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1. 发明公开

EP2484628A1 Pièce de micromécanique à faible ruguosité de surface 审中-公开
标题翻译： Mikromechanisches Bauteil mit geringerOberflächenrauheit
公开(公告)号：EP2484628A1
公开(公告)日：2012-08-08
申请号：EP11153243.8
申请日：2011-02-03
申请人： Nivarox-FAR S.A.
发明人： Cusin, Pierre , Richard, David , Dubois, Philippe
IPC分类号： B81C99/00
CPC分类号： B81B1/006 , B81B2201/035 , B81C1/00634 , B81C99/0085 , Y10T74/19949
摘要： L'invention se rapporte à une pièce de micromécanique (11, 21, 31, 41, 51, 61) en un matériau monobloc. Selon l'invention, elle comporte une section élémentaire formée d'au moins deux segments sécants et non alignés afin qu'un desdits au moins deux segments forme la hauteur (e 3 ) de la pièce de micromécanique (11, 21, 31, 41, 51, 61), ladite hauteur étant supérieure à l'épaisseur (e 1 ) de chaque segment.
L'invention concerne également son procédé de fabrication
摘要翻译：该部分具有层（5），其具有由两个正割和非对准段形成的基本部分，使得一个段形成部分的高度（e3），其中高度大于每个段的厚度（e1）。该部件由单件材料制成，例如非晶形碳基材料，并且通过沿该部分的直线或非直线方向突出而形成。其中一个部分形成一个牙齿。该部分的凹部填充有材料，例如金属或金属合金，以硬化和/或装饰部件。微机械部件的制造方法也包含独立的权利要求。

2. 发明公开

EP1896805A4 APPLICATIONS OF LASER-PROCESSED SUBSTRATE FOR MOLECULAR DIAGNOSTICS 审中-公开
标题翻译：分子诊断激光加工基板中的应用
公开(公告)号：EP1896805A4
公开(公告)日：2010-03-31
申请号：EP06784916
申请日：2006-06-14
申请人： EBSTEIN STEVEN M
发明人： EBSTEIN STEVEN M
IPC分类号： G01J3/44 , G01N1/10 , G01N21/01 , G01N21/65
CPC分类号： G01N21/658 , B01L3/5023 , B01L3/5027 , B01L3/5088 , B01L2200/12 , B01L2300/165 , B81B1/006 , B81C1/00206 , B82Y15/00 , B82Y30/00

3. 发明授权

EP2670700B1 Méthode de fabrication d'une pièce de micromécanique complexe et à faible rugosité 有权
标题翻译：一种用于制备复杂的平滑微机械部分的过程
公开(公告)号：EP2670700B1
公开(公告)日：2014-08-20
申请号：EP12700040.4
申请日：2012-01-05
申请人： Nivarox-FAR S.A.
发明人： CUSIN, Pierre , RICHARD, David , DUBOIS, Philippe
IPC分类号： B81C99/00
CPC分类号： B81B1/006 , B81B2201/035 , B81C1/00634 , B81C99/0085 , Y10T74/19949

4. 发明公开

EP1939136A2 High throughput pressure resistant microfluidic devices 审中-公开
标题翻译： Druckfeste mikrofluidische Vorrichtungen mit hohem Durchsatz
公开(公告)号：EP1939136A2
公开(公告)日：2008-07-02
申请号：EP07300760.1
申请日：2007-02-01
申请人： Corning Incorporated
发明人： Hoysan, Steven F , Lobet, Olivier , Woehl, Pierre
IPC分类号： B81B1/00
CPC分类号： B81B1/006 , B01F5/0603 , B01F5/0643 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01J19/0093 , B01J2219/00783 , B01J2219/00824 , B01J2219/00831 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00984 , B01L3/5027 , B81B2201/058
摘要： A micro fluidic device, comprising wall structures formed of a consolidated frit material positioned between and joined to two or more spaced apart substrates formed of a second material with the wall structures defining one or more fluidic passages between the substrates, has at least one passage with a height in a direction generally perpendicular to the substrates of greater than one millimeter, preferably greater than 1.1 mm, or than 1.2 mm, or than as much as 1.5 mm or more, and may have a non- three-dimensionally tortuous portion of the at least one passage, in which the wall structures have an undulating shape such that no length of wall structure greater than 3 centimeters or greater than 2 centimeters, or greater than 1 centimeter, or even no length at all, is without a radius of curvature. A device may also include the undulations without the height.
摘要翻译：微流体装置，包括由固结的玻璃料材料形成的壁结构，所述玻璃料材料定位在由第二材料形成的两个或更多个间隔开的基底之间并且与第二材料形成并且与第二材料形成，壁结构限定在基板之间的一个或多个流体通道，具有至少一个通道，大致垂直于基板的方向的高度大于1毫米，优选大于1.1毫米，或者大于1.2毫米，或多于1.5毫米或更大，并且可能具有非三维曲折的部分至少一个通道，其中壁结构具有起伏的形状，使得不超过3厘米或大于2厘米，或大于1厘米，或甚至没有长度的壁结构的长度不具有曲率半径。装置还可以包括没有高度的起伏。

