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1. 发明公开

EP4353713A1 T-TYPE CALCIUM CHANNEL BLOCKER 审中-实审
公开(公告)号：EP4353713A1
公开(公告)日：2024-04-17
申请号：EP22820195.0
申请日：2022-06-06
申请人： Kinki University , National University Corporation University Of Toyama , Fuso Pharmaceutical Industries, Ltd.
发明人： KAWABATA, Atsufumi , SEKIGUCHI, Fumiko , TOYOOKA, Naoki , OKADA, Takuya , NISHIKAWA, Hiroyuki
IPC分类号： C07D235/26 , A61K31/4184 , A61K31/454 , A61P3/10 , A61P9/00 , A61P9/12 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/04 , A61P25/04 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P35/00
CPC分类号： A61K31/4184 , A61K31/454 , A61P3/10 , A61P9/00 , A61P13/10 , A61P13/12 , A61P15/00 , A61P9/10 , A61P9/12 , A61P17/00 , A61P17/04 , A61P25/04 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P35/00 , A61P43/00 , C07D235/26 , C07D401/04
摘要： The present invention provides a compound of formula (I) :

wherein R1, R2, R3, R4, k, 1, m and n are as defined in the specification,
or a pharmaceutically acceptable salt thereof with the effect of inhibiting T-type calcium channels and a medicament useful for the treatment of a disease associated with the activation of T-type calcium channels.

2. 发明公开

EP4292593A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING CYTOKINE STORM 审中-实审
公开(公告)号：EP4292593A1
公开(公告)日：2023-12-20
申请号：EP22752864.3
申请日：2022-02-14
申请人： Kinki University
发明人： NISHIDA Shozo , TSUBAKI Masanobu , TAKEDA Tomoya , TANABE Genzoh , TAKASHIMA Katsuki , MORIKAWA Toshio
IPC分类号： A61K31/352 , A23L33/10 , A61P37/02 , A61P43/00
摘要： [Problem]
COVID-19 caused by coronavirus SARS-CoV-2, cytokine release syndrome, cytokine release syndrome with CAR (chimeric antigen receptor)-T therapy, sepsis, systemic inflammatory response syndrome, hemophagocytic syndrome, macrophage activation syndrome, influenza, GVHD, systemic vasculitis, Kawasaki disease, Takayasu arteritis, and other diseases, if severe, can cause acute respiratory distress syndrome, disseminated intravascular coagulation syndrome, acute circulatory insufficiency, multi-organ failure, and other symptoms which are one of the causes of death.
[Solution to Problem]
Compounds represented by formulas (1) to (4) are effective when taken orally and can be expressed in smaller amounts than mangiferin.

3. 发明公开

EP3995566A1 CELL CULTURE SCAFFOLD, PRODUCTION METHOD AND SCAFFOLD PRODUCTION KIT THEREFOR, AND CELL CULTURE CREATION METHOD 审中-实审
公开(公告)号：EP3995566A1
公开(公告)日：2022-05-11
申请号：EP20837127.8
申请日：2020-07-06
申请人： Kinki University
发明人： KUSUNOKI Masanobu , TAKEUCHI Hiroki , TOGO Hidetaka
IPC分类号： C12M3/00 , C12N5/02
摘要： An object is to provide a cell culture scaffold which makes it possible to recover a cell culture product without being destroyed after cell culturing and a method for producing a cell culture product.
The cell culture scaffold according to the present invention includes a substrate having a water-repellent surface and a cell adhesion molecule formed on the water-repellent surface of the substrate. Further, the method for producing a cell culture product according to the present invention includes a step of culturing, using the cell culture scaffold, cells on the surface of the cell adhesion molecule. The cell culture scaffold according to the present invention makes it possible to recover the cells in a spheroid state without causing a damage.

4. 发明授权

EP3042949B1 CULTIVATION METHOD FOR BACTERIA BELONGING TO GENUS COLLIMONAS AND STORAGE METHOD 有权
公开(公告)号：EP3042949B1
公开(公告)日：2018-11-14
申请号：EP13893103.5
申请日：2013-09-04
申请人： New Environmental Technology Council , Kinki University
发明人： ANO, Takashi , HIROSE, Yoichiro
IPC分类号： C12N1/20 , A01N25/22 , A01N63/00
CPC分类号： C12N1/20 , A01N63/00 , C12N1/04 , A01N25/22
摘要： Provided are a novel cultivation method and a storage method that are suitable for storing bacteria belonging to the genus Collimonas for a long period of time. The cultivation method for bacteria belonging to the genus Collimonas is characterized in that bacteria belonging to the genus Collimonas are cultivated in a sealed state on a culture medium that includes a rice bran culture medium and/or a soy pulp culture medium. The storage method for bacteria belonging to the genus Collimonas is characterized in that the cultivated bacteria belonging to the genus Collimonas are stored at room temperature.

