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1. 发明公开

EP3337450A1 IMPROVED LACTAM SOLUBILITY 有权转让
公开(公告)号：EP3337450A1
公开(公告)日：2018-06-27
申请号：EP16744765.5
申请日：2016-07-28
申请人： Unilever PLC , Unilever N.V.
发明人： PRICE, Paul, Damien
IPC分类号： A61K8/49 , A61Q17/00 , A01N33/00
CPC分类号： A01N25/02 , A01N43/36 , A61K8/4913 , A61Q17/005 , C07D207/38 , C07D207/44 , A01N25/30
摘要： Compositions comprising lactams and non-ionic surfactants, suitable for use as antimicrobial, anti-biofilm and bacteriostatic compositions.

2. 发明公开

EP3266765A1 BORON-DIPYRRIN COMPLEX AND PHARMACEUTICAL PRODUCT CONTAINING SAME 有权
标题翻译：硼 - 双甘氨酸络合物和含有该化合物的药物产品
公开(公告)号：EP3266765A1
公开(公告)日：2018-01-10
申请号：EP16761669.7
申请日：2016-03-04
申请人： Japan Science and Technology Agency
发明人： KANAI, Motomu , SOMA, Yohei , SHIMIZU, Yusuke , TANIGUCHI, Atsuhiko , OISAKI, Kounosuke , KUNINOBU, Yoichiro
IPC分类号： C07D207/44 , A61K31/69 , A61P25/28 , C07D207/456 , C07D401/14 , C07D455/04 , C07F5/02 , A61K41/00
CPC分类号： A61K31/69 , A61K31/4025 , A61K31/4725 , A61K41/00 , C07D207/44 , C07D207/456 , C07D207/46 , C07D215/06 , C07D401/14 , C07D455/04 , C07F5/02
摘要： Provided are a compound which is useful as an in vivo applicable, amyloid-oxygenating catalyst selective for amyloid and applicable not only to an Aβ peptide, but also to other amyloids and a drug containing the compound for preventing and/or treating amyloid-related diseases.
Disclosed is a boron-dipyrrin complex represented by the following formula (1)

wherein X 1 and X 2 are the same or different and each represent a halogenoalkyl group or a halogen atom;
R 1 represents a hydrogen atom, an alkyl group, or a group represented by formula (b):

R 2 and R 6 are the same or different and each represent a hydrogen atom or a halogen atom;
R 3 , R 4 , R 5 , and R 7 are the same or different and each represent a hydrogen atom, a halogen atom, or an alkyl group;
R 8 represents a hydrogen atom or -(CH 2 ) l -(Y) m -(CH 2 ) n -Z wherein Y represents -CO-, -CONH-, or a triazole ring, Z represents a carboxyl group, a sulfonic acid group, or a -CO-peptide residue, 1 and n each represent an integer of 1 to 6, and m represents 0 or 1;
R 9 and R 10 are the same or different and each represent a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, an amino group, a nitro group, or a cyano group; and
R 8 and R 10 together optionally form an alkylene group.
摘要翻译：本发明提供可用作淀粉样蛋白选择性体内适用的淀粉样蛋白增氧催化剂的化合物，不仅适用于Aβ肽，而且适用于其他淀粉状蛋白和含有该淀粉样蛋白相关疾病的预防和/或治疗用化合物的药物。公开了由下式（1）表示的硼 - 双联吡啶配合物，其中X 1和X 2相同或不同并且各自表示卤代烷基或卤素原子; R 1表示氢原子，烷基或由式（b）表示的基团：R 2和R 6相同或不同并且各自表示氢原子或卤素原子; R3，R4，R5和R7相同或不同，各自表示氢原子，卤素原子或烷基; R8代表氢原子或 - （CH2）l-（Y）m-（CH2）nZ，其中Y代表-CO - ， - CONH-或三唑环，Z代表羧基，磺酸基或 -CO-肽残基，1和n各自表示1至6的整数，并且m表示0或1; R9和R10相同或不同，分别表示氢原子，烷基，烷氧基，卤素原子，氨基，硝基或氰基。并且R 8和R 10一起任选地形成亚烷基。

