16 , C12Q1/37 , G01N27/62
CPC分类号： C12Q1/34 , C07K14/57 , C12N9/80 , C12Y305/01052 , G01N33/6866 , G01N2333/57 , G01N2333/98 , G01N2440/38
摘要： A method for detecting a site which can be modified with an N-linked glycan chain and to which an N-linked glycan chain is actually linked in a glycoprotein; and a method for determining the state of an N-linked glycan chain addition at the site are provided. A glycoprotein having an N-linked glycan chain linked thereto is subjected to an N-linked glycan chain removal treatment with a peptide N-glycanase, subsequently a site capable of being modified with an N-linked glycan chain, in which an Asn residue has been changed to an Asp residue by the action of the peptide N-glycanase, is treated with an endo-type peptidase capable of recognizing an Asp residue to thereby produce peptide fragments, and subsequently the mass of the fragments is detected. In this manner, a site which can be modified with an N-linked glycan chain and to which an N-linked glycan chain is actually linked can be detected. Furthermore, the proportion or state of of the N-linked glycan chain addition at the site can be determined from the intensity of a signal generated upon the detection.
摘要翻译：用于检测可以用N-连接的聚糖链修饰并且N-连接的聚糖链实际上连接在糖蛋白上的位点的方法; 并提供了用于确定在该位点处N-连接的聚糖链添加状态的方法。将具有与其连接的N-连接的聚糖链的糖蛋白用肽N-聚糖酶进行N-连接的聚糖链去除处理，随后用能够用N-连接的聚糖链修饰的位点进行N-连接的聚糖链去除处理，其中Asn残基具有通过肽N-聚糖酶的作用改变为Asp残基，用能够识别Asp残基的内切型肽酶处理，从而产生肽片段，随后检测片段的质量。以这种方式，可以检测可以用N-连接的聚糖链修饰并且N-连接的聚糖链实际连接到的位点。此外，可以从检测时产生的信号的强度确定在该位点的N-连接的聚糖链添加的比例或状态。

3. 发明授权

EP2694088B1 MACROPHAGE ACTIVATING FACTOR FOR PHARMACEUTICAL COMPOSITIONS 有权
标题翻译：用于药物组合物的巨噬细胞活化因子
公开(公告)号：EP2694088B1
公开(公告)日：2017-06-07
申请号：EP12768091.6
申请日：2012-04-05
申请人： Efranat Ltd.
发明人： YAMAMOTO, Nobuto
IPC分类号： A61K38/14 , A61P31/18 , A61P35/00
CPC分类号： A61K38/19 , A61K38/00 , A61K38/14 , C07K14/52 , C07K14/57 , C12N11/08 , C12P21/005
摘要： Pharmaceutical compositions including macrophage activating factor (MAF) and method of producing same, particularly to MAF compositions essentially devoid of glycosidase enzymes. The compositions of the present invention and pharmaceutical compositions including same are particularly suitable for intravenous administration.
摘要翻译：包括巨噬细胞活化因子（MAF）的药物组合物及其制备方法，特别是涉及基本上不含糖苷酶的MAF组合物。本发明的组合物和包含它们的药物组合物特别适用于静脉内给药。

4. 发明公开

EP2650312A4 HYALURONIC ACID-PROTEIN CONJUGATE AND METHOD FOR PREPARING SAME 审中-公开
标题翻译：透明质酸酸性蛋白质共轭物及其生产方法
公开(公告)号：EP2650312A4
公开(公告)日：2016-08-31
申请号：EP11846761
申请日：2011-12-05
申请人： POSTECH ACAD IND FOUND
发明人： HAHN SEI KWANG , YANG JEONG A , YOON SEUNG KYU , HUR WON HEE , PARK KI TAE , KIM HYE MIN , JUNG HYUN TAE
IPC分类号： C07K17/10 , A61K47/36 , A61K47/48
CPC分类号： C07K14/56 , A61K31/726 , A61K31/728 , A61K38/191 , A61K38/21 , A61K38/212 , A61K38/215 , A61K38/217 , A61K47/36 , A61K47/61 , C07K14/525 , C07K14/565 , C07K14/57 , C07K17/10