5. 发明公开

EP3257946A1 METHOD FOR PRODUCING METABOLITE CAPABLE OF IMPROVING DROUGHT TOLERANCE USING MICROORGANISM, AND METHOD FOR IMPROVING DROUGHT TOLERANCE OF PLANT USING SAID METABOLITE 审中-公开
标题翻译：利用微生物生产能够提高干旱耐性的代谢物的方法以及使用所述代谢物改善植物耐旱性的方法
公开(公告)号：EP3257946A1
公开(公告)日：2017-12-20
申请号：EP15881939.1
申请日：2015-02-10
申请人： New Environmental Technology Council , Kinki University
发明人： ANO Takashi , HIROSE Yoichiro
IPC分类号： C12P7/42 , A01G7/06
CPC分类号： A01G7/06 , C12P7/42
摘要： The purpose of the present invention is: to produce a metabolite capable of improving drought tolerance of a plant to the same level as that achieved by abscisic acid, from a microorganism other than a microorganism that is known to be capable of producing abscisic acid; and to provide a method for improving drought tolerance of a plant using the metabolite. A method for producing a metabolite capable of improving drought tolerance using a microorganism, said method comprising culturing a microorganism that belongs to the genus Collimonas and has an ability of producing a metabolite capable of improving drought tolerance of a plant and then extracting the metabolite from a culture produced by the culturing.
摘要翻译：本发明的目的在于：从已知能够产生脱落酸的微生物以外的微生物产生能够提高与脱落酸达到的水平相同水平的植物耐旱性的代谢物; 并提供一种提高使用代谢物的植物的耐旱性的方法。一种使用微生物制造能够提高耐旱性的代谢物的方法，所述方法包括培养属于Collimonas的微生物并且具有生产能够提高植物的耐旱性的代谢物的能力，然后从所述微生物中提取代谢物的方法培养所产生的文化。

6. 发明公开

EP3222581A1 METHOD FOR PRODUCING CARBON NANOTUBE SHEET, AND CARBON NANOTUBE SHEET 有权
标题翻译：生产碳纳米管片材的方法和碳纳米管片材
公开(公告)号：EP3222581A1
公开(公告)日：2017-09-27
申请号：EP15861197.0
申请日：2015-11-20
申请人： Lintec Corporation , Lintec of America, Inc. , Kinki University
发明人： OVALLE, Raquel , TANAKA, Senku , INOUE, Kanzan
IPC分类号： C01B32/05 , B32B9/00
CPC分类号： C01B32/168 , B32B9/00 , B32B9/04 , B32B37/14 , B82Y30/00 , B82Y40/00 , C01B2202/08 , C01B2202/22 , C01P2006/10 , C01P2006/60 , Y10S977/742 , Y10S977/842 , Y10S977/932
摘要： The present invention provides a method for producing a carbon nanotube sheet that is excellent in light transmittance and conductivity, and the carbon nanotube sheet. The method includes firstly modifying of modifying a free-standing unmodified carbon nanotube sheet in which a plurality of carbon nanotubes are aligned in a predetermined direction. The firstly modifying includes performing a densification process of bringing the unmodified carbon nanotube sheet into contact with either one of or both of vapor and liquid particles of a liquid substance to produce a modified carbon nanotube sheet that contains the carbon nanotubes which are mainly aligned in a predetermined direction, and that includes a high density portion where the carbon nanotubes are assembled together and a low density portion where density of the carbon nanotubes is relatively lower than density in the high density portion.
摘要翻译：本发明提供一种制造透光率和导电性优异的碳纳米管片材和碳纳米管片材的方法。该方法首先包括修改修改自立式未改性碳纳米管片材，其中多个碳纳米管沿预定方向排列。第一次改性包括进行使未改性的碳纳米管片材与液体物质的蒸汽和液体粒子中的任一个或两者接触的致密化过程，以产生包含主要排列在液体物质中的碳纳米管的改性碳纳米管片材包括碳纳米管组装在一起的高密度部分和碳纳米管的密度相对低于高密度部分的密度的低密度部分。

