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1. 发明公开

EP2749555A4 METHOD FOR PRODUCING PEST CONTROLLING AGENT 失效
标题翻译： VERFAHREN ZUR HERSTELLUNG EINESSCHÄDLINGSBEKÄMPFUNGSMITTELS
公开(公告)号：EP2749555A4
公开(公告)日：2015-05-06
申请号：EP12828367
申请日：2012-08-24
申请人： MEIJI SEIKA PHARMA CO LTD
发明人： NAKANISHI NOZOMU , FUKUDA YOSHIMASA , KITSUDA SHIGEKI , OHNO IKUYA
IPC分类号： C07D213/74 , A01N43/40 , A01N43/78 , A01P7/02 , A01P7/04 , C07D401/06 , C07D417/06
CPC分类号： A01N43/40 , A01N43/54 , A01N43/78 , C07D211/84 , C07D213/75 , C07D401/06 , C07D417/06
摘要： To supply a derivative having a 2-acyliminopyridine structure and being represented by the following formula (I) in an amount required as a pest control agent stably and at a low cost, provided is a method comprising the steps of: acylating an amino group at position 2 of a compound represented by formula (A) by use of an acylating agent, to thereby produce a compound represented by formula (B); and further alkylating a nitrogen atom at position 1 of the compound represented by formula (B): [where Ar represents a phenyl group or a 5-to 6-membered heterocycle, R 1 represents a C 1-6 alkyl group, and Y represents a hydrogen atom; a halogen atom; a hydroxyl group; a C 1-6 alkyl group which may be substituted with a halogen atom; a C 1-6 alkyloxy group which may be substituted with a halogen atom; a cyano group; a formyl group; or a nitro group].
摘要翻译：为了以稳定且低成本的方式提供具有2-酰基亚氨基吡啶结构的衍生物并由下式（I）表示，其用量为有害生物防治剂所要求的量，提供的方法包括以下步骤：酰化氨基，通过使用酰化剂由式（A）表示的化合物的第2位，从而制备由式（B）表示的化合物; 并进一步烷化式（B）表示的化合物的第1位的氮原子：其中Ar表示苯基或5-至6-元杂环，R 1表示C 1-6烷基，Y表示氢原子; 卤素原子; 羟基; 可被卤素原子取代的C 1-6烷基; 可被卤素原子取代的C 1-6烷氧基; 氰基; 甲酰基; 或硝基]。

2. 发明公开

EP2380876A4 1-HETERODIENE DERIVATIVE AND HARMFUL ORGANISM CONTROL AGENT 有权
标题翻译： 1个heterodiene衍生物和手段打击有害生物
公开(公告)号：EP2380876A4
公开(公告)日：2012-06-13
申请号：EP09833217
申请日：2009-12-17
申请人： NIPPON SODA CO
发明人： KUTOSE KOICHI , TAKAHASHI JYUN , HAMAMOTO ISAMI , YANO MAKIO , MOROHOSHI JYUNKO , KANAZAWA JYUN
IPC分类号： C07D207/36 , A61K31/341 , A61K31/351 , A61K31/38 , A61K31/381 , A61K31/382 , A61K31/402 , A61K31/451 , A61P33/14 , C07D211/84 , C07D211/86 , C07D307/66 , C07D309/32 , C07D333/36 , C07D335/02 , C07D337/04
CPC分类号： C07D335/06 , A01N43/08 , A01N43/10 , A01N43/12 , A01N43/16 , A01N43/18 , A01N43/40 , A01N43/54 , C07D207/36 , C07D211/84 , C07D211/86 , C07D307/66 , C07D309/32 , C07D333/36 , C07D335/02 , C07D337/04 , C07D405/12 , C07D409/12