3. 发明公开

EP2993197A1 PHTHALOCYANINE COLORANTS AND THEIR USE AS FLUORESCENT SECURITY TAGGANTS 审中-实审
标题翻译： PHARALOCYANINFARBSTOFFE UND DEREN VERWENDUNG ALS FLUORESZIERENDE SICHERHEITSMARKIERUNGSMITTEL
公开(公告)号：EP2993197A1
公开(公告)日：2016-03-09
申请号：EP15185967.5
申请日：2007-11-29
申请人： Sun Chemical Corporation
发明人： SCHWARTZ, Russell , DERUSSY, Don , GLOSTER, Dan , POSTLE, Steve , VIP, Rakesh , COOK, Ewell , ROMANOVA, Tanya
IPC分类号： C08G65/32 , C08G65/325 , C07D471/06 , C09D11/00 , C09B3/28 , C09B5/62 , C09B29/40
CPC分类号： C07D493/06 , C07D207/44 , C07D471/06 , C08G65/331 , C08G65/33341 , C09B11/04 , C09B23/02 , C09B29/0033 , C09B29/3608 , C09B47/04 , C09B69/00 , C09D11/037 , C09D11/101 , C09D11/328 , C09D11/36 , C09D11/50 , C09D171/02 , Y10S252/965
摘要： Certain phthalocyanine colorants are disclosed along with method of preparation thereof. A method of using these colorants as fluorescent security taggants is also disclosed.
摘要翻译：公开了某些酞菁着色剂及其制备方法。还公开了使用这些着色剂作为荧光防伪标签的方法。

4. 发明公开

EP2909200A2 N-(PYRIDIN-2-YL)PYRIMIDIN-4-AMINE DERIVATIVES CONTAINING A SULFONE GROUP 有权
标题翻译：甲砜基团含有N-（吡啶-2-基）嘧啶-4-胺衍生物
公开(公告)号：EP2909200A2
公开(公告)日：2015-08-26
申请号：EP13777070.7
申请日：2013-10-16
申请人： Bayer Pharma Aktiengesellschaft
发明人： LÜCKING, Ulrich , BÖHNKE, Niels , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , BÖMER, Ulf , KOSEMUND, Dirk , BOHLMANN, Rolf , ZORN, Ludwig
IPC分类号： C07D405/14 , C07D401/12 , A61K31/506 , A61P9/00 , A61P31/12 , A61P35/00
CPC分类号： C07D401/12 , A61K31/506 , A61K45/06 , C07D207/44 , C07D233/88 , C07D405/14 , A61K2300/00
摘要： The present invention relates to N-(pyridin-2-yl)pyrimidin-4-amine derivatives containing a sulfone group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

5. 发明授权

EP1836165B1 DIPYRROLE COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATING CANCER OR VIRAL DISEASES 有权
标题翻译： DIPYRROLVERBINDUNGEN，组合物和用于治疗癌症或病毒疾病的方法
公开(公告)号：EP1836165B1
公开(公告)日：2014-02-12
申请号：EP05823816.3
申请日：2005-12-22
申请人： Gemin X Pharmaceuticals Canada Inc.
发明人： ATTARDO, Giorgio , TRIPARTHY, Sasmita , RIOUX, Elise , GONZALEZ, Gerson
IPC分类号： C07D207/44 , C07D409/14 , C07D401/14 , A61P35/00 , A61K31/4439 , A61K31/4025 , A61P31/12 , A61K31/5377 , A61K31/506 , A61K31/4709
CPC分类号： C07D207/44 , A61K31/4025 , A61K31/4439 , A61K31/4709 , A61K31/506 , A61K31/5377 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14

