专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP1721890A1 PROCESS FOR THE ALLYLATION OF N-ACYLHYDRAZONES 审中-公开
标题翻译： VERFAHREN ZUR ALLYLIERUNG VON N-ACYLHYDRAZONEN
公开(公告)号：EP1721890A1
公开(公告)日：2006-11-15
申请号：EP05710632.0
申请日：2005-02-24
申请人： Japan Science and Technology Agency
发明人： KOBAYASHI, Shu , SUGIURA, Masaharu
IPC分类号： C07C241/02 , C07C227/04 , C07C227/18 , C07C229/08 , C07C243/38
CPC分类号： C07C241/02 , C07B53/00 , C07C2601/14 , C07C243/38
摘要： [PROBLEMS] To provide a novel method for the allylation of N-acylhydrazones by which enantioselectively allylated N-acylhydrazines can be efficiently obtained.
[MEANS FOR SOLVING PROBLEMS] A method for the production of enantioselectively allylated N-acylhydrazines represented by the general formula [3]:

[wherein R° is an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, or -COOR 1 (wherein R 1 is a hydrocarbon group) ; R 2 is acyl; R 3 and R 4 are each hydrogen, or one of R 3 and R 4 is hydrogen and the other is a hydrocarbon group; and R 5 and R 6 are each independently hydrogen or a hydrocarbon group], characterized by reacting an N-acylhydrazone represented by the general formula [1]:

[wherein R 0 and R 2 are as defined above] with an allylating agent such as allyltrichlorosilane or crotyltrichlorosilane in the presence of a chiral phosphine oxide.
摘要翻译： [问题]提供N-酰腙的烯丙基化的新方法，通过该方法可以有效地获得对映选择性烯丙化的N-酰肼。用于解决问题的手段制备由通式[3]表示的对映选择性烯丙化N-酰肼的方法：[其中R'是任选取代的烃基，任选取代的杂环基或-COOR 1（其中R 1是烃基）; R 2是酰基; R 3和R 4各自为氢，R 3和R 4中的一个为氢，另一个为烃基; 并且R 5和R 6各自独立地为氢或烃基]，其特征在于使由通式[1]表示的N-酰腙：[其中R 0和R 2如上定义]与烯丙基化试剂如烯丙基三氯硅烷或巴豆基三氯硅烷在手性氧化膦存在下进行。

IPRDB

热门服务

关于我们

友情链接

联系方式