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1. 发明公开

EP4371568A2 LIPASE DEGRADATION RESISTANT SURFACTANTS FOR USE IN LARGE MOLECULE THERAPEUTIC FORMULATIONS 审中-公开
公开(公告)号：EP4371568A2
公开(公告)日：2024-05-22
申请号：EP24167511.5
申请日：2019-08-22
申请人： Janssen Biotech, Inc.
发明人： LABRENZ, Steven , STAHL, Patrick
IPC分类号： A61K38/46
CPC分类号： A61K31/25 , A61K38/465 , C12Y301/01001 , A61K47/10 , A61K39/39591
摘要： The present invention is directed to pharmaceutical formulations of therapeutic proteins that comprise one or more polyethoxylated fatty alcohol (PFA) surfactants that are resistant to lipase mediated degradation. The present invention is also directed to methods of reducing aggregate and/or particulate formation in pharmaceutical formulations of therapeutic proteins and methods of maintaining a stable surfactant level in pharmaceutical formulations of therapeutic proteins.

2. 发明公开

EP3224365A1 METHODS OF PRODUCING 6-CARBON MONOMERS FROM 8-CARBON COMPOUNDS 审中-公开
标题翻译：由8-碳化合物制备6-碳单体的方法
公开(公告)号：EP3224365A1
公开(公告)日：2017-10-04
申请号：EP15805044.3
申请日：2015-11-20
申请人： Invista Technologies S.à r.l.
发明人： BOTES, Adriana Leonora , CONRADIE, Alex Van Eck , HADDOUCHE, Ramdane
IPC分类号： C12P7/42 , C12P7/44 , C12P7/64 , C12N9/02
CPC分类号： C12N9/0071 , C07C47/12 , C07C47/19 , C07C49/185 , C07C223/02 , C07C229/08 , C07C229/12 , C12N9/0008 , C12N9/0073 , C12N9/18 , C12N9/20 , C12P7/42 , C12P7/44 , C12P7/6409 , C12Y114/13 , C12Y114/14001 , C12Y301/01001 , C12Y301/01003
摘要： This document describes biochemical pathways for producing 6-hydroxyhexanoic acid using a
monooxygenase to form a 7-hydroxyoctanoate intermediate, which can be converted to 6-hydroxyhexanoate using a polypeptide having
monooxygenase ,
secondary alcohol dehydrogenase , or
esterase activity. 6-hydroxyhexanoic acid can be enzymatically converted to adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine or 1,6-hexanediol. This document also describes recombinant hosts producing 6-hydroxyhexanoic acid as well as adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine and 1,6-hexanediol.
摘要翻译：该文献描述了使用单加氧酶生成6-羟基己酸以形成7-羟基辛酸酯中间体的生物化学途径，其可以使用具有单加氧酶，仲醇脱氢酶或酯酶活性的多肽转化成6-羟基己酸酯。 6-羟基己酸可以酶促转化为己二酸，己内酰胺，6-氨基己酸，六亚甲基二胺或1,6-己二醇。该文件还描述了生产6-羟基己酸以及己二酸，己内酰胺，6-氨基己酸，六亚甲基二胺和1,6-己二醇的重组宿主。

4. 发明公开

EP2949748A1 NOVEL PROCESS FOR ENZYMATIC ACRYLAMIDE REDUCTION IN FOOD PRODUCTS 有权
标题翻译： LEBENSMITTELPRODUKTEN中的VERFAHREN ZUR ENZYMATISCHEN ACRYLAMIDREDUKTION
公开(公告)号：EP2949748A1
公开(公告)日：2015-12-02
申请号：EP15175933.9
申请日：2006-05-29
申请人： DSM IP Assets B.V.
发明人： DE BOER, Lex
IPC分类号： C12N9/18 , C12N9/20 , C12N9/24 , C12N9/26 , C12N9/42 , C12N9/82 , A21D8/04
CPC分类号： A21D8/042 , C12N9/18 , C12N9/20 , C12N9/2402 , C12N9/2414 , C12N9/2437 , C12N9/82 , C12Y301/01001 , C12Y301/01003 , C12Y302/01001 , C12Y302/01004 , C12Y305/01001
摘要： The present invention relates to a novel enzyme composition comprising asparaginase and at least one hydrolysing enzyme, the use of such composition to reduce acrylamide levels in food products and a method to produce food products involving at least one heating step, comprising adding:
a. asparaginase and
b. at least one hydrolyzing enzyme