5. 发明授权

EP2305312B1 Remodelling and glycoconjugation of follicle-stimulating hormone (FSH) 有权
标题翻译：卵泡刺激素（FSH）的重构和糖缀合
公开(公告)号：EP2305312B1
公开(公告)日：2015-03-04
申请号：EP10012794.3
申请日：2002-10-09
申请人： ratiopharm GmbH
发明人： De Frees, Shawn , Zopf, David , Bayer, Robert , Bowe, Caryn , Hakes, David , Chen, Xi
IPC分类号： A61K47/48 , C07K1/00 , C07K1/13 , A61K38/14 , A61K38/16 , A61K38/24 , A61K38/26 , A61K38/28 , A61K38/29 , A61K38/30 , A61K38/43 , C07K9/00 , C07K14/475 , C07K14/59 , C07K14/61 , C07K14/525 , C07K14/56 , C07K14/565 , C12N9/64 , C12N9/22 , C07K19/00 , C07K14/79 , C07H19/10
CPC分类号： C12N9/2445 , A61K47/549 , A61K47/60 , A61K47/68 , A61K47/6845 , A61K47/6855 , A61K47/6863 , A61K47/6867 , C07K1/006 , C07K1/1077 , C07K1/13 , C07K9/00 , C07K14/505 , C07K14/535 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/59 , C07K14/61 , C07K14/62 , C07K14/7151 , C07K14/755 , C07K14/8125 , C12N9/22 , C12N9/6437 , C12N9/644 , C12N9/6459 , C12N9/6462 , C12Y302/01021 , C12Y304/21021 , C12Y304/21022 , C12Y304/21069 , C12Y304/21073 , Y02A50/472
摘要： The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group a peptide.

6. 发明授权

EP2342320B1 CHINESE HAMSTER OVARY CELL LINES 有权
标题翻译：中国仓鼠卵巢细胞系
公开(公告)号：EP2342320B1
公开(公告)日：2014-11-26
申请号：EP09814854.7
申请日：2009-09-18
申请人： Agency For Science, Technology And Research (A*star)
发明人： SONG, Zhiwei
IPC分类号： C12N5/10 , C12N5/071 , C12N15/85 , C07K14/505 , C12N15/52
CPC分类号： C12N9/1051 , C07K14/505 , C07K14/57 , C12N2510/02 , C12P21/005 , C12Y204/0115

7. 发明授权

EP1499730B1 IMMUNOCONJUGATES FOR THE TREATMENT OF TUMOURS 失效
标题翻译：免疫偶联物用于肿瘤的治疗
公开(公告)号：EP1499730B1
公开(公告)日：2013-10-02
申请号：EP03725526.2
申请日：2003-04-30
申请人： Molmed SpA
发明人： CORTI, Angelo , CURNIS, Flavio
IPC分类号： C07K14/525 , C07K14/57 , A61K47/48
CPC分类号： A61K49/0008 , A61K38/191 , A61K47/64 , A61K47/642 , A61K47/6813 , A61K47/6851 , A61K47/6887 , A61K51/0495 , C07K14/525 , C07K14/57 , C07K2319/01

8. 发明公开

EP2434016A3 Expression of mammalian proteins in Pseudomonas fluorescens 有权转让
标题翻译：哺乳动物蛋白在荧光假单胞菌中的表达
公开(公告)号：EP2434016A3
公开(公告)日：2012-08-15
申请号：EP11176612.7
申请日：2005-01-18
申请人： Pfenex, Inc.
发明人： Retallack, Diane, M. , Squires, Charles, H. , Watkins, David, C. , Gaertner, Frank, H. , Lee, Stacey, Lynn , Shutter, Robert
IPC分类号： C12N15/10 , C12N15/63 , C12N15/64 , C12N15/67 , C12N15/74 , C12N1/21 , C07H21/04 , C07K14/57 , C07K14/61 , C12N15/09 , C12N15/78
CPC分类号： C07K14/61 , C07K14/57 , C12N15/78
摘要： The invention is a process for improved production of a recombinant mammalian protein by expression in a Pseudomonad, particularly in a Pseudomonas fluorescens organism. The process improves production of mammalian proteins, particularly human or human-derived proteins, over known expression systems such as E.coli in comparable circumstances. Processes for improved production of isolated mammalian, particularly human, proteins are provided.
摘要翻译：本发明是一种通过在假单胞菌特别是荧光假单胞菌生物体中表达改进重组哺乳动物蛋白质生产的方法。该过程改善哺乳动物蛋白质，特别是人类或人类来源的蛋白质的产量，在可比情况下比已知的表达系统如大肠杆菌。提供了改善分离的哺乳动物特别是人蛋白质生产的方法。

