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1. 发明公开

EP3283457A1 COMPOUNDS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：化合物和方法治疗神经退行性疾病
公开(公告)号：EP3283457A1
公开(公告)日：2018-02-21
申请号：EP16780518.3
申请日：2016-04-11
申请人： Resilio Therapeutics, LLC
发明人： TAVARES, Francis Xavier , VITEK, Michael Peter
IPC分类号： C07C229/26 , A61K31/22 , A61K31/60 , A61K31/195 , C07C69/76 , C07C229/02
CPC分类号： C07C229/46 , A61K31/195 , A61K31/22 , A61K31/223 , A61K31/27 , A61K31/357 , A61K31/395 , A61K31/421 , A61K31/4422 , A61K31/549 , A61K31/661 , A61K31/6615 , A61K45/06 , A61P25/00 , A61P25/28 , A61P35/00 , C07C229/26 , C07C235/34 , C07C235/78 , C07C251/24 , C07C271/16 , C07C271/22 , C07C275/16 , C07C381/00 , C07C2602/08 , C07D211/86 , C07D211/90 , C07D263/44 , C07D269/00 , C07D285/34 , C07D317/36 , C07D317/40 , C07F9/06 , C07F9/09 , A61K2300/00
摘要： Novel compounds of formula (II) are disclosed. Compounds of formula (II) comprise ornithine derivatives or compounds that may metabolize to ornithine. Also disclosed are methods for the treatment of neurodegenerative diseases such as Alzheimer's Disease using compounds of formula (II).

2. 发明公开

EP3077488A4 COMPOSITION AND METHOD OF FORMING THE SAME 审中-实审
标题翻译： ZUSAMMENSETZUNG UND VERFAHREN ZUR HERSTELLUNG DAVON
公开(公告)号：EP3077488A4
公开(公告)日：2017-06-14
申请号：EP14868196
申请日：2014-12-04
申请人： BASF SE
发明人： HOEY MICHAEL DENNIS , SCANLON EUGENE , MENSAH FREDERICK , BROWN DOUGLAS S , JUNG ALFRED KARL , SEIBEL SHAUN ROBERT , HASENHUETL PATRICK DANIEL , SCHMITT RALF LORENZ
IPC分类号： C10M137/10 , C07F9/165 , C10M159/12
CPC分类号： C10M159/123 , C07F9/06 , C07F9/1651 , C10M137/105 , C10M2223/043 , C10M2223/047 , C10N2220/021 , C10N2230/06 , C10N2230/08 , C10N2230/50 , C10N2230/64 , C10N2240/08 , C10N2240/10 , C10N2240/12 , C10N2240/14 , C10N2240/40
摘要： A composition comprises the reaction product of a dithiophosphate derivative and an amine. The reaction product is present in the composition in an amount of at least about 25 wt. %. The composition may include additional components. A method of forming the composition comprises the step of combining the dithiophosphate derivative and the amine to form the composition. A method of increasing thermal stability of a dithiophosphate derivative comprises the step of combining the dithiophosphate derivative and an amine. The dithiophosphate derivative can decompose to form hydrogen sulfide (H2S). However, the amine substantially prevents thermal decomposition of the dithiophosphate derivative. An example of the dithiophosphate derivative is 3-(di-isobutoxy-thiophosphorylsulfanyl)-2-methyl-propanoic acid. An example of the amine is ditridecyl amine. The composition can be used for a variety of applications. For example, the composition can be used as an antiwear compound/additive in lubricants, metalworking fluids, hydraulic fluids, etc.
摘要翻译：组合物包含二硫代磷酸酯衍生物和胺的反应产物。反应产物在组合物中的存在量为至少约25wt。％。该组合物可以包含其他组分。形成组合物的方法包括将二硫代磷酸酯衍生物和胺组合以形成组合物的步骤。提高二硫代磷酸酯衍生物的热稳定性的方法包括将二硫代磷酸酯衍生物和胺结合的步骤。二硫代磷酸酯衍生物可分解形成硫化氢（H2S）。然而，该胺基本上防止了二硫代磷酸酯衍生物的热分解。二硫代磷酸酯衍生物的实例是3-（二异丁氧基 - 硫代磷酰基硫烷基）-2-甲基 - 丙酸。胺的一个例子是双十三烷基胺。该组合物可以用于各种应用。例如，该组合物可以用作润滑剂，金属加工液，液压液等中的抗磨损化合物/添加剂。

