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1. 发明授权

EP2535324B1 5-NORBORNENE-2-SPIRO- A-CYCLOALKANONE- A'-SPIRO-2''-5''-NORBORNENE AND METHOD FOR PRODUCING SAME 有权
公开(公告)号：EP2535324B1
公开(公告)日：2018-11-14
申请号：EP11742260.0
申请日：2011-02-09
申请人： JX Nippon Oil & Energy Corporation
发明人： KOMATSU, Shinichi , ADACHI, Michiaki
IPC分类号： C07C49/643 , C07C45/68 , C07C45/80
CPC分类号： C07C49/643 , C07C2603/93
摘要： A 5-norbornene-2-spiro-±-cycloalkanone-±'-spiro-2"-5"-norbornene represented by the following general formula (1) : [in the formula (1), R 1 s, R 2 , and R 3 each independently represent a hydrogen atom or the like, and n represents an integer of 0 to 12].

3. 发明公开

EP2535324A4 5-NORBORNENE-2-SPIRO- A-CYCLOALKANONE- A'-SPIRO-2''-5''-NORBORNENE AND METHOD FOR PRODUCING SAME 审中-公开
标题翻译： 5-NORBORNEN-2-SPIRO-A-CYCLOALKANON-A'-SPIRO-2“'5” - NORBORNEN UND VERFAHREN ZU SEINER HERSTELLUNG
公开(公告)号：EP2535324A4
公开(公告)日：2016-01-20
申请号：EP11742260
申请日：2011-02-09
申请人： JX NIPPON OIL & ENERGY CORP
发明人： KOMATSU SHINICHI , ADACHI MICHIAKI
IPC分类号： C07C49/643 , C07C45/68 , C07C45/80
CPC分类号： C07C49/643 , C07C2603/93
摘要： A 5-norbornene-2-spiro-±-cycloalkanone-±'-spiro-2"-5"-norbornene represented by the following general formula (1) : [in the formula (1), R 1 s, R 2 , and R 3 each independently represent a hydrogen atom or the like, and n represents an integer of 0 to 12].
摘要翻译：由下列通式（1）表示的5-降冰片烯-2-螺 - ± - 环烷酮 - ±' - 螺-2“-5” - 降冰片烯：[式（1）中，R 1，R 2， R 3各自独立地表示氢原子等，n表示0〜12的整数]。

4. 发明公开

EP2535324A1 5-NORBORNENE-2-SPIRO- A-CYCLOALKANONE- A'-SPIRO-2''-5''-NORBORNENE AND METHOD FOR PRODUCING SAME 审中-公开
标题翻译： 5-降冰片烯-2-螺-A-CYCLOALKANON- A'-螺-2 '' - 5 '' - 降冰片烯和用于生产
公开(公告)号：EP2535324A1
公开(公告)日：2012-12-19
申请号：EP11742260.0
申请日：2011-02-09
申请人： JX Nippon Oil & Energy Corporation
发明人： KOMATSU Shinichi , ADACHI Michiaki
IPC分类号： C07C49/643 , C07C45/68 , C07C45/80
CPC分类号： C07C49/643 , C07C2603/93
摘要： A 5-norbornene-2-spiro-α-cycloalkanone-α'-spiro-2"-5"-norbornene represented by the following general formula (1) :

[in the formula (1), R 1 s, R 2 , and R 3 each independently represent a hydrogen atom or the like, and n represents an integer of 0 to 12].

5. 发明公开

EP2891675A1 POLYIMIDE, AND ALICYCLIC TETRACARBOXYLIC ACID DIANHYDRIDE FOR USE IN PRODUCTION OF SAME 审中-公开
标题翻译：聚酰亚胺脂环族四用于本及其制备
公开(公告)号：EP2891675A1
公开(公告)日：2015-07-08
申请号：EP13833028.7
申请日：2013-08-29
申请人： JX Nippon Oil & Energy Corporation
发明人： KOMATSU Shinichi , FUJISHIRO Rieko , FUJIWARA Miki , WATANABE Daisuke , SHIIBASHI Akira , MATSUMOTO Takaya
IPC分类号： C08G73/10 , C07D493/10
CPC分类号： C08G73/1067 , C07C2603/93 , C07D493/10 , C08G73/10 , C08G73/1007 , C08G73/1075 , C08G73/1078
摘要： A polyimide comprising at least one of repeating units represented by the following general formulae (1) and (2) :

[in the formulae (1) and (2), R 1 , R 2 , and R 3 each independently represent a hydrogen atom or the like, R 4 represents an aryl group having 6 to 40 carbon atoms, and n represents an integer of 0 to 12], wherein
a total amount of the repeating units represented by the general formulae (1) and (2) is 90% by mole or more relative to all repeating units.