to an intermediate form of said food product in said production process whereby the asparaginase and at least one hydrolyzing enzyme are added prior to said heating step in an amount that is effective in reducing the level of acrylamide of the food product in comparison to a food product whereto no asparaginase and hydrolyzing enzyme were added.
摘要翻译：本发明涉及包含天冬酰胺酶和至少一种水解酶的新型酶组合物，使用这种组合物来降低食品中的丙烯酰胺水平，以及涉及至少一个加热步骤的生产食品的方法，包括：a。天冬酰胺酶和b。在所述制备方法中将至少一种水解酶转化为所述食品的中间形式，由此在所述加热步骤之前加入天冬酰胺酶和至少一种水解酶，其量可有效降低食品中丙烯酰胺的含量与不添加天冬酰胺酶和水解酶的食品相比较。

5. 发明公开

EP2876157A1 Degradation of polyesters under anaerobic conditions 审中-公开
标题翻译： Abbau von Polywest unter anaeroben Bedingungen
公开(公告)号：EP2876157A1
公开(公告)日：2015-05-27
申请号：EP13194450.6
申请日：2013-11-26
申请人： BASF SE
发明人： The designation of the inventor has not yet been filed
IPC分类号： C12N9/18 , C08J11/10 , C08L67/02
CPC分类号： C08J11/105 , C08J2367/02 , C08J2367/04 , C12N9/18 , C12N9/20 , C12Y301/01001 , C12Y301/01003 , C12Y301/01074 , Y02W30/702
摘要： The present invention relates to the field of degradation of polyesters in connection with, e.g., waste management in biogas producing plants. In particular, the present invention concerns a method for the degradation of a polyester comprising the steps of contacting the polyester with at least one esterase and/or lipase and/or cutinase, preferably comprised in a host cell, wherein the said at least one esterase and/or lipase and/or cutinase is obtainable from a microorganism and incubating the said polyester with the said at least one esterase and/or lipase and/or cutinase for a time and under conditions sufficient to allow for degradation of the polyester. Moreover, the invention encompasses the use of at least one esterase and/or lipase for degrading a polyester, wherein the said at least one esterase and/or lipase is obtainable from a microorganism. Further provided are a polynucleotide encoding an esterase, a vector comprising said polynucleotide, a host cell comprising said polynucleotide or said vector as well as an esterase polypeptide. Moreover, the present invention provides a composition comprising the said esterase polypeptide and a further agent which improves the degradation of degrading a polyester.
摘要翻译：本发明涉及与生物气生产设备中的废物管理有关的聚酯的降解领域。特别地，本发明涉及一种降解聚酯的方法，包括使聚酯与至少一种优选包含在宿主细胞中的酯酶和/或脂肪酶和/或角质酶接触的步骤，其中所述至少一种酯酶和/或脂肪酶和/或角质酶可从微生物获得并将所述聚酯与所述至少一种酯酶和/或脂肪酶和/或角质酶温育一段时间并在足以允许聚酯降解的条件下。此外，本发明包括使用至少一种酯酶和/或脂肪酶降解聚酯，其中所述至少一种酯酶和/或脂肪酶可从微生物获得。还提供了编码酯酶的多核苷酸，包含所述多核苷酸的载体，包含所述多核苷酸或所述载体的宿主细胞以及酯酶多肽。此外，本发明提供了包含所述酯酶多肽和改善聚酯降解降解的其它试剂的组合物。

