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1. 发明授权

EP2081912B1 HETEROCYCLIC BRIDGED BIPHENYLS AND THEIR USE IN OLEDS 有权转让
标题翻译：杂环桥联联苯和它们在有机发光二极管
公开(公告)号：EP2081912B1
公开(公告)日：2016-03-30
申请号：EP07803193.7
申请日：2007-09-04
申请人： BASF SE
发明人： WENDEBORN, Frédérique , SCHMIDHALTER, Beat , SCHÄFER, Thomas , MURER, Peter , BARDON, Kristina
IPC分类号： C07D235/18 , C07D241/42 , C07D263/56 , C07D209/58 , C07D403/14 , C07D413/14 , C07F7/10 , C07F9/53 , H01L51/30
CPC分类号： C07D235/18 , C07D209/58 , C07D241/42 , C07D263/57 , C07D403/14 , C07D413/14 , C07F9/65068 , C07F9/65324

2. 发明公开

EP1495129A4 HYBRID PHOSPHOINOSITIDE PHOSPHOLIPIDS: COMPOSITIONS AND USES 审中-公开
标题翻译：混合磷酸肌醇磷脂：组合物及其用途
公开(公告)号：EP1495129A4
公开(公告)日：2006-06-14
申请号：EP03723866
申请日：2003-03-31
申请人： UNIV UTAH RES FOUND
发明人： PRESTWICH GLENN , RZEPECKI PIOTR W , FERGUSON COLIN G , NEILSEN PAUL O , BRANCH ANGIE , CROSBY LEE R
IPC分类号： C07F9/117 , C07F9/653 , C07F9/655 , C12Q1/42 , C12Q1/44 , C12Q1/48 , G01N33/92 , C12Q1/00 , G01N33/53
CPC分类号： C12Q1/42 , C07F9/117 , C07F9/65324 , C07F9/65517 , C12Q1/44 , C12Q1/485 , G01N33/92
摘要： The methods and compositions disclosed herein concern the synthesis of a novel class of "two-headed" phospholipid-phosphoinositide hybrids possessing a carbon backbone, such as 2,3-diacylthreitol, erythritol or a synthetic module. The second phospholipid head group allows introduction of a biochemical or chemical moiety in a position orthogonal in space to those occupied by the phosphoinositide head group and the two acyl chains. The diacyl moieties allow for the incorporation of Pea-PIP2 into a lipid bilayer, while the Ptdlns(4,5)P2 moiety in the aqueous layer is specifically recognized by lipid binding proteins. In alternative embodiments of the invention, reporters, for example biotin, fluorophores and/or spin labels, are attached to the free amino group of the head groups of such molecules to specifically target the reporters to the lipid-water interface.