6. 发明公开

EP2208772A4 LUMINESCENT-ELEMENT MATERIAL AND LUMINESCENT ELEMENT 有权
标题翻译：材料而发光元素和发光元件端
公开(公告)号：EP2208772A4
公开(公告)日：2011-08-17
申请号：EP08844375
申请日：2008-10-28
申请人： TORAY INDUSTRIES
发明人： NAGAO KAZUMASA , TOMINAGA TSUYOSHI
IPC分类号： C09K11/06 , C07D207/44 , C07F5/02 , H01L51/50
CPC分类号： C07F5/022 , C07D207/44 , C07D235/18 , C07D307/80 , C07D471/04 , C09K11/06 , C09K2211/1096 , H01L51/0054 , H01L51/006 , H01L51/0072 , H01L51/0073 , H01L51/008 , H01L51/5012 , H01L51/5048 , H05B33/14 , Y10S428/917

7. 发明公开

EP2121578A2 NEW PROCESS 有权
标题翻译：用于生产5-联苯-4-氨基-2-甲基PENTA ACID
公开(公告)号：EP2121578A2
公开(公告)日：2009-11-25
申请号：EP08706986.0
申请日：2008-01-10
申请人： Novartis AG
发明人： HOOK, David , RUCH, Thomas , RISS, Bernhard , WIETFELD, Bernhard , SEDELMEIER, Gottfried , NAPP, Matthias , BÄNZIGER, Markus , HAWKER, Steven , CISZEWSKI, Lech , WAYKOLE, Liladhar, Murlidhar
IPC分类号： C07C227/22 , C07C227/32 , C07C229/34 , C07C269/06 , C07C271/22 , C07D207/26 , C07D207/28
CPC分类号： C07C231/02 , C07C219/18 , C07C227/16 , C07C227/20 , C07C227/22 , C07C227/32 , C07C229/34 , C07C231/12 , C07C231/14 , C07C233/47 , C07C269/04 , C07C271/22 , C07C2601/16 , C07D207/12 , C07D207/24 , C07D207/26 , C07D207/267 , C07D207/27 , C07D207/273 , C07D207/277 , C07D207/40 , C07D207/404 , C07D207/44 , C07D403/06 , C07F7/10 , Y02P20/55
摘要： The present invention relates to pyrrolidin-2-ones according to the formula (1), or salts thereof, wherein R1 is hydrogen or a nitrogen protecting group, methods for their preparation and their use in the preparation of NEP-inhibitors, particularly in the preparation of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.

8. 发明授权

EP1474440B1 CONIOSULFIDE UND DEREN DERIVATE, VERFAHREN ZUR IHRER HERSTELLUNG UND VERWENDUNG ALS ARZNEIMITTEL 有权
标题翻译： Coniosulfides及其衍生物，用于工艺的生产和使用AS药物
公开(公告)号：EP1474440B1
公开(公告)日：2008-09-10
申请号：EP02777014.8
申请日：2002-09-06
申请人： Sanofi-Aventis Deutschland GmbH
发明人： VERTESY, László , EHRLICH, Klaus , KURZ, Michael , SEGETH, Marian, Paul , TOTI, Luigi
IPC分类号： C07K5/06 , C07K5/083 , A61K38/05 , A61K38/06 , A61K31/4015 , A61P25/28
CPC分类号： C07D207/44 , A61K31/4015 , A61K38/00 , C07K5/06026 , C07K5/0806 , C12P11/00 , C12P13/001 , C12P13/02
摘要： The invention relates to compounds of formula (I), which are formed from the micro-organism Coniochaeta ellipsoidea Udagawa, DSM 13856, or from one of its mutations and/or variants during fermentation and which optionally are chemically converted into derivatives. The invention also relates to a method for producing compounds of formula (I) and to the use of the same as medicaments. In addition, the invention relates to the use of a compound of formula (VI) for producing a medicament for the treatment and prophylaxis of degenerative neuropathies or Alzheimer's disease.

