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1. 发明授权

EP2643346B1 MODULATION OF ANTIGEN IMMUNOGENICITY BY ADDITION OF EPITOPES RECOGNIZED BY NKT CELLS 有权转让
公开(公告)号：EP2643346B1
公开(公告)日：2018-08-29
申请号：EP11787875.1
申请日：2011-11-24
申请人： IMNATE SARL
发明人： SAINT-REMY, Jean-Marie
IPC分类号： C07K14/435
CPC分类号： C07K2/00 , A61K39/0011 , A61K39/04 , A61K39/12 , A61K39/145 , A61K39/35 , A61K39/39 , A61K2039/55505 , A61K2039/57 , C07K14/43531 , C12N2760/16034 , Y02A50/403 , Y02A50/41 , Y02A50/412
摘要： The invention describes a method and compounds for the prevention and treatment of infections with intracellular organisms, the treatment of tumors, and the prevention of infectious and allergic diseases by vaccination.

2. 发明授权

EP1908777B1 Mite fusion proteins 有权转让
标题翻译：螨融合蛋白
公开(公告)号：EP1908777B1
公开(公告)日：2016-02-03
申请号：EP07291219.9
申请日：2007-10-08
申请人： STALLERGENES
发明人： Moingeon, Philippe , Bulder, Ingrid , Bordas, Véronique , Bussieres, Laetitia
IPC分类号： C07K14/435 , C12N15/00 , A61K38/17
CPC分类号： C07K14/43531 , C07K2319/00

3. 发明公开

EP2476437A3 Immunogenic peptides and their use in immune disorders 有权转让
标题翻译：免疫原性肽及其在免疫疾病中的应用
公开(公告)号：EP2476437A3
公开(公告)日：2014-01-01
申请号：EP11187014.3
申请日：2007-08-13
申请人： Life Sciences Research Partners VZW
发明人： Saint-Remy, Jean-Marie
IPC分类号： A61K39/35 , C07K14/435 , C07K14/47
CPC分类号： C07K14/4713 , A61K35/17 , A61K39/0008 , A61K39/35 , A61K2039/572 , C07K14/415 , C07K14/43531 , C07K14/47 , C07K14/4717 , C07K14/62 , C07K2319/00 , C12N9/0065 , C12N9/88 , C12Y111/01008 , C12Y401/01015
摘要： The present invention provides novel peptides and homologues thereof. The peptides of the invention comprise (i) a T-cell epitope of an antigen (self or non-self) with a potential to trigger an immune reaction presented by a class II major histocompatibility complex (MHC) determinant and recognised by CD4+ T cell more specifically of an allergen or auto-antigen, coupled, optionally through the use of a linker to (ii) an amino acid sequence having a reducing activity, such as a thioreductase sequence. The peptides of the invention have been shown to be useful a medicine, more in particular for the prevention or treatment of immune disorders, more specifically of allergic disorders or autoimmune diseases. The present invention thus provides for the use of said peptides for the manufacture of a medicament for the prevention or treatment of an immune disorder and further provides for methods of treatment or preventing immune disorders by using said peptides. The present invention also provides for compositions comprising said peptides.

4. 发明公开

EP2643346A1 MODULATION OF ANTIGEN IMMUNOGENICITY BY ADDITION OF EPITOPES RECOGNIZED BY NKT CELLS 有权转让
标题翻译：调制方式抗原成血管内皮细胞分泌素维生素DONCH NKT-ZELLEN ERKANNTEN EPITOPEN
公开(公告)号：EP2643346A1
公开(公告)日：2013-10-02
申请号：EP11787875.1
申请日：2011-11-24
申请人： IMNATE SARL
发明人： SAINT-REMY, Jean-Marie
IPC分类号： C07K14/435
CPC分类号： C07K2/00 , A61K39/0011 , A61K39/04 , A61K39/12 , A61K39/145 , A61K39/35 , A61K39/39 , A61K2039/55505 , A61K2039/57 , C07K14/43531 , C12N2760/16034 , Y02A50/403 , Y02A50/41 , Y02A50/412
摘要： The invention describes a method and compounds for the prevention and treatment of infections with intracellular organisms, the treatment of tumors, and the prevention of infectious and allergic diseases by vaccination.
摘要翻译：本发明描述了用于预防和治疗细胞内生物体感染，肿瘤治疗以及通过接种预防感染性和过敏性疾病的方法和化合物。