6. 发明公开

EP0428385A1 Cholesterol ester hydrolase inhibitors 失效
标题翻译：胆固醇酯水解酶抑制剂
公开(公告)号：EP0428385A1
公开(公告)日：1991-05-22
申请号：EP90312382.6
申请日：1990-11-13
申请人： AMERICAN HOME PRODUCTS CORPORATION
发明人： Mewshaw, Richard Eric , Commons, Thomas Joseph , Strike, Donald Peter
IPC分类号： C07C271/40 , C07D295/205 , A61K31/325 , A61K31/33
CPC分类号： C07D295/205 , C07C271/40 , C07C2601/14 , C07C2603/93
摘要： The compounds of the formula:
in which R¹ is alkyl of 4 or more carbon atoms, cycloalkyl, 1-adamantyl, 2-adamantyl, 3-noradamantyl, 3-methyl-1-adamantyl, 1-fluorenyl, 9-fluorenyl, cycloalkylalkyl, phenyl, substituted phenyl, alkyl, alkoxy, halo, nitro, cyano or trifluoromethyl, phenylalkyl or substituted phenylalkyl, where the substituent on the benzene ring is alkyl, alkoxy, halo, nitro, cyano, trifluoromethyl or phenyl; R² is hydrogen, alkyl or R¹ taken with R² and the nitrogen atom to which they are attached form a heterocyclic moiety of the formula:
wherein
in which R⁷ is hydrogen, alkyl, hydroxy, alkanoyloxy, hydroxyalkyl, hydroxycarbonyl, alkoxycarbonyl, phenyl or substituted phenyl, in which the substituent is alkyl, alkoxy, halo, nitro, cyano, haloalkyl, perhaloalkyl or dialkylaminoalkyl; R⁸ is hydrogen or alkyl or R⁷ and R⁸ taken together are polymethylene; R⁹ is hydrogen, alkyl, phenyl or substituted phenyl, in which the substituent is alkyl, alkoxy, halo, nitro, cyano or perhaloalkyl; R¹⁰ is hydrogen, alkyl or gemdialkyl; n is one of the integers 0, 1 or 2; and R³, R⁴, R⁵ and R⁶ are, independently, hydrogen, alkyl, alkoxy, halo, nitro, cyano or perhaloalkyl, alkoxycarbonyl or hydroxycarbonyl; and when X is -NR⁹- or R⁷ is an amino alkyl group, a pharmaceutically acceptable salt thereof; useful as inhibitors of cholesterol ester hydrolase.
摘要翻译：下式化合物：其中R 1是4个或更多个碳原子的烷基，环烷基，1-金刚烷基，2-金刚烷基，3-金刚烷基，3-甲基-1-金刚烷基，1-芴基，9-芴基，环烷基烷基，苯基，取代的苯基，烷基，烷氧基，卤素，硝基，氰基或三氟甲基，苯基烷基或取代的苯基烷基，其中苯环上的取代基为烷基，烷氧基，卤素，硝基，氰基，三氟甲基或苯基; R 2为氢，烷基或R 1与R 2和它们所连接的氮原子一起形成下式的杂环部分：其中R 7为氢，烷基，羟基，烷酰氧基，羟烷基，羟基羰基，烷氧基羰基，苯基或取代的苯基其中取代基是烷基，烷氧基，卤素，硝基，氰基，卤代烷基，全卤代烷基或二烷基氨基烷基; R 7是氢或烷基或R 7和R 7一起是聚亚甲基; R 7是氢，烷基，苯基或取代的苯基，其中取代基是烷基，烷氧基，卤素，硝基，氰基或全卤代烷基; R 10是氢，烷基或偕二烷基; n是整数0,1或2中的一个; 和R 3，R 4，R 5和R 6独立地是氢，烷基，烷氧基，卤素，硝基，氰基或全卤代烷基，烷氧基羰基或羟基羰基; 当X是-NR 8 - 或R 7是氨基烷基时，其药学上可接受的盐; 用作胆固醇酯水解酶的抑制剂。

7. 发明公开

EP3390381A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES 审中-公开
公开(公告)号：EP3390381A1
公开(公告)日：2018-10-24
申请号：EP16809633.7
申请日：2016-11-28
申请人： Merck Patent GmbH
发明人： VOGES, Frank , MUJICA-FERNAUD, Teresa , MONTENEGRO, Elvira , ANÉMIAN, Rémi, Manouk
IPC分类号： C07D333/76 , C07C211/54 , C07D407/12 , C07D307/91 , C09K11/06 , H01L51/50 , C07C211/61
CPC分类号： C07D307/91 , C07C211/61 , C07C2603/18 , C07C2603/93 , C07D333/76 , C07D407/12 , C09K11/06 , H01L51/006 , H01L51/0061 , H01L51/0073 , H01L51/0074 , H01L51/5012 , H01L51/5056 , Y02E10/549
摘要： The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds.