3. 发明授权

EP2909215B1 AZIN-METALLPHOSPHATE ALS FLAMMHEMMENDE MITTEL 有权转让
公开(公告)号：EP2909215B1
公开(公告)日：2017-03-29
申请号：EP12775443.0
申请日：2012-10-16
申请人： J.M. Huber Corporation
发明人： WEHNER, Wolfgang
IPC分类号： C07F3/00 , C07F3/02 , C07F3/06 , C09K21/10 , C09K21/12 , C07F9/6521 , C08K5/52 , C08K5/5313 , C07F9/06
CPC分类号： C07F9/6521 , C07F3/003 , C07F3/02 , C07F3/06 , C07F9/06 , C08K5/5205 , C08K5/5313 , C09K21/12

4. 发明公开

EP2995604A4 PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF 有权转让
标题翻译：苯酚衍生物及其在医药方法和用途
公开(公告)号：EP2995604A4
公开(公告)日：2017-01-18
申请号：EP14795509
申请日：2014-05-06
申请人： SICHUAN HAISCO PHARMACEUTICAL CO LTD
发明人： QIN LINLIN , LI FANGQIONG , YI SHIXU , LUO HUADONG , LUO XINFENG , WAN SONGLIN , REN LEI , LIU GUOLIANG , WEI YONGGANG , LIU JIANYU , TANG PENG CHO
IPC分类号： C07C43/02 , A61K31/05 , A61P9/00 , A61P25/00
CPC分类号： C07C39/17 , C07C37/00 , C07C37/001 , C07C37/62 , C07C39/42 , C07C41/18 , C07C43/21 , C07C43/23 , C07C67/10 , C07C68/00 , C07C69/07 , C07C69/157 , C07C69/24 , C07C69/78 , C07C69/82 , C07C69/96 , C07C227/04 , C07C229/08 , C07C229/36 , C07C269/00 , C07C271/22 , C07C271/44 , C07C2601/02 , C07C2601/04 , C07D207/16 , C07D213/80 , C07D213/803 , C07F9/06 , C07F9/091 , C07F9/094 , C07F9/12 , C07F9/242 , C07F9/2458 , C07F9/65744
摘要： The present invention relates to a phenol derivative and the preparation method and use in medicine thereof, and particular to a phenol derivative represented by general formula (A) or a stereoisomer, a solvate, a metabolite, a prodrug, a pharmaceutically acceptable salt or a cocrystal thereof, a preparation method thereof, a pharmaceutical composition comprising the same, and use of the compound or composition of the present invention in the field of the central nervous system; wherein the definitions of substituents in general formula (A) are the same as those in the Description.

5. 发明授权

EP2947089B1 NEUE MONOPHOSPHITLIGANDEN MIT EINER CARBONAT-GRUPPE 有权
标题翻译：与一组新亚磷酸盐碳酸盐
公开(公告)号：EP2947089B1
公开(公告)日：2016-08-24
申请号：EP15166015.6
申请日：2015-04-30
申请人： Evonik Degussa GmbH
发明人： Dyballa, Katrin Marie , Franke, Robert
IPC分类号： C07F9/6574 , C07F9/145 , B01J31/18 , C07C45/50
CPC分类号： C07F9/06 , B01J31/185 , C07C45/50 , C07F9/145 , C07F9/65742 , C07F9/65744 , C07C47/02

6. 发明公开

EP2903971A4 SUBSTITUTED N-(3-(PYRIMIDIN-4-YL)PHENYL)ACRYLAMIDE ANALOGS AS TYROSINE RECEPTOR KINASE BTK INHIBITORS 审中-公开
标题翻译：取代的N-（3-（嘧啶-4-基）苯基）丙烯酰胺类似物如TYROSINREZEPTORKINASE-BTK-缝边
公开(公告)号：EP2903971A4
公开(公告)日：2016-05-25
申请号：EP13844062
申请日：2013-10-04
申请人： UNIV UTAH RES FOUND
发明人： VANKAYALAPATI HARIPRASAD , SORNA VENKATASWAMY , WARNER STEVEN L , BEARSS DAVID J , SHARMA SUNIL
IPC分类号： C07D239/24 , A61K31/505 , A61K31/506 , A61K31/661 , A61K31/6615 , C07D239/42 , C07D487/04 , C07F9/06 , C07F9/6558 , C07F9/6561
CPC分类号： C07D239/42 , A61K31/505 , A61K31/506 , A61K31/661 , A61K31/6615 , C07D487/04 , C07F9/06 , C07F9/65583 , C07F9/6561
摘要： In one aspect, the invention relates to substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the BTK kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the BTK kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