5. 发明授权

EP2190473B1 PEPTIDE WITH REDUCED DIMER FORMATION 有权
标题翻译： PEPTID MIT REDUZIERTER DIMER-BILDUNG
公开(公告)号：EP2190473B1
公开(公告)日：2013-01-16
申请号：EP08788347.6
申请日：2008-08-15
申请人： Circassia Limited
发明人： HAFNER, Roderick, Peter , LAIDLER, Paul
IPC分类号： A61K39/35 , C07K14/415 , C07K14/435
CPC分类号： A61K39/0003 , A61K38/00 , A61K39/0002 , A61K39/0005 , A61K39/0008 , A61K39/35 , A61K39/36 , A61K39/39 , C07K7/06 , C07K7/08 , C07K14/415 , C07K14/435 , C07K14/43531 , C07K16/16 , C07K16/18 , C07K2319/00 , G01N33/56977
摘要： The present invention relates to compositions comprising peptides for preventing or treating allergy to house dust mites, and in particular to optimal combinations of peptides for preventing or treating said allergy.
摘要翻译：本发明涉及包含用于预防或治疗对尘螨的过敏的肽的组合物，特别涉及用于预防或治疗所述变态反应的肽的最佳组合。

6. 发明公开

EP2476436A2 Immunogenic peptides and their use in immune disorders 有权转让
标题翻译：免疫原性肽及其在免疫疾病中的应用
公开(公告)号：EP2476436A2
公开(公告)日：2012-07-18
申请号：EP11187013.5
申请日：2007-08-13
申请人： Life Sciences Research Partners VZW
发明人： Saint-Remy, Jean-Marie
IPC分类号： A61K39/35 , C07K14/435 , C07K14/47
CPC分类号： C07K14/4713 , A61K35/17 , A61K39/0008 , A61K39/35 , A61K2039/572 , C07K14/415 , C07K14/43531 , C07K14/47 , C07K14/4717 , C07K14/62 , C07K2319/00 , C12N9/0065 , C12N9/88 , C12Y111/01008 , C12Y401/01015
摘要： The present invention provides novel peptides and homologues thereof. The peptides of the invention comprise (i) a T-cell epitope of an antigen (self or non-self) with a potential to trigger an immune reaction presented by a class II major histocompatibility complex (MHC) determinant and recognised by CD4+ T cell more specifically of an allergen or auto-antigen, coupled, optionally through the use of a linker to (ii) an amino acid sequence having a reducing activity, such as a thioreductase sequence. The peptides of the invention have been shown to be useful a medicine, more in particular for the prevention or treatment of immune disorders, more specifically of allergic disorders or autoimmune diseases. The present invention thus provides for the use of said peptides for the manufacture of a medicament for the prevention or treatment of an immune disorder and further provides for methods of treatment or preventing immune disorders by using said peptides. The present invention also provides for compositions comprising said peptides.
摘要翻译：本发明提供了新的肽及其同系物。本发明的肽包含（i）具有引发由II类主要组织相容性复合体（MHC）决定簇呈递并且被CD4 + T细胞识别的免疫反应的潜力的抗原（自身或非自身）的T细胞表位更具体地说是变应原或自体抗原，任选地通过使用接头连接（ii）具有还原活性的氨基酸序列，例如硫还还原酶序列。已显示本发明的肽可用于药物，更特别用于预防或治疗免疫病症，更具体地说是过敏性病症或自身免疫性疾病。因此，本发明提供了所述肽在制备用于预防或治疗免疫病症的药物中的用途，并进一步提供了通过使用所述肽治疗或预防免疫病症的方法。本发明还提供了包含所述肽的组合物。

7. 发明公开

EP2436692A3 Hypoallergenic hybrid proteins of major group 1 and 2 mite allergens for use in the treatment of allergies 有权
标题翻译：低变应原性杂合蛋白的较大的组1和2的变应原在治疗过敏使用
公开(公告)号：EP2436692A3
公开(公告)日：2012-06-27
申请号：EP11179771.8
申请日：2009-03-24
申请人： Bial Industrial Farmaceutica, S.A.
发明人： Asturias Ortega, Juan Andres , Ibarrola Lopez De Davalillo, Iñaki , Arilla Rodriguez, Maria Carmen , Martinez Garate, Alberto
IPC分类号： C07K14/435 , A61K39/35
CPC分类号： C07K14/43531 , A61K39/00 , A61K39/35 , A61K48/00 , C07K2319/00
摘要： The present invention refers to recombinant ADN molecules coding to hybrids polypeptides of different allergens from D. pteronyssinus useful for the prevention and treatment of allergies, particularly allergies caused by mites. Specifically, the invention describes hybrid proteins composed of fragments of allergens Derp p1 y Derp p2 with hypoallergenic characteristics and maintain their immunogenic capacity, being particularly useful for the treatment of allergy. The invention also describes the production methods of these polypeptides in heterologous expression systems. Besides, the invention describes efficient purification methods of these hybrid proteins.