5. 发明公开

EP1896805A2 APPLICATIONS OF LASER-PROCESSED SUBSTRATE FOR MOLECULAR DIAGNOSTICS 审中-公开
标题翻译：分子诊断激光加工基板中的应用
公开(公告)号：EP1896805A2
公开(公告)日：2008-03-12
申请号：EP06784916.6
申请日：2006-06-14
申请人： Ebstein, Steven M.
发明人： Ebstein, Steven M.
IPC分类号： G01F1/64
CPC分类号： G01N21/658 , B01L3/5023 , B01L3/5027 , B01L3/5088 , B01L2200/12 , B01L2300/165 , B81B1/006 , B81C1/00206 , B82Y15/00 , B82Y30/00
摘要： Surface enhanced Raman Scattering (SERS) and related modalities offer greatly enhanced sensitivity and selectivity for detection of molecular species through the excitation of plasmon modes and their coupling to molecular vibrational modes. One of the chief obstacles to widespread application is the availability of suitable nanostructured materials that exhibit strong enhancement of Raman scattering, are inexpensive to fabricate, and are reproducible. I describe nanostructured surfaces for SERS and other photonic sensing that use semiconductor and metal surfaces fabricated using femtosecond laser processing. A noble metal film (e.g., silver or gold) is evaporated onto the resulting nanostructured surfaces for use as a substrate for SERS . These surfaces are inexpensive to produce and can have their statistical properties precisely tailored by varying the laser processing. Surfaces can be readily micropatterned and both stochastic and self-organized structures can be fabricated. This material has application to a variety of genomic, proteomic, and biosensing applications including label free applications including binding detection. Using this material, monolithic or arrayed substrates can be designed. Substrates for cell culture and microlabs incorporating microf luidics and electrochemical processing can be fabricated as well. Laser processing can be used to form channels in the substrate or a material sandwiched onto it in order to introduce reagents and drive chemical reactions. The substrate can be fabricated so application of an electric potential enables separation of materials by electrophoresis or electro-osmosis.

6. 发明公开

EP1451584A2 HIGH SURFACE AREA SUBSTRATES FOR MICROARRAYS AND METHODS TO MAKE SAME 有权
标题翻译：具有高表面面积的基片躺在微阵列和方法及其制造
公开(公告)号：EP1451584A2
公开(公告)日：2004-09-01
申请号：EP02795610.1
申请日：2002-11-08
申请人： Biomicroarrays, Inc.
发明人： AGRAWAL, Anoop , CRONIN, John, P. , TONAZZI, Juan Carlos Lopez , GOODYEAR, A., Gordon , LECOMPTE, Robert, S. , HOGAN, Michael, E. , GALBRAITH, David, W.
IPC分类号： G01N33/543 , G01N21/00 , G01N31/00 , G01N15/06 , G05B1/00
CPC分类号： B81C1/00206 , B01J19/0046 , B01J2219/00317 , B01J2219/00378 , B01J2219/00387 , B01J2219/00504 , B01J2219/00527 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00628 , B01J2219/00635 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00734 , B01J2219/00743 , B01L3/5085 , B01L3/5088 , B01L2200/12 , B01L2300/0819 , B01L2300/16 , B01L2300/166 , B81B1/006 , B81B2201/0214
摘要： The present invention is directed to a substrate having a plurality of microfeatures that provide a high surface area and are open to provide ready access to fluids and components therein. Methods of making the high surface area substrates are described and include generating microfeatures and/or microstructures on the surface of the substrate.

7. 发明公开

EP3505489A1 SINGLE-PARTICLE CAPTURING APPARATUS, SINGLE-PARTICLE CAPTURING SYSTEM, AND METHOD FOR CAPTURING SINGLE-PARTICLE 审中-公开
公开(公告)号：EP3505489A1
公开(公告)日：2019-07-03
申请号：EP17843275.3
申请日：2017-07-21
申请人： Sony Corporation
发明人： KOJIMA, Kensuke , MASUHARA, Shin , WATANABE, Toshio
IPC分类号： B81B1/00 , C12M1/34
CPC分类号： B01L3/502761 , B01L3/502738 , B01L2200/0668 , B01L2300/08 , B01L2400/06 , B81B1/00 , B81B1/006 , B81B2201/054 , B81B2203/0338 , C12M47/04 , G01N15/1056
摘要： Provided is a single-particle capturing apparatus in which one particle can be captured in one recess portion (16) while preventing another particle from being accumulated on a captured particle.
A single-particle capturing apparatus including:
a flow channel (12) on a substrate (11),
a wave structure with a mountain portion (13) and a valley portion (14) on the flow channel (12), and
a recess portion (16) at a top portion (15) of the mountain portion (13), the recess portion (16) including a draw-in passage (17).