9. 发明公开

EP1603902A1 NEW HETEROCYCLIC COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS DYES AND PIGMENTS 审中-公开
标题翻译：新的杂环化合物，进程中为其及其作为染料和颜料
公开(公告)号：EP1603902A1
公开(公告)日：2005-12-14
申请号：EP04741425.5
申请日：2004-03-10
申请人： Ciba Specialty Chemicals Holding Inc.
发明人： ADAM, Jean-Marie , DALVI, Pramod V. , EKKUNDI, Vadiraj Subbanna , BACHER, Jean-Pierre , SREENIVASAN, Ramaswami,Wilderness Society , RANE, Deepak M.,Hsg. Society
IPC分类号： C07D407/04 , C07D407/10 , C07D413/10
CPC分类号： C07D207/44 , C07D233/96 , C07D263/40 , C07D307/34
摘要： Compounds of formula (I) wherein R1 is hydrogen, hydroxy, halogen, nitro, cyano, amino, carboxy, carboxylic ester, sulfo, sulfonic ester, carboxylic amide, sulfonic amide, alkylthio, arylthio, alkoxy or aryloxy, R'1 is hydrogen, hydroxy, halogen, nitro, cyano, amino, carboxy, carboxylic ester, sulfo, sulfonic ester, carboxylic amide, sulfonic arnide, alkylthio, arylthio, alkoxy or aryloxy, X is -O-, -S-, -NH- or -N(alkyl)-, X' is -0-, -S-, -NH- or -N(alkyl)-, Y is hydrogen or carboxylic ester, Y' is hydrogen or carboxylic ester, Z is =C- or =N-, Z' is =C- or =N-, x is 0 or 1, when Z is =N-, then x is 0, y is 0 or 1, when Z' is =N-, then y is 0, A is a conjugated linking bridge of the formulae (II), (III), (IV), (V), or (VI), wherein n is 0, 1, 2 or 3, m is 0, 1, 2 or 3, B is a phenyl ring, T is =C(R3)- or =N-, wherein R3 is hydrogen, C1-C12alkyl or CN, W is a heterocyclic, or linear or polycondensed aromatic group which is unsubstituted or substituted by alkyl, halogen, hydroxy, alkoxy, alkylthio or amino, G is -CH= or -N=, and R2 is hydrogen, alkyl, halogen, hydroxy, alkoxy, alkylthio or amino, their preparation and their use in the production of coloured plastics or polymeric color particles.

10. 发明公开

EP1474440A2 CONIOSULFIDE UND DEREN DERIVATE, VERFAHREN ZUR IHRER HERSTELLUNG UND VERWENDUNG ALS ARZNEIMITTEL 有权
标题翻译： Coniosulfides及其衍生物，用于工艺的生产和使用AS药物
公开(公告)号：EP1474440A2
公开(公告)日：2004-11-10
申请号：EP02777014.8
申请日：2002-09-06
申请人： Aventis Pharma Deutschland GmbH
发明人： VERTESY, László , EHRLICH, Klaus , KURZ, Michael , SEGETH, Marian, Paul , TOTI, Luigi
IPC分类号： C07K5/06 , C07K5/083 , A61K38/05 , A61K38/06 , A61K31/4015 , A61P25/28
CPC分类号： C07D207/44 , A61K31/4015 , A61K38/00 , C07K5/06026 , C07K5/0806 , C12P11/00 , C12P13/001 , C12P13/02
摘要： The invention relates to compounds of formula (I), which are formed from the micro-organism Coniochaeta ellipsoidea Udagawa, DSM 13856, or from one of its mutations and/or variants during fermentation and which optionally are chemically converted into derivatives. The invention also relates to a method for producing compounds of formula (I) and to the use of the same as medicaments. In addition, the invention relates to the use of a compound of formula (VI) for producing a medicament for the treatment and prophylaxis of degenerative neuropathies or Alzheimer's disease.

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