专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP0819682A1 Use of novel organoselenium compounds as pro-oxidizing agents, their methods of preparation and pharmaceutical compositions and application containing them 失效
标题翻译：有机硒衍生物作为促氧化剂，它们的制备和含有它们的药物组合物的使用
公开(公告)号：EP0819682A1
公开(公告)日：1998-01-21
申请号：EP97401648.7
申请日：1997-07-09
申请人： Oxis International S.A.
发明人： Xu, Jinzhu , Appere, Georges , Chaudiere, Jean , Yadan, Jean-Claude
IPC分类号： C07D293/12 , C07D293/10 , C07J51/00
CPC分类号： C07D293/12 , C07D293/10 , C07J51/00
摘要： Compounds represented by the following formula I:
in which:
R 1 to R 5 can have various meanings of which alkyl, substituted or non-substituted aryl, and m is equal to 0 or 1, X is selected from (CR 6 R 7 ) n in which n = 0 or 1, and CO are disclosed. These compounds are useful as anti-tumor drugs, especially with pro-oxidizing activity.
摘要翻译：其中：：由下式I表示化合物中，R <1>至R <5>可以具有烷基，substituiertem或非substituiertem芳基的各种含义，并且m是等于0或1，X被选择从（CR <6> - [R <7>）n，其中n = 0或1，和CO是游离缺失盘。这些化合物可用作抗肿瘤药，阁楼亲氧化活性是有用的。

2. 发明授权

EP0138481B1 Leukotriene biosynthesis inhibitors 失效
标题翻译：白蛋白生物合成抑制剂
公开(公告)号：EP0138481B1
公开(公告)日：1991-06-26
申请号：EP84306639.0
申请日：1984-09-28
申请人： MERCK FROSST CANADA INC.
发明人： Fortin, Rejean , Guindon, Yvan , Lau, Cheuk K , Rokach, Josua , Yoakim, Christiane
IPC分类号： C07D279/10 , C07D265/38 , C07D293/10 , A61K31/54 , A61K31/535 , A61K31/33
CPC分类号： C07D265/38 , C07D279/20 , C07D279/22 , C07D279/30 , C07D279/34 , C07D293/10

3. 发明授权

EP0136847B1 Photographically useful chalcogenazolylidene and chalcogenazolium dyes and methods for their preparation 失效
标题翻译：摄影用途的氯化胆碱和氯普鲁诺氏染料及其制备方法
公开(公告)号：EP0136847B1
公开(公告)日：1990-01-17
申请号：EP84306080.7
申请日：1984-09-06
申请人： EASTMAN KODAK COMPANY (a New Jersey corporation)
发明人： Gunther, Wolfgang H. , Przyklek, Rosemary , Leone, Ronald E.
IPC分类号： C07D293/10 , G03C1/34 , G03G5/09
CPC分类号： G03G5/09 , C07D293/10 , G03C1/12 , G03C1/346 , G03G5/0631 , G03G5/067

4. 发明授权

EP0138362B1 Photographic materials containing chalcogenazoles, chalcogenazolines and chalcogenazolinium and chalcogenazolium salts 失效
标题翻译：含有氯化钠，氯化钠和氯化钠和樟脑磺酸钠的摄影材料
公开(公告)号：EP0138362B1
公开(公告)日：1989-02-22
申请号：EP84306081.5
申请日：1984-09-06
申请人： EASTMAN KODAK COMPANY (a New Jersey corporation)
发明人： Gunther, Wolfgang H. , Przyklek, Rosemary , Leone, Ronald E.
IPC分类号： C07D293/10 , G03C1/34 , G03G5/09
CPC分类号： G03G5/09 , C07D293/10 , G03C1/12 , G03C1/346 , G03G5/0631 , G03G5/067

5. 发明公开

EP0138362A3 Photographic materials containing chalcogenazoles, chalcogenazolines and chalcogenazolinium and chalcogenazolium salts 失效
标题翻译：含有化学气相色谱法测定的照相材料，氯化钠和氯化钠和氯化钠盐
公开(公告)号：EP0138362A3
公开(公告)日：1985-06-05
申请号：EP84306081
申请日：1984-09-06
申请人： EASTMAN KODAK COMPANY (a New Jersey corporation)
发明人： Gunther, Wolfgang H. , Przyklek, Rosemary , Leone, Ronald E.
IPC分类号： C07D293/10 , G03C01/34 , G03G05/09
CPC分类号： G03G5/09 , C07D293/10 , G03C1/12 , G03C1/346 , G03G5/0631 , G03G5/067
摘要： Tellurazolium and derivative compounds are disclosed which can be usefully employed as dyes, antifoggants or stabilizers, nucleating agents, latent image keeping addenda, or speed or contrast altering addenda in silver halide photographic systems.

