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1. 发明授权

EP1056710B1 DITERPENE DERIVATIVES AND ANTI-INFLAMMATORY ANALGESIC AGENTS COMPRISING THE SAME 有权
标题翻译： ENTZÜNDUNGSHEMMENDESCHMERZMITTEL DIEE ENTHALTEN的DITERPENDERIVATE
公开(公告)号：EP1056710B1
公开(公告)日：2003-12-10
申请号：EP99901968.0
申请日：1999-01-25
申请人： Sae Han Pharm. Co., Ltd. , Suh, Young Ger
发明人： SUH, Young Ger , CHOI, Young Hoon , LEE, Hye Kyung , KIM, Young Ho , PARK, Hyoung Sup
IPC分类号： C07C63/44 , C07C57/40 , C07C233/00 , C07C311/00 , A61K31/19 , A61K31/16
CPC分类号： C07C69/14 , C07C57/40 , C07C57/42 , C07C62/06 , C07C62/32 , C07C62/34 , C07C69/608 , C07C233/58 , C07C243/36 , C07C259/08 , C07C311/51 , C07C2603/26 , C07D261/04

2. 发明公开

EP0181110A2 Histidine derivatives as renin inhibitors 失效
标题翻译： Histidinderivate ALS Renininhibitoren。
公开(公告)号：EP0181110A2
公开(公告)日：1986-05-14
申请号：EP85307555.4
申请日：1985-10-18
申请人： Kissei Pharmaceutical Co Ltd
发明人： Iizuka, Kinji , Kamijo, Tetsuhide , Kubota, Tetsuhiro , Akahane, Kenji , Umeyama, Hideaki , Kiso, Yoshiaki
IPC分类号： C07K5/06 , C07D233/64 , C07D403/02 , A61K37/02 , A61K31/415
CPC分类号： C07D233/64 , C07C51/487 , C07C57/38 , C07C57/40 , C07C59/66 , C07C59/68 , C07C65/34 , C07D209/18 , C07K5/06147 , Y10S530/86
摘要： @ Dipeptides are described which are represented by the formula

wherein His represents an L-histidyl group, Ar, represents a phenyl group, a naphthyl group or an indolyl group, Ar 2 represents a phenyl group or a naphthyl group, X represents a chemical bond, -NHCO-, -CONH-, -CO-, -CH 2 -, -NH-, -O- or -(CH=CH) P -wherein p is 1 or 2, Z represents an oxygen atom or
in which R 2 represents a hydrogen atom or combines with R, to form a chemical bond, m and n, which may be the same or different, each represents an integer of from 0 to 3, provided that when X is a chemical bond, the sum of n plus m is from 1 to 6 and when X is not a chemical bond, the sum of n plus m is from 1 to 4, Y represents a chemical bond when X is not a chemical bond, or, when X is a chemical bond, an alkylene group having 1 to 3 carbon atoms, R 1 represents a hydrogen atom or combines with R 2 to form a chemical bond, R 3 represents a formyl group or a hydroxymethyl group, R 4 represents an isobutyl group or a benzyl group, and C represents an L-configurational carbon atom; or the pharmaceutically acceptable salt thereof.
These compounds have a strong inhibitory effect on human renin, and are useful as a therapeutically active agent for the treatment of hypertension, especially renin - associated hypertension.

3. 发明授权

EP0028422B1 Process for preparing alcohols from carboxylic acids and process for preparing carboxylic acids 失效
标题翻译：从羧酸制备酒精的方法和制备羧酸的方法
公开(公告)号：EP0028422B1
公开(公告)日：1983-10-05
申请号：EP80106823.0
申请日：1980-11-05
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED
发明人： Takano, Tetsuo , Suzukamo, Gohu , Ishino, Masaru , Ikimi, Kiyoshi
IPC分类号： C07C29/136 , C07C33/18 , C07C33/46 , C07C43/295 , C07C51/12 , C07C57/30 , C07C31/125 , C07C31/36 , C07C31/20 , B01J23/36
CPC分类号： C07C29/149 , B01J23/36 , C07C51/12 , C07C2601/16 , C07C2602/28 , C07C33/20 , C07C31/125 , C07C31/36 , C07C35/21 , C07C57/30 , C07C57/58 , C07C57/40 , C07C57/32