3. 发明公开

EP1339686A2 CYANOGUANIDINE PRODRUGS 有权
标题翻译：双氰胺前体药物
公开(公告)号：EP1339686A2
公开(公告)日：2003-09-03
申请号：EP01983436.5
申请日：2001-11-14
申请人： Leo Pharma A/S
发明人： BINDERUP, Ernst, Torndal , HJARNAA, Pernill-Julia, Vig
IPC分类号： C07D213/75 , A61K31/44 , A61P35/00
CPC分类号： C07D213/75 , C07D211/84 , C07D213/50 , C07D217/22
摘要： The invention relates to compounds of formula (I), wherein X1 and X2 independently represent a bond; a straight, branched and/or cyclic hydrocarbon diradical, optionally substituted with one or more hydroxy, halogen, nitro, amino, cyano, aminosulfonyl, alkylsulfonylamino, alkylcarbonyl, formyl, aminocarbonyl or alkylcarbonylamino; a heteroarylene or non-aromatic heterocyclic hydrocarbon diradical, all of which are optionally substituted with one or more straight, branched and/or cyclic non-aromatic hycrocarbon radical, hydroxyl, halogen, amino, nitro, cyano, aminosulfonyl, alkylsulfonylamino, alkylcarbonyl, formyl, aminocarbonyl or alkylcarbonylamino; Y1 and Y2 independently represent a bond, an ether diradical (R'-O-R''), an amine diradical (R'-N-R''), O, S, S(O), S(O)2, C(O), NH-CO, CO-NH, SO2-N(R'), methylene or N(R')-SO2 wherein R' et R'' independently represent straight or branched hydrocarbon diradicals containing up to 4 carbon atoms; Y3 represents O, O-C(O), C(O)-O, N(R8), R8 being hydrogen or C1-4alkyl; R1 represents hydrogen or straight, branched and/or cyclic alkyl, optionally substituted with phenyl; or an aromatic hydrocarbon radical; R2 represents aryl, heteroaryl or a non-aromatic heterocyclic hydrocarbon radical, all of which are optionally substituted; tetrahydropyranyloxy, di-(C1-4 alkoxy)phosphinoyloxy or C1-4 alkoxycarbonylamino; R3 represents hydrogen; a straight, branched and/or cyclic hydrocarbon radical, optionally substituted with one or more amino, hydroxy, carboxy, halogen, nitro, cyano, alcoxy, aminocarbonyl, C1-4alkoxycarbonyl, C1-4alkoxycarbonylamino, sulfo, hydroxysulfonyloxy, dihydroxyphosphinoyloxy, phosphono, sulfamino, aminosulfonyl, aminoacylamino or dialkoxyphosphinoyl; heteroaryl or a non-aromatic heterocyclic hydrocarbon radical, all of which are optionally substituted with one or more straight, branched and/or cyclic hydrocarbon radical, amino, hydroxy, carboxy, halogen, nitro, cyano, alkoxy, aminocarbonyl, C1-4alkoxycarbonyl, C1-4alkoxycarbonylamino, sulfo, hydroxysulfonyloxy, dihydroxyphosphinoyloxy, phosphono, sulfamino, aminosulfonyl, aminoacylamino or dialkoxyphosphinoyl; (a) wherein s is an integer from 1 to 200; R6 is hydrogen or an optionally substituted non-aromatic hydrocarbon radical; R7 Is independently hydrogen or methyl; R4 and R5 Independently represent hydrogen; a straight, branched and/or cyclic hydrocarbon radical, optionally substituted with halogen, hydroxyl, halogen, amino, nitro or cyano; A represents hydrogen, an optionally substituted, straight, branched and/or cyclic hydrocarbon radical, hydroxy, halogen, nitro, cyano, heteroaryl, heteroaralkyl or thiol; m and r are independently integers from 0 to 4; and n is 0 or 1; Z- is a pharmaceutically acceptable anion, such as chloride, bromide, iodide, sulfate, methanesulfonate, p-toluenesulfonate, nitrate or phosphate. The compounds are well suited as prodrugs in human and veterinary therapy.

4. 发明公开

EP0935600A1 VERFAHREN ZUR HERSTELLUNG VON NAPHTHYRIDINVERBINDUNGEN UND NEUE ZWISCHENPRODUKTE 失效
标题翻译：用于生产萘啶和新中间体
公开(公告)号：EP0935600A1
公开(公告)日：1999-08-18
申请号：EP97913157.0
申请日：1997-10-17
申请人： BAYER AG
发明人： ANTONS, Stefan , GEHRING, Reinhold , BIELFELDT, Tim , BEITZKE, Bernhard
IPC分类号： C07D211 , C07D213 , C07D471
CPC分类号： C07D471/04 , C07D211/84 , C07D213/26 , C07D213/61
摘要： An advantageous method of producing naphthyridine compounds of formulae (Ia) to (1c) wherein R means hydrogen or C1-C4 alkyl, Ar means possibly substituted phenyl, Hal means independently fluorine, chlorine or bromine, and n stands for 1, 2 or 3, whereby a halogenated nicotinic, isonicotinic or picolinic acid is made to react with an amino acrylic acid ester to obtain a halogenated 2-nicotinoyl-, isonicotinoyl- or picolinoyl-3-aminoacrylate which is made to react with an optionally substituted aniline to obtain a halogenated 2-nicotinoyl-, isonicotinoyl- or picolinoyl-3-aminoacrylate which contains an amino group corresponding to the optionally substituted aniline. The second halogenated 2-nicotinoyl-, isonicotinoyl- or picolinoyl-3-aminoacrylate is cyclized by adding an acid scavenger to a compound of formulae (Ia) to (Ic) with R = C1-C4 alkyl and, in the case of production of a compound of formulae (Ia) to (Ic) with R = H, the compound of the formulae (Ia) to (Ic) with R = C1-C4 alkyl is saponified.

