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1. 发明公开

EP3609912A1 METHODS TO PRODUCE PEPTIDES, POLYPEPTIDES OR CELLS FOR MODULATING IMMUNITY 审中-实审转让
公开(公告)号：EP3609912A1
公开(公告)日：2020-02-19
申请号：EP18716632.7
申请日：2018-04-16
申请人： IMNATE SARL
发明人： SAINT-REMY, Jean-Marie
IPC分类号： C07K14/435

2. 发明公开

EP2666782A1 Coagulation factor VIII with reduced immunogenicity. 审中-公开
标题翻译： Gerinnungsfaktor VII mit reduzierter Immunogenittt
公开(公告)号：EP2666782A1
公开(公告)日：2013-11-27
申请号：EP12168800.6
申请日：2012-05-22
申请人： IMNATE SARL
发明人： Saint-Remy, Jean-Marie
IPC分类号： C07K14/435
CPC分类号： C07K14/755 , A23V2200/218 , A61K38/37 , A61M2202/0452 , Y10S514/834
摘要： The invention describes factor VIII molecules with reduced capacity to elicit activation of NKT cells, for use in the treatment of congenital and/or acquired haemophilia A and in bleeding disorders. Said factor VIII molecules having a domain structure Al-al-A2-a2-B-a3-A3-Cl-C2, in which A1, A2, B, A3, C1 and C2 represent domains and al, a2 and a3 acidic regions linking said domains, The factor VIII molecule is obtainable by:
a. identification of at least one NKT cell epitope wherein said epitope comprises hydrophobic aminoacid residues in position P1 and/or P7
b. modification of said epitope(s) by eliminating at least one hydrophobic aminoacid residue in position P1 and/or P7, substituting at least one hydrophobic aminoacid residue in position P1 and/or P7 with a non-hydrophobic residue, or adding a non-hydrophobic residue in position P1 and/or P7.
摘要翻译：本发明描述了具有降低NKT细胞激活能力的因子VIII分子，用于治疗先天性和/或获得性血友病A和出血性疾病。所述具有域结构Al-al-A2-a2-B-a3-A3-C1-C2的所述因子VIII分子，其中A1，A2，B，A3，C1和C2表示结构域和a1，a2和a3酸性区连接所述结构域，因子VIII分子可通过以下方式获得：a。识别至少一个NKT细胞表位，其中所述表位包含位置P1和/或P7 b的疏水性氨基酸残基。通过除去位置P1和/或P7中的至少一个疏水性氨基酸残基，用非疏水性残基取代位置P1和/或P7处的至少一个疏水性氨基酸残基，或加入非疏水性，修饰所述表位位置P1和/或P7处的残基。

3. 发明公开

EP2643347A1 MODULATION OF ANTIGEN IMMUNOGENICITY BY DELETING EPITOPES RECOGNIZED BY NKT CELLS 有权转让
标题翻译：调制剂抗原成瘤细胞毒素ON ON ON CH CH CH CH EN EN EN EN EN EN EN EN EN EN
公开(公告)号：EP2643347A1
公开(公告)日：2013-10-02
申请号：EP11788142.5
申请日：2011-11-24
申请人： IMNATE SARL
发明人： SAINT-REMY, Jean-Marie
IPC分类号： C07K14/435
CPC分类号： C07K2/00 , A01K2207/12 , A61K39/001 , A61K2039/577 , C07K14/415 , C07K14/43531 , C07K14/755 , C07K16/00 , C07K2317/524 , C07K2317/526 , C12N9/641 , C12N2710/10322 , C12N2710/10343
摘要： The invention describes a method and compounds for the prevention of immune responses towards allofactors, towards viral vectors used for gene therapy and gene vaccination, towards proteins to which subjects are naturally exposed, towards genetically-modified organisms and towards undesirable effects related to vaccine administration for allergic or infectious diseases.
摘要翻译：本发明描述了一种用于预防对同种异体的免疫反应的方法和化合物，用于基因治疗和基因疫苗接种的病毒载体，对受试者天然暴露于的蛋白质，转基因修饰的生物体以及与疫苗施用相关的不期望的作用过敏或感染性疾病。

