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1. 发明公开

EP3319971A1 1-ACETYL,2-ACYLGLYCEROPHOSPHOCHOLINES, POUR LE TRAITEMENT D'UNE INFLAMMATION OU D'UN CANCER INTESTINAL 审中-公开
标题翻译：乙酰基1,2-ACYLGLYCEROPHOSPHOCHOLINES，用于治疗炎症或肠癌
公开(公告)号：EP3319971A1
公开(公告)日：2018-05-16
申请号：EP16747824.7
申请日：2016-07-05
申请人： Institut National des Sciences Appliquées de Lyon , Institut National de la Recherche Agronomique , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Université Claude Bernard Lyon I , Centre National de la Recherche Scientifique (CNRS)
发明人： LAGARDE, Michel , BERNOUD-HUBAC, Nathalie , GUICHARDANT, Michel , PICQ, Madeleine , PLAISANCIE, Pascale
IPC分类号： C07F9/10 , A61K31/661 , A61P35/00 , A61P29/00
CPC分类号： C07F9/10 , A61K31/661
摘要： The invention relates to a compound of formula (I): where X and R are defined in claim i, or a drug or pharmaceutical composition comprising such a compound of formula (I) or any pharmaceutically acceptable hydrates, salts or solvates thereof, in the form of a pure isomer or a mixture of isomers in any proportion, for the use thereof in treating intestinal cancer or intestinal inflammation.

2. 发明公开

EP3309242A1 METHOD FOR PRODUCING ETHER PHOSPHOLIPIDS 审中-公开
标题翻译：生产醚磷脂的方法
公开(公告)号：EP3309242A1
公开(公告)日：2018-04-18
申请号：EP15891816.9
申请日：2015-05-12
申请人： Fujino, Takehiko , Mawatari, Shiro
发明人： Fujino, Takehiko , Mawatari, Shiro
IPC分类号： C11B11/00 , C07F9/10 , C12P9/00
CPC分类号： C11B3/003 , C07F9/10 , C07F9/103 , C11B1/10 , C11B3/006 , C11B7/0058 , C11B11/00 , C12P9/00
摘要： [PROBLEM TO BE SOLVED]
To provide a method for producing ether phospholipids of high purity by an easy process. [SOLUTION] This production method comprises: (A) a step of extracting total lipids from organisms with non-polar organic solvent and branched alcohol mixture; and (B) a step of reacting the total lipids obtained by the step (A) with phospholipase A1 to decompose mixed diacyl-glycerophospholipids. This makes it possible to produce plasmalogen-type glycerophospholipids or ether phospholipids of high purity by an easy process.
摘要翻译：本发明提供一种通过简便的工序制造高纯度的醚磷脂的方法。该方法包括：（A）用非极性有机溶剂和支链醇混合物从生物体中提取总脂质的步骤; 和（B）使由步骤（A）获得的总脂质与磷脂酶A1反应以分解混合的二酰基甘油磷脂的步骤。这使得可以通过简单的方法生产高纯度的缩醛磷脂型甘油磷脂或醚磷脂。

3. 发明公开

EP3178927A1 PROTEIN-STABILIZING AGENT AND PROTEIN-STABILIZING METHOD 有权
标题翻译：蛋白质稳定性蛋白酶
公开(公告)号：EP3178927A1
公开(公告)日：2017-06-14
申请号：EP15830388.3
申请日：2015-08-06
申请人： NOF Corporation
发明人： NAKASHIMA, Fumio , MATSUDA, Masaru , NODA, Tomozumi , YAMADA, Satoshi
IPC分类号： C12N9/96 , C12N9/16 , G01N33/68
CPC分类号： C12N9/96 , C07F9/091 , C07F9/10 , C12N9/16 , C12Y301/03001 , G01N33/68
摘要： There is provided a protein stabilizer containing a compound represented by Formula (1) as an active ingredient. The protein stabilizer is capable of stabilizing a protein in a solution state for a long period of time without affecting an assay system, the protein being not limited to enzymes, labeling substances such as fluorescent substances and chemiluminescent substances, and assay target substances. There is also provided a protein stabilization method containing making the protein coexist with the compound represented by Formula (1) in a water-containing solution.

