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1. 发明公开

EP1724263A1 BASIC AMINE COMPOUND AND USE THEREOF 有权
标题翻译： BASISCHE AMINVERBINDUNG UND DEREN VERWENDUNG
公开(公告)号：EP1724263A1
公开(公告)日：2006-11-22
申请号：EP05720460.4
申请日：2005-03-10
申请人： Kureha Corporation
发明人： SAITOU, Atsushi Biomed.Res.Lab. Kureha Corporation , KIKUMOTO, Shigeyuki Biome. Res.Lab. Kureha Corp. , ONO, Masahiro Biomed. Res.Lab. Kureha Corporation , MATSUI, Ryo Biomed. Res.Lab. Kureha Corporation , YAMAMOTO, Masashi Biomed. Res.Lab. Kureha Corp. , SAWA, Tomohiro Biomed. Res.Lab. Kureha Corporation , SUZUKI, Shigeru Biomed.Res.Lab. Kureha Corporation , YANAKA, Mikiro Biomed. Res.Lab. Kureha Corporation
IPC分类号： C07D233/64
CPC分类号： C07D403/12 , C07D263/64 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Novel amine compounds which are represented by the following formula (1) and efficacious against diseases such as a viral infectious disease with HIV, rheumatism, and cancer metastasis;

typically, A 1 and A 2 represent a hydrogen atom or a substitutable monocyclic or polycyclic heteroaromatic ring and W represents a substitutable benzene ring or any group represented by the following formula (10) or (11):

where
X represents O, CH 2 , C(=O), NR 11 , or CHR 35 and D represents a group represented by the following formula (6):

where
Q represents a single bond, NR 12 , or a group represented by the formula (13):

and Y represents a group represented by the following formula (7) :

where
z represents a substitutable monocyclic or polycyclic aromatic ring; and
B represents -NR 25 R 26 ; and R 1 to R 26 in the above formulae represent a hydrogen atom, an alkyl group, an alkenyl group, or an alkynyl group.
摘要翻译：新型胺化合物，其由下式（1）表示，对HIV，风湿病和癌症转移等病毒感染性疾病有效; 通常，A 1和A 2表示氢原子或可取代的单环或多环杂芳族环，W表示可取代的苯环或由下式（10）或（11）表示的任何基团：其中X表示O，CH 2， C（= O），NR 11或CHR 35，D表示由下式（6）表示的基团：其中Q表示单键，NR 12或由式（13）表示的基团：Y表示由下式（7）表示的基团：其中z表示可取代的单环或多环芳环; B表示-NR 25 R 26; 上述式中的R 1至R 26表示氢原子，烷基，烯基或炔基。

2. 发明公开

EP1283205A1 NAPHTHOL DERIVATIVES 有权
标题翻译： NAPHTHOLDERIVATE
公开(公告)号：EP1283205A1
公开(公告)日：2003-02-12
申请号：EP01930124.1
申请日：2001-05-15
申请人： KABUSHIKI KAISHA UENO SEIYAKU OYO KENKYUJO
发明人： UENO, Ryuzo , KITAYAMA, Masaya , MINAMI, Kenji , WAKAMORI, Hiroyuki
IPC分类号： C07D263/56 , C07D263/60 , C07D263/62 , C07D277/66 , C07D235/18 , C07D417/10 , C07D413/10 , C07D413/14 , C07D519/00 , C07D498/04
CPC分类号： C07D263/52 , C07D235/18 , C07D263/57 , C07D263/60 , C07D263/64 , C07D277/66 , C07D413/10 , C07D417/10
摘要： Novel naphthol derivatives, and various azo compounds and metal complexes prepared by using the derivatives are provided.
The instant invention provides naphthol derivatives represented by general formula (1);
wherein at least one of Y 1 and Y 2 is a group represented by formula (2);
wherein X 1 is -O-, -S- or -NH-; and Z is an optionally substituted aromatic group or heterocyclic group having conjugated double bonds,
and salts thereof; mono-, bis-, and trisazo compounds prepared from the derivatives; and metal complexes containing the derivatives as the ligand.
摘要翻译：提供新型萘酚衍生物，以及通过使用衍生物制备的各种偶氮化合物和金属络合物。本发明提供由通式（1）表示的萘酚衍生物。＆lt; CHEM＆gt;其中Y 1和Y 2中的至少一个是由式（2）表示的基团。其中X1是-O - ， - S-或-NH-; Z是任选取代的具有共轭双键的芳族基团或杂环基团及其盐; 由衍生物制备的单，双和三偶氮化合物; 和含有衍生物作为配体的金属络合物。