5. 发明公开

EP0666848A1 SUBSTITUIERTE N-PHENYLGLUTARIMIDE UND N-PHENYLGLUTARSÄUREAMIDE, DEREN HERSTELLUNG UND VERWENDUNG IN DER LANDWIRTSCHAFT 失效
标题翻译：取代的N- phenylglutarimide和正PHENYLGLUTARSÄUREAMIDE，生产和使用农业。
公开(公告)号：EP0666848A1
公开(公告)日：1995-08-16
申请号：EP94900070.0
申请日：1993-10-19
申请人： BASF Aktiengesellschaft
发明人： KLINTZ, Ralf , HAMPRECHT, Gerhard , HEISTRACHER, Elisabeth , SCHAEFER, Peter , KARDORFF, Uwe , WESTPHALEN, Karl-Otto , GERBER, Matthias , WALTER, Helmut
IPC分类号： A01N37 , A01N43 , C07C233 , C07C323 , C07C327 , C07D211
CPC分类号： C07C233/54 , A01N37/46 , C07D211/84 , C07D211/88 , C07D211/90
摘要： Substituted N-phenylglutarimides (I), wherein X1, X2 = O, S; R1 = halogen, NO¿2?, CN, CF3; R?2¿ = H, halogen; R?3, R4, R5¿ = H, halogen, CN, alkyl, cycloalkyl, alkenyl, alkinyl, alkyl halide, alkoxy, alkoxy halide, alkyl thio, alkyl thio halide, cyanoalkyl, alkoxy carbonyl, possibly substituted phenyl or benzyl, or 2 substituents of a C atom of the glutarimide ring are linked via a possibly substituted chain, or 2 substituents of adjacent C atoms of the glutarimide ring are linked via a possibly substituted chain; A = CHR6-CHR7-CO-B or CR6=CR8-CO-B; R6 = H, C¿1?-C6-alkyl or C1-C6-alkyl halide; R?7¿ = halogen, alkyl halide, OH, alkoxy or alkyl carbonyl alkoxy; R8 = H, halogen, CN, alkyl, alkyl halide, OH, alkoxy, alkyl carbonyl, alkoxy carbonyl or alkyl carbonyloxy; B = H, alkyl, alkenyl, alkinyl, alkyl halide, cycloalkyl, alkoxy alkyl, dialkoxy alkyl, alkyl thioalkyl, OR?9, SR9, NR10, R11; R9¿ = H, alkyl, alkenyl, alkinyl, cycloalkyl, alkyl halide, cyanoalkyl, alkenyl halide, alkoxy carbonyl alkyl, alkoxyalkyl, alkyl thioalkyl, alkylimino, alkylimino alkyl, possibly substituted phenyl or benzyl; R10, R11 = H, alkyl, alkenyl, alkinyl, cycloalkyl, alkyl halide, alkyl carbonyl, alkoxy carbonyl, alkoxy alkyl, possibly substituted phenyl, or R?10 und R11¿ together with the common N atom = saturated or unsaturated 4- to 7- membered heterocycle with 1-2 other heteroatoms, as well as salts of (I) that are tolerable to plants; their preparation and use as herbicides and desiccants/defoliants, as well as preproducts for preparing the N-phenylglutarimides (I).

6. 发明公开

EP0255710A3 1,4-Dihydropyridine derivatives with calcium agonist and alpha-1-antagonist activity 失效
标题翻译：具有钙激动剂和阿尔法-1拮抗剂活性的1,4-二氢吡啶衍生物
公开(公告)号：EP0255710A3
公开(公告)日：1989-01-04
申请号：EP87111142.3
申请日：1987-08-01
申请人： THE DU PONT MERCK PHARMACEUTICAL COMPANY
发明人： Johnson, Alexander Lawrence , Timmermans, Petrus Bernardus , Ma, Philip , Wexler, Ruth Richmond
IPC分类号： C07D211/90 , C07D401/12 , C07D491/048 , C07D495/04 , C07D211/84 , C07D211/86 , A61K31/445
CPC分类号： C07D401/04 , C07D211/84 , C07D211/90 , C07D401/12 , C07D491/04
摘要： 1,4-Dihydropyridine derivatives which combine both calcium agonist and alpha 1 -antagonist activity are useful in treating congestive heart failure. These derivatives are compounds having the formula:
wherein Ar, R 3 , R 4 , R 5 and R 6 are defined in the specification.