8. 发明公开

EP3188775A1 MICROFLUIDIC DEVICES AND FABRICATION 审中-公开
标题翻译：微流体器件和制造
公开(公告)号：EP3188775A1
公开(公告)日：2017-07-12
申请号：EP15837736.6
申请日：2015-09-03
申请人： NewSouth Innovations Pty Limited , The University of Birmingham
发明人： FARAJI, Zahra , NORDON, Robert Ernest , DAVIES, Graham Jamex , ANTHONY, Carl John , PREWETT, Philip
IPC分类号： A61M5/162 , A61M37/00 , B29C33/38 , B29C43/00 , B01L3/00 , B81C1/00
CPC分类号： A61M37/0015 , A61B5/150984 , A61M2037/003 , A61M2037/0038 , A61M2037/0053 , B01L3/502707 , B01L3/502715 , B01L2200/12 , B01L2300/0672 , B01L2300/0861 , B01L2300/12 , B01L2300/161 , B29C33/3857 , B29C33/3878 , B29C33/40 , B29C33/405 , B29C33/42 , B29C39/003 , B29C39/26 , B29C43/021 , B29C2043/025 , B29C2059/023 , B29K2101/12 , B29K2821/00 , B29L2031/7544 , B29L2031/756 , B81B1/006 , B81B2201/055 , B81B2203/0361 , B81C1/00111
摘要： Methods for mass production of new microfluidic devices are described. The microfluidic devices may include an array of micro-needles with open channels in fluid communication with multiple reservoirs located within a substrate that supports the micro-needles. The micro-needles are configured so as to sufficiently penetrate the skin in order to collect or sample bodily fluids and transfer the fluids to the reservoirs. The micro-needles may also deliver medicaments into or below the skin.
摘要翻译：描述了用于批量生产新的微流体装置的方法。微流体装置可以包括具有开放通道的微针阵列，其与位于支撑微针的基底内的多个储器流体连通。微针被配置为充分穿透皮肤以收集或采样体液并将流体转移到储存器。微针也可以将药物输送到皮肤中或皮肤下。

9. 发明公开

EP1939136A3 High throughput pressure resistant microfluidic devices 审中-公开
标题翻译：具有高吞吐量隔爆型微流体装置
公开(公告)号：EP1939136A3
公开(公告)日：2013-03-27
申请号：EP07300760.1
申请日：2007-02-01
申请人： Corning Incorporated
发明人： Hoysan, Steven F , Lobet, Olivier , Woehl, Pierre
IPC分类号： B81B1/00
CPC分类号： B81B1/006 , B01F5/0603 , B01F5/0643 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01J19/0093 , B01J2219/00783 , B01J2219/00824 , B01J2219/00831 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00984 , B01L3/5027 , B81B2201/058
摘要： A micro fluidic device, comprising wall structures formed of a consolidated frit material positioned between and joined to two or more spaced apart substrates formed of a second material with the wall structures defining one or more fluidic passages between the substrates, has at least one passage with a height in a direction generally perpendicular to the substrates of greater than one millimeter, preferably greater than 1.1 mm, or than 1.2 mm, or than as much as 1.5 mm or more, and may have a non- three-dimensionally tortuous portion of the at least one passage, in which the wall structures have an undulating shape such that no length of wall structure greater than 3 centimeters or greater than 2 centimeters, or greater than 1 centimeter, or even no length at all, is without a radius of curvature. A device may also include the undulations without the height.

10. 发明公开

EP1244495A1 METHOD OF FORMING VERTICAL, HOLLOW NEEDLES WITHIN A SEMICONDUCTOR SUBSTRATE 有权
标题翻译：用于生产垂直空心针从半导体基板上
公开(公告)号：EP1244495A1
公开(公告)日：2002-10-02
申请号：EP01900817.6
申请日：2001-01-02
申请人： The Regents of the University of California , Stoeber, Boris
发明人： LIEPMANN, Dorian
IPC分类号： A61M37/00
CPC分类号： A61M5/32 , B81B1/006
摘要： A method of forming a needle includes the step of anisotropically etching a channel into the back side of a semiconductor substrate. The front side of the semiconductor substrate is then isotropically etched to form a vertical axial surface surrounding the channel. The resultant needle has an elongated body formed of a semiconductor material. The elongated body includes an axial surface positioned between a first end and a second end. The axial surface defines a channel between the first end and the second end. In one embodiment, the first end has a sloping tip with a single circumferential termination point.

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