4. 发明授权

EP2643346B1 MODULATION OF ANTIGEN IMMUNOGENICITY BY ADDITION OF EPITOPES RECOGNIZED BY NKT CELLS 有权转让
公开(公告)号：EP2643346B1
公开(公告)日：2018-08-29
申请号：EP11787875.1
申请日：2011-11-24
申请人： IMNATE SARL
发明人： SAINT-REMY, Jean-Marie
IPC分类号： C07K14/435
CPC分类号： C07K2/00 , A61K39/0011 , A61K39/04 , A61K39/12 , A61K39/145 , A61K39/35 , A61K39/39 , A61K2039/55505 , A61K2039/57 , C07K14/43531 , C12N2760/16034 , Y02A50/403 , Y02A50/41 , Y02A50/412
摘要： The invention describes a method and compounds for the prevention and treatment of infections with intracellular organisms, the treatment of tumors, and the prevention of infectious and allergic diseases by vaccination.

5. 发明公开

EP2643346A1 MODULATION OF ANTIGEN IMMUNOGENICITY BY ADDITION OF EPITOPES RECOGNIZED BY NKT CELLS 有权转让
标题翻译：调制方式抗原成血管内皮细胞分泌素维生素DONCH NKT-ZELLEN ERKANNTEN EPITOPEN
公开(公告)号：EP2643346A1
公开(公告)日：2013-10-02
申请号：EP11787875.1
申请日：2011-11-24
申请人： IMNATE SARL
发明人： SAINT-REMY, Jean-Marie
IPC分类号： C07K14/435
CPC分类号： C07K2/00 , A61K39/0011 , A61K39/04 , A61K39/12 , A61K39/145 , A61K39/35 , A61K39/39 , A61K2039/55505 , A61K2039/57 , C07K14/43531 , C12N2760/16034 , Y02A50/403 , Y02A50/41 , Y02A50/412
摘要： The invention describes a method and compounds for the prevention and treatment of infections with intracellular organisms, the treatment of tumors, and the prevention of infectious and allergic diseases by vaccination.
摘要翻译：本发明描述了用于预防和治疗细胞内生物体感染，肿瘤治疗以及通过接种预防感染性和过敏性疾病的方法和化合物。

6. 发明公开

EP3936867A1 CD1 PEPTIDE-EPITOPE FOR USE IN THE TREATMENT OF A DISEASE CAUSED BY AN INTRACELLULAR PATHOGEN 审中-公开
公开(公告)号：EP3936867A1
公开(公告)日：2022-01-12
申请号：EP20184175.6
申请日：2020-07-06
申请人： IMNATE SARL
发明人： SAINT-REMY, Jean-Marie
IPC分类号： G01N33/569 , A61K39/00 , C07K14/00 , G01N33/68
摘要： A CD1 peptide-epitope for use in the treatment of a disease caused by an intracellular pathogen, the method for the identification of this CD1 peptide epitope, the pharmaceutical kit comprising this CD1 peptide epitope and the method to treat a patient against a disease caused by an intracellular pathogen or to prevent such infection, based on vaccination with this CD1 peptide-epitope.

7. 发明公开

EP3388447A1 METHODS TO PRODUCE PEPTIDES, POLYPEPTIDES OR CELLS FOR MODULATING IMMUNITY 审中-公开
公开(公告)号：EP3388447A1
公开(公告)日：2018-10-17
申请号：EP17166696.9
申请日：2017-04-14
申请人： IMNATE SARL
发明人： SAINT-REMY, Jean-Marie
IPC分类号： C07K14/435
CPC分类号： C07K14/435
摘要： The invention relates to a method to determine, based on the activation level of NKT cells, the capacity of a peptidic epitope to selectively bind to CD1a, CD1b and/or CD1c proteins, a corresponding method to increase or decrease the selective binding of the peptidic epitope to CD1a, CD1b and/or CD1c proteins by modifying the epitope or its flanking regions, the corresponding modified epitopes and the activated NKT cells or parts thereof obtainable by these methods.