3. 发明公开

EP0246551A2 Sulfonat- oder Sulfonamidgruppen-haltige Bis-benzoxazolylnaphthaline, Verfahren zu deren Herstellung und deren Verwendung 失效
标题翻译：磺酸盐或含磺酰胺 - 双 - benzoxazolylnaphthaline，它们的制备方法和它们的用途。
公开(公告)号：EP0246551A2
公开(公告)日：1987-11-25
申请号：EP87106916.7
申请日：1987-05-13
申请人： HOECHST AKTIENGESELLSCHAFT
发明人： Schinzel, Erich, Dr. , Frischkorn, Hans, Dr. , Martini, Thomas, Dr.
IPC分类号： C07D263/62 , C08K5/35
CPC分类号： C07D263/64
摘要： Verbindungen der allgemeinen Formel
in welcher
n 1 oder 2,
X eine OMe-Gruppe,
Me ein Proton, ein Alkalimetallkation oder ein gegebenenfalls substituiertes Ammoniumkation,
R Wasserstoff, eine niedere Alkylgruppe oder Halogen und für den Fall, daß
n gleich 1 ist,
X auch eine -NR¹R²-Gruppe, wobei R¹ und R² für Wasserstoff oder eine niedere Alkylgruppe steht, bedeuten,
Verfahren zu deren Herstellung und deren Verwendung als Optische Aufheller, insbesondere für Polyamidfasern und Wolle.
摘要翻译：式其中，n是1或2的化合物中，X为OMe基，Me是质子，碱金属阳离子或任选取代的铵阳离子，R为氢，低级烷基或卤素，并且如果n是等于1 中，X是-NR¹R²基团，其中R 1和R 2是氢或低级烷基，它们的制备方法和它们作为荧光增白剂为聚酰胺纤维和羊毛用途，特别是。