8. 发明公开

EP2891675A4 POLYIMIDE, AND ALICYCLIC TETRACARBOXYLIC ACID DIANHYDRIDE FOR USE IN PRODUCTION OF SAME 审中-公开
标题翻译： POLYIMID UND ALICYCLISCHESTETRACARBONSÄUREDIANHYDRIDZUR VERWENDUNG BEI DER HERSTELLUNG DAVON
公开(公告)号：EP2891675A4
公开(公告)日：2016-04-13
申请号：EP13833028
申请日：2013-08-29
申请人： JX NIPPON OIL & ENERGY CORP
发明人： KOMATSU SHINICHI , FUJISHIRO RIEKO , FUJIWARA MIKI , WATANABE DAISUKE , SHIIBASHI AKIRA , MATSUMOTO TAKAYA
IPC分类号： C08G73/10 , C07D493/10
CPC分类号： C08G73/1067 , C07C2603/93 , C07D493/10 , C08G73/10 , C08G73/1007 , C08G73/1075 , C08G73/1078

9. 发明授权

EP0474767B1 DOPAMINE AGONISTS 失效
标题翻译：多巴胺，AGONISTEN
公开(公告)号：EP0474767B1
公开(公告)日：1996-02-21
申请号：EP90909264.5
申请日：1990-05-22
申请人： ABBOTT LABORATORIES
发明人： SCHOENLEBER, Robert, W. , KEBABIAN, John, W. , MARTIN, Yvonne, C. , DeNINNO, Michael, P. , PERNER, Richard, J. , STOUT, David, M. , HSIAO, Chi-Nung, W. , DiDOMENICO, Stanley, Jr. , DeBERNARDIS, John, F. , BASHA, Fatima, Z. , MEYER, Micheal, D. , DE, Biswanath , EHRLICH, Paul, P. , CAMPBELL, James, R. , MORTON, Howard, E. , LIJEWSKI, Linda, M.
IPC分类号： C07D409/04 , C07D311/74 , C07D221/06 , C07D487/00 , C07D209/56 , C07D211/00 , C07C69/76 , A01N43/32 , A01N43/16 , A01N43/42 , A01N43/62
CPC分类号： C07D207/08 , A61K38/00 , C07C215/64 , C07C217/74 , C07C219/28 , C07C233/18 , C07C237/08 , C07C271/16 , C07C271/44 , C07C309/65 , C07C323/60 , C07C2601/14 , C07C2602/10 , C07C2602/28 , C07C2603/28 , C07C2603/74 , C07C2603/93 , C07D209/62 , C07D221/10 , C07D221/20 , C07D311/76 , C07D311/78 , C07D311/96 , C07D313/08 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D493/10 , C07K5/06026
摘要： Novel compounds are provided of formula (I), or a pharmaceutically acceptable salt, ester or amide thereof, wherein A is O, S, CHR2, CR2 or C when n is 0 and A and R6 taken together form a nitrogen-containing 5-, 6- or 7-membered ring, and n is zero or 1. The dotted lines represent optional double bonds. R1 is selected from hydrogen and a readily cleavable group. R2 is selected from hydrogen, alkyl, substituted alkyl, alkenyl and alkynyl. R3 is selected from alkyl, substituted alkyl, alkenyl, alkynyl, cycloalkyl, carbocyclic aryl, carbocyclic arylalkyl and heterocycle. R4 is selected from hydrogen and alkyl or, taken together with R3 and the carbon atom to which they are attached, forms a spirocycloalkyl ring of from 3 to 7 carbons. R5 is selected from hydrogen, alkyl and substituted alkyl or, taken together with R3 and the carbon atoms to which they are attached forms a cycloalkyl ring of from 5 to 7 carbons. R6 is selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, carbocyclic arylalkyl, alkanoyl of from 1 to 8 carbons, amino acid and dipeptide or, taken together with A when A is C and when n is 0, forms a nitrogen-containing 5-, 6-, or 7-membered ring. R7 is hydrogen or alkyl or, taken together with R6 or R8, forms a nitrogen-containing 5-, 6- or 7-membered ring, provided that when R6 is carbocyclic arylalkyl, R7 is not alkyl. R8 is hydrogen or alkyl or, taken together with R6 or R7, forms a nitrogen-containing 5-, 6-, or 7-membered ring or, taken together with the catechol ring at the 8-position and the carbon atoms to which they are attached, forms a 5-, 6- or 7-membered ring. The compounds of the invention are useful for treating dopamine-related neurological, psychological and cardiovascular disorders as well as in the treatment of cognitive impairment, attention deficit disorder, and substance abuse and other addictive behavior disorders.
摘要翻译：作为选择性多巴胺激动剂的新型化合物可用于治疗以异常多巴胺水平为特征的疾病，例如帕金森病，以及心血管疾病。

