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1. 发明授权

EP1517891B1 SÄUREGRUPPEN SUBSTITUIERTE DIPHENYLAZETIDINONE, VERFAHREN ZU DEREN HERSTELLUNG, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND DEREN VERWENDUNG 有权
标题翻译： ACID取代Diphenylazetidinones，方法及其，药品含有它们及其用途
公开(公告)号：EP1517891B1
公开(公告)日：2013-04-03
申请号：EP03735535.1
申请日：2003-06-04
申请人： Sanofi-Aventis Deutschland GmbH
发明人： JAEHNE, Gerhard , FRICK, Wendelin , FLOHR, Stefanie , LINDENSCHMIDT, Andreas , GLOMBIK, Heiner , KRAMER, Werner , HEUER, Hubert , SCHAEFER, Hans-Ludwig
IPC分类号： C07D205/08 , C07F9/568 , A61K31/397 , A61P3/06 , A61P9/10
CPC分类号： C07F9/568 , C07D205/08 , C07F9/5683

2. 发明公开

EP1489088A4 NOVEL ALPHA-AMINO-N-(DIAMINOPHOSPHINYL)LACTAM DERIVATIVE 有权
标题翻译：除了氨基 - 氨基-N-（二氨基磷酰）乳酸
公开(公告)号：EP1489088A4
公开(公告)日：2006-05-10
申请号：EP03712858
申请日：2003-03-24
申请人： NIPPON KAYAKU KK , ZAIDAN HOJIN BISEIBUTSU
发明人： ABE MASATOSHI , NAGAI MASASHI , YAMAMOTO KEIICHIROU , NISHIMURA CHIHIRO
IPC分类号： A61K31/675 , A61P3/10 , A61P5/00 , A61P7/00 , A61P7/06 , A61P29/00 , A61P31/00 , A61P31/18 , A61P37/02 , A61P37/08 , A61P43/00 , C07F9/553 , C07F9/568 , C07F9/572 , C07F9/59
CPC分类号： C07F9/5683 , A61K31/675 , C07F9/5532 , C07F9/5721 , C07F9/591
摘要： A novel alpha -amino-N-(diaminophosphinyl)lactam derivative represented by the general formula (I) [wherein, for example, A represents hydrogen or a substituent such as lower alkyl; W, X, Y, and Z each independently represents hydrogen or a substituent such as lower alkyl, aryl, arylacyl, or arylaminocarbonyl; and Q represents -(CH2)n- (n is 0 to 3)] or a salt of the derivative; and a therapeutic agent and preventive for marrow inhibition, a therapeutic agent for infectious diseases, a leukocyte enhancer, and a dipeptidyl peptidase IV inhibitor which each contains the derivative or salt as an active ingredient.

3. 发明公开

EP1457494A4 PROCESSES FOR PREPARATION OF SULPHOSTIN AND ITS ANALOGUES OR INTERMEDIATES THEREOF 审中-公开
标题翻译：用于生产sulphostatin及其类似物或其中间体
公开(公告)号：EP1457494A4
公开(公告)日：2006-04-12
申请号：EP02790784
申请日：2002-12-16
申请人： NIPPON KAYAKU KK
发明人： NAGAI MASASHI , YAMAZAKI HIROKO , YAMAMOTO KEIICHIROU , ABE MASATOSHI
IPC分类号： C07F9/553 , C07B57/00 , C07C215/30 , C07F9/568 , C07F9/572 , C07F9/59
CPC分类号： C07C215/30 , C07B2200/07 , C07F9/5532 , C07F9/5683 , C07F9/5721 , C07F9/591 , Y02P20/55
摘要： A process for preparation of compounds represented by the general formula (5): (5) [wherein n is an integer of 0 to 3; and Y is an amino-protecting group], which comprises making a silylating agent act on a compound represented by the general formula (3): (3) and then reacting the resulting compound with P(=O)T3 (wherein T is halogeno) and ammonia successively; and a process for preparation of sulphostin or analogues thereof as represented by the general formula (8): (8) [wherein C* and P* each independently take S- or R -configuration], which comprises forming a diastereomeric salt by the use of an optically active amine and resolving this salt by fractional crystallization.