4. 发明公开

EP0028422A1 Process for preparing alcohols from carboxylic acids and process for preparing carboxylic acids 失效
标题翻译：一种用于生产由羧酸和用于制备羧酸的方法醇的方法。
公开(公告)号：EP0028422A1
公开(公告)日：1981-05-13
申请号：EP80106823.0
申请日：1980-11-05
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED
发明人： Takano, Tetsuo , Suzukamo, Gohu , Ishino, Masaru , Ikimi, Kiyoshi
IPC分类号： C07C29/136 , C07C33/18 , C07C33/46 , C07C43/295 , C07C51/12 , C07C57/30 , C07C31/125 , C07C31/36 , C07C31/20 , B01J23/36
CPC分类号： C07C29/149 , B01J23/36 , C07C51/12 , C07C2601/16 , C07C2602/28 , C07C33/20 , C07C31/125 , C07C31/36 , C07C35/21 , C07C57/30 , C07C57/58 , C07C57/40 , C07C57/32
摘要： An alcohol is produced in a high selectivity with a good yield from the corresponding carboxylic acid by reducing the latter with hydrogen in the presence of a rhenium catalyst in the coexistence of an organic base. An arylacetic acid, which is included in the starting carboxylic acid, can be produced in an excellent yield from the corresponding aryl aldehyde by reacting the latter with carbon monoxide and water in the presence of rhodium or its compound and hydrogen iodide.
摘要翻译：的醇与从相应的羧酸通过还原后期与氢气在催化剂的铼的在有机碱的共存存在良好的产率的高选择性制备。在碘化物从通过使后者与一氧化碳和水在铑或它的化合物和氢的存在下芳基乙酸相应的芳基醛，所有这一切都包含在原料羧酸优异的产量，可以在制备。

5. 发明公开

EP1594512A2 COMPOUNDS FOR THE TREATMENT OF VIRAL INFECTION 审中-公开
标题翻译：化合物对于病毒感染的治疗
公开(公告)号：EP1594512A2
公开(公告)日：2005-11-16
申请号：EP04709018.8
申请日：2004-02-06
申请人： Kemia, INC.
发明人： ERNST, Justin, T. , BOMAN, Erik , CEIDE, Susana, C. , MONTALBAN, Antonio, G. , NAKANISHI, Hiroshi , ROBERTS, Edward , SAIAH, Eddine , LUM, Christopher
IPC分类号： A61K31/675 , A61K31/501 , A61K31/4439
CPC分类号： C07D257/04 , C07C57/40 , C07C59/70 , C07C59/72 , C07C69/712 , C07C217/92 , C07C233/25 , C07D311/76 , C07D333/56
摘要： The present invention is related to compounds, their intermediates, processes for their preparation and use, and pharmaceutical compositions comprising the compounds. The novel compounds are useful in therapy, and in particular for the treatment of viral infection, particularly HIV infection.

6. 发明授权

EP1261575B1 PROCEDE PERFECTIONNE DE FABRICATION D'ANHYDRIDES SYMETRIQUES 有权
标题翻译：用于生产对称酸酐
公开(公告)号：EP1261575B1
公开(公告)日：2004-12-29
申请号：EP00968006.7
申请日：2000-10-11
申请人： Atofina
发明人： PAUL, Jean-Michel , FABIS, Frédéric , RAULT, Sylvain
IPC分类号： C07C51/567 , C07C57/04
CPC分类号： C07C51/56 , C07C53/126 , C07C57/30 , C07C57/40 , C07C53/128 , C07C57/42 , C07C57/03 , C07C53/00
摘要： A symmetrical anhydride of formula (I) is produced by reacting a mixed anhydride (II) with a carboxylic acid (III), R1 being alkyl, alkenyl, aryl, alkylaryl, aralkyl; R2 being alkyl in C¿1?-C40, alkenyl in C1-C40, aryl, aryl-(alkyl in C1-C40) and (alkyl en C1-C40)-aryl.

