专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP2751072A1 CRYSTALLINE DIACYLHYDRAZINE AND THE USE THEREOF 有权
标题翻译：结晶酰肼及其用途
公开(公告)号：EP2751072A1
公开(公告)日：2014-07-09
申请号：EP12829775.1
申请日：2012-09-07
申请人： Intrexon Corporation
发明人： HORMANN, Robert, E. , SHULMAN, Inna , RODEL, Eva , HILFIKER, Rolf , DEPAUL, Susan, M.
IPC分类号： C07C243/18 , C12N5/10
CPC分类号： C07C243/38 , A01N37/28 , A01N37/40 , A61K31/166 , A61K47/10 , A61K47/12 , A61K47/22 , A61K47/24 , C07B2200/07 , C07B2200/13 , C07C241/02 , C12N2710/10341 , C12N2830/002 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/423 , Y02A50/475 , Y10T428/2982
摘要： The present disclosure provides crystalline polymorphic and amorphous forms of (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 1) or (S)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 2). The present disclosure further provides compositions comprising crystalline polymorphic and amorphous forms of Compound 1 or Compound 2 and an excipient, methods of making crystalline polymorphic or amorphous forms of Compound 1 or Compound 2, and methods of using crystalline polymorphic or amorphous forms of Compound 1 or Compound 2 to regulate gene expression in a cell or in a subject.

2. 发明授权

EP1697310B9 PROCEDE DE SYNTHESE EN CONTINU DE MONOALKYL-HYDRAZINES A GROUPE ALKYLE FONCTIONNALISE 有权
标题翻译： METHOD FOR与官能化的烷基单烷基的连续合成
公开(公告)号：EP1697310B9
公开(公告)日：2008-12-03
申请号：EP04816421.4
申请日：2004-12-17
申请人： ISOCHEM , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Etablissement Public , UNIVERSITE CLAUDE BERNARD - LYON 1
发明人： DELALU, Henri , COLAS-DURICHE, Cécile , BERTHET, Jacques , LEURENT, Philippe
IPC分类号： C07C241/02
CPC分类号： C07C241/02 , C07C243/16
摘要： The invention relates to a method for the continuous synthesis of monoalkyl-hydrazines with a functionalised alkyl group. The inventive method is characterised in that it comprises a step consisting in demixing a solution containing the synthesised monoalkyl-hydrazine, by reacting an anhydrous amine with monochloramine, in an organic phase and an aqueous phase with the addition of anhydrous sodium hydroxide. The invention can be used to obtain perfect selectivity in relation to monoalkyl-hydrazine without the presence of the di- and tri-substituted forms thereof. According to the invention, the starting amine which has not reacted is collected and reused directly without any additional treatment.

3. 发明公开

EP1762564A1 PROCESS FOR PRODUCING HYDRAZONE COMPOUND 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG EINER HYDRAZONVERBINDUNG
公开(公告)号：EP1762564A1
公开(公告)日：2007-03-14
申请号：EP05755876.9
申请日：2005-06-28
申请人： Hodogaya Chemical Co., Ltd.
发明人： TAKASO, Kiyokazu , ABE, Katsumi , TAKESUE, Atsushi
IPC分类号： C07C249/16 , C07C251/86
CPC分类号： C07C249/16 , C07C241/02 , C07C251/86 , C07C243/22
摘要： The present invention provides a process for producing a hydrazone compound represented by the general formula (5):

which comprises a step of condensing a hydrazine compound represented by the general formula (3):

with a carbonyl compound represented by the general formula (4):

without taking the hydrazine compound out of a reactor. According to the invention, the target hydrazone compound can be obtained in high quality and in a high yield without taking the hydrazine compound out of the reactor at all, the hydrazine compound being a reaction intermediate which is structurally unstable and has a fear of influencing safety of workers owing to its toxicity (mutagenicity).
摘要翻译：本发明提供由通式（5）表示的腙化合物的制造方法：其包括将通式（3）表示的肼化合物与通式（4）表示的羰基化合物缩合的工序，：不将肼化合物从反应器中取出。根据本发明，可以高质量，高收率地得到目标腙化合物，而不需要将肼化合物从反应器中取出，肼化合物是结构不稳定并且具有影响安全性的恐惧的反应中间体的工人由于其毒性（致突变性）。

4. 发明公开

EP1721890A1 PROCESS FOR THE ALLYLATION OF N-ACYLHYDRAZONES 审中-公开
标题翻译： VERFAHREN ZUR ALLYLIERUNG VON N-ACYLHYDRAZONEN
公开(公告)号：EP1721890A1
公开(公告)日：2006-11-15
申请号：EP05710632.0
申请日：2005-02-24
申请人： Japan Science and Technology Agency
发明人： KOBAYASHI, Shu , SUGIURA, Masaharu
IPC分类号： C07C241/02 , C07C227/04 , C07C227/18 , C07C229/08 , C07C243/38
CPC分类号： C07C241/02 , C07B53/00 , C07C2601/14 , C07C243/38
摘要： [PROBLEMS] To provide a novel method for the allylation of N-acylhydrazones by which enantioselectively allylated N-acylhydrazines can be efficiently obtained.
[MEANS FOR SOLVING PROBLEMS] A method for the production of enantioselectively allylated N-acylhydrazines represented by the general formula [3]:

