专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP1112998A1 AMINE DERIVATIVES 有权
标题翻译：阿明衍生物
公开(公告)号：EP1112998A1
公开(公告)日：2001-07-04
申请号：EP98936729.7
申请日：1998-08-11
申请人： POLA CHEMICAL INDUSTRIES, INC.
发明人： YUASA, Masayuki Pola Chemical Industries, Inc. , KAWAZU, Yukio Pola Chemical Industries, Inc. , SUZUKI, Toshimitsu Pola Chemical Ind., Inc. , MAJIMA, Toshiro Pola Chemical Industries, Inc. , ITOH, Takao Pola Chemical Industries, Inc. , NAKASHIMA, Takuji Pola Chemical Industries, Inc. , NOZAWA, Akira Pola Chemical Industries, Inc. , TAKIMOTO, Hiroyuki Pola Chemical Industries, Inc. , YOKOYAMA, Kouji Pola Chemical Industries, Inc.
IPC分类号： C07C211/27 , C07C211/29 , C07C211/35 , C07C215/28 , C07C225/16 , A61K31/135
CPC分类号： C07C215/28 , C07C17/14 , C07C17/16 , C07C45/004 , C07C45/565 , C07C45/63 , C07C211/21 , C07C211/27 , C07C211/28 , C07C211/29 , C07C211/35 , C07C215/30 , C07C223/02 , C07C225/16 , C07C225/26 , C07C2601/02 , C07C25/02 , C07C49/76 , C07C47/546 , C07C49/80
摘要： The present invention relates to amine derivatives represented by formula (1) or salts thereof.
(wherein R 1 is C1-C4 alkyl; R 2 is

or
R 3 represents C1-C3 alkyl, hydroxylated C1-C5 alkyl, C1-C5 acyl; C2-C5 alkenyl, or a halogen atom; and k, l, and m are each an integer of 1 to 4.)
Exhibiting excellent antifungal effect, these compounds are highly useful as antifungal agents, antifungal compositions, drugs, etc.

2. 发明公开

EP1244624A1 ANTHRACENE DERIVATIVES AS ANTI-CANCER AGENTS 审中-公开
标题翻译： ANTHRACEN-DERIVATE ALS ANTIKREBSMITTEL
公开(公告)号：EP1244624A1
公开(公告)日：2002-10-02
申请号：EP00985582.6
申请日：2000-12-15
申请人： BTG INTERNATIONAL LIMITED
发明人： MINCHER, David, John,Napier University , TURNBULL, Agnes,Napier University , KAY, Graeme, Gillies
IPC分类号： C07D211/46 , A61K31/4409 , C07D295/10 , C07D207/16 , A61P39/00
CPC分类号： C07D207/08 , A61K47/64 , C07C225/26 , C07C237/20 , C07C237/22 , C07C271/22 , C07C2601/14 , C07C2603/24 , C07D207/16 , C07D211/26 , C07D211/46 , C07D243/08 , C07D295/116 , C07D295/13 , C07D295/185
摘要： Use of compound of Formula (I): at least one of R?1, R2, R5 and R6¿ is a group -AB and the others are independently selected from hydrogen, hydroxy, alkoxy or acyloxy, a group -AB a group -amino-(R7)nX-Y wherein R7 is a divalent organic radical and n is 0 or 1; R?3 and R4¿ are independently oxo, hydroxy or hydrogen; the or each A is independently a spacer group of formula -amino-(R7)n-X- which is bonded to the anthracene ring via the amino group nitrogen and to B via -X-, X is independently selected from O, NH and C(O); B is an amino acid residue or a peptide group or isostere thereof and Y is hydrogen or a capping group, or a physiologically acceptable derivative of such compound for the manufacture of a medicament for the treatment of cancers or microbial infections having cells exhibiting topoisomerase I activity characterised in that the group -amino-(R7)n-X- incorporates an optionally substituted heterocyclic ring directly attached to the anthroquinone ring through an amino nitrogen in the heterocycclic ring, or an optionally substituted heterocyclic or carbocyclic ring that is spaced from the anthraquinone ring by no more than an amino nitrogen and up to four carbon atoms.
摘要翻译：式（I）化合物的用途：R 1，R 2，R 5和R 6中的至少一个为-AB基团，其余各自独立地选自氢，羟基，烷氧基或酰氧基，基团-AB a基 - 氨基 - （ R7）nX-Y其中R7是二价有机基团，n是0或1; R3和R4独立地是氧代，羟基或氢; 该或每个A独立地是式 - 氨基 - （R7）nX-的间隔基，其通过氨基氮键合到蒽环，并且通过-X-与B键合，X独立地选自O，NH和C（ O）; B是一种氨基酸残基或其肽基团或等价基因，Y是氢或封端基，或该化合物的生理上可接受的衍生物，用于制备用于治疗具有展现拓扑异构酶I活性的细胞的癌症或微生物感染的药物其特征在于基团 - 氨基 - （R 7）n X-包含通过杂环环中的氨基氮直接连接到蒽醌环的任选取代的杂环，或与蒽醌环间隔开的任选取代的杂环或碳环，所述杂环或碳环与不超过氨基氮和最多四个碳原子。