7. 发明公开

EP3052129A2 PROTEIN BIOMARKER AND USES THEREOF 审中-公开
标题翻译：蛋白质标记在VERWENDUNGEN DAVON
公开(公告)号：EP3052129A2
公开(公告)日：2016-08-10
申请号：EP14848404.1
申请日：2014-09-30
申请人： Daiichi Sankyo Company, Limited , U3 Pharma GmbH , Kinki University , Amgen Inc.
发明人： SCHNEIDER, Matthias , BLUM, Sabine , YONESAKA, Kimio , NAKAGAWA, Kazuhiko , FREEMAN, Daniel J. , BECKMAN, Robert Allen , JIN, Xiaoping , MENDELL-HARARY, Renee Jeanne
IPC分类号： A61K39/395
CPC分类号： C07K16/32 , A61K31/517 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07K16/2863 , C07K16/40 , C07K2317/21 , C07K2317/76 , G01N33/5695 , G01N33/57423 , G01N2333/4756
摘要： The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as low. The invention is also directed to methods of performing an ELISA, including sequential steps of contacting a solid surface with a plurality of solutions each comprising in turn a capture antibody, a blocking agent, a sample suspected of containing an analyte, a detection antibody and an enzyme conjugate, in which the solid surface is subjected to a wash process after each sequential step.
摘要翻译：本发明涉及鉴定和治疗携带肿瘤或其他疾病的人类受试者的方法，包括评估人受试者的蛋白质水平的HRG基因表达，并向人受试者施用包含抗HER3抗体的治疗，其中HRG基因在蛋白质水平的表达被评估为高。本发明还涉及鉴定携带肿瘤或其它疾病的人类受试者的方法，其包括评价人受试者的蛋白质水平的HRG基因表达，并且将对HRG基因表达的人受试者包含抗HER3抗体的治疗在蛋白质水平被评估为低。本发明还涉及进行ELISA的方法，包括使固体表面与多个溶液接触的顺序步骤，每个溶液各自包含捕获抗体，封闭剂，怀疑含有分析物的样品，检测抗体和酶缀合物，其中固体表面在每个顺序步骤之后经受洗涤过程。

8. 发明公开

EP3000465A1 T-TYPE CALCIUM CHANNEL INHIBITOR 有权
标题翻译： T-TYP-CALCIUMKANALINHIBITOR
公开(公告)号：EP3000465A1
公开(公告)日：2016-03-30
申请号：EP14801611.6
申请日：2014-05-16
申请人： Kinki University , Fuso Pharmaceutical Industries, Ltd.
发明人： KAWABATA, Atsufumi , MATSUDA, Hideaki , SEKIGUCHI, Fumiko , MURATA, Kazuya , NISHIKAWA, Hiroyuki
IPC分类号： A61K31/352 , A61P3/14 , A61P25/04
CPC分类号： C07D311/32 , A61K31/352
摘要： The present invention provides a T-type calcium channel inhibitor which is a compound represented by formula (1), a pharmaceutically acceptable salt of this compound or a solvate of this compound. The present invention also provides: this T-type calcium channel inhibitor; a pharmaceutical product containing this T-type calcium channel inhibitor; and a therapeutic agent or prophylactic agent for diseases, the effective action of which is a T-type calcium channel inhibitory action. (In formula (1), each of R 1 and R 2 independently represents H, -OH or -OR 11 , wherein R 11 represents a C 1-3 alkyl group; each of R 3 and R 4 independently represents H, -OH or -OR 12 , wherein R 12 represents a C 1-3 alkyl group; and each of R 5 and R 6 independently represents H, a halogen atom, a C 1-10 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a phenyl group (which may be substituted by a C 1-6 alkoxy group or a halogen atom), a -C 1-3 alkyl-phenyl group (which may be substituted by a C 1-6 alkyloxy group or a halogen atom) or a C 10-50 prenyl group.)
摘要翻译：本发明提供了一种T型钙通道抑制剂，其为由式（1）表示的化合物，该化合物的药学上可接受的盐或该化合物的溶剂合物。本发明还提供：该T型钙通道抑制剂; 含有该T型钙通道抑制剂的药物产品; 以及用于疾病的治疗剂或预防剂，其有效作用是T型钙通道抑制作用。（式（1）中，R 1和R 2各自独立地表示H，-OH或-OR 11，其中R 11表示C 1-3烷基; R 3和R 4各自独立地表示H，-OH 或-OR 12，其中R 12表示C 1-3烷基; R 5和R 6各自独立地表示H，卤素原子，C 1-10烷基，C 2-6烯基， C 2-6炔基，苯基（其可以被C 1-6烷氧基或卤素原子取代），-C 1-3烷基 - 苯基（其可以被C 1-6取代）烷氧基或卤素原子）或C 10-50异戊烯基）。