[wherein R° is an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, or -COOR 1 (wherein R 1 is a hydrocarbon group) ; R 2 is acyl; R 3 and R 4 are each hydrogen, or one of R 3 and R 4 is hydrogen and the other is a hydrocarbon group; and R 5 and R 6 are each independently hydrogen or a hydrocarbon group], characterized by reacting an N-acylhydrazone represented by the general formula [1]:

[wherein R 0 and R 2 are as defined above] with an allylating agent such as allyltrichlorosilane or crotyltrichlorosilane in the presence of a chiral phosphine oxide.
摘要翻译： [问题]提供N-酰腙的烯丙基化的新方法，通过该方法可以有效地获得对映选择性烯丙化的N-酰肼。用于解决问题的手段制备由通式[3]表示的对映选择性烯丙化N-酰肼的方法：[其中R'是任选取代的烃基，任选取代的杂环基或-COOR 1（其中R 1是烃基）; R 2是酰基; R 3和R 4各自为氢，R 3和R 4中的一个为氢，另一个为烃基; 并且R 5和R 6各自独立地为氢或烃基]，其特征在于使由通式[1]表示的N-酰腙：[其中R 0和R 2如上定义]与烯丙基化试剂如烯丙基三氯硅烷或巴豆基三氯硅烷在手性氧化膦存在下进行。

5. 发明授权

EP1177165B1 PROCESSES FOR PREPARING PESTICIDAL INTERMEDIATES 有权
标题翻译：制备杀虫剂中间体的过程
公开(公告)号：EP1177165B1
公开(公告)日：2004-07-14
申请号：EP00936766.5
申请日：2000-05-11
申请人： Bayer CropScience S.A.
发明人： ANCEL, Jean-Erick , PERRIN-JANET, Gilles , LEROY, Pierre
IPC分类号： C07C209/42 , C07C211/52
CPC分类号： C07C209/42 , C07C241/02 , C07C211/52 , C07C243/22
摘要： The invention relates to processes for the preparation of compounds of formula (I), wherein R?1 and R2¿ each independently represent a halogen atom.
摘要翻译：本发明涉及制备式（I）化合物的方法，其中R 1和R 2各自独立地代表卤素原子。

6. 发明公开

EP1175393A1 PROCESS FOR THE PREPARATION OF PHENYLHYDRAZINES 有权
标题翻译：用于生产苯肼
公开(公告)号：EP1175393A1
公开(公告)日：2002-01-30
申请号：EP00906658.0
申请日：2000-03-03
申请人： SUMITOMO CHEMICAL COMPANY LIMITED
发明人： TANAKA, Kazuyuki , ODA, Yoshiaki
IPC分类号： C07C241/02 , C07C243/22
CPC分类号： C07C241/02 , C07C243/22
摘要： A process for the preparation of a phenylhydrazine or an inorganic acid salt thereof of the formula (1): wherein X is a hydrogen or halogen atom; Y is a halogen atom; and W is a hydrogen atom or -ZR in which Z is an oxygen or sulfur atom, and R is a hydrogen atom, an alkyl group, a haloalkyl group, and so on, by the hydrolysis of a phenylhydrazine derivative of the formula (2): where X, Y and W are the same as defined above, and the Q groups are a hydrogen atom, an ammonium group or an alkali metal atomin the presence of water and an inorganic acid, in which the concentration of the inorganic acid is at least 6 moles per 1 kg of water in a reaction system.

7. 发明公开

EP0959067A1 Verfahren zur Herstellung von Arylhydrazinen 有权
公开(公告)号：EP0959067A1
公开(公告)日：1999-11-24
申请号：EP99108843.6
申请日：1999-05-04
申请人： Clariant GmbH
发明人： Schach, Thomas Dr. , Volk, Heinrich Dr. , Koch, Manfred Dr.
IPC分类号： C07C241/02 , C07C243/22
CPC分类号： C07C241/02 , C07C243/22
摘要： Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von Arylhydrazinen der Formel R 1 R 2 R 3 Ar-NH-NH 2 (I), indem man ein Arylhydrazindisulfonat der Formel
worin R 1 , R 2 , R 3 gleich oder verschieden sind und H, C 1 -C 4 -Alkyl, C 1 -C 4 -Alkoxy, Halogen oder OH bedeuten, Ar Phenyl oder Naphthyl ist, M 1 und M 2 gleich oder verschieden sind und für H, NH 4 , ein Alkalimetall oder ½ Erdalkalimetall stehen und R 1 , R 2 , R 3 und Ar in Formel (I) und (II) dieselbe Bedeutung haben, mit Wasser und einer anorganischen Säure bei 0 bis 100°C in Gegenwart eines inerten organischen Lösungsmittels zu dem entsprechenden Arylhydrazinsatz umsetzt und das Arylhydrazinsalz mit einer Base behandelt.
摘要翻译：芳基肼（I）的制备包括使芳基肼二磺酸盐（II）与水和无机酸在0-100℃的惰性有机溶剂中反应，并用碱处理得到的芳基肼盐。式（I）的芳基肼的制备包括使式（II）的芳基肼二磺酸盐与水和无机酸在0-100℃的惰性有机溶剂中反应，并用碱处理得到的芳基肼盐： 1→-R 3 = H，1-4C烷基，1-4C烷氧基，卤素或OH; Ar =苯基或萘基; M 1，M 2 = H，NH 4或碱（ne earth）金属。