7. 发明公开

EP2671886A2 METHOD FOR PRODUCING POLYPRENYL PHOSPHATES 有权
标题翻译：生产聚丙烯酸磷酸酯的方法
公开(公告)号：EP2671886A2
公开(公告)日：2013-12-11
申请号：EP11858365.7
申请日：2011-12-28
申请人： Obschestvo S Ogranichennoy Otvetstvennostyu GamaVetFarm (OOO GamaVetFarm)
发明人： DANILOV, Leonid Leonidovich
IPC分类号： C07F9/113
CPC分类号： C07F9/06 , C07F9/113
摘要： The invention relates to organic chemistry. Its use in isoprenoid chemistry allow to achieve the technical result in the form of a universal, workable and economical method for producing polyprenyl phosphates. This result is achieved in that in the method for producing polyprenyl phosphates of general structural formula (I) ,

where each isoprene unit contains 5 carbon atoms, W means a ω-end isoprene unit, T means a trans-isoprene unit, C means a cis-isoprene unit, S means a 2,3-dihydroisoprene unit, a = 0-10, b = 0-39, c = 0-1, a + b + c = 4-40, and X means a group of the formula OPO 3 MM', wherein M and M' are identical or different and are a hydrogen cation or monovalent inorganic or organic cation, or M and M' together are divalent inorganic or organic cation, the phosphorylation of the relevant polyprenol or a mixture of oligomer homologues, where X means hydroxyl group, using a substituted ammonium salt of phosphoric acid in the presence of condensing agent, is carried out in a medium consisting of first aprotic organic solvent; and a polyprenyl phosphate in the form of mono- or disubstituted salts thereof with monovalent cations or in the form of salts thereof with divalent cations is isolated by extraction and precipitation.
摘要翻译：本发明涉及有机化学。其在类异戊二烯化学中的用途使得能够以通用，可行和经济的生产聚异戊二烯磷酸酯的方式获得技术结果。该结果是通过用于制备通式（I）的聚异戊烯基磷酸酯的方法来实现的，其中每个异戊二烯单元含有5个碳原子，W代表ω-末端异戊二烯单元，T代表反式异戊二烯单元，C代表顺式异戊二烯单元，S表示2,3-二氢异戊二烯单元，a = 0-10，b = 0-39，c = 0-1，a + b + c = 4-40，X表示其中M和M'相同或不同并且是氢阳离子或单价无机或有机阳离子，或M和M'一起为二价无机或有机阳离子，相关聚异戊二烯醇或低聚物同系物混合物的磷酸化其中X代表羟基，在缩合剂存在下使用取代的磷酸铵盐，在由第一非质子有机溶剂组成的介质中进行; 通过萃取和沉淀分离出单价或二价阳离子形式的单磷酸或二取代磷酸盐形式的聚异戊二烯基磷酸酯或其与二价阳离子形式的盐。

8. 发明公开

EP2596002A2 SYNTHESIS OF RESVERATROL-BASED COMPOUNDS 审中-公开
标题翻译：合成VONBINDUNGEN AUF DER BASIS VON RESVERATROL
公开(公告)号：EP2596002A2
公开(公告)日：2013-05-29
申请号：EP11810391.0
申请日：2011-07-21
申请人： The Trustees of Columbia University in the City of New York
发明人： SNYDER, Scott Alan
IPC分类号： C07F9/09
CPC分类号： C07F9/06 , C07C39/17 , C07C49/747 , C07C69/017 , C07C69/21 , C07C69/738 , C07C323/17 , C07C2602/08 , C07F9/093
摘要： A compound having the structure: wherein bond alpha is present or absent, wherein when bond alpha is absent, then R1 is =O or S(CH2)1-3-phenyl and when bond alpha is present, then R1 is H, wherein the phenyl is substituted or unsubstituted; R2, R3, R4, R5, R6, R7, R8, R9 and R10 are independently H or OR11 wherein each occurrence of R11 is independently H, methyl, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, phosphate, sulfate, sulfonic ester, or ester; when alpha is absent and R1 is =O, then R10 is other than OH; and when alpha is absent and R1 is S(CH2)1-3-phenyl, then R10 is other than OCH3, or a salt thereof.
摘要翻译：具有以下结构的化合物：其中键α存在或不存在，其中当不存在α键时，则R1为= O或S（CH2）1-3-苯基，当存在键α时，则R1为H，其中苯基是取代或未取代的; R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和R 10独立地为H或OR 11，其中每次出现的R 11独立地为H，甲基，取代或未取代的烷基，取代或未取代的芳基，磷酸酯，硫酸酯，磺酸酯，或酯; 当α不存在且R1为= O时，则R10不是OH; 并且当不存在α并且R 1是S（CH 2）1-3 - 苯基时，则R 10不是OCH 3或其盐。