4. 发明授权

EP1339723B1 PROCESS AND ESTER DERIVATIVES USEFUL FOR PREPARATION OF CEPHALOSPORINS 有权
标题翻译：方法和酯衍生物用于制备CEPHALOSPHORINEN
公开(公告)号：EP1339723B1
公开(公告)日：2006-03-08
申请号：EP01999226.2
申请日：2001-11-19
申请人： Pfizer Products Inc.
发明人： COLBERG, J. C., Pfizer Global Res. and Developmt. , TUCKER, J. L., Pfizer Global Res. and Devlpomt. , ZENONI, M., ACS Dobfar S.p.A. , FOGLIATO, Giovanni, ACS Dobfar S.p.A. , DONADELLI, Alessandro, ACS Dobfar S.p.A. , NAGAKURA, Isao , MORITA, Hiromasa , MATSUO, Hideyuki
IPC分类号： C07D501/08 , C07D501/18 , C07D501/20 , C07D405/12 , C07F9/568 , C07D205/095 , C07D513/04 , C07D277/00 , C07D205/00
CPC分类号： C07D405/12 , C07D205/095 , C07D501/00 , C07D513/04 , C07F9/5683 , C07F9/65586
摘要： This invention relates a process for preparing a compound of formula (I) wherein R1 is para-nitrobenzyl or allyl; and X is halo, which is useful to prepare 3-cyclic-ether-substituted cephalosporins, from trimethylphosphinic compounds. This invention also relates to compounds useful in such process.

5. 发明授权

EP0581501B1 Antibiotic carbapenem compounds 有权
标题翻译：抗生素Carbapenemverbindungen
公开(公告)号：EP0581501B1
公开(公告)日：1998-09-09
申请号：EP93305608.7
申请日：1993-07-16
申请人： ZENECA LIMITED , ZENECA Pharma S.A.
发明人： Jung, Frederic Henri
IPC分类号： C07D477/00 , C07F9/568 , C07D401/12 , C07D401/14 , A61K31/40
CPC分类号： C07D477/20 , C07D401/12 , C07D401/14 , C07F9/5683

6. 发明公开

EP0820230A1 HERBICIDAL AZA BISPHOSPHONIC ACIDS AND COMPOSITIONS CONTAINING THE SAME 失效
标题翻译：除草剂AZA双膦和含组合物
公开(公告)号：EP0820230A1
公开(公告)日：1998-01-28
申请号：EP96911660.0
申请日：1996-04-08
申请人： ZENECA LIMITED
发明人： FISHER, Karl, J. , WOOLARD, Frank, X. , LEADBETTER, Michael, R. , GERDES, John, M.
IPC分类号： A01N57 , C07F9
CPC分类号： C07F9/5532 , A01N57/18 , C07F9/3873 , C07F9/405 , C07F9/5683 , C07F9/5721 , C07F9/5722 , C07F9/582 , C07F9/588 , C07F9/591 , C07F9/592 , C07F9/60 , C07F9/65032 , C07F9/65061 , C07F9/65062 , C07F9/65121 , C07F9/65181 , C07F9/6533
摘要： Herbicidal compositions containing a bisphosphonic acid compound of formula (I) wherein n is 1, 2, 3, 4, 5 or 6, or an agrochemically acceptable salt or hydrolyzable ester thereof and methods of controlling undesirable plant growth using these bisphosphonic acid containing compositions. The herbicidal compositions exhibit desirable efficacy when applied to plants post-emergence, but exhibit little significant activity when applied to plants pre-emergence. Novel aza-bisphosphonic acid compounds are also disclosed.

7. 发明授权

EP0232966B1 Process for the preparation of penem compounds and intermediates for this preparation 有权转让
标题翻译：一种用于生产青霉烯衍生物和中间体的对该制备方法
公开(公告)号：EP0232966B1
公开(公告)日：1997-10-08
申请号：EP87300193.7
申请日：1987-01-09
申请人： BEECHAM GROUP PLC
发明人： Coulton, Steven , Harbridge, John Barry , Osborne, Neal Frederick , Walker, Graham
IPC分类号： C07D499/00
CPC分类号： C07D417/12 , C07D205/09 , C07D499/88 , C07F9/5683

8. 发明公开

EP0581502A1 Antibiotic carbapenem compounds 失效
标题翻译：抗生素碳青霉烯
公开(公告)号：EP0581502A1
公开(公告)日：1994-02-02
申请号：EP93305609.5
申请日：1993-07-16
申请人： ZENECA LIMITED , ZENECA Pharma S.A.
发明人： Jung, Frederic Henri , Lohmann, Jean Jacques
IPC分类号： C07D477/00 , C07F9/568 , C07D417/12 , C07D403/12 , C07D207/34 , C07D417/14 , C07D403/14 , A61K31/40
CPC分类号： C07D477/20 , C07D207/34 , C07D403/12 , C07D403/14 , C07D417/12 , C07D417/14 , C07F9/5683
摘要： The present invention relates to carbapenems and provides a compound of the formula (I)

wherein :