6. 发明公开

EP3347460A1 MODIFIED ONCOLYTIC VACCINIA VIRUSES EXPRESSING A CYTOKINE AND A CAR- BOXYLESTERASE AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：EP3347460A1
公开(公告)日：2018-07-18
申请号：EP16844635.9
申请日：2016-09-02
申请人： Sillajen, Inc.
发明人： HWANG, Tae Ho , LEE, Nam Hee , CHO, Euna
IPC分类号： C12N7/00 , C07K14/52 , C07K14/565 , C12N9/18 , A61K35/768 , A61K38/19 , A61K38/46 , A61K45/06
CPC分类号： A61K35/768 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/7068 , A61K38/215 , A61K38/465 , A61K45/06 , A61K48/005 , A61P35/00 , C07K14/52 , C07K14/565 , C12N9/18 , C12N2710/24132 , C12N2710/24134 , C12N2710/24141 , C12N2710/24143 , C12Y301/01001 , A61K2300/00
摘要： The present disclosure pertains to a compositions and combinations for simultaneous, separate or sequential use which comprises (a) an oncolytic vaccinia virus that expresses a cytokine and a carboxylesterase enzyme, and, preferably, (b) a cancer co-drug, and to their uses for the treatment of cancer.

7. 发明授权

EP2767586B1 NOVEL PROCESS FOR ENZYMATIC ACRYLAMIDE REDUCTION IN FOOD PRODUCTS 有权
标题翻译：方法中丙烯酰胺含量的食物中酶法羞辱
公开(公告)号：EP2767586B1
公开(公告)日：2017-03-22
申请号：EP14168497.7
申请日：2006-05-29
申请人： DSM IP Assets B.V.
发明人： De Boer, Lex
IPC分类号： C12N9/18 , C12N9/20 , C12N9/24 , C12N9/26 , C12N9/42 , C12N9/82 , A21D8/04
CPC分类号： A21D8/042 , C12N9/18 , C12N9/20 , C12N9/2402 , C12N9/2414 , C12N9/2437 , C12N9/82 , C12Y301/01001 , C12Y301/01003 , C12Y302/01001 , C12Y302/01004 , C12Y305/01001

8. 发明公开

EP2342327A1 MULTI-COMPONENT PERACID GENERATION SYSTEM 有权
标题翻译：多组分PERACID生成系统
公开(公告)号：EP2342327A1
公开(公告)日：2011-07-13
申请号：EP09793240.4
申请日：2009-10-01
申请人： E.I. DUPONT DE NEMOURS AND COMPANY
发明人： DICOSIMO, Robert , BEN-BASSAT, Arie , CAHILL, William R. , DIPIETRO, David George , HANN, Eugenia Costa , PAYNE, Mark S. , REYNOLDS, Richard Alan , ZOLANDZ, Raymond Richard
IPC分类号： C12N9/18 , A61L2/23 , C11D3/00 , C12P7/40
CPC分类号： C12N9/18 , A61L2/183 , A61L2/186 , A61L2/22 , A61L2202/24 , C11D3/06 , C11D3/10 , C11D3/201 , C11D3/2017 , C11D3/2044 , C11D3/2048 , C11D3/2068 , C11D3/2079 , C11D3/2082 , C11D3/2086 , C11D3/2093 , C11D3/221 , C11D3/226 , C11D3/32 , C11D3/361 , C11D3/38636 , C11D3/3947 , C11D17/041 , C12P7/40 , C12Y301/01001 , Y02E50/16
摘要： Disclosed herein are multi-component peroxycarboxylic acid generation systems for enzymatically producing aqueous formulations for peroxycarboxylic acids suitable for use in, e.g., disinfectant and/or bleaching applications. The multi-component peroxycarboxylic acid generation systems comprise at least one carbohydrate esterase family 7 enzyme having perhydrolytic activity.
摘要翻译：本文公开了用于酶产生适用于例如消毒剂和/或漂白应用的过氧羧酸的水性制剂的多组分过氧羧酸生成体系。多组分过氧羧酸生成系统包含至少一种具有过水解活性的碳水化合物酯酶家族7酶。