8. 发明公开

EP0790233A3 Method of producing 2-hydrazinonaphtalene compound 失效
标题翻译：一种用于2- hydrazinonaphthalene化合物的制备方法
公开(公告)号：EP0790233A3
公开(公告)日：1998-08-05
申请号：EP97102234
申请日：1997-02-12
申请人： FUJI PHOTO FILM CO LTD
发明人： YAMAKAWA KATSUYOSHI , SATO TADAHISA
IPC分类号： B01J31/02 , C07B61/00 , C07C241/02 , C07C243/22
CPC分类号： C07C241/02 , C07C243/22
摘要： A method of producing a 2-hydrazinonaphthalene compound represented by the following formula (III) which comprises making a 2-naphthol compound represented by the following formula (I) react with a hydrazine compound represented by the following formula (II) in the presence of an acid catalyst: wherein each of R
1 groups represents a substituent, m represents 0 or an integer of from 1 to 7, and R
2 , R
3 and R
4 each represents a substituent, e.g., a hydrogen atom, an alkyl group or an aryl group.

9. 发明公开

EP0790233A2 Method of producing 2-hydrazinonaphtalene compound 失效
标题翻译： Verfahren zur Herstellung von 2-Hydrazinonaphthalin-Verbindungen
公开(公告)号：EP0790233A2
公开(公告)日：1997-08-20
申请号：EP97102234.8
申请日：1997-02-12
申请人： FUJI PHOTO FILM CO., LTD.
发明人： Yamakawa, Katsuyoshi , Sato, Tadahisa
IPC分类号： C07C241/02 , C07C243/22
CPC分类号： C07C241/02 , C07C243/22
摘要： A method of producing a 2-hydrazinonaphthalene compound represented by the following formula (III) which comprises making a 2-naphthol compound represented by the following formula (I) react with a hydrazine compound represented by the following formula (II) in the presence of an acid catalyst:
wherein each of R 1 groups represents a substituent, m represents 0 or an integer of from 1 to 7, and R 2 , R 3 and R 4 each represents a substituent, e.g., a hydrogen atom, an alkyl group or an aryl group.
摘要翻译：由下式（III）表示的2-肼基萘化合物的制造方法，其特征在于，使下式（I）表示的2-萘酚化合物与下述式（II）表示的肼化合物在下述式酸催化剂：其中R 1各自表示取代基，m表示0或1至7的整数，R 2，R 3和R 4各自表示取代基，例如氢原子，烷基或芳基。

10. 发明公开

EP0779274A1 Process for the preparation of tertiary butyl hydrazine hydrohalogenide 失效
标题翻译：维他命Zur Herstellung vontertiär丁基氢化物 - 卤素
公开(公告)号：EP0779274A1
公开(公告)日：1997-06-18
申请号：EP96308699.6
申请日：1996-12-02
申请人： JAPAN HYDRAZINE CO., LTD.
发明人： Hasegawa, Yoichi, Japan Hydrazine Co., Ltd. , Nakagawa, Mineo, Japan Hydrazine Co., Ltd. , Hyoda, Shunji, Japan Hydrazine Co., Ltd. , Fujita, Hiroyuki, Japan Hydrazine Co., Ltd. , Kawada, Takafumi, Japan Hydrazine Co., Ltd.
IPC分类号： C07C241/02
CPC分类号： C07C241/02 , C07C243/14
摘要： A process for the preparation of a tertiary butyl hydrazine hydrohalogenide comprising reacting a hydrazine hydrohalogenide with methyl tertiary butyl ether in the presence of an acid. The product may subsequently to converted to free tertiary butyl hydrazine by reaction with alkali. The process uses starting materials which are cheaply available and provides tertiary butyl hydrazine hydrohalgenide in high yield.
摘要翻译：一种制备叔丁基肼氢卤化物的方法，包括在酸存在下使氢卤酸肼与甲基叔丁基醚反应。随后可通过与碱反应将产物转化为游离的叔丁基肼。该方法使用廉价的起始原料，并以高产率提供叔丁基肼氢卤化物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式