3. 发明授权

EP1112998B1 AMINE DERIVATIVES 有权
标题翻译：阿明衍生物
公开(公告)号：EP1112998B1
公开(公告)日：2004-12-08
申请号：EP98936729.7
申请日：1998-08-11
申请人： POLA CHEMICAL INDUSTRIES, INC.
发明人： YUASA, Masayuki Pola Chemical Industries, Inc. , KAWAZU, Yukio Pola Chemical Industries, Inc. , SUZUKI, Toshimitsu Pola Chemical Ind., Inc. , MAJIMA, Toshiro Pola Chemical Industries, Inc. , ITOH, Takao Pola Chemical Industries, Inc. , NAKASHIMA, Takuji Pola Chemical Industries, Inc. , NOZAWA, Akira Pola Chemical Industries, Inc. , TAKIMOTO, Hiroyuki Pola Chemical Industries, Inc. , YOKOYAMA, Kouji Pola Chemical Industries, Inc.
IPC分类号： C07C211/27 , C07C211/29 , C07C211/35 , C07C215/28 , C07C225/16 , A61K31/135
CPC分类号： C07C215/28 , C07C17/14 , C07C17/16 , C07C45/004 , C07C45/565 , C07C45/63 , C07C211/21 , C07C211/27 , C07C211/28 , C07C211/29 , C07C211/35 , C07C215/30 , C07C223/02 , C07C225/16 , C07C225/26 , C07C2601/02 , C07C25/02 , C07C49/76 , C07C47/546 , C07C49/80
摘要： Amine derivatives represented by general formula (1) or their salts, wherein R1 represents C¿1-4? alkyl; R?2¿ represents (i), or (ii), (iii); R3 represents C¿1-3? alkyl, hydroxylated C1-5 alkyl, C1-5 acyl, C2-5 alkenyl or halogeno; and k, l and m are each an integer of 1 to 4. Because of being excellent in antifungal effect, these compounds are highly useful as antifungal agents, antifungal compositions, drugs, etc.

4. 发明公开

EP1112998A4 AMINE DERIVATIVES 有权
标题翻译： AMINDERIVATE
公开(公告)号：EP1112998A4
公开(公告)日：2002-09-11
申请号：EP98936729
申请日：1998-08-11
申请人： POLA CHEM IND INC
发明人： YUASA MASAYUKI , KAWAZU YUKIO , SUZUKI TOSHIMITSU , MAJIMA TOSHIRO , ITOH TAKAO , NAKASHIMA TAKUJI , NOZAWA AKIRA , TAKIMOTO HIROYUKI , YOKOYAMA KOUJI
IPC分类号： A61K31/135 , A61P31/04 , A61P31/10 , C07C17/14 , C07C17/16 , C07C25/02 , C07C45/00 , C07C45/56 , C07C45/63 , C07C49/80 , C07C209/08 , C07C211/21 , C07C211/27 , C07C211/28 , C07C211/29 , C07C211/35 , C07C211/37 , C07C213/02 , C07C215/28 , C07C215/30 , C07C221/00 , C07C223/02 , C07C225/16 , C07C225/26
CPC分类号： C07C215/28 , C07C17/14 , C07C17/16 , C07C45/004 , C07C45/565 , C07C45/63 , C07C211/21 , C07C211/27 , C07C211/28 , C07C211/29 , C07C211/35 , C07C215/30 , C07C223/02 , C07C225/16 , C07C225/26 , C07C2601/02 , C07C25/02 , C07C49/76 , C07C47/546 , C07C49/80
摘要： Amine derivatives represented by general formula (1) or their salts, wherein R1 represents C¿1-4? alkyl; R?2¿ represents (i), or (ii), (iii); R3 represents C¿1-3? alkyl, hydroxylated C1-5 alkyl, C1-5 acyl, C2-5 alkenyl or halogeno; and k, l and m are each an integer of 1 to 4. Because of being excellent in antifungal effect, these compounds are highly useful as antifungal agents, antifungal compositions, drugs, etc.
摘要翻译：由通式（1）表示的胺衍生物或其盐，其中R1代表C 1-4 - 烷基; R 2表示（i）或（ii），（iii）; R3代表C1-3 烷基，羟基化的C 1-5烷基，C 1-5酰基，C 2-5烯基或卤代; k，l和m各自为1至4的整数。由于抗真菌作用优异，这些化合物作为抗真菌剂，抗真菌组合物，药物等是非常有用的

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式