6. 发明公开

EP0115394A2 Phenothiazone derivatives and analogs 失效
标题翻译：吩噻嗪衍生物
公开(公告)号：EP0115394A2
公开(公告)日：1984-08-08
申请号：EP84300239.5
申请日：1984-01-16
申请人： MERCK FROSST CANADA INC.
发明人： Guindon, Yvan , Fortin, Rejean , Lau, Cheuk K. , Rokach, Joshua , Yoakim, Christiane
IPC分类号： A61K31/54 , A61K31/535 , A61K31/495 , C07D279/18 , C07D265/38 , C07D241/46 , C07D293/10 , C07D279/34 , C07D279/36 , C07D265/34
CPC分类号： C07D293/10 , A61K31/495 , A61K31/535 , A61K31/54 , C07C46/06 , C07D241/46 , C07D265/34 , C07D265/38 , C07D279/18 , C07D279/34 , C07D279/36 , C07C50/28
摘要： Phenothiazine compounds of formula
where

X is in the 1 or 3 position and is O, S or NR;
R is H, C 1 -C 6 branched or linear alkyl, CN or phenyl;
Y is 0, Se, S, SO, SO 2 or NR; and the broken line represents an optional double bond between the 1 and 2 or 2 and 3 position;
each of R 1 , R 2 , R 3 and R 4 , independently of the others, is

(1) hydrogen
(2) C 1-6 alkyl,
(3) C 2-6 alkenyl,
(4) -(CH 2 ) n M
where n is 0 or an integer from 1 to 6 and M is

(a) OR 5 ,
(b) halogen,
(c) CF 3 ,
(d) SR 5 where R 5 is H;
alkoxyalkyl; acyloxyalkyl; C 1-6 alkyl; benzyl;
phenyl or substituted phenyl where the substituents are C 1-3 alkyl, halogen, CN, CF 3 , COOR 6 , CH 2 COOR 6 , (CH 2 ) n NR 8 R 9 where n is 0, 1 or 2, C 1-3 alkoxy, OH, C 1-6 haloalkyl, -(CH 2 ) m COOR 6 , where m is 0 or an integer from 1 to 6 and R 6 is H, phenyl or C 1-6 alkyl; CN, formyl; perfluoroalkyl; or CH 2 -R 12 , where R 12 is C 1-5 alkyl, phenyl or dimethylamino;
(e) phenyl or substituted phenyl as defined above for R 5 ;
(f) COOR 6 ;
(g)
where R 14 is H, (CH 2 ) n COOR 6 where n is 0 or an integer from 1 to 4, C 1-6 alkyl, CF 3 , phenyl, or substituted phenyl as defined above for R 5 ;
(h) tetrazole;
(i)
where R 7 is C 1-8 alkyl, benzyl or phenyl;
(j) -NR 8 R 9 where R e and R 9 are independently selected from H, phenyl or substituted phenyl as defined above for R 5 , C 1 -C 4 alkyl or C 1 -C 4 alkylaminoalkyl, or are joined through the N to form a heterocycloalkyl of 5-8 ring atoms;
(k) -NHSO 2 R 10 where R 10 is OH, C 1 -C 6 alkyl, C 1 -C 6 - alkoxy, phenyl or CF 3 ;

(m) -SOR 11 where R 11 is C 1 -C 6 alkyl, phenyl or substituted phenyl as defined above for R 5 , (CH 2 ) m COOR 6 where m is 1 to 6, CN, formyl or C 1-4 perfluoroalkyl;

(p) -SO 2 R 13 where R 13 is OH, H, C 1 -C 6 alkyl, phenyl or substituted phenyl as defined above for R 5 , (CH 2 ) m COOR 6 where m is 1 to 6, CN or C 1-4 perfluoroalkyl;
(q) NO 2 ;
(r)