3. 发明公开

EP1625134A2 SUBSTITUTED PHOSPHONATE FLUORESCENT SENSORS AND USE THEREOF 审中-公开
标题翻译：取代的磷酸盐荧光传感器及其用途
公开(公告)号：EP1625134A2
公开(公告)日：2006-02-15
申请号：EP04733014.7
申请日：2004-05-14
申请人： QUEEN MARY & WESTFIELD COLLEGE
发明人： WILSON, John Robert Howe, Department of Chemistry , SULLIVAN, Alice Caroline, Department of Chemistry , MAN, Suid Pui, Department of Chemistry , ROBSON, Lesley, Inst. of Cell & Molecular Science
IPC分类号： C07F9/60 , C07F9/655 , C07F9/572 , C07F9/40 , C07F9/6539 , C07F9/653 , C07F9/6503 , C07F9/64 , C07F9/38 , C07F9/6533 , C09K11/06 , G01N33/53
CPC分类号： C07F9/65616 , C07F9/3882 , C07F9/4006 , C07F9/4028 , C07F9/4056 , C07F9/5535 , C07F9/5728 , C07F9/60 , C07F9/64 , C07F9/65033 , C07F9/65324 , C07F9/65335 , C07F9/6541 , C07F9/65522
摘要： The invention relates to new compounds of formula (1) wherein R is hydrogen or a linear or branched Cl-40 alkyl; where X is O, S, or NR1 where R1 is a hydrogen, a linear or branched C1-40 alkyl, C2-40 alkenyl or C2-40 alkynyl group, an aryl, a heteroaryl or C1- 40 alkylaryl or alkylheteroaryl group and where one or both of C and D is OR2, SR2, NR3R4 where R2, R3, and R4 are each independently hydrogen, a linear or branched C1-40 alkyl, C2-40 alkenyl or C2-40 alkynyl group, an aryl or C1-40 alkylaryl group or a linear or branched C1-40 alkyl NR5R6 chain where R5 and R6 are each independently hydrogen, a linear or branched C1-40 alkyl; or an optionally complex metal ion Mn+/n wherein n is an integer from 1 to 8; or where one or both of C and D are amino acids or nucleic acids attached via either N, O or S; and wherein m is an integer from 1 to 8; and wherein either: I) A is a known aryl or heteroaryl fluorescent group and B is hydrogen, a linear or branched Cl-40 alkyl, C2-40 alkenyl or C2-40 alkynyl group, an aryl, a heteroaryl or C1-40 alkylaryl or alkylheteroaryl group or phosphonate P(O)(OR2)2; II) B is a known aryl or heteroaryl fluorescent group and A is hydrogen, a linear or branched Cl-40 alkyl, C2-40 alkenyl or C2-40 alkynyl group, an aryl, a heteroaryl or C1-40 alkylaryl or alkylheteroaryl group or a linear or branched C1-40 alkyl NR5R6 chain, or a linear or branched C1-40 alkyl mono or di ester Cl-40 alkylphosphonate or a linear or branched Cl-40 alkylphosphonic acid; III) Both A and B are known aryl or heteroaryl fluorescent groups. The compounds are useful as fluorescent sensors for metal cations and have the advantages of excellent water solubility, selectivity and sensitivity to a variety of metal cations even in the presence of high concentrations of Ca+2, Na+ and K+, good cell permeability, flexible and simple syntheses, ease of attachment to polymers and bio-polymers to aid the identification of both chemical and biological processes as well as for assaying physiological samples and for the attachment to surfaces such as glasses, ceramics and apatites.
摘要翻译：本发明涉及新的式（1）化合物，其中R为氢或直链或支链C1-40烷基; 其中X是O，S或NR 1，其中R 1是氢，直链或支链C 1-40烷基，C 2-40烯基或C 2-40炔基，芳基，杂芳基或C 1-40烷基芳基或烷基杂芳基， C和D中的一个或两个是OR2，SR2，NR3R4，其中R2，R3和R4各自独立地是氢，直链或支链C1-40烷基，C2-40链烯基或C2-40炔基，芳基或C1- 40烷基芳基或直链或支链C1-40烷基NR5R6链，其中R5和R6各自独立地为氢，直链或支链C1-40烷基; 或任选的复合金属离子Mn + / n，其中n是1至8的整数; 或者C和D之一或两者都是氨基酸或通过N，O或S连接的核酸; 并且其中m是1至8的整数; 并且其中：I）A是已知的芳基或杂芳基荧光基团，并且B是氢，直链或支链C1-40烷基，C2-40烯基或C2-40炔基，芳基，杂芳基或C1-40烷基芳基或烷基杂芳基或膦酸酯P（O）（OR 2）2; II）B是已知的芳基或杂芳基荧光基团，A是氢，直链或支链C 1-40烷基，C 2-40烯基或C 2-40炔基，芳基，杂芳基或C 1-40烷基芳基或烷基杂芳基，或直链或支链C1-40烷基NR5R6链或直链或支链C1-40烷基单或二酯C1-40烷基膦酸酯或直链或支链C1-40烷基膦酸; III）A和B都是已知的芳基或杂芳基荧光基团。这些化合物可用作金属阳离子的荧光传感器，并且即使在高浓度的Ca + 2，Na +和K +存在下，具有优异的水溶性，选择性和对各种金属阳离子的敏感性，良好的细胞渗透性，柔韧性和简单的合成，与聚合物和生物聚合物的连接方便，有助于鉴定化学和生物学过程，以及测定生理样品和附着于表面，如玻璃，陶瓷和磷灰石。