8. 发明授权

EP2643347B1 MODULATION OF ANTIGEN IMMUNOGENICITY BY DELETING EPITOPES RECOGNIZED BY NKT CELLS 有权转让
标题翻译： NKT细胞识别表位降低抗原免疫原性的研究
公开(公告)号：EP2643347B1
公开(公告)日：2017-12-27
申请号：EP11788142.5
申请日：2011-11-24
申请人： IMNATE SARL
发明人： SAINT-REMY, Jean-Marie
IPC分类号： A61K39/00 , C07K14/435 , C07K14/755 , C07K16/00 , C07K2/00 , C07K14/415 , C12N9/64
CPC分类号： C07K2/00 , A01K2207/12 , A61K39/001 , A61K2039/577 , C07K14/415 , C07K14/43531 , C07K14/755 , C07K16/00 , C07K2317/524 , C07K2317/526 , C12N9/641 , C12N2710/10322 , C12N2710/10343
摘要： The invention describes a method and compounds for the prevention of immune responses towards allofactors, towards viral vectors used for gene therapy and gene vaccination, towards proteins to which subjects are naturally exposed, towards genetically-modified organisms and towards undesirable effects related to vaccine administration for allergic or infectious diseases.

9. 发明公开

EP2643345A2 IMMUNOGENIC PEPTIDES FOR USE IN THE PREVENTION AND/OR TREATMENT OF INFECTIOUS DISEASES, AUTOIMMUNE DISEASES, IMMUNE RESPONSES TO ALLOFACTORS, ALLERGIC DISEASES, TUMORS, GRAFT REJECTION AND IMMUNE RESPONSES AGAINST VIRAL VECTORS USED FOR GENE THERAPY OR GENE VACCINATION 有权转让
标题翻译：免疫原性肽用于本预防和/或治疗感染性疾病，自身免疫性疾病，免疫反应ALLOFAKTOREN，过敏性疾病，肿瘤，移植排斥反应和免疫反应病毒载体的基因治疗或GENIMPFUNGEN的
公开(公告)号：EP2643345A2
公开(公告)日：2013-10-02
申请号：EP11787873.6
申请日：2011-11-24
申请人： IMNATE SARL
发明人： SAINT-REMY, Jean-Marie
IPC分类号： C07K14/435
CPC分类号： C12N9/0051 , A61K35/17 , A61K39/0008 , A61K39/0011 , A61K39/12 , A61K39/35 , A61K39/385 , A61K2039/5158 , A61K2039/55505 , A61K2039/57 , A61K2039/6031 , A61K2039/627 , C07K2319/40 , C12N5/0646 , C12N9/90 , C12N2710/10334 , C12Y503/04001
摘要： The invention describes new peptides containing epitopes recognized by CD4+ natural killer T (NKT) cells for increasing activity for use in infectious diseases, autoimmune diseases, immune reaction to administration of allofactors, allergic diseases, therapy of tumors, prevention of graft rejection and prevention of immunization against viral proteins used in gene therapy or gene vaccination.
摘要翻译：本发明描述了含有表位的新的肽由CD4 +天然杀伤T（NKT）识别的细胞用于在感染性疾病，自身免疫性疾病，以同种异体因子，变应性疾病，肿瘤的治疗，预防移植物排斥和预防的给药免疫反应中使用越来越多的活动免疫抵抗基因治疗或基因疫苗接种中使用的病毒蛋白。

10. 发明公开

EP3915575A1 VACCINE FORMULATIONS 审中-公开
公开(公告)号：EP3915575A1
公开(公告)日：2021-12-01
申请号：EP20177311.6
申请日：2020-05-29
申请人： IMNATE SARL
发明人： SAINT-REMY, Jean-Marie
IPC分类号： A61K39/00
摘要： A method to elicit CD4+ T cells with an immune suppressive function towards a given MHC Class II epitope present in a specific target tissue and/or to elicit CD4+ T cells harbouring homeostasis restoration properties for a specific target tissue, based on an MHC Class II epitope modified by the addition of a redox motif, the corresponding modified epitopes, pharmaceutical uses, kits of parts, and gene edition system for use in a patient.

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