4. 发明公开

EP0125702A3 Polycyclic aromatic compounds 失效
标题翻译：多环芳香化合物
公开(公告)号：EP0125702A3
公开(公告)日：1985-03-13
申请号：EP84105585
申请日：1984-05-16
申请人： THE WELLCOME FOUNDATION LIMITED
发明人： Bair, Kenneth Walter
IPC分类号： C07C91/10 , C07C93/04 , C07C93/14 , C07C91/14 , C07C89/00 , C07C47/575 , A61K31/13 , A61K31/645 , A61K31/12 , C07C119/10 , C07C103/78
CPC分类号： A61K31/045 , C07C205/15 , C07C215/10 , C07C215/28 , C07C215/42 , C07C217/48 , C07C217/58 , C07C255/58 , C07C317/32 , C07C323/32 , C07C2601/14 , C07C2603/24 , C07C2603/26 , C07C2603/40 , C07C2603/42 , C07C2603/48 , C07C2603/50 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/52 , C07D263/64 , C07D295/135 , C07D309/12 , C07D319/06 , C07J63/008 , Y10S514/908
摘要： Compounds of the formula (I)
or monomethyl or monoethyl ethers thereof, the compounds including their ethers containing no more than 28 carbon atoms in total, or esters or salts thereof; wherein Ar is selected from the group comprising:
optionally substituted by one or two substituents which taken together contain not more than four carbon atoms in total and which are the same or different and are selected from halo; cyano; Ci-3 alkyl or Ci- 3 alkoxy each optionally substituted by hydroxy or C 1-2 alkoxy; halo substituted C 1-2 alkyl or C 1-2 alkoxy; a group S(O)nR 5 wherein n is an integer 0,1 or 2 and R 5 is C 1-2 alkyl optionally substituted by hydroxy or C 1-2 alkoxy; or Ar is optionally substituted by a group NR 6 R 7 containing not more than 5 carbon atoms wherein R 6 and R 7 are the same or different and each is a C 1-3 alkyl group or NR 6 R 7 forms a five or six membered heterocyclic ring optionally containing one or two additional hetero atoms; R' is Ci-3 alkyl substituted by hydroxy; R 2 is hydrogen, C 1-3 alkyl or hydroxymethyl; R 3 and R 4 are the same or different and each is hydrogen, methyl or ethyl; R 1 , R 2 , R 3 and R 4 taken together containing not more than five carbon atoms; or the group:
wherein -C-C- is a five or six membered saturated carbocyclic ring containing two or three hydroxy groups; R a is hydrogen, methyl or hydroxymethyl; R 9 and R 10 are the same or different and each is hydrogen or methyl; R 11 is hydrogen, hydroxy, methyl or hydroxymethyl; R 5 , R 9 , R 10 , R 11 and the -C-C- ring taken together containing less than seven carbon atoms which have biocidal, and particularly antitumour, activity are described as are methods for their preparation, their use in medicine and pharmaceutical formulations containing them.
摘要翻译：式（I）化合物或其单甲醚或单乙醚，其中包括总共不超过28个碳原子的醚，或其酯或盐; 其中Ar选自包括以下的基团：任选地被一个或两个取代基取代的取代基，它们总共包含不超过四个碳原子，并且相同或不同并且选自卤素; 氰基; 各自任选被羟基或C 1-2烷氧基取代的C 1-3烷基或C 1-3烷氧基; 卤素取代的C 1-2烷基或C 1-2烷氧基; S（O）n R 5基团，其中n是整数0,1或2，R 6是任选被羟基或C 1-2烷氧基取代的C 1-2烷基; 或Ar任选被含有不多于5个碳原子的基团NR 6 R 7取代，其中R 6和R 7相同或不同，并且各自为C 1-3烷基或NR' 6> R 7形成任选地含有一个或两个另外的杂原子的五元或六元杂环; R 1是被羟基取代的C 1-3烷基; R 2是氢，C 1-3烷基或羟甲基; R 3和R 4相同或不同，各自为氢，甲基或乙基; R 1，R 2，R 3和R 4一起含有不超过5个碳原子; 或组; 其中 - @@@ - 是含有两个或三个羟基的五或六元饱和碳环; R 8是氢，甲基或羟甲基; R 9和R 1相同或不同，各自为氢或甲基; R 1是氢，羟基，甲基或羟甲基; R 8，R 9，R 1，O，R 1，和 - @@-环一起含有少于7个具有杀生物活性的碳原子，特别是抗肿瘤活性被描述为它们的制备方法，它们在医药中的应用和含有它们的药物制剂。