4. 发明公开

EP1495129A2 HYBRID PHOSPHOINOSITIDE PHOSPHOLIPIDS: COMPOSITIONS AND USES 审中-公开
标题翻译：混合磷酸肌醇磷脂：组合物及其用途
公开(公告)号：EP1495129A2
公开(公告)日：2005-01-12
申请号：EP03723866.4
申请日：2003-03-31
申请人： The University of Utah Research Foundation
发明人： PRESTWICH, Glenn , RZEPECKI, Piotr, W. , FERGUSON, Colin, G. , NEILSEN, Paul, O. , BRANCH, Angie , CROSBY, Lee, R.
IPC分类号： C12Q1/00 , C12Q1/42 , C12Q1/48 , G01N33/53
CPC分类号： C12Q1/42 , C07F9/117 , C07F9/65324 , C07F9/65517 , C12Q1/44 , C12Q1/485 , G01N33/92
摘要： The methods and compositions disclosed synthesis of a novel class of 'two-headed' phospholipid-phosphoinositide hybrids possessing a carbon backbone, such as 2,3-diacylthreitol, erythritol or a synthetic module. The second phospholipid head group allows introduction of a biochemical or chemical moiety in a position orthogonal in space to those occupied by the phosphoinositide head group and the two acyl chains. The diacyl moieties allow for the incorporation of Pea-PIP2 into a lipid bilayer, while the Ptdlns(4,5)P2 moiety in the aqueous layer is specifically recognized by lipid binding proteins. In alternative embodiments of the invention, reporters, for example biotin, fluorophores and/or spin labels, are attached to the free amino group of the head groups of such molecules to specifically target the reporters to the lipid-water interface. Figure (1) illustrates (at c) an exemplary hybrid lipid of the present invention that possess a phosphatidylethanolamine (PE, or Pea) head group at the 1-position and a Ptdlns(4, 5)P2 head group at the 4-position.

5. 发明授权

EP1115729B1 PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B 有权
标题翻译：膦酸衍生物作为PTP-1B的抑制剂
公开(公告)号：EP1115729B1
公开(公告)日：2003-02-19
申请号：EP99944200.7
申请日：1999-09-21
申请人： Merck Frosst Canada & Co.
发明人： LEBLANC, Yves , DUFRESNE, Claude , WANG, Zhaoyin , LI, Chun, Sing , GAUTHIER, Jacques, Y. , THERIEN, Michel , LAU, Cheuk, K. , ROY, Patrick
IPC分类号： C07F9/38 , A61K31/66 , C07F9/553 , C07F9/6539 , C07F9/6518 , C07F9/6524 , C07F9/653 , C07F9/6541 , C07F9/6506
CPC分类号： H04M3/42314 , C07F9/3856 , C07F9/386 , C07F9/3865 , C07F9/3869 , C07F9/3882 , C07F9/5537 , C07F9/65068 , C07F9/65188 , C07F9/6524 , C07F9/65318 , C07F9/65324 , C07F9/6539 , C07F9/65395 , C07F9/6541 , H04Q3/625 , H04Q2213/13104 , H04Q2213/13107 , H04Q2213/1322 , H04Q2213/1329 , H04Q2213/13389