7. 发明公开

EP0244713A2 3-Amino-dihydropyridine, ein Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln 失效
标题翻译： 3-氨基二氢吡啶，其制备方法和其医药用途的方法。
公开(公告)号：EP0244713A2
公开(公告)日：1987-11-11
申请号：EP87106013.3
申请日：1987-04-24
申请人： BAYER AG
发明人： Stoltefuss, Jürgen, D.I. , Heiker, Fred Robert, Dr. , Bechem, Martin, Dr. , Gross, Rainer, Prof. Dr. , Kayser, Michael, Dr. , Schramm, Matthias, Dr. , Thomas, Günter, Dr.
IPC分类号： C07D211/90 , C07D211/84 , C07D491/04 , A61K31/44
CPC分类号： C07D491/04 , C07D211/84 , C07D211/90
摘要： Die Erfindung betrifft Dihydropyridine der allgemeinen Formel (I)
mit den in der Beschreibung angegebenen Substituentendefinitionen, ein Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln, insbesondere in kreislaufbeeinflussenden Arzneimitteln.
摘要翻译：本发明涉及通式（I）在本说明书中，其制备方法和其医药用途的过程中给出的取代基定义的二氢吡啶，特别是在循环-影响药物。

8. 发明授权

EP0071819B1 Dihydropyridine mit positiv inotroper Wirkung, neue Verbindungen, ihre Verwendung in Arzneimitteln und Verfahren zu ihrer Herstellung 有权
标题翻译：具有阳性非精神活性的二氢吲哚，它们在药物制备中的应用及其制备方法
公开(公告)号：EP0071819B1
公开(公告)日：1987-04-22
申请号：EP82106537.2
申请日：1982-07-20
申请人： BAYER AG
发明人： Franckowiak, Gerhard, Dr. , Böshagen, Horst, Dr. , Bossert, Friedrich, Dr. , Goldmann, Siegfried, Dr. , Meyer, Horst, Dr. , Wehinger, Egbert, Dr. , Stoltefuss, Jürgen, Dr. , Schramm, Matthias, Dr. , Thomas, Günter, Dr. , Towart, Robertson, Dr.
IPC分类号： C07D211/90 , C07D211/84 , C07D401/04 , C07D471/04 , C07D491/04 , C07D491/10 , C07D491/048 , C07D491/052 , A61K31/435
CPC分类号： C07D401/04 , C07D211/84 , C07D211/90 , C07D409/04 , C07D471/04 , C07D491/04 , C07D491/10

9. 发明授权

EP0086510B1 Process for the preparation of enamines; novel enamines and the use of enamines in the preparation of dihydropyridines 失效
标题翻译：程序的制定过程; 新技术及其在制备二氢吡啶中的用途
公开(公告)号：EP0086510B1
公开(公告)日：1985-11-13
申请号：EP83200055.8
申请日：1983-01-14
申请人： SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.
发明人： Feringa, Bernard Lucas
IPC分类号： C07C147/04 , C07C147/08 , C07D211/82 , C07C147/06
CPC分类号： C07C317/00 , C07D211/84

10. 发明公开

EP0071819A1 Dihydropyridine mit positiv inotroper Wirkung, neue Verbindungen, ihre Verwendung in Arzneimitteln und Verfahren zu ihrer Herstellung 有权
标题翻译：二氢吡啶类带正性肌力作用，新的化合物，其医药用途，以及它们的制备方法。
公开(公告)号：EP0071819A1
公开(公告)日：1983-02-16
申请号：EP82106537.2
申请日：1982-07-20
申请人： BAYER AG
发明人： Franckowiak, Gerhard, Dr. , Böshagen, Horst, Dr. , Bossert, Friedrich, Dr. , Goldmann, Siegfried, Dr. , Meyer, Horst, Dr. , Wehinger, Egbert, Dr. , Stoltefuss, Jürgen, Dr. , Schramm, Matthias, Dr. , Thomas, Günter, Dr. , Towart, Robertson, Dr.
IPC分类号： C07D211/90 , C07D211/84 , C07D401/04 , C07D471/04 , C07D491/04 , C07D491/10 , C07D491/048 , C07D491/052 , A61K31/435
CPC分类号： C07D401/04 , C07D211/84 , C07D211/90 , C07D409/04 , C07D471/04 , C07D491/04 , C07D491/10
摘要： Die vorliegende Erfindung betrifft die Verwendung von neuen und bekannten Dihydropyridinen in Arzneimitteln mit positiv inotroper Wirkung der allgemeinen Formel I
in weicher n, R 1 , R 2 , R', R 4 , R 6 , R 6 und R 7 die in der Beschreibung angegebene Bedeutung besitzen, neue Verbindungen aus dieser Stoffklasse, diese enthaltende Arznelmittel und ihre Herstellung.
摘要翻译：本发明涉及使用新的和已知的二氢吡啶在药物具有通式的正性肌力作用I 其中n，R 1，R 2，R 3，R <4>，R <5> - [R <6>和R <7>是如在说明书中给出的含义限定，从这类化合物的新化合物，含有它们和它们的制备药物组合物。

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