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1. 发明公开

EP1599466A2 2-OXO-1,3,5-PERHYDROTRIAZAPINE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE, ANGIOGENESIS, AND INFLAMMATRORY DISORDERS 有权
标题翻译： 2-氧代-1,3,5- PERHYDROTRIAZAPINDERIVATE所产生的过度增殖性治疗，血管发生性和炎性疾病是合适
公开(公告)号：EP1599466A2
公开(公告)日：2005-11-30
申请号：EP04716136.9
申请日：2004-03-01
申请人： Bayer Pharmaceuticals Corporation
发明人： BOYER, Stephen , DUMAS, Jacques , PHILLIPS, Barton , SCOTT, William J. , SMITH, Roger, A. , CHEN, Jianqing , JONES, Benjamin , WANG, Gan
IPC分类号： C07D401/12 , A61K31/35 , A61P35/00
CPC分类号： A61K31/35 , C07D213/00 , C07D251/00 , C07D401/12 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/473
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.

2. 发明授权

EP0778844B1 FUNKTIONELLE TERPYRIDIN-METALLKOMPLEXE, VERFAHREN ZU DEREN HERSTELLUNG UND OLIGONUKLEOTID-KONJUGATE MIT TERPYRIDIN-METALLKOMPLEXEN 失效
标题翻译：功能三联吡啶金属络合物用于生产和寡核苷酸缀合物金属配合物三联吡啶
公开(公告)号：EP0778844B1
公开(公告)日：2002-12-18
申请号：EP95931224.0
申请日：1995-08-30
申请人： Novartis AG , Novartis-Erfindungen Verwaltungsgesellschaft m.b.H.
发明人： HÄNER, Robert , HALL, Jonathan , HÜSKEN, Dieter , PIELES, Uwe , MOSER, Heinz
IPC分类号： C07H21/00 , C12Q1/68 , C07D213/00
CPC分类号： C07H21/00 , C07D213/00 , C12Q1/6816 , G01N2458/40

3. 发明公开

EP3366669A2 MONOSUBSTITUTED OR POLYSUBSTITUTED AMPHIPHILIC HYPOCRELLIN DERIVATIVE, PREPARATION METHOD THEREFOR, AND USES THEREOF 审中-公开
公开(公告)号：EP3366669A2
公开(公告)日：2018-08-29
申请号：EP16856928.3
申请日：2016-10-21
申请人： Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences
发明人： WANG, Pengfei , WU, Jiasheng , LIU, Weimin , GU, Ying , GE, Jiechao , ZHENG, Xiuli , ZHANG, Hongyan
IPC分类号： C07C221/00 , C07C225/32 , C07C249/02 , C07C251/24 , C07C319/18 , C07C323/25 , C07C213/06 , C07C217/12 , A61K41/00 , A61P35/00
CPC分类号： A61K31/473 , A61K31/122 , A61K31/135 , A61K41/0057 , A61K47/54 , A61K47/543 , A61K47/60 , A61P35/00 , C07C50/36 , C07C217/12 , C07C221/00 , C07C225/22 , C07C225/32 , C07C229/18 , C07C237/08 , C07C239/14 , C07C243/22 , C07C249/02 , C07C251/24 , C07C251/56 , C07C251/86 , C07C309/69 , C07C319/18 , C07C323/25 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D213/00 , C07D221/02
摘要： The invention discloses a monosubstituted or polysubstituted amphiphilic hypocrellin derivative, and a preparation method and application thereof. The amphiphilic hypocrellin derivative substituted by a group containing PEG, a quaternary ammonium salt or the like prepared according to the invention has an obvious red shift in its absorption spectrum and a significantly enhanced molar extinction coefficient, compared with the parent hypocrellin, can efficiently produce singlet state oxygen and other reactive oxygen species under photosensitive conditions; has different amphiphilicities and increased biocompatibility with cells or tissues by regulating its hydrophilicity and hydrophobicity; can meet the requirements of different clinical drugs, and solves the requirements of different drug delivery methods for different drug hydrophilicity and lipophilicity. Under identical conditions, the amphiphilic hypocrellin derivative photosensitizer according to the invention has higher ability to photodynamically inactivate tumor cells than the first and second generation commercial photosensitizers.