In Formula (1), X is a hydrogen atom or a methyl group, and n is an integer of 3 to 17.
摘要翻译：提供含有式（1）表示的化合物作为活性成分的蛋白质稳定剂。蛋白质稳定剂能够长时间稳定处于溶液状态的蛋白质，而不影响测定系统，蛋白质不限于酶，标记物质如荧光物质和化学发光物质以及测定目标物质。还提供了一种蛋白质稳定化方法，其包含在含水溶液中使蛋白质与式（1）表示的化合物共存。式（1）中，X为氢原子或甲基，n为3〜17的整数。

4. 发明公开

EP3106465A1 METHOD FOR PREPARING RACEMIC OR OPTICALLY ACTIVE GLYCEROPHOSPHORYL CHOLINE 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG VON RACEMISCHEM ODER OPTISCH AKTIVEM GLYCEROPHOSPHORYLCHOLIN
公开(公告)号：EP3106465A1
公开(公告)日：2016-12-21
申请号：EP15746936.2
申请日：2015-02-05
申请人： Enzytech, Ltd.
发明人： HWANG, Soon Ook , YUN, Dae Myoung
IPC分类号： C07F9/09 , C07C211/63
CPC分类号： C07F9/10 , C07B2200/07 , C07F9/091 , C07F9/3808 , C07F9/65515 , C07F9/65742
摘要： The present invention relates to a method of preparing racemic or optically active D or L-α-glycerophosphorylcholine in large amounts by subjecting choline phosphate or a salt thereof, and racemic or optically highly pure (S) or (R)-3-halo-1,2-propanediol to a substitution reaction in a medium at high temperature in the presence of an inorganic base which increases the activity of the reaction. The method for preparing racemic or optically active D or L-α-glycerophosphorylcholine is cost-effective because of the use of starting materials which are inexpensive compared to those in a conventional method. Moreover, the method is simple and convenient because it is performed via a one-pot reaction without a separate purification process. In addition, it enables a large amount of racemic or optically active D or L-α-glycerophosphorylcholine, or a salt thereof, to be quantitatively produced in a medium without side reactions by using the inorganic base which increases the reaction activity.
摘要翻译：本发明涉及一种通过使磷酸胆碱或其盐和外消旋或光学上高纯度（S）或（R）-3-卤代 - 吡咯烷酮制备外消旋或光学活性的D或L-±甘油磷酰胆碱的方法， 1,2-丙二醇在无机碱存在下在高温下在介质中进行取代反应，这增加了反应的活性。制备外消旋或光学活性的D或L-±甘油磷酰胆碱的方法是成本有效的，因为使用与常规方法相比便宜的原料。此外，该方法简单方便，因为它是通过一锅反应而不进行单独的纯化过程进行的。此外，通过使用增加反应活性的无机碱，能够在无副反应的培养基中定量生成大量的外消旋或光学活性的D或L-±甘油磷酰胆碱或其盐。

5. 发明公开

EP2912044A1 METHOD FOR THE FRACTIONATION OF PHOSPHOLIPIDS FROM PHOSPHOLIPID-CONTAINING MATERIAL 有权
标题翻译： VERFAHREN ZUR FRAKTIONIERUNG VON PHOSPHOLIPIDEN AUS磷脂酰胆碱药物
公开(公告)号：EP2912044A1
公开(公告)日：2015-09-02
申请号：EP13786391.6
申请日：2013-10-24
申请人： Cargill, Incorporated
发明人： BRUECHER, Tobias , DEMEY, Johan , KATTE, Matthias , MOLNAR, Jeff , TIROK, Susanne
IPC分类号： C07F9/10 , B01F17/00 , A23D9/04 , A23L1/30 , C11B1/10
CPC分类号： C07F9/103 , A21D2/32 , A23D9/013 , A23D9/04 , A23J7/00 , A23L33/12 , A23V2002/00 , B01D11/048 , B01D11/0488 , B01D2011/002 , B01F17/0064 , C07F9/10 , C07F9/11 , C11B1/102
摘要： The present invention relates to a counter-current extraction process involving a plurality of mixing and separation stages for fractionating a phospholipid-containing feed material into two or more fractions enriched in one or more phospholipids, comprising (a) contacting the phospholipid-containing starting material under agitation with an extractant comprising an aliphatic alcohol selected from C1 to C3 alcohols; (b) separating the obtained emulsion into a phospholipid-enriched extract from a residual raffinate.
摘要翻译：本发明涉及一种逆流提取方法，其包括用于将含磷脂饲料分馏成富含一种或多种磷脂的两种或多种级分的多个混合和分离阶段，其包括（a）使含磷脂的原料在搅拌下用包含选自C 1至C 3醇的脂族醇的萃取剂; （b）将所得乳液从剩余残液中分离成富含磷脂的提取物。

6. 发明授权

EP2496586B1 SYNTHESE VON PHOSPHORESTERN 有权
标题翻译：合成磷酯的研究
公开(公告)号：EP2496586B1
公开(公告)日：2013-12-18
申请号：EP10763324.0
申请日：2010-10-08
申请人： Merck Patent GmbH
发明人： GLUESENKAMP, Karl-Heinz
IPC分类号： C07F9/10 , C07F9/22
CPC分类号： C07F9/65586 , C07F9/10 , C07F9/65181
摘要： The present invention relates to a process for the preparation of phosphoric esters, and to selected compounds.