10. 发明公开

EP0474767A1 DOPAMINE AGONISTS 失效
标题翻译：多巴胺，AGONISTEN。
公开(公告)号：EP0474767A1
公开(公告)日：1992-03-18
申请号：EP90909264.0
申请日：1990-05-22
申请人： ABBOTT LABORATORIES
发明人： SCHOENLEBER, Robert, W. , KEBABIAN, John, W. , MARTIN, Yvonne, C. , DeNINNO, Michael, P. , PERNER, Richard, J. , STOUT, David, M. , HSIAO, Chi-Nung, W. , DiDOMENICO, Stanley, Jr. , DeBERNARDIS, John, F. , BASHA, Fatima, Z. , MEYER, Micheal, D. , DE, Biswanath , EHRLICH, Paul, P. , CAMPBELL, James, R. , MORTON, Howard, E. , LIJEWSKI, Linda, M.
IPC分类号： A61K31 , A61K38 , A61P9 , A61P25 , C07C41 , C07C215 , C07C217 , C07C219 , C07C233 , C07C237 , C07C271 , C07C309 , C07C323 , C07D207 , C07D209 , C07D221 , C07D311 , C07D313 , C07D405 , C07D407 , C07D493 , C07K5
CPC分类号： C07D207/08 , A61K38/00 , C07C215/64 , C07C217/74 , C07C219/28 , C07C233/18 , C07C237/08 , C07C271/16 , C07C271/44 , C07C309/65 , C07C323/60 , C07C2601/14 , C07C2602/10 , C07C2602/28 , C07C2603/28 , C07C2603/74 , C07C2603/93 , C07D209/62 , C07D221/10 , C07D221/20 , C07D311/76 , C07D311/78 , C07D311/96 , C07D313/08 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D493/10 , C07K5/06026
摘要： L'invention concerne des nouveaux composés de la formule (I), où un sel, un esther ou un amide pharmaceutiquement acceptables de ceux-ci, dans laquelle A représente O, S, CHR2, CR2 ou C lorsque n est égal à 0, et A ainsi que R6 forment ensemble un anneau à 5, 6 ou 7 éléments contenant de l'azote, et n est égal à 0 ou à 1. Les lignes pointillées représentent des doubles liaisons facultatives. R1 est choisi entre l'hydrogène et un groupe facilement clivable. R2 est choisi entre hydrogène, alkyle, alkyle substitué, alcényle et alkynyle. R3 est choisi entre alkyle, alkyle substitué, alcényle, alkynyle, cycloalkyle, aryle carbocyclique, arylalkyle carbocyclique et un hétérocycle. R4 est choisi entre hydrogène et alkyle ou, pris avec R3 et l'atome de carbone auquel ils sont fixés, il forme un anneau spirocycloalkyle comportant 3 à 7 atomes de carbone. R5 est choisi entre hydrogène, alkyle et alkyle substitué ou, pris avec R3 et les atomes de carbone auxquels ils sont fixés, il forme un anneau cycloalkyle comprenant 5 à 7 atomes de carbone. R6 est choisi entre hydrogène, alkyle, acényle, alkynyle, cycloalkyle, arylalkylcarbocyclique, alcanoyle comportant 1 à 8 atomes de carbone, un acide aminé et bipeptide ou, pris ensemble avec A lorsque A représente C et lorsque n est égal à 0, il forme un anneau à 5, 6 ou 7 éléments contenant de l'azote. R7 représente hydrogène ou alkyle ou, pris avec R7 ou R8, il forme un anneau à 5, 6 ou 7 éléments contenant de l'azote, à condition que lorsque R6 représente arylalkyl carbocyclique, R7 ne représente pas alkyle. R8 représente hydrogène ou alkyle ou, pris avec R6 ou R7, il forme un anneau à 5, 6 ou 7 éléments contenant de l'azote, ou pris avec l'anneau de pyrocatéchine à la position 8 et les atomes de carbone auxquels ils sont fixés, il forme un anneau à 5, 6 ou 7 éléments. Les composés de l'invention sont utiles pour traiter les troubles neurologiques, psychologiques et cardiovasculaires liés à la dopamine, ainsi que dans le traitement de l'insuffisance cognitive, des troubles
摘要翻译：作为选择性多巴胺激动剂的新型化合物可用于治疗以异常多巴胺水平为特征的疾病，例如帕金森病，以及心血管疾病。

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