9. 发明公开

EP2856999A1 EXPOSURE-PREVENTING CAP 有权
标题翻译：暴露 - 预防措施
公开(公告)号：EP2856999A1
公开(公告)日：2015-04-08
申请号：EP13797404.4
申请日：2013-05-15
申请人： Kinki University , GTO Ltd. , Nipro Corporation
发明人： ISHIWATA, Shunji , TAGA, Atsushi , NISHIDA, Shozo , KITA, Ayako , SUGIURA, Reiko , FUJITA, Hideki , HASEGAWA, Mitsuru
IPC分类号： A61J1/05
CPC分类号： A61J1/1443 , A61J1/1406 , A61J1/1425 , A61J1/145 , A61J1/1456 , A61J1/1468 , A61J1/2096 , B65D51/002
摘要： Provided is an exposure-preventing cap of a novel and simple structure that, by being mounted on a vial, can more reliably inhibit leaking of drug solution to an outside when pulling out and collecting drug solution in a syringe from the vial. An exposure-preventing cap, which is mounted on a mouth (64) of a vial (16) sealed with a rubber stopper (66), wherein a puncturing hole (34) is formed in a center part of a cap-shaped housing (12) that is attached to a mouth (64) of the vial (16), and a rubber membrane (14) is arranged at the puncturing hole (34) so as to form an internal space (74) between facing surfaces of the rubber membrane (14) and the rubber stopper (66). The rubber membrane (14) has a dome shape that is convex facing the rubber stopper (66).
摘要翻译：本发明提供一种新型且简单的结构的防露罩，其通过安装在小瓶上，能够更可靠地抑制从药瓶中取出注射器内的药液时向外部泄漏药液。一种安装在用橡皮塞（66）密封的小瓶（16）的口部（64）上的防
露盖，其中穿刺孔（34）形成在帽形壳体（16）的中心部分（14），该橡胶膜（14）安装在所述穿刺孔（34）处，以在所述橡胶的相对表面之间形成内部空间（74）膜（14）和橡胶塞（66）。橡胶膜（14）具有朝向橡胶塞（66）凸起的圆顶形状。

10. 发明公开

EP2692471A1 TOOL FOR FRICTION STIR PROCESSING AND METHOD FOR FRICTION STIR PROCESSING USING SAME 失效
标题翻译： REIBRÜHRSCHWEISSWERKZEUGUNDREIBRÜHRSCHWEISSVERFAHRENDAMIT
公开(公告)号：EP2692471A1
公开(公告)日：2014-02-05
申请号：EP12763193.5
申请日：2012-03-27
申请人： Osaka Prefecture University Public Corporation , Kinki University , Isel Co., Ltd
发明人： TAKASUGI Takayuki , KANENO Yasuyuki , OKI Sachio , HIRATA Tomotake , MOCHIZUKI Noboru
IPC分类号： B23K20/12 , C22C19/03 , C22F1/10 , C22F1/00
CPC分类号： B23K20/125 , B23K20/1255 , C22C19/007 , C22C19/03 , C22F1/10
摘要： A friction stir processing tool is formed from a Ni-based dual multi-phase intermetallic compound alloy containing rhenium(Re). The Ni-based dual multi-phase intermetallic compound alloy is preferably formed by casting, while gradually cooling, a melt containing all the components of the composition and is preferably heat treated after casting. Moreover, in a method for friction stir processing, a work is softened by friction heat generated when the friction stir processing tool, while rotating, is pressed against the work to be processed. The friction stir processing tool includes the Ni-based dual multi-phase intermetallic compound alloy, and therefore further high hardness is exhibited to improve abrasion resistance, so that even a long period of friction stir processing can be endured.
摘要翻译：摩擦搅拌处理工具由含有铼（Re）的Ni基双相金属间化合物合金形成。 Ni基双相金属间化合物合金优选通过在逐渐冷却的同时浇铸含有组合物的全部组分的熔体而形成，并且优选在铸造后进行热处理。此外，在摩擦搅拌处理方法中，当摩擦搅拌处理工具旋转时产生的摩擦热被压在待加工的工件上，使工件软化。摩擦搅拌处理工具包括Ni基双相金属间化合物合金，因此显示出更高的硬度以改善耐磨性，从而可以承受长时间的摩擦搅拌加工。

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