9. 发明公开

EP2145904A1 Verfahren zur enzymkatalysierten Hydrolyse von Polyacrylsäureestern sowie dafür zu verwendende Esterasen 审中-公开
标题翻译： Verfahren zur enzymemcatalysierten Hydrolyse vonPolyacrylsäureesternsowiedafürzu verwendende Esterasen
公开(公告)号：EP2145904A1
公开(公告)日：2010-01-20
申请号：EP08160774.9
申请日：2008-07-18
申请人： BASF SE
发明人： Hauer, Bernhard, Prof. Dr. , Höffken, Hans Wolfgang, Dr. , Kvarnström Branneby, Cecilia, Dr. , Schwab, Helmut, Prof. , Feichtenhöfer, Sabine, Dr. , Buchebner, Marlene , Pohn, Brigitte
IPC分类号： C08F8/12 , C12N9/18
CPC分类号： C12P7/62 , C08F8/12 , C12N9/16 , C12N9/18 , C12Y301/01001 , C08F120/18
摘要： Die vorliegende Erfindung betrifft ein Verfahren zur enzymkatalysierten Hydrolyse von Polyacrylsäureestern, wobei man wenigstens einen Polyacrylsäureester bereitstellt, den wenigstens einen Polyacrylsäureester mit wenigstens einem Enzym inkubiert, das ausgewählt ist unter auf Esterbindungen einwirkenden Enzymen (EC 3.1), bis die in dem Polyacrylsäureester enthaltenen Estergruppen teilweise oder vollständig hydrolytisch gespalten sind, und gegebenenfalls das dadurch erhaltene modifizierte Polymer isoliert. Die vorliegende Erfindung betrifft weiterhin die dabei verwendeten Enzyme und Mutanten davon, die Enzyme kodierende Nukleinsäuren, die Nukleinsäuren umfassende Vektoren, die Vektoren umfassende Mikroorganismen, die Verwendung der Enzyme, der Vektoren oder der Mikroorganismen zur Durchführung eines Verfahrens zur enzymkatalysierten Hydrolyse von Polyacrylsäureestern. Die vorliegende Anmeldung betrifft weiterhin durch das Verfahren erhältliche polymere Reaktionsprodukte sowie Verfahren zur Herstellung von Esterasen.
摘要翻译：聚丙烯酸酯的酶催化水解方法包括（a）提供至少一种聚丙烯酸酯; （b）将聚丙烯酸酯与作为酯键作用的酶的至少一种酶一起孵育直到聚丙烯酸酯中所含的酯基部分或完全被水解裂解; 和（c）分离改性聚合物。包括以下独立权利要求：（1）功能性酯酶突变体; （2）核酸，（a）编码酯酶突变体，（b）是与（a），（c）互补的核酸，在严格条件下与核酸（a）或（b）杂交，优选地，显示至少80％的序列同一性的这种核酸编码VIII族的酯酶的突变体或编码C型酯酶突变体的代码，该水解聚丙烯酸酯; （3）包含核酸的载体; （4）包含所述至少一种载体的微生物; （5）产生酯酶，包括培养用于表达酯酶的宿主生物体，任选地诱导酯酶的表达并任选地从宿主生物体和/或培养基中分离酯酶; 和（6）由聚丙烯酸酯的酶催化水解获得的聚合物反应产物。

10. 发明授权

EP0872540B1 FLAVORING AGENT 失效
标题翻译： AROMASTOFF
公开(公告)号：EP0872540B1
公开(公告)日：2002-05-22
申请号：EP96916341.9
申请日：1996-06-07
申请人： KYOWA HAKKO KOGYO CO., LTD.
发明人： EGI, Makoto , HAZAMA, Atsuko , OGATA, Nobuo , OHTA, Shigenori
IPC分类号： C11B9/00 , A61K7/46 , A23L1/22 , A23L1/235
CPC分类号： C12Y301/01001 , A23C9/1216 , A23C13/16 , A23L27/2028 , A23L27/24 , A23L27/25 , A23L27/29 , C11B9/0003 , C12Y301/01003
摘要： A process for producing a perfume which comprises treating milk or a processed milk product successively with a lipase and, in the presence of an alcohol, an enzyme originating in an animal which has the activity of forming an ester with the use of an organic acid and an alcohol as the substrates (hereinafter referred to as the ester synthetase). A perfume having a rich fruity fragrance can be produced by using as the ester synthetase the enzyme which has an activity of synthesizing at least 0.1 (U/mg protein) of ethyl butyrate in the enzymatic reaction between 0.5 % (w/w) of ethanol and 2.6 % (w/w) of butyric acid employed as the substrates. The perfume is usable not only in processed milk products but also in processing various foods.

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