9. 发明公开

EP2064177A2 PROTEASE INHIBITORS 有权
标题翻译： PROTEASEHEMMER
公开(公告)号：EP2064177A2
公开(公告)日：2009-06-03
申请号：EP07872067.9
申请日：2007-09-20
申请人： Ambrilia Biopharma Inc.
发明人： STRANIX, Brent Richard , LAVALLEE, Jean-Francois , LEBERRE, Nicolas , PERRON, Valerie , HERBART, Dominik , MILOT, Guy , PANCHAL, Chandra J.
IPC分类号： C07C311/00
CPC分类号： C07C311/41 , C07C271/22 , C07C311/42 , C07C2601/14 , C07D213/56 , C07D213/82 , C07D265/36 , C07D307/79 , C07D317/62 , C07D319/18 , C07D405/12 , C07D413/12 , C07F9/06 , C07F9/091 , C07F9/582
摘要： The present invention provides HIV protease inhibitors of formulas I, IA, IB, Ib or II, or pharmaceutically acceptable salts thereof, wherein R
2 may be, for example, 2-pyridyl-CH
2 -, 3- pyridyl-CH
2 -, 4-pyridyl-CH
2 -, a sulfonyl group as described in the formulas herein including benzenesulfonyl or thiophenesulfonyl groups, R
2a -CO)-, R
2a being selected from the group consisting of piperonyl, 2-pyranzinyl (unsubstituted or substituted with H, or an alkyl of 1 to 4 carbon atoms) or a picolylamine group as described herein, wherein R3 may be, for example, a phenyl group or diphenylmethyl group as described herein, and wherein Cx may be, for example, COOH, CONR
5 R
6 , CH
2 OH or CH
2 OR
7 .
摘要翻译：本发明提供式I，IA，IB，Ib或II的HIV蛋白酶抑制剂或其药学上可接受的盐，其中R 2可以是例如2-吡啶基-CH 2 - ，3-吡啶基-CH 2 - ，4-吡啶基 -CH 2 - ，如本文所述的磺酰基，包括苯磺酰基或噻吩磺酰基，R2a-CO-，R2a选自胡椒基，2-吡嗪基（未取代或被H取代或由1至 4个碳原子）或吡啶基胺基团，其中R 3可以是例如本文所述的苯基或二苯基甲基，并且其中C x可以是例如COOH，CONR 5 R 6，CH 2 OH或CH 2 OR 7。

10. 发明公开

EP1791567A2 CHEMICALLY MODIFIED OLIGONUCLEOTIDES 有权
标题翻译：化学修饰的寡核苷酸
公开(公告)号：EP1791567A2
公开(公告)日：2007-06-06
申请号：EP05786618.8
申请日：2005-08-10
申请人： Alnylam Pharmaceuticals Inc.
发明人： MANOHARAN, Muthiah , KESAVAN, Venkitasamy , RAJEEV, Kallanthottathil G.
IPC分类号： A61K48/00 , A61K31/675
CPC分类号： C12N15/113 , A61K31/7088 , A61K31/713 , A61K47/54 , A61K47/543 , A61K47/551 , A61K47/554 , C07F9/06 , C12N15/111 , C12N15/87 , C12N2310/113 , C12N2310/14 , C12N2310/351 , C12N2310/3515 , C12N2320/32 , C12N2320/51
摘要： This invention relates composition and methods for making and using chemically modified oligonucleotides agents for inhibiting gene expression.

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