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1. 发明公开

EP3004199A1 VERFAHREN ZUR HERSTELLUNG VON URETHAN(METH)ACRYLATEN 审中-公开
标题翻译：用于生产聚氨酯（甲基）丙烯酸酯
公开(公告)号：EP3004199A1
公开(公告)日：2016-04-13
申请号：EP14724463.6
申请日：2014-05-16
申请人： BASF SE
发明人： SCHWALM, Reinhold , NEUMANN, Susanne , KIMPEL, Delphine , BECK, Erich , MENZEL, Klaus
IPC分类号： C08G18/67 , C08G18/68 , C08G18/78 , C08G18/81 , C09D175/16
CPC分类号： C09D4/00 , C07C269/02 , C07C271/20 , C08G18/672 , C08G18/6725 , C08G18/68 , C08G18/7837 , C08G18/8175 , C09D175/16
摘要： The present invention relates to a novel method for producing urethane (meth)acrylates.

2. 发明公开

EP2604591A4 PROCESS FOR PREPARING AMINOADAMANTYL CARBAMATE DERIVATIVES 审中-公开
标题翻译：用于生产氨基金刚烷 - 氨基甲酸酯衍生物
公开(公告)号：EP2604591A4
公开(公告)日：2015-07-22
申请号：EP11816388
申请日：2011-08-08
申请人： SHIONOGI & CO
发明人： NISHINO YUTAKA , SHIMIZU HIDEKI , TSURITANI TAKAYUKI , SUZUKI NATSUKO , TAKAKI MUTSUMI , KOBAYASHI TATSUYA , SAKAMOTO HIDEAKI
IPC分类号： C07C269/06 , A61K31/415 , A61P3/10 , C07C269/02 , C07C269/08 , C07C271/34 , C07D231/14
CPC分类号： C07D231/14 , A61K31/415 , C07B2200/07 , C07C269/02 , C07C269/06 , C07C269/08 , C07C271/34 , C07C2603/74

3. 发明公开

EP2744778A4 META-SUBSTITUTED BIPHENYL PERIPHERALLY RESTRICTED FAAH INHIBITORS 有权
标题翻译：外设进行LIMITED FAAH抑制剂FROM META-取代的联苯
公开(公告)号：EP2744778A4
公开(公告)日：2015-04-08
申请号：EP12826376
申请日：2012-08-17
申请人： UNIV CALIFORNIA , FOND ISTITUTO ITALIANO DI TECNOLOGIA , UNIVERSIT DEGLI STUDI DI URBINO CARLO BO , UNIVERSIT DEGLI STUDI DI PARMA
发明人： PIOMELLI DANIELE , MORENO-SANZ GUILLERMO , BANDIERA TIZIANO , MOR MARCO , TARZIA GIORGIO
IPC分类号： C07C233/06 , A61K31/165 , A61P29/00 , C07C233/23 , C07D309/14
CPC分类号： C07C271/56 , C07C269/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D309/14
摘要： The present invention provides methods of making and using peripherally restricted inhibitors of fatty acid amide hydrolase (FAAH). The present invention provides compounds and compositions that suppress FAAH activity and increases anandamide levels outside the central nervous system (CNS). The present invention also sets forth methods for inhibiting FAAH as well as methods for treating conditions such as, but not limited to, pain, inflammation, immune disorders, dermatitis, mucositis, the over reactivity of peripheral sensory neurons, neurodermatitis, and an overactive bladder. Accordingly, the invention also provides compounds, methods, and pharmaceutical compositions for treating conditions in which the selective inhibition of peripheral FAAH (as opposed to CNS FAAH) would be of benefit.