(s)

(t)

(u) -CN; or
(v) NR 15 R 16 where R 15 and R 16 are such that HNR 15 R 16 is an essential amino acid;

or any two of R 1 , R 2 , R 3 and R 4 are joined to form a fourth saturated or unsaturated C 5-6 ring, and T is H, halogen or CF 3 . are useful as inhibitors of mammalian leukotriene biosynthesis and therefore are useful therapeutic agents for treatng pain, skin conditions, allergic conditions, pulmonary conditions, asthma, cardiovascular disorders and inflammation. They are included in pharmaceutical compositions. Certain of the compounds are novel.
摘要翻译：其中X为1或3位，为O，S或NR的式的吩噻嗪化合物; R是H，C 1 -C 6支链或直链烷基，CN或苯基; Y是O，Se，S，SO，So2或NR; 虚线表示1和2或2和3位之间的可选双键; （1）氢（2）C 1-6烷基，（3）C 2-6烯基，（4） - （CH 2）n nM，其中n是O或一个或多个，其中R 1，R 2，R 3和R 4独立地是 1至6的整数，M为（a）OR 5，（b）卤素，（c）CF 3，（d）SR 5，其中R 5为H; 烷氧基; 酰氧基; C 1-6烷基; 苄基; 苯基或取代的苯基，其中取代基是C 1-3烷基，卤素，CN，CF 3，COOR 6，CH 2 COOR 6，（CH 2）n NR 8 R 9，其中n是0,1或2，C 1-3烷氧基，OH，C 1-6卤代烷基 - （ CH2）mCOOR6，其中m为0或1-6的整数，R6为H，苯基或C1-6烷基; CN，甲酰基; 全氟烷基; 或CH 2 -R 12，其中R 12是C 1-5烷基，苯基或二甲基氨基; （e）如R5所定义的苯基或取代的苯基; （f）COOR6; （g）@ -R14其中R14是H，（CH2）n COOR6，其中n是0或1-4的整数，C1-6烷基，CF3，苯基或如对R5的定义的取代的苯基; （h）四唑; （i）-NH-R 7，其中R 7是C 1-6烷基，苄基或苯基; （j）-NR 8 R 9，其中R 8和R 9独立地选自H，苯基或如上定义的对于R 5，C 1 -C 4烷基或C 1 -C 4烷基氨基烷基的取代的苯基，或者通过N连接形成5-8环的杂环烷基原子; （k）-NHSO 2 R 10，其中R 10是OH，C 1 -C 6烷基，C 1 -C 6 - 烷氧基，苯基或CF 3：（1） - [ - CH 2 OH] （m）-SOR 11其中R11是C1-C6烷基，如R5所定义的苯基或取代的苯基，（CH2）mCOOR6，其中m为1-6，CN，甲酰基或C1-4全氟烷基; （n）-CONR 8 R 9; （o）-SO 2 NR 8 R 9; （p）-SO 2 R 13，其中R 13是OH，H，C 1 -C 6烷基，苯基或如上对R 5所定义的取代的苯基，（CH 2）m COOR 6，其中m为1至6，CN或C 1-4全氟烷基; （q）NO2; （R）-O - @ -R14; （S）-O - @ - NR8R9; （t）-O - ， - OR 7：（u）-CN; 或（v）NR 15，R 16，其中R 15和R 16使得HNR 15 R 16是必需氨基酸; 或任何两个R 1，R 2，R 3和R 4连接形成第四饱和或不饱和的C 5-6环，并且T为H，卤素或CF 3，可用作哺乳动物白三烯双向合成的抑制剂，因此可用于治疗疼痛的治疗剂，皮肤状况，过敏状况，肺部疾病，哮喘，心血管疾病和炎症。它们被包括在药物组合物中。某些化合物是新颖的。

7. 发明授权

EP0701554B1 NOUVEAUX COMPOSES DE STRUCTURE BENZISOSELEN-AZOLIN ET -AZINE, LEUR PROCEDE DE PREPARATION ET LEURS APPLICATIONS THERAPEUTIQUES 失效
标题翻译： BENZISOSELEN-azolines和嗪衍生物，工艺及其使用及其治疗
公开(公告)号：EP0701554B1
公开(公告)日：2001-06-27
申请号：EP95916723.0
申请日：1995-04-07
申请人： OXIS Isle of Man, Limited
发明人： ERDELMEIER, Irène , CHAUDIERE, Jean , MOUTET, Marc , YADAN, Jean-Claude
IPC分类号： C07D293/12 , C07D293/10 , C07D421/12 , A61K31/41
CPC分类号： C07D293/10 , C07D293/12 , Y10T436/108331