6. 发明公开

EP1112275A1 NOVEL HETEROAROMATIC INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE 有权
标题翻译：新杂果糖-1,6-二磷酸酶抑制剂
公开(公告)号：EP1112275A1
公开(公告)日：2001-07-04
申请号：EP99954595.7
申请日：1999-09-03
申请人： Metabasis Therapeutics Inc.
发明人： DANG, Qun , KASIBHATLA, Srinivas, Rao , REDDY, K., Raja , ERION, Mark, D. , REDDY, M., Rami , AGARWAL, Atul
IPC分类号： C07F9/6558 , A61K31/675 , A61P3/10 , C07F9/655 , C07F9/6553 , C07F9/6509 , C07F9/6512 , C07F9/58 , C07F9/6539 , C07F9/653 , C07F9/6541 , C07F9/6571 , C07F9/6578
CPC分类号： C07F9/4006 , C07F9/5728 , C07F9/582 , C07F9/588 , C07F9/650964 , C07F9/650988 , C07F9/65122 , C07F9/65127 , C07F9/653 , C07F9/65324 , C07F9/6539 , C07F9/65395 , C07F9/6541 , C07F9/65515 , C07F9/65517 , C07F9/655345 , C07F9/65583 , C07F9/65586 , C07F9/657181 , C07F9/6578 , C07F9/65846
摘要： Novel FBPase inhibitors of formula (I) and (X) are useful in the treatment of diabetes and other conditions associated with elevated blood glucose.

7. 发明公开

EP0399409A3 Fluorogene Verbindungen und ihre Verwendung 失效
标题翻译：氟化合物及其使用
公开(公告)号：EP0399409A3
公开(公告)日：1991-05-08
申请号：EP90109520.8
申请日：1990-05-19
申请人： BEHRINGWERKE Aktiengesellschaft
发明人： Habenstein, Klaus, Dr.
IPC分类号： C07D263/56 , C07D277/64 , C12Q1/34 , G01N33/58 , C12N11/00 , C07F9/09
CPC分类号： C07D263/57 , C07D263/58 , C07D277/66 , C07D277/68 , C07F9/65324 , C12Q1/34 , C12Q2334/00 , G01N2333/924 , Y10S435/805
摘要： Die Erfindung bezieht sich auf fluorogene Verbindungen für den Nachweis hydrolysierender Enzyme und die Verwendung der fluorogenen Verbindungen.

8. 发明公开

EP0067792A1 Stilbenverbindungen 失效
标题翻译：茋化合物。
公开(公告)号：EP0067792A1
公开(公告)日：1982-12-22
申请号：EP82810243.4
申请日：1982-06-07
申请人： CIBA-GEIGY AG
发明人： Weber, Kurt, Dr.
IPC分类号： C07D263/56 , C07D498/04 , C07C131/00 , C07D249/24 , C07D249/20 , C07D271/10 , C07D261/08 , C07D249/06 , C07D471/04 , C07D237/14 , D06L3/12
CPC分类号： C07D263/57 , C07C255/00 , C07D237/14 , C07D249/06 , C07D249/20 , C07D249/24 , C07D261/08 , C07D271/107 , C07D271/113 , C07D471/04 , C07F9/4056 , C07F9/65324
摘要： Die Stilbenverbindungen der Formel
worin Q Wasserstoff; einen monocyclischen 5- oder 6- gliedrigen unsubstituierten oder nicht-chromophor substituierten, 0, 1 oder 2 ankondensierte Benzolringe aufweisenden aromatischen heterocyclischen Ring; einen bicyclischen 9- gliedrigen aromatischen heterocyclischen Ring oder den Rest -CH=C(R 1 )(R 2 ), worin R, für Wasserstoff, unsubstituiertes oder nicht-chromophor substituiertes C 1-6 -Alkyl und R 2 für Alkoxycarbonyl mit insgesamt 2 bis 7 C-Atomen, Cyano, Carboxy, Carbamoyl, Phosphonsäuredialkylester, C 1-6 -Alkyl-oder Arylsulfonyl stehen oder Q auch
bedeuten kann, R o Wasserstoff oder C 1-6 -Alkyl, R unsubstituiertes oder nichtchromophor substituiertes C 1-6 -Alkyl, C 2-5 -Alkenyl, C 2-5 -Alkinyl, Di-C 1-4 -alkylamino-C 1-4 -alkyl, Hydroxy-C 1-4 -alkyl, Phenyl-C 1-4 -alkyl oder Cycloalkyl mit 5 bis 12 Ringgliedern und m und n unabhängig voneinander die Zahl 1 oder 2 bedeuten, können zum optischen Aufhellen von hochmolekularen, synthetischen, halbsynthetischen und natürlichen organischen Materialien verwendet werden.
摘要翻译：式的芪化合物其中，Q是氢; monocyciischen的5-或6-元未取代或取代的非发色，0，具有芳族杂环1个或2个稠合苯环; 双环9元芳族杂环或基团-CH = C（R1）（R2），其中R1是氢，未取代的或不发色团取代的C 1-6烷基，和R 2表示烷氧基羰具有总共2至7个C原子的是氰基，羧基，氨基甲酰基二烷基膦酸酯，C 1-6烷基或芳基磺酰，或Q还可意味着R0为氢或C1-6烷基，R是未取代的或取代的nonchromophoric C 1-6烷基，C 2-5 链烯基，C2-5炔基，二-C1-4烷基氨基-C 1-4 - 烷基，羟基-C 1-4 - 烷基，苯基-C 1-4 - 烷基或具有5至12个环成员的环烷基，并且m和n独立地一个的另一个表示1或2，可以使用高分子量的，合成的，半合成和天然有机材料的光学增亮的数量。