7. 发明公开

EP0181110A3 Histidine derivatives as renin inhibitors 失效
标题翻译：作为RENIN抑制剂的HISTIDINE DERIVATIVES
公开(公告)号：EP0181110A3
公开(公告)日：1988-05-11
申请号：EP85307555
申请日：1985-10-18
申请人： Kissei Pharmaceutical Co Ltd
发明人： Iizuka, Kinji , Kamijo, Tetsuhide , Kubota, Tetsuhiro , Akahane, Kenji , Umeyama, Hideaki , Kiso, Yoshiaki
IPC分类号： C07K05/06 , C07D233/64 , C07D403/02 , A61K37/02 , A61K31/415
CPC分类号： C07D233/64 , C07C51/487 , C07C57/38 , C07C57/40 , C07C59/66 , C07C59/68 , C07C65/34 , C07D209/18 , C07K5/06147 , Y10S530/86
摘要： @ Dipeptides are described which are represented by the formula

wherein His represents an L-histidyl group, Ar, represents a phenyl group, a naphthyl group or an indolyl group, Ar 2 represents a phenyl group or a naphthyl group, X represents a chemical bond, -NHCO-, -CONH-, -CO-, -CH 2 -, -NH-, -O- or -(CH=CH) P -wherein p is 1 or 2, Z represents an oxygen atom or
in which R 2 represents a hydrogen atom or combines with R, to form a chemical bond, m and n, which may be the same or different, each represents an integer of from 0 to 3, provided that when X is a chemical bond, the sum of n plus m is from 1 to 6 and when X is not a chemical bond, the sum of n plus m is from 1 to 4, Y represents a chemical bond when X is not a chemical bond, or, when X is a chemical bond, an alkylene group having 1 to 3 carbon atoms, R 1 represents a hydrogen atom or combines with R 2 to form a chemical bond, R 3 represents a formyl group or a hydroxymethyl group, R 4 represents an isobutyl group or a benzyl group, and C represents an L-configurational carbon atom; or the pharmaceutically acceptable salt thereof. These compounds have a strong inhibitory effect on human renin, and are useful as a therapeutically active agent for the treatment of hypertension, especially renin - associated hypertension.