8. 发明公开

EP0948500A1 CYCLIC ORGANOSELENIUM COMPOUNDS, THEIR PREPARATION AND THEIR USES 失效
标题翻译：循环ORGANOSELENDERIVATE，生产和使用
公开(公告)号：EP0948500A1
公开(公告)日：1999-10-13
申请号：EP97954472.0
申请日：1997-12-23
申请人： OXIS Isle of Man, Limited
发明人： ERDELMEIER, Irène , TAILHAN-LOMONT, Catherine , MOUTET, Marc , CHAUDIERE, Jean , YADAN, Jean-Claude
IPC分类号： A61K31 , A61P1 , A61P9 , A61P11 , A61P27 , A61P31 , A61P39 , A61P43 , C07D293 , C07D329 , C07D343 , C07D517
CPC分类号： C07D517/04 , C07D293/10 , C07D293/12 , C07D329/00 , C07D343/00
摘要： The objects of the present invention are: novel cyclic organoselenium compounds; the use of said novel compounds as antioxidant; pharmaceutical compositions containing them; and a method of preparation of said novel compounds. Said novel cyclic organoselenium compounds have general formula (I).

9. 发明公开

EP0701554A1 NOUVEAUX COMPOSES DE STRUCTURE BENZISOSELEN-AZOLIN ET -AZINE, LEUR PROCEDE DE PREPARATION ET LEURS APPLICATIONS THERAPEUTIQUES 失效
标题翻译： BENZISOSELEN-azolines和嗪衍生物，工艺及其使用及其治疗
公开(公告)号：EP0701554A1
公开(公告)日：1996-03-20
申请号：EP95916723.0
申请日：1995-04-07
申请人： OXIS INTERNATIONAL S.A.
发明人： ERDELMEIER, Irène , CHAUDIERE, Jean , MOUTET, Marc , YADAN, Jean-Claude
IPC分类号： A61K31 , A61P9 , A61P11 , A61P27 , A61P29 , A61P37 , A61P43 , C07D293 , C07D421 , C12N5
CPC分类号： C07D293/10 , C07D293/12 , Y10T436/108331
摘要： Novel benzisoselen-azoline and -azine derivatives of general formula (II), wherein R?1-R8 and R10¿ have various meanings, especially H, alkyl, etc...; R9 is (a); Y- is a pharmaceutically acceptable acid anion; n = 0 or 1; m = 0, 1 or 2; p = 1, 2 or 3; q = 2, 3 or 4; r = 0 or 1; and pharmaceutically acceptable acid or base salts thereof; with the proviso that there is at most one substituent R9 within each molecule of general formula (II). Said novel derivatives are useful as a drug.

10. 发明公开

EP0312122A1 Tellurazolylidene and tellurazolium dye intermediates 失效
标题翻译： Tellurazolylidene和tellurazolium染料中间体
公开(公告)号：EP0312122A1
公开(公告)日：1989-04-19
申请号：EP88118411.3
申请日：1984-09-06
申请人： EASTMAN KODAK COMPANY (a New Jersey corporation)
发明人： Gunther, Wolfgang H. , Przyklek, Rosemary , Leone, Ronald E.
IPC分类号： C07D293/10
CPC分类号： C07D293/10 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/102 , C09B23/105 , C09B23/107 , C09B23/145 , G03G5/0633 , G03G5/067
摘要： A compound containing an aromatic ring and, fused with the aromatic ring, a five or six membered ring containing a chalcogen atom, a nitrogen atom, and an oxygen atom bonded to the chalcogen atom and interposed between the chalcogen and nitrogen atoms characterized by the chalcogen atom being a tellurium atom.
摘要翻译：一种含有芳环并与芳环稠合的五元或六元环的化合物，该五元或六元环包含硫族原子，氮原子和与硫属元素原子键合的氧原子并介于硫族元素和氮原子之间，其特征在于硫族元素原子是碲原子。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式