9. 发明公开

EP3174892A1 SYNTHESIS OF PHOSPHORAMIDATES 审中-公开
标题翻译：合成锑磷酸盐
公开(公告)号：EP3174892A1
公开(公告)日：2017-06-07
申请号：EP15752965.2
申请日：2015-07-31
申请人： Sandoz AG
发明人： WILHELM, Thorsten , SPITZENSTÄTTER, Hans-Peter , SCHÖNE, Olga , RICHTER, Frank , SCHREINER, Erwin
IPC分类号： C07H19/06 , C07F9/24
CPC分类号： C07H19/06 , C07F9/5725 , C07F9/65215 , C07F9/65324 , C07F9/65586
摘要： A process for the preparation of a compound of formula (I) including all isomers, stereoisomers, enantiomers and diastereomers thereof (I), and salts thereof; the process comprising providing a mixture comprising a compound of formula (II) and a compound of formula (III) subjecting the mixture provided in a) to reaction conditions in the presence of one or more Lewis acids to the mixture provided in a), obtaining a mixture comprising the compound of formula (I).
摘要翻译：一种制备包括其所有异构体，立体异构体，对映异构体和非对映异构体（I）的式（I）化合物及其盐的方法; 该方法包括提供包含式（II）化合物和式（III）化合物的混合物，使在a）中提供的混合物在一种或多种路易斯酸存在下的反应条件下，在a）中提供的混合物中，获得包含式（I）化合物的混合物。

10. 发明授权

EP2522394B1 Substituted phosphonates and their use decreasing amyloid aggregates 有权
标题翻译：替代膦酸盐和稀释剂Verwendung mit Verringerung von Amyloidaggregaten
公开(公告)号：EP2522394B1
公开(公告)日：2016-12-28
申请号：EP12164946.1
申请日：2008-05-02
申请人： QUEEN MARY & WESTFIELD COLLEGE
发明人： Sullivan, Alice , Robson, Lesley , Michael-Titus, Adina
IPC分类号： A61P25/28 , C07F9/40 , C07F9/572 , C07F9/60 , C07F9/64 , C07F9/6506 , C07F9/653 , C07F9/655 , C07F9/6561 , A61K31/662 , A61K31/665 , A61K31/675
CPC分类号： C07F9/65522 , A61K31/662 , A61K31/665 , A61K31/675 , C07F9/4006 , C07F9/4056 , C07F9/5728 , C07F9/60 , C07F9/64 , C07F9/65068 , C07F9/65324 , C07F9/6561

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