7. 发明公开

EP2348864A4 OXIDIZED THIOPHOSPHOLIPID COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：氧化苯硫酚化合物及其用途
公开(公告)号：EP2348864A4
公开(公告)日：2013-07-31
申请号：EP09818874
申请日：2009-10-01
申请人： VASCULAR BIOGENICS LTD
发明人： BREITBART EYAL , KOVALEVSKI-ISHAI ETI , FEIGE EREZ , MENDEL ITZHAK , ZINIUK ZEEV , HALPERIN GIDEON
IPC分类号： A01N57/00 , A61K31/66 , C07F9/10
CPC分类号： C07F9/10

8. 发明公开

EP2604614A3 Oxidized phospholipids 有权
标题翻译：氧化磷脂
公开(公告)号：EP2604614A3
公开(公告)日：2013-07-17
申请号：EP12179533.0
申请日：2005-07-10
申请人： Vascular Biogenics Ltd.
发明人： Halperin, Gideon , Kovalevski-Ishai, Eti
IPC分类号： C07F9/10 , A61K31/66
CPC分类号： C07F9/10
摘要： Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed and the oxidized phospholipids obtained via these routes. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.

9. 发明公开

EP2367532A4 METHOD OF MAKING SMALL LIPOSOMES 审中-公开
标题翻译：用于生产小脂质体
公开(公告)号：EP2367532A4
公开(公告)日：2012-12-12
申请号：EP09836955
申请日：2009-12-17
申请人： ONCOTHYREON INC
发明人： DUPUIT ROBERT A , REILLEY WILLIAM J
IPC分类号： A61K9/127 , C07K14/775
CPC分类号： C07F9/10 , A61K9/1277 , A61K39/00
摘要： Liposomes of constrained particle size are prepared by substantially continuously mixing substantially continuously flowing streams of water, and of an organic solvent contain lipid(s) capable of forming liposomes, and cooling the mixture so liposomes form, the ratio of the flow rate of the stream of water to the flow rate of the stream of organic solvent, and the rate of cooling of said mixture, being controlled so as to obtain a preparation of liposomes such that at least about 90% of the liposomes are of a particle size less than about 200 nm.

10. 发明授权

EP1890706B1 PROCESS FOR THE PREPARATION AND ISOLATION OF PHOSPHATIDES 无效
标题翻译：方法用于生产和磷脂的隔震
公开(公告)号：EP1890706B1
公开(公告)日：2012-02-22
申请号：EP06753893.4
申请日：2006-05-26
申请人： FIDIA FARMACEUTICI S.p.A.
发明人： ZANELLATO, Anna, Maria , PITTARELLO, Mara , GAMBILLARA, Antonio , VACCARO, Susanna
IPC分类号： A61K31/685 , A61K8/14 , A61K47/48 , A23J7/00 , C07F9/10 , C12P9/00
CPC分类号： A23J7/00 , A61K8/14 , A61K8/553 , A61Q19/00 , C07F9/10 , C12P9/00 , C12P13/06
摘要： Process for the preparation of phosphatidylserine of formula CH2OR1 CHOR2 CH2O-P(=O)-OCH2-CH(NH2)-COOH X wherein R1 and R2 independently represent a saturated, mono-unsaturated or polyunsaturated acyl C10-C30, X=OH or OM where M=alkaline or alkaline earth metal, ammonium, alkylammonium (including the inner salt) including the transphosphatidylation reaction between phosphatidylcholine of the general formula CH2OR1 CHOR2 CH2O-P(=O)-OR3 X wherein R1 and R2 and X have the above specified meanings, R3=CH2-CH2- NH2 or CH2-CH2-N+(CH3)3 and Serine in D, L or racemic form catalysed hy the phospholipase D enzyme (PLD), characterised in that said reaction is carried out in a hydroalcoholic medium containing an aliphatic alcohol and in the presence of bivalent metal oxide.

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