4. 发明公开

EP2744778A2 META-SUBSTITUTED BIPHENYL PERIPHERALLY RESTRICTED FAAH INHIBITORS 有权
标题翻译：外设EINGESCHRÄNKTEFAAH-HEMMER AUS META-SUBSTITUIERTEM BIPHENYL
公开(公告)号：EP2744778A2
公开(公告)日：2014-06-25
申请号：EP12826376.1
申请日：2012-08-17
申请人： The Regents of the University of California , Fondazione Istituto Italiano Di Tecnologia , Università Degli Studi Di Urbino "Carlo Bo" , Università degli Studi di Parma
发明人： PIOMELLI, Daniele , MORENO-SANZ, Guillermo , BANDIERA, Tiziano , MOR, Marco , TARZIA, Giorgio
IPC分类号： C07C233/06 , C07C233/23 , C07D309/14 , A61K31/165 , A61P29/00
CPC分类号： C07C271/56 , C07C269/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D309/14
摘要： The present invention provides methods of making and using peripherally restricted inhibitors of fatty acid amide hydrolase (FAAH). The present invention provides compounds and compositions that suppress FAAH activity and increases anandamide levels outside the central nervous system (CNS). The present invention also sets forth methods for inhibiting FAAH as well as methods for treating conditions such as, but not limited to, pain, inflammation, immune disorders, dermatitis, mucositis, the over reactivity of peripheral sensory neurons, neurodermatitis, and an overactive bladder. Accordingly, the invention also provides compounds, methods, and pharmaceutical compositions for treating conditions in which the selective inhibition of peripheral FAAH (as opposed to CNS FAAH) would be of benefit.
摘要翻译：本发明提供制备和使用外周限制性脂肪酸酰胺水解酶抑制剂（FAAH）的方法。本发明提供抑制FAAH活性并增加中枢神经系统（CNS）外的氨基酰胺水平的化合物和组合物。本发明还提出了用于抑制FAAH的方法以及治疗诸如但不限于疼痛，炎症，免疫病症，皮炎，粘膜炎，周围感觉神经元，神经性皮炎和膀胱过度活动症的过度反应的病症的方法。因此，本发明还提供了用于治疗其中选择性抑制外周FAAH（与CNS FAAH相反））有益的化合物，方法和药物组合物。

5. 发明公开

EP2723798A1 (PER)FLUOROPOLYETHER BLOCK COPOLYMERS 无效
标题翻译：（PER）含氟聚醚嵌段共聚物
公开(公告)号：EP2723798A1
公开(公告)日：2014-04-30
申请号：EP12729557.4
申请日：2012-06-20
申请人： Solvay Specialty Polymers Italy S.p.A.
发明人： TONELLI, Claudio Adolfo Pietro , FONTANA, Simonetta, Antonella , GALIMBERTI, Marco , GAVEZOTTI, Piero
IPC分类号： C08G65/08 , C08G65/18
CPC分类号： C07C271/24 , C07C41/22 , C07C43/126 , C07C55/32 , C07C67/00 , C07C69/708 , C07C269/02 , C08G65/007
摘要： The invention relates to (per)fluoropolyether block copolymers comprising: A) a fluoropolyoxyalkylene segment (chain R
a ) comprising one or more units of formula (CHXCF
2 CF
2 O)- in which X is hydrogen or fluorine; B) a (per)fluoropolyoxyalkylene segment (chain Rf), that is to say a segment comprising recurring units having at least one catenary ether bond and at least one fluorocarbon moiety, said (per)fluoropolyoxyalkylene segment being different from chain R
a and having a molecular weight higher than 400 g/mol. These copolymers are endowed with improves lubricant properties or with improved water and oil-repellence properties.
摘要翻译：本发明涉及（全）氟聚醚嵌段共聚物，其包含：A）包含一个或多个式（CHXCF 2 CF 2 O）单元的氟聚氧化烯链段（链R a） - 其中X是氢或氟; B）（全）氟聚氧化烯链段（链Rf），即包含具有至少一个链状醚键和至少一个氟碳部分的重复单元的链段，所述（全）氟聚氧化烯链段不同于链R a并且具有分子量高于400g / mol。这些共聚物具有改善的润滑性能或改善的防水和防油性能。

6. 发明公开

EP2076488A4 CARBAMOYLATION OF AMINES, THIOPHENOLS, MERCAPTANES AND PHENOLS EMPLOYING ORGANIC AZIDES 有权
标题翻译：胺，苯硫酚，硫醇和酚氨甲酰使用有机叠氮化物
公开(公告)号：EP2076488A4
公开(公告)日：2013-10-09
申请号：EP07823212
申请日：2007-10-25
申请人： METKINEN CHEMISTRY OY
发明人： YAGODKIN ANDREY , AZHAYEV ALEX
IPC分类号： C07C269/02 , C07C263/00 , C07C265/00 , C07C273/18 , C07C333/02 , C07H21/00
CPC分类号： C07C273/1827 , C07B2200/11 , C07C39/00 , C07C247/00 , C07C263/00 , C07C269/02 , C07C273/1818 , C07C321/00 , C07C333/02 , C07H21/00 , C07C265/04 , C07C275/10