R 1 is i-hydroxyethyl, 1-fluoroethyl or hydroxymethyl ;
R 2 is hydrogen or C 1-4 alkyl;
R 3 is hydrogen or C 1-4 alkyl;
A is a 5-membered heteroaryl ring containing one nitrogen atom and up to two additional heteroatoms selected from nitrogen, oxygen and sulphur ; and is bonded to the nitrogen of the linking carbamoyl group by a carbon atom in the ring, is substituted with the carboxy group on a carbon atom in the ring and is optionally further substituted on a carbon atom in the ring ; and

in any ring -NH-, H is optionally replaced by C 1-4 alkyl;
or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof. Processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them are also described.
摘要翻译：本发明涉及碳青霉烯并提供式（I）化合物其中：R 1是1-羟乙基，1-氟乙基或羟甲基; R 2是氢或C 1-4烷基; R 3是氢或C 1-4烷基; A是含有一个氮原子和多达两个另外选自氮，氧和硫的杂原子的5元杂芳基环; 并且通过环中的碳原子与连接的氨基甲酰基的氮键合，被环中的碳原子上的羧基取代，并且任选地在环中的碳原子上进一步取代; 并且在任何环-NH-中，H任选被C 1-4烷基取代; 或其药学上可接受的盐或体内可水解的酯。还描述了其制备方法，其制备中的中间体，它们作为治疗剂的用途和含有它们的药物组合物。

9. 发明公开

EP0521203A1 Improved process for recovering organic vapors from air 失效
标题翻译： Verfahren zurRückgewinnung组织者Dämpfeaus Luft。
公开(公告)号：EP0521203A1
公开(公告)日：1993-01-07
申请号：EP91305901.0
申请日：1991-06-28
申请人： E.I. DU PONT DE NEMOURS AND COMPANY
发明人： Lee, Kung Hsing
IPC分类号： B01D53/22 , B01D53/04
CPC分类号： C07D477/04 , C07D205/08 , C07D477/10 , C07F7/186 , C07F9/5683
摘要： A process for separating and recovering organic vapors (e.g., chlorofluorocarbons) from a feed stream of organic vapors and air wherein organic vapors are present in the "window concentration" range being too high for conventional carbon adsorption and too low for efficient compression/condensation recovery. By passing the organic vapor and air feed stream through the feed side of a semipermeable membrane unit, a vapor depleted stream exiting the membrane unit can then be processed by conventional carbon adsorption while a vapor enriched stream from the membrane unit can be processed by conventional compression and condensation.
摘要翻译：从有机蒸汽和空气的进料流中分离和回收有机蒸气（例如氯氟烃）的方法，其中有机蒸气存在于“窗口浓度”范围内对于常规碳吸附来说太高，而对于有效的压缩/冷凝回收来说太低。通过将有机蒸汽和空气进料流通过半透膜单元的进料侧，可以通过常规的碳吸附来处理离开膜单元的蒸气贫化物流，同时来自膜单元的蒸气富集流可以通过常规压缩和冷凝。

10. 发明公开

EP0510066A1 1-AZETIDYL AND 1-HEXAMETHYLENIMINE ALKYL OR ARYL BISPHOSPHONIC ACIDS AND THEIR USE AS PHARMACOLOGICAL AGENTS 失效
标题翻译： 1 - 六亚甲基亚胺-1氮杂环丁烷基或芳二膦酸及其作为代理药理
公开(公告)号：EP0510066A1
公开(公告)日：1992-10-28
申请号：EP91902492.0
申请日：1991-01-03
申请人： RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC.
发明人： YOUSSEFYEH, Raymond, D. , CHENEY, Daniel, L. , BURNS, Christopher, J.
IPC分类号： A61K31 , A61P3 , A61P29 , A61P43 , C07F9
CPC分类号： C07F9/5683 , C07F9/5532 , C07F9/6561
摘要： L'invention se rapporte à des composés comprenant: (A) un groupe terminal d'acide bisphosphonique, (B) un groupe terminal azacyclique dérivé d'azétidine ou d'hexaméthylènimine; et (C) un groupe alkyle/ou aryle reliant le groupe d'acide bisphosphonique et le groupe azacyclique entre eux par l'intermédiaire de l'atome d'azote du groupe azacyclique. Ces composés sont utiles comme agents régulateurs du métabolisme d'ions polyvalents, en particulier du calcium. Cette invention se rapporte également à des préparations pharmaceutiques contenant ces composés, ainsi qu'à des procédés de traitement, au moyen de ces composés, d'états dans lesquels est impliqué un tel métabolisme.
摘要翻译：本发明涉及包含以下的化合物：（A）末端双膦酸基团，（B）衍生自氮杂环丁烷或六亚甲基亚胺的氮杂端基; 和（C）通过氮杂环基的氮原子将双膦酸基和氮杂环基彼此连接的烷基或芳基。这些化合物可用作多价离子代谢的调节剂，特别是钙。本发明还涉及含有这些化合物的药物制剂，以及使用这些化合物治疗涉及这种代谢的病症的方法。

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