9. 发明授权

EP1492814B1 Peptide dérivé de l'interleukine-1-beta et son application thérapeutique 有权
标题翻译：从白介素-1-β衍生的肽以及它们的治疗用途
公开(公告)号：EP1492814B1
公开(公告)日：2011-10-05
申请号：EP03740584.2
申请日：2003-04-09
申请人： Vaxconsulting
发明人： ZAGURY, Jean-Francois
IPC分类号： A61K38/19 , C07K14/545 , A61P37/02
CPC分类号： C07K14/57 , A61K38/00 , A61K39/00 , A61K2039/57 , C07K14/485 , C07K14/495 , C07K14/523 , C07K14/525 , C07K14/54 , C07K14/5406 , C07K14/5409 , C07K14/5412 , C07K14/5428 , C07K14/5434 , C07K14/5437 , C07K14/5443 , C07K14/545 , C07K14/56 , C07K2299/00
摘要： The invention relates to a peptide which comprises between 5 and 40 amino acids, is obtained from a cytokine, and in which at least one of the amino acids contains at least one atom that is spaced (d) less than 5 angstroms from an atom of the receptor corresponding to said cytokine, the spacing (d) being evaluated on structural data, derivatives thereof, and an immunogenic compound comprising said peptide or peptide derivatives, the use of a peptide or peptide derivative or immunogenic compound for preparing a therapeutic or prophylactic medicament used for treating or preventing diseases that are associated with an excess or the presence of cytokines or for treating an autoimmune disease, and pharmaceutical compositions containing at least one inventive peptide or peptide derivative or immunogenic compound as an active principle.

10. 发明公开

EP2292271A3 Remodelling and glycoconjugation of an antibody 审中-公开
标题翻译： Neumodulierung和抗体的Glykokonjugation
公开(公告)号：EP2292271A3
公开(公告)日：2011-09-14
申请号：EP10012795.0
申请日：2002-10-09
申请人： BioGeneriX AG
发明人： De Frees, Shawn , Zopf, David , Bayer, Robert , Bowe, Caryn , Hakes, David , Chen, Xi
IPC分类号： A61K47/48 , C07K1/00 , C07K1/13 , A61K38/14 , A61K38/16 , A61K38/24 , A61K38/26 , A61K38/28 , A61K38/29 , A61K38/30 , A61K38/43 , C07K9/00 , C07K14/475 , C07K14/59 , C07K14/61 , C07K14/525 , C07K14/56 , C07K14/565 , C12N9/64 , C12N9/22 , C07K19/00 , C07K14/79 , C07H19/10
CPC分类号： C12N9/6437 , A61K38/00 , A61K47/549 , A61K47/60 , A61K47/68 , A61K47/6845 , A61K47/6855 , A61K47/6863 , A61K47/6867 , C07K1/006 , C07K1/1077 , C07K1/13 , C07K9/00 , C07K14/505 , C07K14/535 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/57 , C07K14/59 , C07K14/61 , C07K14/62 , C07K14/7151 , C07K14/755 , C07K14/8125 , C12N9/22 , C12N9/2445 , C12N9/644 , C12N9/6459 , C12N9/6462 , C12Y302/01021 , C12Y304/21021 , C12Y304/21022 , C12Y304/21069 , C12Y304/21073 , Y02A50/472
摘要： The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group a peptide.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式