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1. 发明公开

EP1019095A1 METHOD FOR THE PREPARATION OF FACIAL METAL TRICARBONYL COMPOUNDS AND THEIR USE IN THE LABELLING OF BIOLOGICALLY ACTIVE SUBSTRATES 失效
标题翻译：用于生产金属面部三羰基化合物及应用进行标记biosubstrates
公开(公告)号：EP1019095A1
公开(公告)日：2000-07-19
申请号：EP98918501.2
申请日：1998-04-21
申请人： Mallinckrodt Inc.
发明人： ALBERTO, Roger , SCHIBLI, Roger , EGLI, André
IPC分类号： A61K51/04 , C01G45/04 , C07F13/00
CPC分类号： A61K51/0476 , A61K51/0478 , C01G45/04 , C01G99/006 , C01P2006/88 , C07B59/004 , C07F13/005
摘要： The invention relates to a method of preparing a compound of the general formula (I): fac-[M(CO)3(OH2)3]+ wherein M is Mn, ?99mTc, 186Re or 188¿Re, by reacting a metal in the permetallate form with carbon monoxide and a reducing agent, characterized in that a mixture of a base, a reducing agent soluble in water but not substantially decomposed by water, and optionally a stabilizing agent is solved in a water containing solvent system containing a solution of the metal in the permanganate, pertechnetate or perrhenate form in the presence of carbon monoxide and optionally in the presence of a halide. The invention further relates to a method of preparing a labeled compound with the aid of the compound of general formula (I), to a method of direct preparation of labeled compounds, to a method of labeling of substrates such as amino acids, peptides, proteins, sugars, small receptor binding molecules and body cells with the aid of compound of general formula (I) and to a kit for the preparation of a labeling composition and a kit for the preparation of a diagnostic of therapeutic pharmaceutical composition.

2. 发明授权

EP1019095B1 METHOD FOR THE PREPARATION OF FACIAL METAL TRICARBONYL COMPOUNDS AND THEIR USE IN THE LABELLING OF BIOLOGICALLY ACTIVE SUBSTRATES 失效
标题翻译：用于生产金属面部三羰基化合物及应用进行标记biosubstrates
公开(公告)号：EP1019095B1
公开(公告)日：2002-01-16
申请号：EP98918501.2
申请日：1998-04-21
申请人： Mallinckrodt Inc.
发明人： ALBERTO, Roger , SCHIBLI, Roger , EGLI, André
IPC分类号： A61K51/04 , C01G45/04 , C07F13/00
CPC分类号： A61K51/0476 , A61K51/0478 , C01G45/04 , C01G99/006 , C01P2006/88 , C07B59/004 , C07F13/005

3. 发明公开

EP0879606A1 Method for the preparation of facial metal tricarbonyl compounds and their use in the labelling of biologically active substrates 失效
标题翻译：一种用于面部金属三羰基化合物的制备方法以及它们用于标记biosubstrates使用过程
公开(公告)号：EP0879606A1
公开(公告)日：1998-11-25
申请号：EP97201232.2
申请日：1997-04-25
申请人： PAUL SCHERRER INSTITUT
发明人： The designation of the inventor has not yet been filed
IPC分类号： A61K51/04 , C01G45/04 , C07F13/00
CPC分类号： A61K51/0476 , A61K51/0478 , C01G45/04 , C01G99/006 , C01P2006/88 , C07B59/004 , C07F13/005
摘要： The invention relates to a method of preparing a compound of the general formula

fac -[M(CO) 3 (OH 2 ) 3 ] + (I)

wherein M is Mn, 99m Tc, 186 Re or 188 Re,
by reacting a metal in the permetallate form with carbon monoxide and a reducing agent, characterized in that a mixture of a base, a reducing agent soluble in water but not substantially decomposed by water, and optionally a stabilizing agent is solved in a water containing solvent system containing a solution of the metal in the permanganate, pertechnetate or perrhenate form in the presence of carbon monoxide and optionally in the presence of a halide. The invention further relates to a method of preparing a labelled compound with the aid of the compound of general formula I, to a method of direct preparation of labeled compounds, to a method of labeling of substrates such as amino acids, peptides, proteins, sugars, small receptor binding molecules and body cells with the aid of compound of general formal I and to a kit for the preparation of a labelling composition and a kit for the preparation of a diagnostic of therapeutic pharmaceutical composition.
摘要翻译：本发明涉及制备通式FAC-AM（CO）的化合物的方法3（OH 2）3U <+> worin M为Mn，<99米> Tc时，<186> Re或<188> RE，通过使在permetallate形式与一氧化碳的金属和还原剂，其特征在于在没有碱，还原剂溶于水，但由水基本上不分解，以及任选的稳定剂是在含有溶剂系统含有水解决的混合物在一氧化碳的存在下和任选在卤化物存在下的金属的高锰酸盐，高锝酸盐或高铼酸盐形式的溶液。本发明进一步涉及一种制备经标记的化合物与通式I的化合物的辅助下，以直接制备标记的化合物的方法，以基片的标记的方法的方法：如氨基酸，肽，蛋白质，糖，小受体结合分子和体细胞与一般正规I的化合物的助剂和一种用于标记组合物的制备和用于诊断治疗药物组合物的制备试剂盒的试剂盒。

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