4. 发明公开

EP2289880A1 2-Pyridinylcyclopropylbenzamide fungicides 审中-公开
标题翻译： 2-吡啶基环丙基苯甲酰胺类杀真菌剂
公开(公告)号：EP2289880A1
公开(公告)日：2011-03-02
申请号：EP09356045.6
申请日：2009-07-08
申请人： Bayer CropScience AG
发明人： Coqueron, Pierre-Yves
IPC分类号： C07D213/00 , C07D213/36 , A01N43/40
CPC分类号： C07D213/00 , C07D213/36
摘要： The present invention relates to novel N-[2-(2-pyridinyl)cyclopropyl]benzamide derivatives (I), their process of preparation, their use as fungicides, particularly in the form of fungicidal compositions, and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
摘要翻译：本发明涉及新的N- [2-（2-吡啶基）环丙基]苯甲酰胺衍生物（I），它们的制备方法，它们作为杀真菌剂的用途，特别是杀真菌组合物的形式，以及防治植物病原性真菌使用这些化合物或其组合物的植物。

5. 发明公开

EP2882712A2 PROCESS FOR THE SYNTHESIS OF SUBSTITUTED UREA COMPOUNDS 审中-公开
标题翻译： VERFAHREN ZUR SYNTHESE VON SUBSTITUIERTEN HARNSTOFFVERBINDUNGEN
公开(公告)号：EP2882712A2
公开(公告)日：2015-06-17
申请号：EP13750964.2
申请日：2013-07-26
申请人： BIAL - Portela & Cª S.A.
发明人： RUSSO, Domenico , WAHNON, Jorge Bruno Reis , MATON, William , ESZENYI, Tibor
IPC分类号： C07D213/00
CPC分类号： C07D401/04 , C07D213/00 , C07D213/50 , C07D213/53
摘要： A process for preparing a substituted urea compound of Formula II or Formula I, or a pharmaceutically acceptable salt or ester thereof, Formula II, Formula I the process comprising the reaction of an intermediate of Formula II′ or Formula 1′, Formula II′, Formula I′ with a carbamoyl halide of the formula: R1R2NC(=0)Hal, in a solvent consisting essentially of pyridine, wherein Hal represents Cl, F, I or Br, and wherein ring A, and R1, R2, R5, V, W, X, Y and Z are as defined herein.
摘要翻译：制备式II或式I的取代的脲化合物或其药学上可接受的盐或其酯，式II，式I的方法包括式II'或式1'的中间体，式II'，式I'与具有式R 1 R 2 NC（= O）Hal的氨基甲酰卤在基本上由吡啶组成的溶剂中，其中Hal表示Cl，F，I或Br，其中环A和R1，R2，R5，V ，W，X，Y和Z如本文所定义。

6. 发明授权

EP1599466B1 2-OXO-1,3,5-PERHYDROTRIAZAPINE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE, ANGIOGENESIS, AND INFLAMMATRORY DISORDERS 有权
标题翻译： 2-氧代-1,3,5- PERHYDROTRIAZAPINDERIVATE所产生的过度增殖性治疗，血管发生性和炎性疾病是合适
公开(公告)号：EP1599466B1
公开(公告)日：2010-11-24
申请号：EP04716136.9
申请日：2004-03-01
申请人： Bayer HealthCare LLC
发明人： BOYER, Stephen , DUMAS, Jacques , PHILLIPS, Barton , SCOTT, William J. , SMITH, Roger, A. , CHEN, Jianqing , JONES, Benjamin , WANG, Gan
IPC分类号： C07D401/12 , A61K31/35 , A61P35/00
CPC分类号： A61K31/35 , C07D213/00 , C07D251/00 , C07D401/12 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/473
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.