8. 发明授权

EP2205742B1 B CELL TOLERANCE INDUCTION 有权
标题翻译： B细胞耐受诱导
公开(公告)号：EP2205742B1
公开(公告)日：2011-11-09
申请号：EP08837232.1
申请日：2008-10-08
申请人： VIB VZW , Life Sciences Research Partners VZW
发明人： VANDENDRIESSCHE, Thierry , CHUAH, Marinee , SAINT-REMY, Jean-Marie , JACQUEMIN, Marc
IPC分类号： C12N15/11 , C12N5/0781
CPC分类号： C12N5/0635 , A61K2035/122 , A61K2039/6031 , C07K14/43531 , C12N2510/00
摘要： The present invention relates to the induction of immune tolerance, by a novel method of induction of IL-10 production in B cells, whereby said B cells can be loaded with antigen before, during or after the induction of the IL-10 production. More specifically, the invention relates to the transduction of the B cell with a retroviral vector encoding an antigen, whereby the retroviral envelop induces IL-10 production in the B cell by activation the TLR2 receptor, in combination with its viral receptor.

9. 发明公开

EP2368574A1 Allergen peptide fragments and use thereof 审中-公开
标题翻译：过敏原Peptidfragmente und deren Verwendungen
公开(公告)号：EP2368574A1
公开(公告)日：2011-09-28
申请号：EP10011428.9
申请日：2004-03-15
申请人： ANERGIS SA
发明人： Corthesy, Blaise , Spertini, Francois
IPC分类号： A61K39/35 , A61K39/36 , A61P37/08 , C07K14/415 , C07K14/435
CPC分类号： A61K38/168 , A61K39/35 , C07K14/415 , C07K14/43531 , C07K14/43563 , C07K14/43572
摘要： The present invention relates generally to methods for generating compositions designed for allergen specific immunotherapy. The compositions include contiguous overlapping peptide fragments which together form an entire amino acid sequence of an allergen.
摘要翻译：本发明一般涉及产生为变应原特异性免疫疗法设计的组合物的方法。组合物包括连续重叠的肽片段，其一起形成变应原的完整氨基酸序列。

10. 发明公开

EP2316844A2 Peptide complex 审中-公开
标题翻译： PEPTIDKOMPLEX
公开(公告)号：EP2316844A2
公开(公告)日：2011-05-04
申请号：EP10181570.2
申请日：2004-05-18
申请人： BIOTECH TOOLS S.A.
发明人： Hénot, Frederic , Legon, Thierry , Galy-Fauroux, Isabelle , Duchateau, Jean
IPC分类号： C07K5/00 , C12N15/00 , C12N1/21 , G01N33/00 , C07K7/08 , A61K48/00
CPC分类号： C07K14/005 , C07K14/245 , C07K14/43531 , C07K14/4713 , C07K14/62 , C07K14/70539 , C12N2740/16122
摘要： A complex comprising at least one heat shock protein (HSP) and at least one peptide selected from the group consisting of

DYEYLINVIHAFQYV (PLP 56-70)
SEQ ID No 6

EKLIETYFSKNYQDYEYLINVI (PLP 43-64)
SEQ ID No 7

KTTICGKGLSATVT (PLP 104-117)
SEQ ID No 8

HSLGKWLGHPDKF (PLP 139-151 C 140 →S 140 )
SEQ ID No 9

PRHPIRVELPCRISP (MOG 8-22)
SEQ ID No 10

DEGGYTCFFRDHSYQ (MOG 92-106)
SEQ ID No 11

Ac-ASQKRPSQRHG (MBP ac1-11)
SEQ ID No 12

TGILDSIGRFFSG (MBP 35-47)
SEQ ID No 13

VHFFKNIVTPRTP (MBP 89-101)
SEQ ID No 14

HCLGKWLGHPDKF (PLP 139-151)
SEQ ID No 15

MEVGWYRSPFSRVVHLYRNGK (MOG)
SEQ ID No 16

IYPPNANK (DER p1)
SEQ ID No 3

GIEYIQHNGVVQESYYR (DER P1)
SEQ ID No 4.
摘要翻译：包含至少一种热休克蛋白（HSP）和至少一种选自DYEYLINVIHAFQYV（PLP 56-70）SEQ ID No 6 EKLIETYFSKNYQDYEYLINVI（PLP 43-64）SEQ ID No 7 KTTICGKGLSATVT（PLP104- SEQ ID No 8 HSLGKWLGHPDKF（PLP 139-151 C 140†'S1 140）SEQ ID NO 9 PRHPIRVELPCRISP（MOG 8-22）SEQ ID NO 10 DEGGYTCFFRDHSYQ（MOG 92-106）SEQ ID No 11 Ac-ASQKRPSQRHG（MBP ac1-11）SEQ ID No 12 TGILDSIGRFFSG（MBP 35-47）SEQ ID No 13 VHFFKNIVTPRTP（MBP 89-101）SEQ ID No 14 HCLGKWLGHPDKF（PLP 139-151）SEQ ID No 15 MEVGWYRSPFSRVVLYRNGK（MOG）SEQ ID No 16 IYPPNANK （DER p1）SEQ ID No 3 GIEYIQHNGVVQESYYR（DER P1）SEQ ID No.4。

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