5. 发明公开

EP0125701A3 Polycyclic aromatic compounds 失效
标题翻译：多环芳香化合物
公开(公告)号：EP0125701A3
公开(公告)日：1985-03-13
申请号：EP84105584
申请日：1984-05-16
申请人： THE WELLCOME FOUNDATION LIMITED
发明人： Bair, Kenneth Walter
IPC分类号： C07C91/10 , C07C91/04 , C07C93/187 , C07C93/04 , C07C91/14 , C07C89/00 , A61K31/13 , A61K31/645 , A61K31/22 , C07C119/10 , C07C103/78
CPC分类号： A61K31/045 , C07C205/15 , C07C215/10 , C07C215/28 , C07C215/42 , C07C217/48 , C07C217/58 , C07C255/58 , C07C317/32 , C07C323/32 , C07C2601/14 , C07C2603/24 , C07C2603/26 , C07C2603/40 , C07C2603/42 , C07C2603/48 , C07C2603/50 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/52 , C07D263/64 , C07D295/135 , C07D309/12 , C07D319/06 , C07J63/008 , Y10S514/908
摘要： Compounds of the formula (I)
or monomethyl or monoethyl ethers thereof, the compounds of formula (I) including their ethers containing no more than 30 carbon atoms in total, or esters or salts thereof; wherein Aris perylene,fluoranthene, chrysene, pyrene or triphenylene, optionally substituted by one or two substituents, or when Ar is anthracene or phenanthrene optionally substituted by one, two or three substituents; said substituents containing not more than four carbon atoms in total when taken together being the same or different and are selected from halogen; cyano; C 1-4alkyl or C 1-4alkoxy , each optionally substituted by hydroxy or C 1-2alkoxy ; halogen substituted C l - 2 alkyl or C 1 - 2 alkoxy; halogen substituted Ci-2 alkyl or C 1-2alkoxy ; a group S(O)nR 2 wherein n is an integer 0,1 or 2 and R 2 is C 1-2alkyl optionally substituted by hydroxy or C 1 - 2 alkoxy; or Ar is optionally substituted by a group NR 3 R 4 containing not more than 5 carbon atoms wherein R 3 and R' are the same or different and each is a Ci-3alkyl group or NR 3 R 4 forms a five-or six-membered heterocyclic ring optionally containing one or two additional heteroatoms; R' contains not more than eight carbon atoms and is a group
or
wherein m is 0 or 1;
R 5 is hydrogen or methyl; R 6 and R' are the same or different and each is hydrogen or C1-3alkyl optionally substituted by hydroxy; R 8 and R 9 are the same or different and each is hydrogen or Ci-3alkyl; -C-C- is a five-or six-membered saturated carbocyclic ring; R 10 is hydrogen, methyl or hydroxymethyl; R", R 12 and R 13 are the same or different and each is hydrogen or methyl; R 14 is hydrogen, methyl, hydroxy, or hydroxymethyl; and provided that when Ar is 6-chrysenyl, 3- or 7-fluoranthenyl, 2-triphenylenyl, or 1- or 9-anthracenyl optionally substituted by one or two substituents as hereinbefore defined; other than optionally substituted butyl or butoxy R 6 is C 1-3 alkyl optionally substituted by hydroxy; R 7 is hydrogen, C1-3alkyl or hydroxymethyl; R'to R 12 and R" are as hereinbefore defined; R 13 is hydrogen; and m is 0; R 5 is methyl, are disclosed as having biocidal and, in particular, antitumour activity. Methods for preparing the compounds, formulations containing them and their use in medicine are also described.

7. 发明公开

EP1358167A1 NOVEL 2-BENZOXAZOLYL BENZENE DERIVATIVES AND THEIR USE AS UV SCREENING AGENTS 审中-公开
标题翻译：新的2 BENZOXAZOLYLBENZOLDERIVATE及其使用防晒霜
公开(公告)号：EP1358167A1
公开(公告)日：2003-11-05
申请号：EP02710042.9
申请日：2002-01-28
申请人： Roche Vitamins AG
发明人： HUBER, Ulrich
IPC分类号： C07D263/62 , C07F7/08 , A61K7/42 , C07C233/75
CPC分类号： A61K8/49 , A61Q17/04 , C07C233/75 , C07D263/64 , C07F7/0854
摘要： Novel benzoxazolyl benzene derivatives of formula (I) wherein R1 is hydrogen, C¿1-20?-alkyl or C2-20-alkenyl; R?2 and R3¿ are independently a group -C(R?4, R5)C(R6)=C(R7, R8¿) (a) or a group -C(R?4',R5')CH(R6')CH(R7',R8'¿) (b), wherein R?4, R5, R6, R7, R8, R4', R6', R7' and R8'¿ are independently, hydrogen, C¿1-10?-alkyl or C2-10-alkenyl, or C2-10-alkyl or C3-10-alkenyl containing at least one oxygen atom interrupting the hydrocarbon chain; or wherein R?4, R5, R6, R4', R5' and R6'¿ are hydrogen, C¿1-10?-alkyl or C2-10 alkyl containing at least one oxygen atom interrupting the hydrocarbon chain, or alkyl substituted by a silane or oligosiloxane moiety, and one of R?7 and R8 or R7' and R8'¿ is a silane or oligosiloxane moiety and the other one of R?7 and R8 or R7' and R8'¿ is hydrogen; and X is phenylene or naphthylene, or substituted phenylene or naphthylene for use as UV screening agents for protecting human skin or hair against UV radiation, and in UV screening compositions, particularly topical compositions for cosmetic or dermatological use.