7. 发明公开

EP0778844A1 FUNKTIONELLE TERPYRIDIN-METALLKOMPLEXE, VERFAHREN ZU DEREN HERSTELLUNG UND OLIGONUKLEOTID-KONJUGATE MIT TERPYRIDIN-METALLKOMPLEXEN 失效
标题翻译：功能三联吡啶金属络合物用于生产和寡核苷酸缀合物金属配合物三联吡啶
公开(公告)号：EP0778844A1
公开(公告)日：1997-06-18
申请号：EP95931224.0
申请日：1995-08-30
申请人： Novartis AG
发明人： HÄNER, Robert , HALL, Jonathan , HÜSKEN, Dieter , PIELES, Uwe , MOSER, Heinz
IPC分类号： C12N15 , A61K31 , A61P35 , C07D213 , C07D471 , C07F5 , C07F9 , C07H21 , C12Q1
CPC分类号： C07H21/00 , C07D213/00 , C12Q1/6816 , G01N2458/40
摘要： Disclosed are compounds of formula (V), wherein R2 and R7, independently of each other, are H, C1-C4 alkyl, C1-C4 alkoxy, C7-C12 aralkyl, C6-C16 aryl or halogen; R3 and R6, independently of each other, are H, C1-C4 alkyl, C7-C12 aralkyl or C6-C16 aryl; R4 is H, C1-C20 alkyl, C5-C8 cycloalkyl, C6-C12 aryl or C7-C12 aralkyl, the alkyl, cycloalkyl, aralkyl and aryl radicals being unsubstituted or substituted with C1-C4 alkoxy, F, Cl, Br, -CN, C1-C4 alkyl or -NO2; Me is a lanthanide metal or yttrium; Y is an anion of an acid; n stands for 2 or 3 and m is 1, 2 or 3; R9 is a radical of formula (VI) -Xp-A-X'q-A'r-Oligo, and R8 is H, C1-C4 alkyl, C1-C4 alkoxy, C7-C12 aralkyl, C6-C16 aryl, or R9 is H, C1-C4 alkyl, C1-C4 alkoxy, C7-C12 aralkyl, C6-C16 aryl and R8 is a radical of formula (VI); p, q and r, independently of one another, are 0 or 1; X and X', independently of each other, are a radical unsubstituted or substituted by C1-C4 alkoxy, F, Cl, Br, -CN, C1-C4 alkyl or -NO2 substituted radical selected from the group consisting of C1-C20 alkylene, C2-C12 alkenylene, C2-C12 alkinylene, -(CxH2xO)y-, wherein x equals a number from 2 to 6 and y equals a number from 1 to 20, C5-C8 cycloalkylene, C6-C12 arylene and C7-C12 aralkylene; A and A', independently of each other, are -O-, -S-, -S-S-, -NR12-CO-NR12-CO-NR12-, -NR12-CS-NR12-, -NR12-, -NR12-C(O)-O-, -C(O)O-, -C(O)S-, -C(O)NR12-, -C(S)S-, -C(S)O-, -C(S)NR12-, -SO2NR12-, -SO2-, -P(O)(OH)O-, P(S)(SH)S-, -P(S)(SH)O-, -P(S)(OH)O-, -P(O)(SH)S-, -P(O)(OH)S-, -P(O)(SH)O-, -P(O)(OH)-NR12-, -P(S)(SH)-NR12-, -P(S)(OH)-NR12-, -P(O)(SH)-NR12-, -HP(O)O-, -HP(S)S-, -HP(O)NR12- or -HP(S)NR12-, R12 being H or C1-C6 alkyl; and oligo is a natural, modified or synthetic sequence of natural, modified or synthetic deoxynucleosides or peptide nucleic acid units which are bonded via a nucleic base, an internucleotide bridge or a sugar and whose inner region is complementary to a target RNA.

8. 发明公开

EP4414359A1 CATALYTIC PROCESS FOR THE PREPARATION OF AMIDES 审中-公开
公开(公告)号：EP4414359A1
公开(公告)日：2024-08-14
申请号：EP24154384.2
申请日：2024-01-29
申请人： Università di Pisa
发明人： CIRRI, Damiano , MARZO, Tiziano , PRATESI, Alessandro
IPC分类号： C07C231/06 , C07C233/05 , C07C233/09 , C07C233/11 , C07C233/65 , C07D213/00
CPC分类号： C07C231/065 , C07D213/00
摘要： The present invention relates to a palladium-arsenic catalytic process for the preparation of amides capable of advantageously converting a nitrile into the respective amide under mild reaction conditions, such as a neutral pH and low temperatures.

9. 发明公开

EP3013794A1 STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI 审中-公开
标题翻译：用于控制植物病原真菌甲氧基丙烯酸酯类CONNECTIONS
公开(公告)号：EP3013794A1
公开(公告)日：2016-05-04
申请号：EP14732577.3
申请日：2014-06-25
申请人： BASF SE
发明人： WINTER, Christian , RHEINHEIMER, Joachim , WOLF, Antje , POONOTH, Manojkumar , TERTERYAN, Violeta , WIEBE, Christine , KREMZOW-GRAW, Doris , RÖHL, Franz , GRAMMENOS, Wassilios , ROHRER, Sebastian Georgios , WIEJA, Andy , ROSENBAUM, Claudia
IPC分类号： C07C271/12 , C07C231/00 , C07C239/00 , C07C213/00 , A01N43/00 , A01N47/10 , A01N47/24 , A01N55/00
CPC分类号： C07C271/10 , A01N47/10 , A01N47/12 , A01N47/24 , C07C271/12 , C07D213/00 , C07D213/30 , C07D231/00 , C07D231/12 , C07D239/00 , C07D239/26 , C07F7/1852
摘要： The present invention relates to novel strobilurine type compounds, to compositions comprising at least one such compound, to methods for combating phytopathogenic fungi, to the use of such compounds and to seeds coated with at least one such compound.

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