7. 发明公开

EP2644632A1 Isocyanate-based prepolymer 审中-公开
标题翻译：异氰酸酯类
公开(公告)号：EP2644632A1
公开(公告)日：2013-10-02
申请号：EP12162092.6
申请日：2012-03-29
申请人： HUNTSMAN INTERNATIONAL LLC
发明人： The designation of the inventor has not yet been filed
IPC分类号： C08G18/10 , C08G18/12 , C08G18/28 , C08G18/32 , C08G18/76 , C08G18/80 , C09J175/04
CPC分类号： C08G18/2815 , C07C269/02 , C07C271/10 , C07C271/28 , C07C275/04 , C07C275/28 , C08G18/10 , C08G18/12 , C08G18/18 , C08G18/1825 , C08G18/282 , C08G18/2825 , C08G18/284 , C08G18/2865 , C08G18/288 , C08G18/34 , C08G18/7614 , C08G18/7664 , C08G18/7671 , C08G2170/20 , C09J175/04 , C09J175/06
摘要： The invention relates to an isocyanate-containing prepolymer obtainable by reacting at least one isocyanate with at least one first compound selected from the group comprising monohydric alcohols, thiols and secondary amines; wherein the ratio of the NCO value of the isocyanate-containing prepolymer, to the OH, SH or NH value, of said monohydric alcohol, thiol or secondary amine respectively ranges from 0.0005 to 1.0000.
摘要翻译：本发明涉及通过使至少一种异氰酸酯与选自一元醇，硫醇和仲胺的至少一种第一化合物反应得到的含异氰酸酯的预聚物; 其中所述一元醇，硫醇或仲胺的含异氰酸酯的预聚物的NCO值与OH，SH或NH值的比率分别为0.0005至1.0000。

8. 发明公开

EP2623191A1 MICROMIXER 无效
标题翻译：微混合器
公开(公告)号：EP2623191A1
公开(公告)日：2013-08-07
申请号：EP11829110.3
申请日：2011-09-27
申请人： DIC Corporation
发明人： ISHIYAMA Fumihiko , HIZAWA Takeshi , NAKAMURA Masayuki
IPC分类号： B01F5/00 , B01F15/06 , B01J19/00 , B81B1/00 , F28F3/00
CPC分类号： B01F13/0066 , B01F15/065 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , C07C269/02 , C08G18/672 , F28D9/0037 , F28F3/08 , C07C271/28
摘要： A micromixer includes a stack unit in which a first plate and a second plate are stacked, the first plate having a first microtubular flow path connected to a fluid supply path through which a first fluid flows, the second plate having a second microtubular flow path through which a second fluid flows and which is connected to a fluid supply path through which the second fluid flows; and a mixing space which is connected to an outlet of the first microtubular flow path and an outlet of the second microtubular flow path and in which the first fluid and the second fluid are mixed. In at least one of the first plate and the second plate, the microtubular flow path has an inlet portion connected to the fluid supply path and constituted by a single flow path, and an outlet portion connected to the mixing space, and a cross-sectional area of the fluid that liquid-tightly flows through the microtubular flow path in the outlet portion is smaller than a cross-sectional area of the fluid that liquid-tightly flows through the single microtubular flow path in the inlet portion.
摘要翻译：微混合器包括堆叠单元，第一板和第二板堆叠在该堆叠单元中，第一板具有连接到第一流体流过的流体供应路径的第一微管流动路径，第二板具有穿过第二微管流动路径其中第二流体流动并且连接到第二流体流过的流体供应路径; 以及混合空间，所述混合空间连接到所述第一微管流动路径的出口和所述第二微管流动路径的出口，并且所述第一流体和所述第二流体混合在所述混合空间中。在第一板和第二板中的至少一个中，微管流路具有与流体供给路径连接的由单一流路构成的入口部和与该混合空间连接的出口部，流过出口部分中的微管流动路径的液体流动区域的面积小于流入入口部分的单个微管流动路径中液体流动的流体的横截面面积。