8. 发明公开

EP0110671A1 Preparation of optically active alpha-arylalkanoic acids and precursors thereof 失效
标题翻译：一种制备光学活性的α-芳基链烷酸和它们的前体的过程。
公开(公告)号：EP0110671A1
公开(公告)日：1984-06-13
申请号：EP83307158.2
申请日：1983-11-23
申请人： SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED
发明人： Erickson, Gary W.
IPC分类号： C07C51/353 , C07C59/64 , C07C57/30 , C07C57/38 , C07C57/40 , C07C57/58 , C07C69/736 , C07C69/612 , C07C69/616
CPC分类号： C07C51/353 , C07C51/347 , C07C57/38 , C07C59/64 , C07C57/30 , C07C57/40 , C07C57/58
摘要： This invention concerns a process of preparing optically active a-arylalkanoic acids useful as pharmaceutical (e.g., anti-inflammatory) agents, and their precursors. These a-arylalkanoic acids, esters, amides, nitriles, oxazolines and metal salts are stereoselectively prepared by forming the metal or metal halide of the corresponding acid, ester, amide, oxazoline, nitrile, or metal salt and treating the compound so prepared with an aryl halide in the presence of a chiral (optically active) transition metal catalyst, optionally in the presence of a dipolar aprotic solvent or mixtures thereof, for a time sufficient to form the corresponding optically active a-arylalkanoic acid, ester, amide, nitrile, oxazoline or metal salt, and optionally concomitantly or sequentially hydrolyzing any ester, amide, nitrile, oxazoline or metal salt formed to the corresponding optically active α-arylalkanoic acid. The process optionally further includes removal of halogen atom from the aromatic portion or methylation of the aryl hydroxyl portion of the a-arylalkanoic acid, as well as subsequent formation of the pharmaceutically acceptable salts and esters of the optically active a-arylalkanoic acid.
摘要翻译：本发明涉及制备作为药物（例如，抗炎）剂，及其前体的有用的光学活性的α-氨基酸-arylalkanoic的处理。这些α--arylalkanoic酸，酯，酰胺，腈，恶唑啉和金属盐立体选择性地通过形成相应的酸的金属或金属卤化物，酯，酰胺，恶唑啉，腈，或金属盐和处理该化合物，从而与制备制备芳基卤化物在手性（光学活性）的过渡金属催化剂的存在下，任选在偶极非质子溶剂或存在它们的混合物，足够长的时间以形成所述光学活性的α-CORRESPONDING -arylalkanoic酸，酯，酰胺，腈，恶唑啉或金属的盐，以及任选地同时或相继水解任何酯，酰胺，腈，在对应于所述光学活性的α--arylalkanoic酸恶唑啉或金属盐。的方法可选地还包括由芳族部分或α-arylalkanoic酸的羟基芳基部分的甲基化去除卤素原子的，以及光学活性的α--arylalkanoic酸的药学上可接受的盐和酯的后续形成。

9. 发明授权

EP0011279B1 Process for the preparation of aromatically substituted acetic acids 失效
标题翻译：制备芳香取代的乙酸的方法
公开(公告)号：EP0011279B1
公开(公告)日：1982-05-05
申请号：EP79104475.3
申请日：1979-11-13
申请人： SAGAMI CHEMICAL RESEARCH CENTER
发明人： Kondo, Kiyosi , Fujimoto, Tamotsu , Suda, Minoru , Tunemoto, Daiei
IPC分类号： C07C51/00 , C07C29/38
CPC分类号： C07D207/337 , C07C51/093 , C07C323/00 , C07D317/60 , C07D333/24 , C07C57/58 , C07C57/40 , C07C57/32 , C07C59/64 , C07C57/30 , C07C59/66

10. 发明公开

EP3160508A1 NOVEL REXINOID COMPOUNDS AND METHODS OF USING REXINOID COMPOUNDS FOR TREATING METABOLIC DISORDERS AND CANCER 有权
标题翻译：新型REXINOIDVERBINDUNGEN及其使用方法REXINOIDVERBINDUNGEN代谢性疾病和癌症的治疗
公开(公告)号：EP3160508A1
公开(公告)日：2017-05-03
申请号：EP15815081.3
申请日：2015-06-30
申请人： The UAB Research Foundation
发明人： MUCCIO, Donald D. , ATIGADDA, Venkatram Reddy , BROUILLETTE, Wayne J. , GRUBBS, Clinton J. , KIM, Jeonga
IPC分类号： A61K45/06 , A61K31/203
CPC分类号： C07C57/42 , A61K45/06 , A61P3/04 , A61P3/06 , A61P3/10 , A61P35/00 , C07C57/40 , C07C57/60 , C07C57/62 , C07C59/56 , C07C63/331 , C07C2602/10 , C07D307/54
摘要： Novel rexinoid compounds are provided herein. Also provided herein are methods of using the compounds to treat disorders, such as metabolic disorders, diabetes, insulin resistance, glucose intolerance, obesity, steatosis, inflammation, and/or cancer.
摘要翻译：中提供rexinoid新化合物。所以提供了所使用的化合物来治疗疾病，代谢疾病的方法：如，糖尿病，胰岛素抵抗，葡萄糖耐受不良，肥胖，脂肪变性，炎症和/或癌症。

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