8. 发明公开

EP1265876A1 PREPARATION OF MIXTURES OF BENZOXAZOLYL-STILBENE COMPOUNDS 审中-公开
标题翻译：制备苯并二苯乙烯连接的化合物的
公开(公告)号：EP1265876A1
公开(公告)日：2002-12-18
申请号：EP01916086.0
申请日：2001-02-12
申请人： EASTMAN CHEMICAL COMPANY
发明人： CHAMBERLIN, Kim, Steven
IPC分类号： C07D263/56 , C07D263/62 , C07D263/64
CPC分类号： C07D263/64
摘要： Disclosed is a process for the preparation of a mixture of benzoxazolyl-stilbene compounds by the reaction of unsubstituted 4,4'-bis(benzoxazol-2-yl)stilbene with a substituted o-aminophenol or o-aminonaphthol to obtain a mixture comprising the unsubstituted 4,4'-bis(benzoxazol-2-yl)stilbene and at least one substituted 4,4'-bis(benzoxazol-2-yl)stilbene, 4-naphthoxazol-2-yl-4'-benzoxazol-2-ylstilbene and/or 4,4'-bis(naphthoxazol-2-yl)stilbene. These mixtures are useful as fluorescent brightening agents and light stabilizers for synthetic polymeric materials such as polyesters, polyamide and polyolefin textile materials and shaped articles.

9. 发明公开

EP0472525A1 PROCESS FOR THE PREPARATION OF STILBENE DERIVATIVES 失效
标题翻译：用于生产二苯乙烯衍生物。
公开(公告)号：EP0472525A1
公开(公告)日：1992-03-04
申请号：EP90904494.0
申请日：1990-02-26
申请人： EASTMAN KODAK COMPANY
发明人： BOWERS, Joseph, Stanton, Jr. , MAYBERRY, Gerald, Lee
IPC分类号： C07D263
CPC分类号： C07D263/64
摘要： On a mis au point un procédé de préparation de composés de stilbène tels que bis(2-benzoxazolyle) stilbènes, consistant à faire réagir un stilbènedicarboxylate tel que diméthyle-4,4'-stilbène-dicarboxylate avec un o-aminophénol dans un solvant organique tel que le chloronaphtalène, en présence d'une quantité catalytique d'un composé d'étain ou de titane. On procède typiquement à la réaction à une température d'environ 200 à 250°C, un catalyseur préféré étant soit l'oxyde d'étain de dibutyle soit le tétra-alkoxyde de titane.

10. 发明公开

EP0385890A1 Pocess for the preparation of stilbene derivatives 失效
标题翻译： Verfahren zur Herstellung von Stilbenderivaten。
公开(公告)号：EP0385890A1
公开(公告)日：1990-09-05
申请号：EP90420101.9
申请日：1990-02-26
申请人： EASTMAN CHEMICAL COMPANY
发明人： Bowers, Joseph Stanton Jr., c/o Eastman Kodak Co. , Mayberry, Gerald Lee, c/o Eastman Kodak Co.
IPC分类号： C07D263/64 , D06L3/12
CPC分类号： C07D263/64
摘要： Disclosed is a process for the preparation of stilbene compounds such as bis(2-benzoxazolyl) stilbenes by reacting a stilbenedicarboxylate such as dimethyl-4,4′-stilbenedicarboxylate with an o-aminophenol in an organic solvent such as chloronaphthalene in the presence of a catalytic amount of a tin or titanium compound. The reaction is typically carried out at a temperature of about 200-250°C and a preferred catalyst is either dibutyl tin oxide or titanium tetra-alkoxide.
摘要翻译：公开了通过使二苯乙烯二羧酸酯如二甲基-4,4min - 二苯乙烯二羧酸酯与邻氨基苯酚在有机溶剂如氯萘中反应来制备二苯乙烯化合物如二（2-苯并恶唑基）二苯乙烯的方法，催化量的锡或钛化合物。反应通常在约200-250℃的温度下进行，优选的催化剂是二丁基氧化锡或四烷氧基钛。

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