9. 发明公开

EP2527314A1 Process for preparation of phenyl carbamate derivatives 有权
标题翻译： Verfahren zur Herstellung von Phenylcarbamat-Derivaten
公开(公告)号：EP2527314A1
公开(公告)日：2012-11-28
申请号：EP12169507.6
申请日：2012-05-25
申请人： Bio-Pharm Solutions Co., Ltd.
发明人： Choi, Yong, Moon
IPC分类号： C07C33/46 , C07F7/18 , C07C17/26 , C07C25/02 , C07C29/09 , C07C29/48 , C07C269/02 , C07C269/06 , C07C271/12
CPC分类号： C07F7/188 , C07B2200/07 , C07C17/263 , C07C29/10 , C07C29/48 , C07C41/48 , C07C45/455 , C07C269/02 , C07C269/06 , C07F7/1852 , Y02P20/55 , C07C33/46 , C07C49/255 , C07C43/315 , C07C271/12 , C07C25/02
摘要： The invention relates to a process for preparing of phenyl carbamate derivatives useful in the treatment of CNS (central nervous system) disorders and representing compounds of formula (1):

which process comprises carbamating, by reacting it with chlorosulfonyl isocyanate, a compound of formula (6):

wherein
X each independently is selected from halogens,
n is an integer of 1-5,
* denotes a chiral carbon atom,
R 1 is linear or branched C 1-10 -alkyl, and
the protecting group is one or more selected from trialkyl silyl groups and trialkylaryl silyl groups, wherein each alkyl group independently is linear, branched or cyclic C 1-4 -alkyl groups, and each aryl group independently is C 5-8 -aryl.
Furthermore, the invention relates to certain intermediates useful in the above process and to methods for preparing them.
摘要翻译：本发明涉及一种制备可用于治疗CNS（中枢神经系统）病症并代表式（1）化合物的氨基甲酸苯酯衍生物的方法：该方法包括氨基甲酸酯化，通过与异氰酸氯磺酰酯反应，式 6）：其中X各自独立地选自卤素，n为1-5的整数，*表示手性碳原子，R 1为直链或支链C 1-10 - 烷基，保护基为一个或多个选自三烷基甲硅烷基和三烷基芳基甲硅烷基，其中每个烷基独立地是直链，支链或环状的C 1-4 - 烷基，每个芳基独立地是C 5-8 - 芳基。此外，本发明涉及在上述方法中有用的某些中间体及其制备方法。

10. 发明授权

EP2258678B1 PROCESS FOR PRODUCING URETHANE (METH)ACRYLATE 有权
标题翻译：用于生产聚氨酯（甲基）丙烯酸酯
公开(公告)号：EP2258678B1
公开(公告)日：2012-07-11
申请号：EP09719026.8
申请日：2009-03-12
申请人： DIC Corporation
发明人： ISHIYAMA, Humihiko , HIZAWA, Takeshi , WATANABE, Hideki
IPC分类号： C07C269/02 , C07C271/28
CPC分类号： C07C269/02 , C07C271/28
摘要： Provided is a process by which a urethane (meth)acrylate can be safely produced with satisfactory productivity. The process is a continuous process for urethane (meth)acrylate production which comprises causing a liquid mixture of a compound (A) having a hydroxy group and a (meth)acryloyl group and a compound (B) having an isocyanate group to pass continuously and densely through a tubular microchannel formed in a heat-conducting reaction vessel and reacting the hydroxy group of the compound (A) with the isocyanate group of the compound (B) in the tubular microchannel. The tubular microchannel formed in the reaction vessel has such a space size that the fluid densely passing through the tubular microchannel has a sectional area of 0.1-4.0 mm
2 . In the process, the heat-conducting reaction vessel is heated to 100-250°C, and the reactants are reacted so that the reactant liquid which is passing through the tubular microchannel has a Reynolds number in the range of 0.2-300. After completion of the reaction, a reaction product discharged from the heat-conducting reaction vessel is continuously cooled.

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